KEGG   ORTHOLOGY: K15669
Entry
K15669                      KO                                     
Symbol
hddC
Name
D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase [EC:2.7.7.71]
Pathway
map00540  Lipopolysaccharide biosynthesis
map01100  Metabolic pathways
map01250  Biosynthesis of nucleotide sugars
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00540 Lipopolysaccharide biosynthesis
    K15669  hddC; D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.71  D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase
     K15669  hddC; D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase
Other DBs
RN: R09772
COG: COG1208
Genes
YPB: YPTS_1057
YPQ: DJ40_1346
YPU: BZ21_256
YPR: BZ20_1033
YPC: BZ23_532
PLU: plu4824(wblY)
PLUM: A4R40_23995
LSOL: GOY17_03460
LHX: LYSHEL_08780(hddC)
LCAS: LYSCAS_08780(hddC)
VSR: Vspart_00205(rfbF_2)
PALL: UYA_23035
AMAG: I533_13330
ASIP: AQUSIP_18120(hddC_2)
METL: U737_03410
HCH: HCH_06180
TOL: TOL_2195
BMA: BMA2294(hddC)
BMV: BMASAVP1_A0534(hddC)
BML: BMA10229_A1066(wcbM)
BMN: BMA10247_2172(wcbM)
BMAL: DM55_1490
BMAE: DM78_2664
BMAQ: DM76_1468
BMAI: DM57_1069
BMAF: DM51_1935
BMAZ: BM44_1069
BMAB: BM45_2460
BPS: BPSL2794(wcbM)
BPM: BURPS1710b_3290(wcbM)
BPL: BURPS1106A_3276(wcbM)
BPD: BURPS668_3241(wcbM)
BPSE: BDL_2651
BPSM: BBQ_515
BPSU: BBN_643
BPSD: BBX_1049
BPZ: BP1026B_I0516(wcbM)
BPK: BBK_2136
BPSH: DR55_1724
BPSA: BBU_2768
BPSO: X996_1364
BUT: X994_3362
BTD: BTI_922
BTHA: DR62_527
BCEW: DM40_4221
BLAT: WK25_23470
NET: Neut_0159
MEH: M301_2250
CJE: Cj1423c(hddC)
CJB: BN148_1423c(hddC)
CJS: CJS3_1516
CJEJ: N564_02350
CJEU: N565_02430
CJEN: N755_02485
CJEI: N135_01513
CJER: H730_08135
CJY: QZ67_01562(hddC_2)
CJQ: UC78_1364(hddC_2)
CJR: CJE1608
CCF: YSQ_01745
CIS: CINS_0294
CCUN: CCUN_1150
CLX: CLAN_0154
COJ: CORN_0315
CARM: CARM_0283
ALK: ALEK_0997
AMYT: AMYT_0705
GLO: Glov_0792
CSE: Cseg_1878
MAG: amb0798
MAGX: XM1_1801
MAGN: WV31_16780
ASOC: CB4_00634(hddC)
CAC: CA_C3056
CAE: SMB_G3092
CAY: CEA_G3062
AOC: Aocu_04610(hddC)
EYY: EGYY_07220(GCD1)
SYY: SYNGTS_2223(slr0007)
SYT: SYNGTI_2222(slr0007)
SYS: SYNPCCN_2221(slr0007)
SYQ: SYNPCCP_2221(slr0007)
GEN: GM3709_95
MAR: MAE_55660
MPK: VL20_391
CYT: cce_0965
CEO: ETSB_0017
SNG: SNE_A16750(mpg1)
ULI: ETAA1_11120(hddC)
FVA: FV113G1_09570(hddC)
TLI: Tlie_1237
BTH: BT_0476
BTHO: Btheta7330_02886(hddC_2)
CPI: Cpin_3113
FLN: FLA_2279
PAA: Paes_1744
NDE: NIDE3423
MPI: Mpet_1391
AG: AAK27852(hddC)
 » show all
Reference
  Authors
Karlyshev AV, Champion OL, Churcher C, Brisson JR, Jarrell HC, Gilbert M, Brochu D, St Michael F, Li J, Wakarchuk WW, Goodhead I, Sanders M, Stevens K, White B, Parkhill J, Wren BW, Szymanski CM
  Title
Analysis of Campylobacter jejuni capsular loci reveals multiple mechanisms for the generation of structural diversity and the ability to form complex heptoses.
