KEGG   ORTHOLOGY: K15856
Entry
K15856                      KO                                     
Symbol
rmd
Name
GDP-4-dehydro-6-deoxy-D-mannose reductase [EC:1.1.1.281]
Pathway
map00051  Fructose and mannose metabolism
map00520  Amino sugar and nucleotide sugar metabolism
map00541  O-Antigen nucleotide sugar biosynthesis
map01100  Metabolic pathways
map01250  Biosynthesis of nucleotide sugars
Reaction
R03397  GDP-6-deoxy-D-mannose:NAD+ 4-oxidoreductase
R03399  GDP-6-deoxy-D-mannose:NADP+ 4-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00051 Fructose and mannose metabolism
    K15856  rmd; GDP-4-dehydro-6-deoxy-D-mannose reductase
   00520 Amino sugar and nucleotide sugar metabolism
    K15856  rmd; GDP-4-dehydro-6-deoxy-D-mannose reductase
  09107 Glycan biosynthesis and metabolism
   00541 O-Antigen nucleotide sugar biosynthesis
    K15856  rmd; GDP-4-dehydro-6-deoxy-D-mannose reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.281  GDP-4-dehydro-6-deoxy-D-mannose reductase
     K15856  rmd; GDP-4-dehydro-6-deoxy-D-mannose reductase
Other DBs
COG: COG0451
GO: 0033705
Genes
YPB: YPTS_1054
YPQ: DJ40_1349
YPU: BZ21_253
YPR: BZ20_1036
YPC: BZ23_529
XAL: XALC_2707(rmd)
XVA: C7V42_18455
PDD: MNQ95_09680
LCP: LC55x_4380
LGU: LG3211_4185
LEZ: GLE_4243
LEM: LEN_0958
LUE: DCD74_08535
LYA: RDV84_11810
LSY: H8L67_09155
THES: FHQ07_06210
TCN: H9L16_07610
TBV: H9L17_06870
DYG: DYGSA30_16510(rmd)
LAEO: L2Y97_04270
PAE: PA5454(rmd)
PAEV: N297_5642
PAEI: N296_5642
PAU: PA14_72000(rmd)
PAP: PSPA7_6244
PAG: PLES_58491(rmd)
PAF: PAM18_5576(rmd)
PNC: NCGM2_6231(rmd)
PAEB: NCGM1900_6309(rmd)
PDK: PADK2_29015
PSG: G655_28685
PRP: M062_28735
PAEP: PA1S_29460
PAER: PA1R_gp3389
PAEM: U769_29965
PAEL: T223_29925
PAES: SCV20265_6187
PAEU: BN889_06061(rmd)
PAEG: AI22_04525
PAEC: M802_5640
PAEO: M801_5507
SECH: B18_08485
PALC: A0T30_02620
PCQ: PcP3B5_01740(rmd)
PMUI: G4G71_02280
PPAA: B7D75_28305
PPJ: RK21_03607
PST: PSPTO_1007
PSYR: N018_21315
PSAV: PSA3335_07955
PCI: PCH70_01440
PAVL: BKM03_05930
PCAB: JGS08_04655
PCOF: POR16_19790
PTRE: I9H09_04235
PAST: N015_26065
PLIJ: KQP88_00690
PFE: PSF113_5885(rmd)
PFO: Pfl01_5681
PMAN: OU5_3478
PKR: AYO71_00205
PBA: PSEBR_a5628
PPUU: PputUW4_01530
PDR: H681_00575
PCH: EY04_29645
PCZ: PCL1606_00120
PCP: JM49_00325
PSES: PSCI_5345
PSEM: TO66_31495
PKE: DLD99_28840
PALL: UYA_23050
PGY: AWU82_06540
PBZ: GN234_18540
PATA: JWU58_00740
PZE: HU754_000880
PPII: QL104_10135
PTZ: HU718_000865
PHV: HU739_017845
PASG: KSS96_21040
PAZE: KSS91_08605
PIE: HU724_000850
PGF: J0G10_00830
PSII: NF676_27390
PFIT: KJY40_00810
PNB: NK667_27595
PKJ: Q1W70_10455
PCUC: PSH97_28260
PRHZ: CRX69_26140
PSKU: KUIN1_08900
PSHS: JJN09_20005
PHEF: PSH57_28915
PLIS: NN484_06715
PZD: KQ248_07510
ACX: Achr_26730
PDEN: F1C79_25075
ASIP: AQUSIP_18140(rmd)
MMOB: F6R98_01275
HTR: EPV75_08920
APRS: BI364_12375
EPS: L0Y14_14445
MME: Marme_2111
BSAN: CHH28_01970
AQL: BXU06_15900
MAER: DAI18_08270
REU: Reut_A0719
BML: BMA10229_A1069
BMAL: DM55_1487
BMAE: DM78_2667
BMAQ: DM76_1465
BMAI: DM57_1072
BMAF: DM51_1938
BMAZ: BM44_1066
