KEGG ORTHOLOGY: K14970

ORTHOLOGY: K14970

Entry

K14970                      KO

Symbol

MEN1, MNN1

Name

menin

Pathway

map04934

Cushing syndrome

map05202

Transcriptional misregulation in cancer

Disease

H00033

Adrenal carcinoma

H00034

Carcinoid

H00045

Pancreatic neuroendocrine tumor

H00246

Primary hyperparathyroidism

H00247

Multiple endocrine neoplasia syndrome

H01102

Pituitary adenomas

H01431

Cushing syndrome

H01522

Zollinger-Ellison syndrome

H01667

Medulloblastoma

H02049

Bilateral macronodular adrenal hyperplasia

Brite

KEGG Orthology (KO) [BR:ko00001]
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K14970  MEN1, MNN1; menin
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K14970  MEN1, MNN1; menin
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K14970  MEN1, MNN1; menin
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMT complexes
    MLL-HCF complex
     K14970  MEN1, MNN1; menin

Genes

HSA:	4221(MEN1)

PTR:	743979(MEN1)

PPS:	100995950(MEN1)

GGO:	101127917(MEN1)

PON:	100441476(MEN1)

PPYG:

129008289(MEN1)

NLE:	100604705(MEN1)

HMH:	116468969(MEN1)

SSYN:

129464982(MEN1)

MCC:	106995582(MEN1)

MCF:	102134847(MEN1)

MTHB:

126935569

MNI:	105469535(MEN1)

CSAB:

103233027(MEN1)

CATY:

105577475(MEN1)

PANU:

100137471(MEN1)

TGE:	112606904(MEN1)

MLEU:

105549114(MEN1)

RRO:	104662845(MEN1)

RBB:	108542951(MEN1)

TFN:	117079816(MEN1)

PTEH:

111522336(MEN1)

CANG:

105512196(MEN1)

CJC:	100411101(MEN1)

SBQ:	101054218(MEN1)

CIMI:

108310275(MEN1)

ANAN:

105724458(MEN1)

CSYR:

103250522(MEN1)

MMUR:

105878491(MEN1)

LCAT:

123641407(MEN1)

ERUF:

138384635(MEN1)

PCOQ:

105827468(MEN1)

OGA:	100964188(MEN1)

MMU:	17283(Men1)

MCAL:

110285613(Men1)

MPAH:

110320933(Men1)

RNO:	29417(Men1)

MCOC:

116103449(Men1)

ANU:	117716997(Men1)

ASYL:

127691667(Men1)

MUN:	110549349(Men1)

CGE:	100757636(Men1)

MAUA:

101842388(Men1)

PROB:

127228738(Men1)

PLEU:

114680691(Men1)

PMAV:

102927023(Men1)

MORG:

121454520(Men1)

MFOT:

126498237

AAMP:

119813223(Men1)

CNL:	130880073(Men1)

NGI:	103738777(Men1)

HGL:	101709865(Men1)

CPOC:

100722977(Men1)

CCAN:

109687171(Men1)

DORD:

105989266(Men1)

DSP:	122105132(Men1)

DMER:

138806817 138824276

PLOP:

125362356(Men1)

NCAR:

124958610

MMMA:

107135986(Men1)

ITI:	101978613(Men1)

OPI:	101536455(MEN1)

OCZ:	121150237(MEN1)

TUP:	102475076(MEN1)

GVR:	103590603(MEN1)

CFA:	483758(MEN1)

CLUD:

112659404(MEN1)

VVP:	112924296(MEN1)

VLG:	121472292(MEN1)

NPO:	129503198(MEN1)

AML:	100472417(MEN1)

UMR:

121104790

UAH:	113244156(MEN1)

UAR:	123778292(MEN1)

ELK:

111150075

LLV:

125078650

MPUF:

101676080(MEN1)

MNP:	132019251(MEN1)

MLK:	131814967(MEN1)

NVS:	122913075(MEN1)

ORO:	101368194(MEN1)

EJU:	114220417(MEN1)

ZCA:	113915311(MEN1)

MLX:	118016012(MEN1)

MANO:

123856996(MEN1)

NSU:	110576349(MEN1)

LWW:	102737587(MEN1)

FCA:	692344(MEN1)

PYU:	121023668(MEN1)

PCOO:

112851918(MEN1)

PBG:	122483977(MEN1)

PVIV:

125147213(MEN1)

LRUF:

124506389

LGF:	123601911(MEN1)

AJU:

113595438

PTG:	102958009(MEN1)

PPAD:

109246686(MEN1)

PUC:

125931380

PLEZ:

122200570(MEN1)

HHV:	120240186(MEN1)

CCRU:

144227941(MEN1)

