KEGG   ORTHOLOGY: K15515
Entry
K15515                      KO                                     
Symbol
sauS
Name
sulfoacetaldehyde dehydrogenase [EC:1.2.1.81]
Pathway
map00430  Taurine and hypotaurine metabolism
Reaction
R09557  2-sulfoacetaldehyde:NADP+ oxidoreductase (CoA-acetylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00430 Taurine and hypotaurine metabolism
    K15515  sauS; sulfoacetaldehyde dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.81  sulfoacetaldehyde dehydrogenase (acylating)
     K15515  sauS; sulfoacetaldehyde dehydrogenase
Other DBs
COG: COG1012
Genes
BGJ: AWC36_05910
BNG: EH206_07455
BIZ: HC231_15885
SLIG: GTU79_10145
SHAI: LMH63_05605
GAI: IMCC3135_23095(sauS)
HPIS: P1P91_06520
PAUR: FGL86_09035
MRZ: KDW95_20215
NJP: NEJAP_1576(sauS)
SVA: SVA_0813
TSN: W908_04745
RPJ: N234_15545
REH: H16_A2747(h16_A2747)
CNC: CNE_1c26440(sucD2)
CUH: BJN34_14795
REU: Reut_A0867
COX: E0W60_22990
CUK: KB879_25670
BYI: BYI23_C010330
BUE: BRPE67_CCDS00590
BXE: Bxe_B0701
BXB: DR64_6032
BPH: Bphy_6218
BPY: Bphyt_4382
BFN: OI25_4376
PARA: BTO02_11375
PARB: CJU94_25795
PEW: KZJ38_11905
PBRY: NDK50_10310
PPAI: E1956_27740
PANI: DCO16_07820
PYT: PKF023_05270
PPK: U875_18455
PPNO: DA70_10965
PPNM: LV28_20085
PRB: X636_15655
PSPU: NA29_22760
PTX: ABW99_12080
PFG: AB870_16590
PCOM: NTU39_06470
CABA: SBC2_17240(sauS)
BUO: BRPE64_CCDS00820
CABK: NK8_76920
TVL: FAZ95_11780
BOH: AKI39_13675
AKA: TKWG_02680
RHF: EUB48_15050
VEI: Veis_4280
VAP: Vapar_3831
VPE: Varpa_4409
VPD: VAPA_1c39430(sucD1)
VAZ: H7F35_02270
DIH: G7047_16580
DRG: H9K76_05380
GLC: JQN73_01135
AZA: AZKH_2613(gabD)
RPE: RPE_3204
OCA: OCAR_6738
OCG: OCA5_c13340(sucD1)
OCO: OCA4_c13340(sucD1)
PCAX: AFIC_002211
MDI: METDI0777
MCH: Mchl_4208
META: Y590_17370
METD: C0214_07130
METS: DK389_25455 DK389_30405
RVA: Rvan_3429
RLAC: QMO75_16340
FIL: BN1229_v1_2532(sauS)
FIY: BN1229_v1_3384(sauS)
PSIN: CAK95_09385
RUA: D1823_07690
RUT: FIU92_17625(sauS)
RCON: K3740_08305
RUY: NOR97_00110
JAN: Jann_1566
RDE: RD1_2918(adhE)
RLI: RLO149_c015190
RPON: G3256_00045
RFU: ROLI_009600(sauS)
LMD: METH_04545
LEJ: ETW24_05665
LEV: ETW23_14030
SUAM: BOO69_18705
SULZ: C1J03_10940
TOM: BWR18_19590
RMM: ROSMUCSMR3_02418(sauS)
ROK: RAK1035_0765
ROH: FIU89_14815(sauS)
PDE: Pden_1013
PYE: A6J80_14110
PAMN: pAMV3p0587(sauS)
PSEW: JHW44_08720
PVER: E3U25_15825
PFEO: E3U26_04465
PTP: RCA23_c28350(sucD2)
AMYL: QBD29_03035
BOSG: GKR98_14020
ABS: AZOBR_p480045
ABQ: ABAZ39_30000
ABF: AMK58_25725
AZT: TSH58p_19695
AARE: D3093_29155
BACA: FAY30_11795
NMK: CHR53_14040
DSY: DSY0244
DHD: Dhaf_0190
DRU: Desru_3835
MSIM: MSIM_08960
CCAW: CCANI_02880(sauS)
CFEU: CFELI_05790(sauS)
SVIO: HWN34_17615
KBU: Q4V64_44220
SGRG: L0C25_12205
PHH: AFB00_27935
HALJ: G9465_20580
HLA: Hlac_0665
HEZZ: EO776_04580
HALQ: Hrr1229_003530
HSS: J7656_12245
HSAI: HPS36_02610
HAZZ: KI388_02185
HXA: Halxa_2456
NARA: QQ977_05455 QQ977_09450
 » show all
Reference
PMID:20693281
  Authors
Weinitschke S, Hollemeyer K, Kusian B, Bowien B, Smits TH, Cook AM
  Title
Sulfoacetate is degraded via a novel pathway involving sulfoacetyl-CoA and sulfoacetaldehyde in Cupriavidus necator H16.