BMAB: BM45_2463
BPM: BURPS1710b_3293(wcbK)
BPD: BURPS668_3244
BPR: GBP346_A3422
BPSE: BDL_2648
BPSM: BBQ_512
BPSU: BBN_640
BPSD: BBX_1046
BPZ: BP1026B_I0513(wcbK)
BPQ: BPC006_I3327
BPK: BBK_2133
BPSH: DR55_1721
BPSA: BBU_2765
BPSO: X996_1361
BUT: X994_3359
BTHA: DR62_530
BSTL: BBJ41_08345
PCOS: C2747_01690
PLG: NCTC10937_04677(gmd_1)
TVL: FAZ95_17380
PVAC: HC248_00496(rmd)
VPE: Varpa_0776
HHT: F506_01240
CFU: CFU_1116(rmd)
CARE: LT85_3694
CPRA: CPter91_3974
NET: Neut_0156
DOE: DENOEST_3345 DENOEST_3930(rmd)
MBAT: BN1208_0921(wcbK)
SLAC: SKTS_36170(rmd)
REN: EF513_04490
MOP: Mesop_2616
MAM: Mesau_05024
MERD: EB233_24835
MMEI: LRP31_12195
PHT: BLM14_22615
PLA: Plav_3348
ALEG: CFBP4996_24270
REC: RHECIAT_CH0000835
RLT: Rleg2_0410
RLB: RLEG3_12110
RHN: AMJ98_CH00792
RPHA: AMC79_CH00800
RHX: AMK02_CH00795
REZ: AMJ99_CH00792
RJG: CCGE525_26930
RAD: CO657_02135
RII: FFM53_009075
RHID: FFM81_017170
RLN: J0663_12565
RBAN: J2J98_03760
RLS: HB780_25405
RBW: RLCC275e_02175
RHIZ: QMO80_001809
RFV: RFYW14_04607
PDES: FE840_018905
BAUT: QA635_39080
RPA: TX73_020475
RPD: RPD_1646
RPE: RPE_4260
RPT: Rpal_4473
RPX: Rpdx1_4326
RHOR: ONR75_25225
RHOL: RBJ75_13405
NHA: Nham_2781
VGO: GJW-30_1_00102(rmd)
TRB: HB776_03030
BOP: AXW83_22490
BOSE: RMR04_27240
AZC: AZC_0053
MRD: Mrad2831_1050 Mrad2831_3464
MET: M446_5188
MOR: MOC_1268 MOC_3977
MPHY: MCBMB27_00644 MCBMB27_00801 MCBMB27_02951
MEE: DA075_19405
METD: C0214_18365
METX: A3862_14145 A3862_25325
METS: DK389_04280
MMES: MMSR116_25040 MMSR116_30875
MTAD: M6G65_05335 M6G65_05720 M6G65_20570
BBAR: RHAL1_00379
RVA: Rvan_2460
DAG: PSQ19_17225
MSC: BN69_2011
MBRY: B1812_17900
MROS: EHO51_15185
MHEY: H2LOC_014770
MPAR: F7D14_06745
MIWA: SS37A_01050
MESZ: LNB28_09430
MTW: CQW49_16720
MECQ: MSC49_13800
PLEO: OHA_1_01728(rmd)
HDI: HDIA_0149(rmd_1)
AALM: LUX29_06815
AUB: LXB15_15305
ACUT: MRB58_13375
BSB: Bresu_3279
BRG: A4249_12990
BDM: EQG53_06295
BGOE: IFJ75_18540
BFQ: JX001_02515
BREA: HZ989_04000
SIT: TM1040_1485
PHQ: D1820_14000
RSU: NHU_00140
RHM: B5V46_02120
PGV: SL003B_2556
HNE: HNE_0794
ZMN: Za10_0101
ZMI: ZCP4_0102
ZMC: A265_00102(rfbE)
ZMR: A254_00102(rfbE)
ZMP: Zymop_1692
SNAP: PQ455_06375
GOX: GOX1292 GOX1611
GOH: B932_0830
GOY: GLS_c13770 GLS_c17320
GAL: A0U94_14000
GTI: FXF46_06825
GSP: IGS75_09465
GFA: MKW11_06770
GBE: GbCGDNIH1_1716
GBH: GbCGDNIH2_1716
GBC: GbCGDNIH3_1716
GBS: GbCGDNIH4_1716
ACR: Acry_0507
AMV: ACMV_05820(rmd)
KBA: A0U89_02310
RGI: RGI145_01425
ROS: CTJ15_19565
RMUC: FOB66_18950
RMT: IAI58_04410
RFL: Rmf_22700
LCK: HN018_20315
RAP: RHOA_5432
ACIM: GT370_03245
AOZ: HUE56_00500
AZS: E6C72_30875
SKT: IGS68_03080
SMUC: JL100_003195
SROE: JL101_002965
MAGQ: MGMAQ_1159
AFR: AFE_3291
AFE: Lferr_2889
ACU: Atc_0208
AFI: Acife_1159 Acife_2355
AFJ: AFERRID_14960
AFP: K1Y48_08195
HWI: A0Z60_06610
HPUL: NCTC13154_01560(gmd)
CJJ: CJJ81176_1426(wcbK)
CJN: ICDCCJ07001_1357
CJS: CJS3_1519(wcbK)
CJER: H730_08150
CJQ: UC78_1367(rmd_2)
CJR: CJE1611(wcbK)
CJX: BN867_14030
CLR: UPTC16701_0315
CLM: UPTC16712_0313
CLN: UPTC3659_0325
CCF: YSQ_01730
CAMR: CAQ16704_0314