BTA:	539431(MEN1)

BOM:	102272654(MEN1)

BIU:	109554071(MEN1) 109554124

BBUB:

102415673(MEN1)

BKE:	129652365(MEN1)

BBIS:

104987199(MEN1)

CHX:	102184226(MEN1)

OAS:	101118395(MEN1)

BTAX:

128068624(MEN1)

CSUM:

138082821(MEN1)

ODA:	120874646(MEN1)

CCAD:

122430782(MEN1)

MREE:

136169702(MEN1)

OVR:	110136229(MEN1)

MBEZ:

129548801(MEN1)

SSC:	100523533(MEN1)

CFR:	102516114(MEN1)

CBAI:

105070650(MEN1)

CDK:	105101561(MEN1)

VPC:	102543531(MEN1)

BACU:

102998963(MEN1)

BMUS:

118899137(MEN1)

LVE:	103076298(MEN1)

OOR:	101280709(MEN1)

LALB:

132525674(MEN1)

GMF:	115840576(MEN1)

DDP:	132430045(MEN1)

DLE:	111183792(MEN1)

PCAD:

102993679(MEN1)

PSIU:

116757627(MEN1)

PPHC:

136127646(MEN1)

NASI:

112402408(MEN1)

ECB:	100050500(MEN1)

EPZ:	103559130(MEN1)

EAI:	106833613(MEN1)

MYB:	102259887(MEN1)

MYD:	102752874(MEN1)

MMYO:

118665345(MEN1)

MLF:	102441685(MEN1)

MDT:	132241459(MEN1)

MYUM:

139018718(MEN1)

PKL:	118714967(MEN1)

EFUS:

103302058(MEN1)

MNA:	107533650(MEN1)

DRO:	112317094(MEN1)

SHON:

118991691(MEN1)

AJM:	119050286(MEN1)

PDIC:

114500001(MEN1)

PHAS:

123829580(MEN1)

MMF:	118627987(MEN1)

PPAM:

129068596(MEN1)

HAI:	109384103(MEN1)

RFQ:	117030991(MEN1)

PALE:

102881190(MEN1)

PGIG:

120600710(MEN1)

PVP:	105297861(MEN1)

RAY:	107517161(MEN1)

MJV:	108396375(MEN1)

TOD:	119250009(MEN1)

SARA:

101554080(MEN1)

SFUM:

130039739(MEN1)

SETR:

126019024(MEN1)

LAV:	100666867(MEN1)

TMU:

101346513

DNM:	101434306(MEN1)

GAS:	123256484(MEN1)

SHR:	105750976(MEN1)

AFZ:

127540088

PCW:	110195442(MEN1)

TVP:	118855517(MEN1)

PBRV:

138144832(MEN1)

MLAO:

141518813(MEN1)

OAA:	103169404(MEN1)

TACU:

119943356(MEN1)

PMOA:

120497219(MEN1)

ATRC:

139586324(MEN1)

PHI:	102103039(MEN1)

PMAJ:

109022439(MEN1)

CCW:	120412307(MEN1)

ACOE:

138100408

ETL:	114070360(MEN1)

ZLE:	135460306(MEN1)

SVG:	106863851(MEN1)

MMEA:

130587430(MEN1)

CCIC:

134055532(MEN1)

FPG:	106112054(MEN1)

BBUT:

142045590(MEN1)

CBOR:

142077643(MEN1)

CBOY:

140660205(MEN1)

CNIC:

136002890(MEN1)

CUCA:

104058039(MEN1)

ASN:	102372086(MEN1)

AMJ:	102569660(MEN1)

PSS:	102444159(MEN1)

CIZ:	142019098(MEN1)

CMY:	102938582(MEN1)

CCAY:

125640570(MEN1)

LKP:	140914367(MEN1)

NDS:	141991467(MEN1)

DCC:	119859439(MEN1)

CPIC:

101950064(MEN1)

TST:	117879879(MEN1)

EOB:	135881270(MEN1)

CABI:

116835451(MEN1)

MRV:	120409498(MEN1)

ACS:	100559104(men1)

ASAO:

132764357(MEN1)

PVT:	110089978(MEN1)

SUND:

121916224(MEN1)

PBI:	103066776(MEN1)

PMUR:

107293226(MEN1)

CTIG:

120318531(MEN1)

TSR:	106546905(MEN1)

PGUT:

117669694(MEN1)

PCAE:

139321617(MEN1)

APRI:

131186827(MEN1)

PTEX:

113447489(MEN1)

NSS:	113424369(MEN1)

VKO:	123032553(MEN1)

PMUA:

114586634(MEN1)

PRAF:

128403955(MEN1)

ZVI:	118075767(MEN1)