  Journal
J Biol Chem 285:35249-54 (2010)
DOI:10.1074/jbc.M110.127043
  Sequence
[reh:H16_A2747]
LinkDB

KEGG   ENZYME: 1.2.1.81
Entry
EC 1.2.1.81                 Enzyme                                 
Name
sulfoacetaldehyde dehydrogenase (acylating);
SauS
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
2-sulfoacetaldehyde:NADP+ oxidoreductase (CoA-acetylating)
Reaction(IUBMB)
2-sulfoacetaldehyde + CoA + NADP+ = sulfoacetyl-CoA + NADPH + H+ [RN:R09557]
Reaction(KEGG)
R09557
Substrate
2-sulfoacetaldehyde [CPD:C00593];
CoA [CPD:C00010];
NADP+ [CPD:C00006]
Product
sulfoacetyl-CoA [CPD:C19685];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme is involved in degradation of sulfoacetate. In this pathway the reaction is catalysed in the reverse direction. The enzyme is specific for sulfoacetaldehyde and NADP+.
History
EC 1.2.1.81 created 2011
Pathway
ec00430  Taurine and hypotaurine metabolism
Orthology
K15515  sulfoacetaldehyde dehydrogenase
Genes
BGJ: AWC36_05910
BNG: EH206_07455
BIZ: HC231_15885
SLIG: GTU79_10145
SHAI: LMH63_05605
GAI: IMCC3135_23095(sauS)
HPIS: P1P91_06520
PAUR: FGL86_09035
MRZ: KDW95_20215
NJP: NEJAP_1576(sauS)
SVA: SVA_0813
TSN: W908_04745
RPJ: N234_15545
REH: H16_A2747(h16_A2747)
CNC: CNE_1c26440(sucD2)
CUH: BJN34_14795
REU: Reut_A0867
COX: E0W60_22990
CUK: KB879_25670
BYI: BYI23_C010330
BUE: BRPE67_CCDS00590
BXE: Bxe_B0701
BXB: DR64_6032
BPH: Bphy_6218
BPY: Bphyt_4382
BFN: OI25_4376
PARA: BTO02_11375
PARB: CJU94_25795
PEW: KZJ38_11905
PBRY: NDK50_10310
PPAI: E1956_27740
PANI: DCO16_07820
PYT: PKF023_05270
PPK: U875_18455
PPNO: DA70_10965
PPNM: LV28_20085
PRB: X636_15655
PSPU: NA29_22760
PTX: ABW99_12080
PFG: AB870_16590
PCOM: NTU39_06470
CABA: SBC2_17240(sauS)
BUO: BRPE64_CCDS00820
CABK: NK8_76920
TVL: FAZ95_11780
BOH: AKI39_13675
AKA: TKWG_02680
RHF: EUB48_15050
VEI: Veis_4280
VAP: Vapar_3831
VPE: Varpa_4409
VPD: VAPA_1c39430(sucD1)
VAZ: H7F35_02270
DIH: G7047_16580
DRG: H9K76_05380
GLC: JQN73_01135
AZA: AZKH_2613(gabD)
RPE: RPE_3204
OCA: OCAR_6738
OCG: OCA5_c13340(sucD1)
OCO: OCA4_c13340(sucD1)
PCAX: AFIC_002211
MDI: METDI0777
MCH: Mchl_4208
META: Y590_17370
METD: C0214_07130
METS: DK389_25455 DK389_30405
RVA: Rvan_3429
RLAC: QMO75_16340
FIL: BN1229_v1_2532(sauS)
FIY: BN1229_v1_3384(sauS)