CSM: CSUB8521_0326
CLX: CLAN_0158
CAMZ: CVIC12175_0180
COJ: CORN_0312
CNV: CNZW441b_0359
CDEV: CIGN_0118
GEM: GM21_3399
TAMM: GEAMG1_2508
DOV: DSCO28_03330
DWD: DSCW_50670(rfbB)
MXA: MXAN_5328(rmd)
MSD: MYSTI_05892
MYM: A176_001583
MFB: MFUL124B02_31580
MLAN: JY572_37490
CCX: COCOR_02240(rmd)
MFU: LILAB_34470
MMAS: MYMAC_005188
PPAK: JY651_04885
SUR: STAUR_6036(rmd)
LPAK: GDS87_03105
PSYO: PB01_03670
TEI: QS257_18565 QS257_18570
BBE: BBR47_17540
BFM: BP422_03945
BCHS: JNE38_09525
BPAB: PSE45_08690
BHUI: LOK74_08520
BBOR: RFB14_13695
BREH: HP435_09260
PJD: Pjdr2_3512
PMS: KNP414_03315 KNP414_06543
PMQ: PM3016_3535 PM3016_6150
PMW: B2K_18235 B2K_31225
PLV: ERIC2_c02840(gmd)
PSON: JI735_05780
PSWU: SY83_13105
PCX: LPB68_14475
PLUT: EI981_25875
PPRT: ET464_03300
PALO: E6C60_3795
PCEL: HUB94_07815
PTHI: NDS46_22630
PDY: QJQ58_25285 QJQ58_29620
PHEX: L0M14_12300
ANX: ACH33_01790
COHN: KCTCHS21_54750 KCTCHS21_55810(rfbB)
CHEB: HH215_19395
COHL: J4772_32735
AFX: JZ786_22515
AACO: K1I37_06350
ACUR: JZ785_22290
FFE: LSG31_04330 LSG31_20470
CGEL: psyc5s11_31690(gca)
CCL: Clocl_3957
RCH: RUM_03120
STH: STH1372
DAI: Desaci_4421
DED: DHBDCA_p1070
DEC: DCF50_p1140
DRU: Desru_3675
AACX: DEACI_0201
SAY: TPY_1421 TPY_2530
SAP: Sulac_2236 Sulac_3283
BPEN: NQ488_00275
CBAF: JS518_12155
BPB: bpr_I0151(gmd1) bpr_I0396
BHU: bhn_I0589
BLUI: Blut17040_12340
CHYL: CE91St63_29530(gca)
KIB: RBB56_12655 RBB56_12735
HHJ: NQ487_03980
CLE: Clole_3815
CEW: EKH84_00475
CALK: HUE98_16880
EYY: EGYY_07230(Gmd)
RTS: CE91St31_13150(gca)
MTU: Rv0112(gca)
MTV: RVBD_0112
MTC: MT0121
MRA: MRA_0118(gca)
MTF: TBFG_10113
MTB: TBMG_00113
MTK: TBSG_00113
MTZ: TBXG_000113
MTI: MRGA423_00730
MTE: CCDC5079_0098
MTUR: CFBS_0121(gca)
MTL: CCDC5180_0098
MTO: MTCTRI2_0115(gca)
MTD: UDA_0112(gca)
MTN: ERDMAN_0130(gca)
MTJ: J112_00620
MTUB: MT7199_0114(gca)
MTUC: J113_00800
MTUE: J114_00620
MTX: M943_00620
MTUH: I917_00860
MTUL: TBHG_00112
MTUT: HKBT1_0121(gca)
MTUU: HKBT2_0121(gca)
MTQ: HKBS1_0121(gca)
MBO: BQ2027_MB0116(gca)
MBB: BCG_0145(gca)
MBT: JTY_0116(gca)
MBM: BCGMEX_0116(gca)
MBK: K60_001250
MBX: BCGT_3909
MAF: MAF_01130(gca)
MMIC: RN08_0130
MCE: MCAN_01151(gca)
MCQ: BN44_10135(gca)
MCV: BN43_10130(gca)
MCX: BN42_10151(gca)
MCZ: BN45_10128(gca)
MORY: MO_000122
MAIC: MAIC_46420(rmd)
MTS: MTES_0931
MIH: BJP65_06395 BJP65_14830
MWA: E4K62_03120
MRG: SM116_05850
DCP: RN607_02060
NMAR: HPC71_18470
PLK: CIK06_06155
NAB: B1sIIB91_05480
ABAI: IMCC26256_111953
RXY: Rxyl_0568
AFO: Afer_0745
ATQ: GH723_12295
AQZ: KSP35_08645
IAM: HC251_09120
IMA: PO878_13500
DHI: LH044_20025
PMH: P9215_14361
NSH: GXM_02821
RRS: RoseRS_1853 RoseRS_3655 RoseRS_4076
RCA: Rcas_0917 Rcas_3281
CAU: Caur_1970 Caur_2686
CHL: Chy400_2124 Chy400_2903
CAG: Cagg_0939 Cagg_2042
HAU: Haur_3742 Haur_4820
CALL: OZ401_001251
CAP: CLDAP_16990
PBF: CFX0092_A0151(rmd)
THUG: KNN16_09480
TTR: Tter_1710
PMET: G4Y79_14310
TRO: trd_0916
STI: Sthe_1123
TRA: Trad_2861
VAB: WPS_29120
VBA: IMCC26134_03175
BVO: Pan97_02120(rmd)
BREM: PSR63_10020
TTF: THTE_3576
PLH: VT85_25320(rmd_3)
GES: VT84_32605(rmd_2)