  Journal
Mol Microbiol 55:90-103 (2005)
DOI:10.1111/j.1365-2958.2004.04374.x
  Sequence
LinkDB

KEGG   ENZYME: 2.7.7.71
Entry
EC 2.7.7.71                 Enzyme                                 
Name
D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase;
hddC (gene name);
gmhD (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
GTP:D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase
Reaction(IUBMB)
D-glycero-alpha-D-manno-heptose 1-phosphate + GTP = GDP-D-glycero-alpha-D-manno-heptose + diphosphate [RN:R09772]
Reaction(KEGG)
R09772
Substrate
D-glycero-alpha-D-manno-heptose 1-phosphate [CPD:C19880];
GTP [CPD:C00044]
Product
GDP-D-glycero-alpha-D-manno-heptose [CPD:C19881];
diphosphate [CPD:C00013]
Comment
The enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D-manno-heptose, which is required for assembly of S-layer glycoprotein in some Gram-positive bacteria.
History
EC 2.7.7.71 created 2010
Pathway
ec00540  Lipopolysaccharide biosynthesis
ec01100  Metabolic pathways
Orthology
K15669  D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase
Genes
YPBYPTS_1057
YPQDJ40_1346
YPUBZ21_256
YPRBZ20_1033
YPCBZ23_532
PLUplu4824(wblY)
PLUMA4R40_23995
LSOLGOY17_03460
LHXLYSHEL_08780(hddC)
LCASLYSCAS_08780(hddC)
THESFHQ07_06195
TCNH9L16_07625
TBVH9L17_06855
VAFD1115_23000
VSRVspart_00205(rfbF_2)
VZIG5S32_14895
PGBH744_2c2396
PGHFH974_09830
PPBPPUBIRD1_1474
PALLUYA_23035
PBZGN234_10455
PKHJLK41_16275
PMUYKSS95_17175
PORYEJA05_20070
PWZJ7655_08605
PAGRE2H98_17305
SBBSbal175_1479
AMAGI533_13330
CEBB0D95_15710
ASIPAQUSIP_18120(hddC_2)
METLU737_03410
MMOBF6R98_01285
MEINmethR_P2383
MESLKKZ03_15205
HTREPV75_08905
TVIThivi_4047
HCHHCH_06180
HAHEENC22_26650
TOLTOL_2195
TORR615_06680
REUReut_A0722
CUPBKK80_17030
CUUBKK79_15325
BMABMA2294(hddC)
BMVBMASAVP1_A0534(hddC)
BMLBMA10229_A1066(wcbM)
BMNBMA10247_2172(wcbM)
BMALDM55_1490
BMAEDM78_2664
BMAQDM76_1468
BMAIDM57_1069
BMAFDM51_1935
BMAZBM44_1069
BMABBM45_2460
BPSBPSL2794(wcbM)
BPMBURPS1710b_3290(wcbM)
BPLBURPS1106A_3276(wcbM)
BPDBURPS668_3241(wcbM)
BPRGBP346_A3419
BPSEBDL_2651
BPSMBBQ_515
BPSUBBN_643
BPSDBBX_1049
BPZBP1026B_I0516(wcbM)
BPQBPC006_I3324
BPKBBK_2136
BPSHDR55_1724
BPSABBU_2768
BPSOX996_1364
BUTX994_3362
BTDBTI_922
BTHADR62_527
BCEWDM40_4221
BLATWK25_23470
BSTLBBJ41_08330
BPLAbpln_1g18360
BUZAYM40_03130 AYM40_03410
BCAIK788_0007829
PHSC2L64_13955
PMEGFNZ07_18190
PACSFAZ98_02535
RSBRS694_17780
HSEHsero_4416
HSZACP92_22055
HFRG5S34_23460
MASSCR152_19315
AONDEH84_17470
NETNeut_0159
MEHM301_2250
MBATBN1208_0915
MEUACJ67_08020
ARESIWH25_01540
HWIA0Z60_06595
CJECj1423c(hddC)
CJBBN148_1423c(hddC)
CJJCJJ81176_1422
CJNICDCCJ07001_1353
CJSCJS3_1516
CJEJN564_02350
CJEUN565_02430
CJENN755_02485
CJEIN135_01513
CJERH730_08135