PSIN: CAK95_09385
RUA: D1823_07690
RUT: FIU92_17625(sauS)
RCON: K3740_08305
RUY: NOR97_00110
JAN: Jann_1566
RDE: RD1_2918(adhE)
RLI: RLO149_c015190
RPON: G3256_00045
RFU: ROLI_009600(sauS)
LMD: METH_04545
LEJ: ETW24_05665
LEV: ETW23_14030
SUAM: BOO69_18705
SULZ: C1J03_10940
TOM: BWR18_19590
RMM: ROSMUCSMR3_02418(sauS)
ROK: RAK1035_0765
ROH: FIU89_14815(sauS)
PDE: Pden_1013
PYE: A6J80_14110
PAMN: pAMV3p0587(sauS)
PSEW: JHW44_08720
PVER: E3U25_15825
PFEO: E3U26_04465
PTP: RCA23_c28350(sucD2)
AMYL: QBD29_03035
BOSG: GKR98_14020
ABS: AZOBR_p480045
ABQ: ABAZ39_30000
ABF: AMK58_25725
AZT: TSH58p_19695
AARE: D3093_29155
BACA: FAY30_11795
NMK: CHR53_14040
DSY: DSY0244
DHD: Dhaf_0190
DRU: Desru_3835
MSIM: MSIM_08960
CCAW: CCANI_02880(sauS)
CFEU: CFELI_05790(sauS)
SVIO: HWN34_17615
KBU: Q4V64_44220
SGRG: L0C25_12205
PHH: AFB00_27935
HALJ: G9465_20580
HLA: Hlac_0665
HEZZ: EO776_04580
HALQ: Hrr1229_003530
HSS: J7656_12245
HSAI: HPS36_02610
HAZZ: KI388_02185
HXA: Halxa_2456
NARA: QQ977_05455 QQ977_09450
 » show all
Reference
1  [PMID:20693281]
  Authors
Weinitschke S, Hollemeyer K, Kusian B, Bowien B, Smits TH, Cook AM
  Title
Sulfoacetate is degraded via a novel pathway involving sulfoacetyl-CoA and sulfoacetaldehyde in Cupriavidus necator H16.
  Journal
J Biol Chem 285:35249-54 (2010)
DOI:10.1074/jbc.M110.127043
  Sequence
[reh:H16_A2747]
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.81
IUBMB Enzyme Nomenclature: 1.2.1.81
ExPASy - ENZYME nomenclature database: 1.2.1.81
BRENDA, the Enzyme Database: 1.2.1.81
LinkDB

KEGG   REACTION: R09557
Entry
R09557                      Reaction                               
Name
2-sulfoacetaldehyde:NADP+ oxidoreductase (CoA-acetylating)
Definition
Sulfoacetaldehyde + CoA + NADP+ <=> Sulfoacetyl-CoA + NADPH + H+
Equation
C00593 + C00010 + C00006 <=> C19685 + C00005 + C00080
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C19685
RC00184  C00593_C19685
Enzyme
1.2.1.81
Pathway
rn00430  Taurine and hypotaurine metabolism
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.81
     R09557  Sulfoacetaldehyde + CoA + NADP+ <=> Sulfoacetyl-CoA + NADPH + H+
Orthology
K15515  sulfoacetaldehyde dehydrogenase [EC:1.2.1.81]
Other DBs
RHEA: 29598
LinkDB

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