GOG: C1280_12470
GMS: SOIL9_61690
TIM: GMBLW1_14760
LRS: PX52LOC_03147
FTJ: FTUN_0673
ULI: ETAA1_19690(rmd)
TSPH: KIH39_19790
IPA: Isop_0504 Isop_3611
SACI: Sinac_0262
PBOR: BSF38_03321(rmd_3) BSF38_04700(rmd_4)
AGV: OJF2_00280(rmd_1)
TPLA: ElP_38840(rmd_3) ElP_70320(rmd_4)
PBAP: Pla133_24840(rmd)
VAI: BU251_02255
LIL: LA_0235(rfbB)
LIE: LIF_A0204(rfbB)
LIC: LIC_10203(rmd)
LIS: LIL_10203(rfbB1)
LBJ: LBJ_0170 LBJ_1162
LBL: LBL_1216 LBL_2913
LBI: LEPBI_I3261
LBF: LBF_3148
LST: LSS_04696
LAJ: A0128_01075
LMAY: DPV73_04570
LKM: EFP84_11920
LWL: FHG68_01110 FHG68_08475
LKB: LPTSP3_g34060(rfbB_2)
LNO: MAL08_01050
LKR: FH602_06560
TPSC: RBB77_18765
ABAC: LuPra_05853(rmd)
LUB: TBR22_A48280
GEX: GETHOR_16780
GEP: Q9293_00430
FUL: C4N20_11210
LOT: AXF11_05710
LSZ: JCM16776_1906 JCM16776_1907
ACO: Amico_1359
AMIZ: RBH88_03100
TLI: Tlie_1236
AMO: Anamo_1479 Anamo_1883
FSU: Fisuc_2243
FSC: FSU_2786(rmd)
GAU: GAU_1969
GPH: GEMMAAP_10230
GGR: HKW67_04485
GBA: J421_3572
PSPC: Strain318_001836
FEI: K9M53_05440
FLP: LK994_03645
MMAB: HQ865_06420
CAMU: CA2015_3251
HYZ: AXW84_10635
HTB: MTX78_04920
HVL: MUN86_04770
TMG: US01_C0001G0477
MIB: UY43_C0001G0736
FSH: Q2T83_18055
METB: AW729_04020
MCHK: MchiMG62_18220
MPI: Mpet_1407
MANQ: L1994_11640
HALY: HYG82_08675
PIS: Pisl_1490
TNE: Tneu_0491
FLT: Sv326_1260
LOKI: Lokiarch_35700(rmd)
LOB: NEF87_004320
AGW: QT03_C0001G0689
AG: AAS55712(rmd)
 » show all
Reference
PMID:11096116
  Authors
Kneidinger B, Graninger M, Adam G, Puchberger M, Kosma P, Zayni S, Messner P
  Title
Identification of two GDP-6-deoxy-D-lyxo-4-hexulose reductases synthesizing GDP-D-rhamnose in Aneurinibacillus thermoaerophilus L420-91T.
  Journal
J Biol Chem 276:5577-83 (2001)
DOI:10.1074/jbc.M010027200
  Sequence
[ag:AAS55712]
Reference
PMID:11856318
  Authors
Maki M, Jarvinen N, Rabina J, Roos C, Maaheimo H, Renkonen R
  Title
Functional expression of Pseudomonas aeruginosa GDP-4-keto-6-deoxy-D-mannose reductase which synthesizes GDP-rhamnose.
  Journal
Eur J Biochem 269:593-601 (2002)
DOI:10.1046/j.0014-2956.2001.02688.x
  Sequence
[pae:PA5454]
LinkDB

KEGG   ENZYME: 1.1.1.281
Entry
EC 1.1.1.281                Enzyme                                 
Name
GDP-4-dehydro-6-deoxy-D-mannose reductase;
GDP-4-keto-6-deoxy-D-mannose reductase [ambiguous];
GDP-6-deoxy-D-lyxo-4-hexulose reductase;
Rmd;
GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming);
GDP-6-deoxy-alpha-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
GDP-alpha-D-rhamnose:NAD(P)+ 4-oxidoreductase
Reaction(IUBMB)
GDP-alpha-D-rhamnose + NAD(P)+ = GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H + H+ [RN:R03397 R03399]
Reaction(KEGG)
R03397 R03399
Substrate
GDP-alpha-D-rhamnose [CPD:C03117];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
GDP-4-dehydro-alpha-D-rhamnose [CPD:C01222];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
This enzyme differs from EC 1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-alpha-D-rhamnose. D-Rhamnose is a constituent of lipopolysaccharides of Gram-negative plant and human pathogenic bacteria.
