KEGG   ORTHOLOGY: K15669
Entry
K15669                      KO                                     
Symbol
hddC
Name
D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase [EC:2.7.7.71]
Pathway
map00540  Lipopolysaccharide biosynthesis
map01100  Metabolic pathways
map01250  Biosynthesis of nucleotide sugars
Reaction
R09772  GTP:D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00540 Lipopolysaccharide biosynthesis
    K15669  hddC; D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.71  D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase
     K15669  hddC; D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase
Other DBs
COG: COG1208
Genes
YPB: YPTS_1057
YPQ: DJ40_1346
YPU: BZ21_256
YPR: BZ20_1033
YPC: BZ23_532
YAS: N0H69_17355
PLU: plu4824(wblY)
PLUM: A4R40_23995
LSOL: GOY17_03460
LHX: LYSHEL_08780(hddC)
LCAS: LYSCAS_08780(hddC)
THES: FHQ07_06195
TCN: H9L16_07625
TBV: H9L17_06855
VAF: D1115_23000
VSR: Vspart_00205(rfbF_2)
VZI: G5S32_14895
VJP: NP165_18360
VRU: RND59_05065
PGB: H744_2c2396
PGH: FH974_09830
PPB: PPUBIRD1_1474
PEN: PSEEN2466
PALL: UYA_23035
PBZ: GN234_10455
PKH: JLK41_16275
PMUY: KSS95_17175
PORY: EJA05_20070
PWZ: J7655_08605
PSIH: LOY51_19415
PASI: LG197_25605
PAGR: E2H98_17305
SBB: Sbal175_1479
PSHO: KQ246_01930
AMAG: I533_13330
CEB: B0D95_15710
ASIP: AQUSIP_18120(hddC_2)
METL: U737_03410
MEEP: JWZ98_02700
MMOB: F6R98_01285
MEIN: methR_P2383
MESL: KKZ03_15205
HTR: EPV75_08905
TVI: Thivi_4047
HCH: HCH_06180
HAHE: ENC22_26650
HAHH: O5O45_29345
TOL: TOL_2195
TOR: R615_06680
ENW: MJO57_17215
REU: Reut_A0722
CUP: BKK80_17030
CUU: BKK79_15325
BMA: BMA2294(hddC)
BMV: BMASAVP1_A0534(hddC)
BML: BMA10229_A1066(wcbM)
BMN: BMA10247_2172(wcbM)
BMAL: DM55_1490
BMAE: DM78_2664
BMAQ: DM76_1468
BMAI: DM57_1069
BMAF: DM51_1935
BMAZ: BM44_1069
BMAB: BM45_2460
BPS: BPSL2794(wcbM)
BPM: BURPS1710b_3290(wcbM)
BPL: BURPS1106A_3276(wcbM)
BPD: BURPS668_3241(wcbM)
BPR: GBP346_A3419
BPSE: BDL_2651
BPSM: BBQ_515
BPSU: BBN_643
BPSD: BBX_1049
BPZ: BP1026B_I0516(wcbM)
BPQ: BPC006_I3324
BPK: BBK_2136
BPSH: DR55_1724
BPSA: BBU_2768
BPSO: X996_1364
BUT: X994_3362
BTD: BTI_922
BTHA: DR62_527
BCEW: DM40_4221
BLAT: WK25_23470
BSTL: BBJ41_08330
BARI: NLX30_31955
BAEN: L3V59_19735
BPLA: bpln_1g18360
BUZ: AYM40_03130 AYM40_03410
BCAI: K788_0007829
PHS: C2L64_13955
PMEG: FNZ07_18190
PACS: FAZ98_02535
PCOS: C2747_01705
TVL: FAZ95_17365
TCAR: U0034_03655
RSB: RS694_17780
ATER: MW290_21690
HSE: Hsero_4416
HSZ: ACP92_22055
HFR: G5S34_23460
HEW: HBDW_45220
MASS: CR152_19315
AON: DEH84_17470
NET: Neut_0159
MEH: M301_2250