HCG:	128337354(MEN1)

GJA:	107121073(MEN1)

STOW:

125442787(MEN1)

EMC:	129330975(MEN1)

XLA:	100158320(men1.L)

XTR:	549115(men1)

NPR:	108795772(MEN1)

RTEM:

120917466(MEN1)

ACAT:

141112344(MEN1)

PADS:

140338513(MEN1)

BBUF:

120980684(MEN1)

BGAR:

122920915(MEN1)

DTC:	141092367(MEN1)

PWL:	138259981(MEN1)

MUO:	115479687(MEN1)

GSH:	117366194(MEN1)

DRE:	30130(men1)

SRX:	107708606 107731945

SANH:

107660721 107679288

SGH:	107574673 107597878(men1)

CCAR:

109069113 109091724

CAUA:

113049116 113071381 113105501

CGIB:

127961505 128017288

PTET:

122349675(men1)

LROH:

127168918(men1)

GRF:	141332212(men1)

OMC:	131543614(men1)

PPRM:

120469625(men1) 120469777

RKG:	130091378(men1)

MAMB:

125265442(men1)

CIDE:

127515207

CERY:

137030560(men1)

MASI:

127415122 127443183

TROS:

130557928(men1)

MANU:

129438121(men1)

PDAB:

135750784(men1)

IPU:

108268124

IFU:	128609927(men1)

PHYP:

113540615(men1)

SMEO:

124387874(men1)

TFD:	113657582(men1)

TVC:	132848504(men1)

CGAR:

128529516(men1)

NGRA:

132894325(men1)

TRN:	134312260(men1)

AMEX:

103032489(men1)

CMAO:

118826692(men1)

EEE:	113581812(men1)

CHAR:

105903139(men1)

SPIL:

134059465(men1)

ASAD:

121690251(men1)

TRU:	101075305(men1)

TFS:	130522295(men1)

TNG:	GSTEN00008454G001

LCO:	104931451(men1)

NCC:

104964257

TBEN:

117482706(men1)

CGOB:

115023901(men1)

PGEO:

117463934(men1)

GACU:

117551804(men1)

EMAC:

134876270(men1)

ELY:	117246448(men1)

EFO:	125884217(men1)

PLEP:

121962072(men1)

SLUC:

116043547(men1)

ECRA:

117934773(men1)

ESP:	116707291(men1)

PFLV:

114546240(men1)

GAT:	120821319(men1)

PPUG:

119223346(men1)

AFB:	129093328(men1)

CLUM:

117747903(men1)

PSWI:

130211955(men1)

CANA:

137792300(men1)

CVE:	137874752(men1)

MSAM:

119913429(men1)

SCHU:

122870770(men1)

EARM:

139305881(men1)

CUD:	121504748(men1)

SPUL:

138600794(men1)

LMIX:

132958308(men1)

HTC:	141784389(men1)

ALAT:

119027662(men1)

ASTR:

137590833(men1)

PKLU:

139223043(men1)

MZE:	101472638(men1)

ONL:	100697108(men1)

OAU:	116321162(men1)

OLA:	101155467(men1)

OML:	112155715(men1)

CSAI:

133420118(men1)

XMA:	102236011(men1)

XCO:	114157510(men1)

XHE:	116732771(men1)

PRET:

103480117(men1)

PFOR:

103148881(men1)

PLAI:

106956284(men1)

PMEI:

106918375(men1)

GAF:	122820438(men1)

PPRL:

129378394(men1)

CVG:	107102359(men1)

CTUL:

119794822(men1)

GMU:	124880078(men1)

NFU:	107384721(men1)

KMR:	108242247(men1)

ALIM:

106526853(men1)

NWH:	119415126(men1)

AOCE:

111587498(men1)

EJA:	138203969(men1)

BFRE:

138626411(men1)

MCEP:

125017010(men1)

CSEM:

103391704

POV:	109637700(men1)

SSEN:

122767179(men1)

SSOE:

131457204(men1)

HHIP:

117779433(men1)

HSP:	118102684(men1)

PPLT:

128430099(men1)

SMAU:

118284993(men1)

LCF:

108879711

SDU:	111223605(men1)

SLAL:

111668007(men1)

XGL:	120797559(men1)

HCQ:	109508447(men1)

SSCV:

125983817(men1)

SBIA:

133494910(men1)

PEE:	133397668(men1)

PTAO:

133472448(men1)

BPEC:

110170768(men1)

ENY:	140371497(men1)

MALB:

109957227(men1)

BSPL:

114845215(men1)

SJO:	128384316(men1)

SSCO:

134005724(men1)

TTY:	137174406(men1)

GMH:	115529640(men1)

SASA:

106577528 106608591

STRU:

115194141 115198152

OTW:	112214791(men1) 112260072

OMY:	110500710 110531851

OGO:	124008205 124014037

ONE:	115133641 115138176

OKI:	109897108 109906591

OKE:	118368658 118391891(men1)

OMM:	135510708 135516410

OCLA:

139379470 139416177

SALP:

111955206 111960230

SNH:	120030441 120049587(men1)

SFON:

129835093 129865853(men1)

CCLU:

121554305 121571107

ELS:	105020713(men1)

OEP:	134009889(men1)

SFM:	108929688(men1)

PKI:	111858526(men1)

AANG:

118223720(men1)

AROT:

135249972(men1)

CCOG:

133124282(men1)

PSPA:

121308051(men1)

ARUT:

117398703 117967838

PSEX:

120539336(men1)

LCM:	102348464(MEN1)

CPLA:

122543803(men1)

CPUN:

140458749(men1) 140473161

HOC:	132836112(men1)

LERI:

129715845(men1)

HAKA:

140717644(men1)

PMRN:

116956050(MEN1)

LRJ:	133357910(MEN1)

BFO:

BBEL:

CIN:

SCLV:

CLEP:

SPU:	115929642 589807

LPIC:

LVG:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

SKO:

PFLL:

DME:	Dmel_CG13778(Mnn1)

DER:

6541494

DSE:

6611494

DSI:	Dsimw501_GD23452(Dsim_GD23452)

DYA:	Dyak_GE14373

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI14382

DAZ:

108609462

DNV:

115562723

DHE:

111595934

DVI:	6635643(Mnn1)

CCAT:

BOD:

RZE:

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135950963(Mnn1)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

ANIL:

AALI:

ADAR:

ACOS:

AAG:

AALB:

109421019 109428855 115264812

ASUA:

134216941

CQU:	CpipJ_CPIJ000921

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:	108727585(Mnn1)

CCOA:

TCZ:

TSEP:

PBAR:

VEM:

COBS:

139104302(Mnn1)

TLN:	139820810(Mnn1)

TAME:

143905017(Mnn1)

HST:

DQU:

CFO:

FEX:

PMEC:

138942448(Mnn1)

LHU:	105677685(Mnn1)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

CTYP:

141529648(Mnn1)

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124215078(Mnn1)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138132413(Mnn1)

DPA:

109544723

ESIM:

136412820(Mnn1)

EFOR:

136343642(Mnn1)

SOY:

115878382

RFG:	143204576(Mnn1)

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_208567

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137932737(Mnn1)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

ECLR:

140749906(Mnn1)

PXY:

PGW:

LGLY:

CSTB:

CFUM:

141431901(Mnn1)

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

LDA:	142326997(Mnn1)

HVI:

124356928

MQU:	128985355 128985969

PHU:	Phum_PHUM350950

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138706425(Mnn1)

SGRE:

126277964

BROR:

134538427

IEL:

124157660

HAMR:

139700163(Mnn1)

FCD:

110848694

DPX:	DAPPUDRAFT_303383 DAPPUDRAFT_63144

DMK:

116918239

AFRA:

136039250

PVM:	113809563(Mnn1)

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123759041(Mnn1)

CQD:	128689333(Mnn1)

PTRU:

SPRM:

ESN:

MNZ:

MRJ:	136828445(Mnn1)

PORN:

139764473(Mnn1)

HAZT:

108664439

OOT:	143027621(Mnn1)

EAF:	111698503 111698522

TCF:

131890122

PPOI:

119099959 119099972

DSV:

119464503

DALB:

135912113(Mnn1)

RSAN:

RMP:

VDE:

VJA:

GOE:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136980359(Mnn1)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

HRO:	HELRODRAFT_191256 HELRODRAFT_193799

LGI:	LOTGIDRAFT_121605

PVUL:

PCAN:

LSAX:

BARL:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

YBA:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_163760

OVI:	T265_11583

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

HSY:

CCLM:

CVR:	CHLNCDRAFT_142596

APRO:

F751_6495

FCY:	FRACYDRAFT_192277

TPS:	THAPSDRAFT_263558

» show all

Reference

PMID:19075677

Authors

Wu X, Hua X

Title

Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective.

Journal

Curr Mol Med 8:805-15 (2008)
DOI:10.2174/156652408786733702

Reference

PMID:11274402

Authors

Kaji H, Canaff L, Lebrun JJ, Goltzman D, Hendy GN

Title

Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling.

Journal

Proc Natl Acad Sci U S A 98:3837-42 (2001)
DOI:10.1073/pnas.061358098

Sequence

[hsa:4221] [rno:29417]

LinkDB

DBGET integrated database retrieval system