History
EC 1.1.1.281 created 2004
Pathway
ec00051  Fructose and mannose metabolism
ec00520  Amino sugar and nucleotide sugar metabolism
ec00541  O-Antigen nucleotide sugar biosynthesis
ec01100  Metabolic pathways
Orthology
K15856  GDP-4-dehydro-6-deoxy-D-mannose reductase
Genes
YPB: YPTS_1054
YPQ: DJ40_1349
YPU: BZ21_253
YPR: BZ20_1036
YPC: BZ23_529
XAL: XALC_2707(rmd)
XVA: C7V42_18455
PDD: MNQ95_09680
LCP: LC55x_4380
LGU: LG3211_4185
LEZ: GLE_4243
LEM: LEN_0958
LUE: DCD74_08535
LYA: RDV84_11810
LSY: H8L67_09155
THES: FHQ07_06210
TCN: H9L16_07610
TBV: H9L17_06870
DYG: DYGSA30_16510(rmd)
LAEO: L2Y97_04270
PAE: PA5454(rmd)
PAEV: N297_5642
PAEI: N296_5642
PAU: PA14_72000(rmd)
PAP: PSPA7_6244
PAG: PLES_58491(rmd)
PAF: PAM18_5576(rmd)
PNC: NCGM2_6231(rmd)
PAEB: NCGM1900_6309(rmd)
PDK: PADK2_29015
PSG: G655_28685
PRP: M062_28735
PAEP: PA1S_29460
PAER: PA1R_gp3389
PAEM: U769_29965
PAEL: T223_29925
PAES: SCV20265_6187
PAEU: BN889_06061(rmd)
PAEG: AI22_04525
PAEC: M802_5640
PAEO: M801_5507
SECH: B18_08485
PALC: A0T30_02620
PCQ: PcP3B5_01740(rmd)
PMUI: G4G71_02280
PPAA: B7D75_28305
PPJ: RK21_03607
PST: PSPTO_1007
PSYR: N018_21315
PSAV: PSA3335_07955
PCI: PCH70_01440
PAVL: BKM03_05930
PCAB: JGS08_04655
PCOF: POR16_19790
PTRE: I9H09_04235
PAST: N015_26065
PLIJ: KQP88_00690
PFE: PSF113_5885(rmd)
PFO: Pfl01_5681
PMAN: OU5_3478
PKR: AYO71_00205
PBA: PSEBR_a5628
PPUU: PputUW4_01530
PDR: H681_00575
PCH: EY04_29645
PCZ: PCL1606_00120
PCP: JM49_00325
PSES: PSCI_5345
PSEM: TO66_31495
PKE: DLD99_28840
PALL: UYA_23050
PGY: AWU82_06540
PBZ: GN234_18540
PATA: JWU58_00740
PZE: HU754_000880
PPII: QL104_10135
PTZ: HU718_000865
PHV: HU739_017845
PASG: KSS96_21040
PAZE: KSS91_08605
PIE: HU724_000850
PGF: J0G10_00830
PSII: NF676_27390
PFIT: KJY40_00810
PNB: NK667_27595
PKJ: Q1W70_10455
PCUC: PSH97_28260
PRHZ: CRX69_26140
PSKU: KUIN1_08900
PSHS: JJN09_20005
PHEF: PSH57_28915
PLIS: NN484_06715
PZD: KQ248_07510
ACX: Achr_26730
PDEN: F1C79_25075
ASIP: AQUSIP_18140(rmd)
MMOB: F6R98_01275
HTR: EPV75_08920
APRS: BI364_12375
EPS: L0Y14_14445
MME: Marme_2111
BSAN: CHH28_01970
AQL: BXU06_15900
MAER: DAI18_08270
REU: Reut_A0719
BML: BMA10229_A1069
BMAL: DM55_1487
BMAE: DM78_2667
BMAQ: DM76_1465
BMAI: DM57_1072
BMAF: DM51_1938
BMAZ: BM44_1066
BMAB: BM45_2463
BPM: BURPS1710b_3293(wcbK)
BPD: BURPS668_3244
BPR: GBP346_A3422
BPSE: BDL_2648
BPSM: BBQ_512
BPSU: BBN_640
BPSD: BBX_1046
BPZ: BP1026B_I0513(wcbK)
BPQ: BPC006_I3327
BPK: BBK_2133
BPSH: DR55_1721
BPSA: BBU_2765
BPSO: X996_1361
BUT: X994_3359
BTHA: DR62_530
BSTL: BBJ41_08345
PCOS: C2747_01690
PLG: NCTC10937_04677(gmd_1)
TVL: FAZ95_17380
PVAC: HC248_00496(rmd)
VPE: Varpa_0776
HHT: F506_01240
CFU: CFU_1116(rmd)
CARE: LT85_3694
CPRA: CPter91_3974
NET: Neut_0156
DOE: DENOEST_3345 DENOEST_3930(rmd)
MBAT: BN1208_0921(wcbK)
SLAC: SKTS_36170(rmd)
REN: EF513_04490
MOP: Mesop_2616
MAM: Mesau_05024
MERD: EB233_24835
MMEI: LRP31_12195
PHT: BLM14_22615
PLA: Plav_3348
ALEG: CFBP4996_24270
REC: RHECIAT_CH0000835
RLT: Rleg2_0410
RLB: RLEG3_12110
RHN: AMJ98_CH00792
RPHA: AMC79_CH00800
RHX: AMK02_CH00795
REZ: AMJ99_CH00792
RJG: CCGE525_26930
RAD: CO657_02135
RII: FFM53_009075
RHID: FFM81_017170
RLN: J0663_12565