MBAT: BN1208_0915
MEU: ACJ67_08020
ARES: IWH25_01540
REN: EF513_03800
BRN: D1F64_11925
CSE: Cseg_1878
CMB: CSW64_13085
BND: KWG56_04320
AZS: E6C72_17750
MAGX: XM1_1801
MAGN: WV31_16780
FER: FNB15_03140
MAG: amb0798
APB: SAR116_0975
HWI: A0Z60_06595
HPUL: NCTC13154_01557(rmlA1)
CJE: Cj1423c(hddC)
CJB: BN148_1423c(hddC)
CJJ: CJJ81176_1422
CJN: ICDCCJ07001_1353
CJS: CJS3_1516
CJEJ: N564_02350
CJEU: N565_02430
CJEN: N755_02485
CJEI: N135_01513
CJER: H730_08135
CJY: QZ67_01562(hddC_2)
CJQ: UC78_1364(hddC_2)
CJW: PJ18_07290
CJR: CJE1608
CJD: JJD26997_1755
CJZ: M635_02840
CJX: BN867_14000
CLR: UPTC16701_0318
CLM: UPTC16712_0316
CLN: UPTC3659_0328
CCF: YSQ_01745
CIS: CINS_0294
CAMR: CAQ16704_0317
CSM: CSUB8521_0329
CHV: CHELV3228_0219
CCUN: CCUN_1150
CLX: CLAN_0154
CHW: A2J15_004895
CAMZ: CVIC12175_0186
COJ: CORN_0315
CUX: CUP3940_1431
CARM: CARM_0283
CNV: CNZW441b_0370
CVU: CVULP_1505
CDEV: CIGN_0114
ANT: Arnit_2924
ALK: ALEK_0997
AMYT: AMYT_0705
HMR: Hipma_1691
GLO: Glov_0792
DMA: DMR_p1_00350
DOV: DSCO28_03320
TCM: HL41_06280
APAU: AMPC_02940(hddC)
PPSC: EHS13_28190
PRZ: GZH47_12300
ASOC: CB4_00634(hddC)
ACUR: JZ785_20285
CAC: CA_C3056
CAE: SMB_G3092
CAY: CEA_G3062
CFER: D4Z93_01725
CRW: CROST_039040(hddC)
CFB: CLFE_008780(hddC)
CAUN: CLAUR_036220(hddC)
DEC: DCF50_p1136
CSH: Closa_3799
LXA: OW255_03125
CASP: NQ535_04230
HHJ: NQ487_27320
PBIF: KXZ80_16775
AOC: Aocu_04610(hddC)
SYN: slr0007
SYZ: MYO_122470
SYY: SYNGTS_2223(slr0007)
SYT: SYNGTI_2222(slr0007)
SYS: SYNPCCN_2221(slr0007)
SYQ: SYNPCCP_2221(slr0007)
SYJ: D082_33180
SYO: C7I86_11615
SYNH: HTZ78_02885
PMH: P9215_14341
GEN: GM3709_95
GEE: GM3708_2173
CAN: Cyan10605_0114
MAR: MAE_55660
MPK: VL20_391
MIQ: B5D77_10620
MVZ: myaer102_27900
CYU: UCYN_11560
CYT: cce_0965
CWA: CwatDRAFT_2259
CYP: PCC8801_1636
CYH: Cyan8802_1663
CEO: ETSB_0017
CER: RGRSB_1051
CEEC: P3F56_10000
SNG: SNE_A16750(mpg1)
GAW: V144x_54480(hddC_2)
ULI: ETAA1_11120(hddC)
KST: KSMBR1_2292
BPIT: BPIT_11880 BPIT_20160
TPSC: RBB77_18785
MSIL: METEAL_02450(hddC)
FVA: FV113G1_09570(hddC)
HABY: HLVA_19740(hddC)
ACO: Amico_1360
AMIZ: RBH88_03095
TLI: Tlie_1237
AMO: Anamo_1480
BTH: BT_0476
BTHO: Btheta7330_02886(hddC_2)
BFG: BF638R_1446
PCLR: PC1C4_23770
ALD: GFH31_01605
AIT: AI2BBH_01750
AIU: NQ491_03840
CPI: Cpin_3113
CHIH: GWR21_07435
COY: HF329_02880
CFIL: MYF79_22185
CHF: KTO58_06615
CSAC: SIO70_23820
CHIM: CK934_22445
NKO: Niako_2549
NSO: NIASO_09040
NIA: A8C56_12860
NYN: U0035_05275
NDF: KRR40_00670
FLA: SY85_01480
ARK: D6B99_15400
FLN: FLA_2279
PSEG: D3H65_10795
PGIN: FRZ67_05020
PGO: FSB84_23210
