KEGG   ORTHOLOGY: K14976
Entry
K14976            Tight     KO                                     
Symbol
T6ODM
Name
thebaine 6-O-demethylase [EC:1.14.11.31]
Pathway
map00950  Isoquinoline alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00944  Morphine biosynthesis, (S)-reticuline => morphine
Reaction
R03698  oripavine,2-oxoglutarate:oxygen oxidoreductase (6-O-demethylating)
R05126  thebaine,2-oxoglutarate:oxygen oxidoreductase (6-O-demethylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K14976  T6ODM; thebaine 6-O-demethylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.31  thebaine 6-O-demethylase
     K14976  T6ODM; thebaine 6-O-demethylase
Other DBs
GO: 0102802
Genes
PSOM: 113272570 113347785 113347786 113347787 113347789 113347790
AG: ADD85329(T6ODM)
Reference
PMID:20228795
  Authors
Hagel JM, Facchini PJ
  Title
Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy.
  Journal
Nat Chem Biol 6:273-5 (2010)
DOI:10.1038/nchembio.317
  Sequence
[ag:ADD85329]
LinkDB

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