RBAN: J2J98_03760
RLS: HB780_25405
RBW: RLCC275e_02175
RHIZ: QMO80_001809
RFV: RFYW14_04607
PDES: FE840_018905
BAUT: QA635_39080
RPA: TX73_020475
RPD: RPD_1646
RPE: RPE_4260
RPT: Rpal_4473
RPX: Rpdx1_4326
RHOR: ONR75_25225
RHOL: RBJ75_13405
NHA: Nham_2781
VGO: GJW-30_1_00102(rmd)
TRB: HB776_03030
BOP: AXW83_22490
BOSE: RMR04_27240
AZC: AZC_0053
MRD: Mrad2831_1050 Mrad2831_3464
MET: M446_5188
MOR: MOC_1268 MOC_3977
MPHY: MCBMB27_00644 MCBMB27_00801 MCBMB27_02951
MEE: DA075_19405
METD: C0214_18365
METX: A3862_14145 A3862_25325
METS: DK389_04280
MMES: MMSR116_25040 MMSR116_30875
MTAD: M6G65_05335 M6G65_05720 M6G65_20570
BBAR: RHAL1_00379
RVA: Rvan_2460
DAG: PSQ19_17225
MSC: BN69_2011
MBRY: B1812_17900
MROS: EHO51_15185
MHEY: H2LOC_014770
MPAR: F7D14_06745
MIWA: SS37A_01050
MESZ: LNB28_09430
MTW: CQW49_16720
MECQ: MSC49_13800
PLEO: OHA_1_01728(rmd)
HDI: HDIA_0149(rmd_1)
AALM: LUX29_06815
AUB: LXB15_15305
ACUT: MRB58_13375
BSB: Bresu_3279
BRG: A4249_12990
BDM: EQG53_06295
BGOE: IFJ75_18540
BFQ: JX001_02515
BREA: HZ989_04000
SIT: TM1040_1485
PHQ: D1820_14000
RSU: NHU_00140
RHM: B5V46_02120
PGV: SL003B_2556
HNE: HNE_0794
ZMN: Za10_0101
ZMI: ZCP4_0102
ZMC: A265_00102(rfbE)
ZMR: A254_00102(rfbE)
ZMP: Zymop_1692
SNAP: PQ455_06375
GOX: GOX1292 GOX1611
GOH: B932_0830
GOY: GLS_c13770 GLS_c17320
GAL: A0U94_14000
GTI: FXF46_06825
GSP: IGS75_09465
GFA: MKW11_06770
GBE: GbCGDNIH1_1716
GBH: GbCGDNIH2_1716
GBC: GbCGDNIH3_1716
GBS: GbCGDNIH4_1716
ACR: Acry_0507
AMV: ACMV_05820(rmd)
KBA: A0U89_02310
RGI: RGI145_01425
ROS: CTJ15_19565
RMUC: FOB66_18950
RMT: IAI58_04410
RFL: Rmf_22700
LCK: HN018_20315
RAP: RHOA_5432
ACIM: GT370_03245
AOZ: HUE56_00500
AZS: E6C72_30875
SKT: IGS68_03080
SMUC: JL100_003195
SROE: JL101_002965
MAGQ: MGMAQ_1159
AFR: AFE_3291
AFE: Lferr_2889
ACU: Atc_0208
AFI: Acife_1159 Acife_2355
AFJ: AFERRID_14960
AFP: K1Y48_08195
HWI: A0Z60_06610
HPUL: NCTC13154_01560(gmd)
CJJ: CJJ81176_1426(wcbK)
CJN: ICDCCJ07001_1357
CJS: CJS3_1519(wcbK)
CJER: H730_08150
CJQ: UC78_1367(rmd_2)
CJR: CJE1611(wcbK)
CJX: BN867_14030
CLR: UPTC16701_0315
CLM: UPTC16712_0313
CLN: UPTC3659_0325
CCF: YSQ_01730
CAMR: CAQ16704_0314
CSM: CSUB8521_0326
CLX: CLAN_0158
CAMZ: CVIC12175_0180
COJ: CORN_0312
CNV: CNZW441b_0359
CDEV: CIGN_0118
GEM: GM21_3399
TAMM: GEAMG1_2508
DOV: DSCO28_03330
DWD: DSCW_50670(rfbB)
MXA: MXAN_5328(rmd)
MSD: MYSTI_05892
MYM: A176_001583
MFB: MFUL124B02_31580
MLAN: JY572_37490
CCX: COCOR_02240(rmd)
MFU: LILAB_34470
MMAS: MYMAC_005188
PPAK: JY651_04885
SUR: STAUR_6036(rmd)
LPAK: GDS87_03105
PSYO: PB01_03670
TEI: QS257_18565 QS257_18570
BBE: BBR47_17540
BFM: BP422_03945
BCHS: JNE38_09525
BPAB: PSE45_08690
BHUI: LOK74_08520
BBOR: RFB14_13695
BREH: HP435_09260
PJD: Pjdr2_3512
PMS: KNP414_03315 KNP414_06543
PMQ: PM3016_3535 PM3016_6150
PMW: B2K_18235 B2K_31225
PLV: ERIC2_c02840(gmd)
PSON: JI735_05780
PSWU: SY83_13105
PCX: LPB68_14475
PLUT: EI981_25875
PPRT: ET464_03300
PALO: E6C60_3795
PCEL: HUB94_07815
PTHI: NDS46_22630
PDY: QJQ58_25285 QJQ58_29620
PHEX: L0M14_12300
ANX: ACH33_01790
COHN: KCTCHS21_54750 KCTCHS21_55810(rfbB)
CHEB: HH215_19395
COHL: J4772_32735
AFX: JZ786_22515
AACO: K1I37_06350
ACUR: JZ785_22290
FFE: LSG31_04330 LSG31_20470