FLS: GLV81_14345
FEI: K9M53_08230
FLP: LK994_12850
THEO: IMW88_11155
CHRW: KA713_13915
PAA: Paes_1744
NDE: NIDE3423
NALL: PP769_09065
NNEO: PQG83_20300
LFI: LFML04_1776
NVA: G3M78_07675
MPI: Mpet_1391
AG: AAK27852(hddC)
 » show all
Reference
PMID:15612919
  Authors
Karlyshev AV, Champion OL, Churcher C, Brisson JR, Jarrell HC, Gilbert M, Brochu D, St Michael F, Li J, Wakarchuk WW, Goodhead I, Sanders M, Stevens K, White B, Parkhill J, Wren BW, Szymanski CM
  Title
Analysis of Campylobacter jejuni capsular loci reveals multiple mechanisms for the generation of structural diversity and the ability to form complex heptoses.
  Journal
Mol Microbiol 55:90-103 (2005)
DOI:10.1111/j.1365-2958.2004.04374.x
  Sequence
[cjj:CJJ81176_1422]
LinkDB

KEGG   ENZYME: 2.7.7.71
Entry
EC 2.7.7.71                 Enzyme                                 
Name
D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase;
hddC (gene name);
gmhD (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
GTP:D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase
Reaction(IUBMB)
D-glycero-alpha-D-manno-heptose 1-phosphate + GTP = GDP-D-glycero-alpha-D-manno-heptose + diphosphate [RN:R09772]
Reaction(KEGG)
R09772
Substrate
D-glycero-alpha-D-manno-heptose 1-phosphate [CPD:C19880];
GTP [CPD:C00044]
Product
GDP-D-glycero-alpha-D-manno-heptose [CPD:C19881];
diphosphate [CPD:C00013]
Comment
The enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D-manno-heptose, which is required for assembly of S-layer glycoprotein in some Gram-positive bacteria.
History
EC 2.7.7.71 created 2010
Pathway
ec00540  Lipopolysaccharide biosynthesis
ec01100  Metabolic pathways
Orthology
K15669  D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase
Genes
YPB: YPTS_1057
YPQ: DJ40_1346
YPU: BZ21_256
YPR: BZ20_1033
YPC: BZ23_532
YAS: N0H69_17355
PLU: plu4824(wblY)
PLUM: A4R40_23995
LSOL: GOY17_03460
LHX: LYSHEL_08780(hddC)
LCAS: LYSCAS_08780(hddC)
THES: FHQ07_06195
TCN: H9L16_07625
TBV: H9L17_06855
VAF: D1115_23000
VSR: Vspart_00205(rfbF_2)
VZI: G5S32_14895
VJP: NP165_18360
VRU: RND59_05065
PGB: H744_2c2396
PGH: FH974_09830
PPB: PPUBIRD1_1474
PEN: PSEEN2466
PALL: UYA_23035
PBZ: GN234_10455
PKH: JLK41_16275
PMUY: KSS95_17175
PORY: EJA05_20070
PWZ: J7655_08605
PSIH: LOY51_19415
PASI: LG197_25605
PAGR: E2H98_17305
SBB: Sbal175_1479
PSHO: KQ246_01930
AMAG: I533_13330
CEB: B0D95_15710
ASIP: AQUSIP_18120(hddC_2)
METL: U737_03410
MEEP: JWZ98_02700
MMOB: F6R98_01285
MEIN: methR_P2383
MESL: KKZ03_15205
HTR: EPV75_08905
TVI: Thivi_4047
HCH: HCH_06180
HAHE: ENC22_26650
HAHH: O5O45_29345