CJYQZ67_01562(hddC_2)
CJQUC78_1364(hddC_2)
CJWPJ18_07290
CJRCJE1608
CJDJJD26997_1755
CJZM635_02840
CJXBN867_14000
CLRUPTC16701_0318
CLMUPTC16712_0316
CLNUPTC3659_0328
CCFYSQ_01745
CISCINS_0294
CAMRCAQ16704_0317
CSMCSUB8521_0329
CHVCHELV3228_0219
CCUNCCUN_1150
CLXCLAN_0154
CHWA2J15_004895
CAMZCVIC12175_0186
COJCORN_0315
CUXCUP3940_1431
CARMCARM_0283
CNVCNZW441b_0370
ANTArnit_2924
ALKALEK_0997
AMYTAMYT_0705
GLOGlov_0792
DMADMR_p1_00350
DOVDSCO28_03320
HMRHipma_1691
RENEF513_03800
BRND1F64_11925
CSECseg_1878
CMBCSW64_13085
BNDKWG56_04320
MAGamb0798
MAGXXM1_1801
MAGNWV31_16780
FERFNB15_03140
APBSAR116_0975
PPSCEHS13_28190
PRZGZH47_12300
ASOCCB4_00634(hddC)
CACCA_C3056
CAESMB_G3092
CAYCEA_G3062
CFERD4Z93_01725
PBIFKXZ80_16775
CSHClosa_3799
DECDCF50_p1136
AOCAocu_04610(hddC)
EYYEGYY_07220(GCD1)
SYZMYO_122470
SYYSYNGTS_2223(slr0007)
SYTSYNGTI_2222(slr0007)
SYSSYNPCCN_2221(slr0007)
SYQSYNPCCP_2221(slr0007)
SYJD082_33180
SYOC7I86_11615
PMHP9215_14341
GENGM3709_95
GEEGM3708_2173
MARMAE_55660
MPKVL20_391
MIQB5D77_10620
MVZmyaer102_27900
CANCyan10605_0114
CYUUCYN_11560
CYTcce_0965
CWACwatDRAFT_2259
CYPPCC8801_1636
CYHCyan8802_1663
CEOETSB_0017
CERRGRSB_1051
SNGSNE_A16750(mpg1)
ULIETAA1_11120(hddC)
KSTKSMBR1_2292
BPITBPIT_11880 BPIT_20160
FVAFV113G1_09570(hddC)
ACOAmico_1360
TLITlie_1237
AMOAnamo_1480
BTHBT_0476
BTHOBtheta7330_02886(hddC_2)
BFGBF638R_1446
ALDGFH31_01605
AITAI2BBH_01750
CPICpin_3113
CHIHGWR21_07435
COYHF329_02880
NKONiako_2549
NSONIASO_09040
NIAA8C56_12860
FLASY85_01480
ARKD6B99_15400
FLNFLA_2279
PSEGD3H65_10795
PGINFRZ67_05020
PGOFSB84_23210
FLSGLV81_14345
FEIK9M53_08230
FLPLK994_12850
PAAPaes_1744
NDENIDE3423
LFILFML04_1776
TCMHL41_06280
MPIMpet_1391
 » show all
Reference
1  [PMID:11279237]
  Authors
Kneidinger B, Graninger M, Puchberger M, Kosma P, Messner P
  Title
Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose.
  Journal
J Biol Chem 276:20935-44 (2001)
DOI:10.1074/jbc.M100378200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.71
IUBMB Enzyme Nomenclature: 2.7.7.71
ExPASy - ENZYME nomenclature database: 2.7.7.71
BRENDA, the Enzyme Database: 2.7.7.71
LinkDB

KEGG   REACTION: R09772
Entry
R09772                      Reaction                               
Name
GTP:D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase
Definition
D-glycero-alpha-D-manno-Heptose 1-phosphate + GTP <=> GDP-D-glycero-alpha-D-manno-heptose + Diphosphate
Equation
Reaction class
RC00002  C19880_C19881
Enzyme
Pathway
rn00540  Lipopolysaccharide biosynthesis
rn01100  Metabolic pathways
rn01250  Biosynthesis of nucleotide sugars
Orthology
K15669  D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase [EC:2.7.7.71]
Other DBs
RHEA: 27464
LinkDB

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