CGEL: psyc5s11_31690(gca)
CCL: Clocl_3957
RCH: RUM_03120
STH: STH1372
DAI: Desaci_4421
DED: DHBDCA_p1070
DEC: DCF50_p1140
DRU: Desru_3675
AACX: DEACI_0201
SAY: TPY_1421 TPY_2530
SAP: Sulac_2236 Sulac_3283
BPEN: NQ488_00275
CBAF: JS518_12155
BPB: bpr_I0151(gmd1) bpr_I0396
BHU: bhn_I0589
BLUI: Blut17040_12340
CHYL: CE91St63_29530(gca)
KIB: RBB56_12655 RBB56_12735
HHJ: NQ487_03980
CLE: Clole_3815
CEW: EKH84_00475
CALK: HUE98_16880
EYY: EGYY_07230(Gmd)
RTS: CE91St31_13150(gca)
MTU: Rv0112(gca)
MTV: RVBD_0112
MTC: MT0121
MRA: MRA_0118(gca)
MTF: TBFG_10113
MTB: TBMG_00113
MTK: TBSG_00113
MTZ: TBXG_000113
MTI: MRGA423_00730
MTE: CCDC5079_0098
MTUR: CFBS_0121(gca)
MTL: CCDC5180_0098
MTO: MTCTRI2_0115(gca)
MTD: UDA_0112(gca)
MTN: ERDMAN_0130(gca)
MTJ: J112_00620
MTUB: MT7199_0114(gca)
MTUC: J113_00800
MTUE: J114_00620
MTX: M943_00620
MTUH: I917_00860
MTUL: TBHG_00112
MTUT: HKBT1_0121(gca)
MTUU: HKBT2_0121(gca)
MTQ: HKBS1_0121(gca)
MBO: BQ2027_MB0116(gca)
MBB: BCG_0145(gca)
MBT: JTY_0116(gca)
MBM: BCGMEX_0116(gca)
MBK: K60_001250
MBX: BCGT_3909
MAF: MAF_01130(gca)
MMIC: RN08_0130
MCE: MCAN_01151(gca)
MCQ: BN44_10135(gca)
MCV: BN43_10130(gca)
MCX: BN42_10151(gca)
MCZ: BN45_10128(gca)
MORY: MO_000122
MAIC: MAIC_46420(rmd)
MTS: MTES_0931
MIH: BJP65_06395 BJP65_14830
MWA: E4K62_03120
MRG: SM116_05850
DCP: RN607_02060
NMAR: HPC71_18470
PLK: CIK06_06155
NAB: B1sIIB91_05480
ABAI: IMCC26256_111953
RXY: Rxyl_0568
AFO: Afer_0745
ATQ: GH723_12295
AQZ: KSP35_08645
IAM: HC251_09120
IMA: PO878_13500
DHI: LH044_20025
PMH: P9215_14361
NSH: GXM_02821
RRS: RoseRS_1853 RoseRS_3655 RoseRS_4076
RCA: Rcas_0917 Rcas_3281
CAU: Caur_1970 Caur_2686
CHL: Chy400_2124 Chy400_2903
CAG: Cagg_0939 Cagg_2042
HAU: Haur_3742 Haur_4820
CALL: OZ401_001251
CAP: CLDAP_16990
PBF: CFX0092_A0151(rmd)
THUG: KNN16_09480
TTR: Tter_1710
PMET: G4Y79_14310
TRO: trd_0916
STI: Sthe_1123
TRA: Trad_2861
VAB: WPS_29120
VBA: IMCC26134_03175
BVO: Pan97_02120(rmd)
BREM: PSR63_10020
TTF: THTE_3576
PLH: VT85_25320(rmd_3)
GES: VT84_32605(rmd_2)
GOG: C1280_12470
GMS: SOIL9_61690
TIM: GMBLW1_14760
LRS: PX52LOC_03147
FTJ: FTUN_0673
ULI: ETAA1_19690(rmd)
TSPH: KIH39_19790
IPA: Isop_0504 Isop_3611
SACI: Sinac_0262
PBOR: BSF38_03321(rmd_3) BSF38_04700(rmd_4)
AGV: OJF2_00280(rmd_1)
TPLA: ElP_38840(rmd_3) ElP_70320(rmd_4)
PBAP: Pla133_24840(rmd)
VAI: BU251_02255
LIL: LA_0235(rfbB)
LIE: LIF_A0204(rfbB)
LIC: LIC_10203(rmd)
LIS: LIL_10203(rfbB1)
LBJ: LBJ_0170 LBJ_1162
LBL: LBL_1216 LBL_2913
LBI: LEPBI_I3261
LBF: LBF_3148
LST: LSS_04696
LAJ: A0128_01075
LMAY: DPV73_04570
LKM: EFP84_11920
LWL: FHG68_01110 FHG68_08475
LKB: LPTSP3_g34060(rfbB_2)
LNO: MAL08_01050
LKR: FH602_06560
TPSC: RBB77_18765
ABAC: LuPra_05853(rmd)
LUB: TBR22_A48280
GEX: GETHOR_16780
GEP: Q9293_00430
FUL: C4N20_11210
LOT: AXF11_05710
LSZ: JCM16776_1906 JCM16776_1907
ACO: Amico_1359
AMIZ: RBH88_03100
TLI: Tlie_1236
AMO: Anamo_1479 Anamo_1883
FSU: Fisuc_2243
FSC: FSU_2786(rmd)
GAU: GAU_1969
GPH: GEMMAAP_10230
GGR: HKW67_04485
GBA: J421_3572
PSPC: Strain318_001836
FEI: K9M53_05440
FLP: LK994_03645
MMAB: HQ865_06420
CAMU: CA2015_3251
HYZ: AXW84_10635
HTB: MTX78_04920
HVL: MUN86_04770
TMG: US01_C0001G0477
MIB: UY43_C0001G0736