TOL: TOL_2195
TOR: R615_06680
ENW: MJO57_17215
REU: Reut_A0722
CUP: BKK80_17030
CUU: BKK79_15325
BMA: BMA2294(hddC)
BMV: BMASAVP1_A0534(hddC)
BML: BMA10229_A1066(wcbM)
BMN: BMA10247_2172(wcbM)
BMAL: DM55_1490
BMAE: DM78_2664
BMAQ: DM76_1468
BMAI: DM57_1069
BMAF: DM51_1935
BMAZ: BM44_1069
BMAB: BM45_2460
BPS: BPSL2794(wcbM)
BPM: BURPS1710b_3290(wcbM)
BPL: BURPS1106A_3276(wcbM)
BPD: BURPS668_3241(wcbM)
BPR: GBP346_A3419
BPSE: BDL_2651
BPSM: BBQ_515
BPSU: BBN_643
BPSD: BBX_1049
BPZ: BP1026B_I0516(wcbM)
BPQ: BPC006_I3324
BPK: BBK_2136
BPSH: DR55_1724
BPSA: BBU_2768
BPSO: X996_1364
BUT: X994_3362
BTD: BTI_922
BTHA: DR62_527
BCEW: DM40_4221
BLAT: WK25_23470
BSTL: BBJ41_08330
BARI: NLX30_31955
BAEN: L3V59_19735
BPLA: bpln_1g18360
BUZ: AYM40_03130 AYM40_03410
BCAI: K788_0007829
PHS: C2L64_13955
PMEG: FNZ07_18190
PACS: FAZ98_02535
PCOS: C2747_01705
TVL: FAZ95_17365
TCAR: U0034_03655
RSB: RS694_17780
ATER: MW290_21690
HSE: Hsero_4416
HSZ: ACP92_22055
HFR: G5S34_23460
HEW: HBDW_45220
MASS: CR152_19315
AON: DEH84_17470
NET: Neut_0159
MEH: M301_2250
MBAT: BN1208_0915
MEU: ACJ67_08020
ARES: IWH25_01540
REN: EF513_03800
BRN: D1F64_11925
CSE: Cseg_1878
CMB: CSW64_13085
BND: KWG56_04320
AZS: E6C72_17750
MAGX: XM1_1801
MAGN: WV31_16780
FER: FNB15_03140
MAG: amb0798
APB: SAR116_0975
HWI: A0Z60_06595
HPUL: NCTC13154_01557(rmlA1)
CJE: Cj1423c(hddC)
CJB: BN148_1423c(hddC)
CJJ: CJJ81176_1422
CJN: ICDCCJ07001_1353
CJS: CJS3_1516
CJEJ: N564_02350
CJEU: N565_02430
CJEN: N755_02485
CJEI: N135_01513
CJER: H730_08135
CJY: QZ67_01562(hddC_2)
CJQ: UC78_1364(hddC_2)
CJW: PJ18_07290
CJR: CJE1608
CJD: JJD26997_1755
CJZ: M635_02840
CJX: BN867_14000
CLR: UPTC16701_0318
CLM: UPTC16712_0316
CLN: UPTC3659_0328
CCF: YSQ_01745
CIS: CINS_0294
CAMR: CAQ16704_0317
CSM: CSUB8521_0329
CHV: CHELV3228_0219
CCUN: CCUN_1150
CLX: CLAN_0154
CHW: A2J15_004895
CAMZ: CVIC12175_0186
COJ: CORN_0315
CUX: CUP3940_1431
CARM: CARM_0283
CNV: CNZW441b_0370
CVU: CVULP_1505
CDEV: CIGN_0114
ANT: Arnit_2924
ALK: ALEK_0997
AMYT: AMYT_0705
HMR: Hipma_1691
GLO: Glov_0792
DMA: DMR_p1_00350
DOV: DSCO28_03320
TCM: HL41_06280
APAU: AMPC_02940(hddC)
PPSC: EHS13_28190
PRZ: GZH47_12300
ASOC: CB4_00634(hddC)
ACUR: JZ785_20285
CAC: CA_C3056
CAE: SMB_G3092
CAY: CEA_G3062
CFER: D4Z93_01725
CRW: CROST_039040(hddC)
CFB: CLFE_008780(hddC)
CAUN: CLAUR_036220(hddC)
DEC: DCF50_p1136
CSH: Closa_3799
LXA: OW255_03125
CASP: NQ535_04230
HHJ: NQ487_27320
PBIF: KXZ80_16775
AOC: Aocu_04610(hddC)
SYN: slr0007
SYZ: MYO_122470
SYY: SYNGTS_2223(slr0007)
SYT: SYNGTI_2222(slr0007)
SYS: SYNPCCN_2221(slr0007)
