baiCD (gene name);
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
(1) 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD+ = 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+ [RN:
(2) 7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD+ = 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+ [RN:
Contains flavin. The enzyme, characterized from the bacterium Clostridium scindens, participates in the bile acid 7alpha-dehydroxylation pathway. The enzyme catalyses the stereo-specific oxidation of its substrates and has no activity with the 7beta anomers. cf. EC
, 7beta-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase.
EC 126.96.36.199 created 2018
ec00121 Secondary bile acid biosynthesis
K15870 3-oxocholoyl-CoA 4-desaturase
Kang DJ, Ridlon JM, Moore DR 2nd, Barnes S, Hylemon PB
Clostridium scindens baiCD and baiH genes encode stereo-specific 7alpha/7beta-hydroxy-3-oxo-delta4-cholenoic acid oxidoreductases.
ExPASy - ENZYME nomenclature database: 188.8.131.52
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