FSH: Q2T83_18055
METB: AW729_04020
MCHK: MchiMG62_18220
MPI: Mpet_1407
MANQ: L1994_11640
HALY: HYG82_08675
PIS: Pisl_1490
TNE: Tneu_0491
FLT: Sv326_1260
LOKI: Lokiarch_35700(rmd)
LOB: NEF87_004320
AGW: QT03_C0001G0689
 » show all
Reference
1  [PMID:11096116]
  Authors
Kneidinger B, Graninger M, Adam G, Puchberger M, Kosma P, Zayni S, Messner P
  Title
Identification of two GDP-6-deoxy-D-lyxo-4-hexulose reductases synthesizing GDP-D-rhamnose in Aneurinibacillus thermoaerophilus L420-91T.
  Journal
J Biol Chem 276:5577-83 (2001)
DOI:10.1074/jbc.M010027200
  Sequence
[ag:AAS55712]
Reference
2  [PMID:11856318]
  Authors
Maki M, Jarvinen N, Rabina J, Roos C, Maaheimo H, Renkonen R
  Title
Functional expression of Pseudomonas aeruginosa GDP-4-keto-6-deoxy-D-mannose reductase which synthesizes GDP-rhamnose.
  Journal
Eur J Biochem 269:593-601 (2002)
DOI:10.1046/j.0014-2956.2001.02688.x
  Sequence
[pae:PA5454]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.281
IUBMB Enzyme Nomenclature: 1.1.1.281
ExPASy - ENZYME nomenclature database: 1.1.1.281
BRENDA, the Enzyme Database: 1.1.1.281
LinkDB

KEGG   REACTION: R03397
Entry
R03397                      Reaction                               
Name
GDP-6-deoxy-D-mannose:NAD+ 4-oxidoreductase
Definition
GDP-6-deoxy-D-mannose + NAD+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+
Equation
C03117 + C00003 <=> C01222 + C00004 + C00080
Comment
NADP+ (see R03399)
Reaction class
RC00001  C00003_C00004
RC00182  C01222_C03117
Enzyme
1.1.1.187       1.1.1.281
Pathway
rn00051  Fructose and mannose metabolism
rn00520  Amino sugar and nucleotide sugar metabolism
rn00541  O-Antigen nucleotide sugar biosynthesis
rn01100  Metabolic pathways
rn01250  Biosynthesis of nucleotide sugars
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.187
     R03397  GDP-6-deoxy-D-mannose + NAD+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+
    1.1.1.281
     R03397  GDP-6-deoxy-D-mannose + NAD+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+
Orthology
K15856  GDP-4-dehydro-6-deoxy-D-mannose reductase [EC:1.1.1.281]
Other DBs
RHEA: 13828
LinkDB

KEGG   REACTION: R03399
Entry
R03399                      Reaction                               
Name
GDP-6-deoxy-D-mannose:NADP+ 4-oxidoreductase
Definition
GDP-6-deoxy-D-mannose + NADP+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+
Equation
C03117 + C00006 <=> C01222 + C00005 + C00080
Comment
NAD+ (see R03397)
Reaction class
RC00001  C00005_C00006
RC00182  C01222_C03117
Enzyme
1.1.1.187       1.1.1.281
Pathway
rn00051  Fructose and mannose metabolism
rn00520  Amino sugar and nucleotide sugar metabolism
rn00541  O-Antigen nucleotide sugar biosynthesis
rn01100  Metabolic pathways
rn01250  Biosynthesis of nucleotide sugars
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.187
     R03399  GDP-6-deoxy-D-mannose + NADP+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+
    1.1.1.281
     R03399  GDP-6-deoxy-D-mannose + NADP+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+
Orthology
K15856  GDP-4-dehydro-6-deoxy-D-mannose reductase [EC:1.1.1.281]
Other DBs
RHEA: 13832
LinkDB

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