SYQ: SYNPCCP_2221(slr0007)
SYJ: D082_33180
SYO: C7I86_11615
SYNH: HTZ78_02885
PMH: P9215_14341
GEN: GM3709_95
GEE: GM3708_2173
CAN: Cyan10605_0114
MAR: MAE_55660
MPK: VL20_391
MIQ: B5D77_10620
MVZ: myaer102_27900
CYU: UCYN_11560
CYT: cce_0965
CWA: CwatDRAFT_2259
CYP: PCC8801_1636
CYH: Cyan8802_1663
CEO: ETSB_0017
CER: RGRSB_1051
CEEC: P3F56_10000
SNG: SNE_A16750(mpg1)
GAW: V144x_54480(hddC_2)
ULI: ETAA1_11120(hddC)
KST: KSMBR1_2292
BPIT: BPIT_11880 BPIT_20160
TPSC: RBB77_18785
MSIL: METEAL_02450(hddC)
FVA: FV113G1_09570(hddC)
HABY: HLVA_19740(hddC)
ACO: Amico_1360
AMIZ: RBH88_03095
TLI: Tlie_1237
AMO: Anamo_1480
BTH: BT_0476
BTHO: Btheta7330_02886(hddC_2)
BFG: BF638R_1446
PCLR: PC1C4_23770
ALD: GFH31_01605
AIT: AI2BBH_01750
AIU: NQ491_03840
CPI: Cpin_3113
CHIH: GWR21_07435
COY: HF329_02880
CFIL: MYF79_22185
CHF: KTO58_06615
CSAC: SIO70_23820
CHIM: CK934_22445
NKO: Niako_2549
NSO: NIASO_09040
NIA: A8C56_12860
NYN: U0035_05275
NDF: KRR40_00670
FLA: SY85_01480
ARK: D6B99_15400
FLN: FLA_2279
PSEG: D3H65_10795
PGIN: FRZ67_05020
PGO: FSB84_23210
FLS: GLV81_14345
FEI: K9M53_08230
FLP: LK994_12850
THEO: IMW88_11155
CHRW: KA713_13915
PAA: Paes_1744
NDE: NIDE3423
NALL: PP769_09065
NNEO: PQG83_20300
LFI: LFML04_1776
NVA: G3M78_07675
MPI: Mpet_1391
 » show all
Reference
1  [PMID:11279237]
  Authors
Kneidinger B, Graninger M, Puchberger M, Kosma P, Messner P
  Title
Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose.
  Journal
J Biol Chem 276:20935-44 (2001)
DOI:10.1074/jbc.M100378200
  Sequence
[ag:AAK27852]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.71
IUBMB Enzyme Nomenclature: 2.7.7.71
ExPASy - ENZYME nomenclature database: 2.7.7.71
BRENDA, the Enzyme Database: 2.7.7.71
LinkDB

KEGG   REACTION: R09772
Entry
R09772                      Reaction                               
Name
GTP:D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase
Definition
D-glycero-alpha-D-manno-Heptose 1-phosphate + GTP <=> GDP-D-glycero-alpha-D-manno-heptose + Diphosphate
Equation
C19880 + C00044 <=> C19881 + C00013
Reaction class
RC00002  C19880_C19881
Enzyme
2.7.7.71
Pathway
rn00540  Lipopolysaccharide biosynthesis
rn01100  Metabolic pathways
rn01250  Biosynthesis of nucleotide sugars
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.71
     R09772  D-glycero-alpha-D-manno-Heptose 1-phosphate + GTP <=> GDP-D-glycero-alpha-D-manno-heptose + Diphosphate
Orthology
K15669  D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase [EC:2.7.7.71]
Other DBs
RHEA: 27464
LinkDB

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