KEGG   ORTHOLOGY: K15941
Entry
K15941                      KO                                     
Symbol
snoaB, dnrG, aknX
Name
deoxynogalonate / 12-deoxyaklanonic acid monooxygenase [EC:1.13.12.22 1.13.12.-]
Pathway
map01057  Biosynthesis of type II polyketide products
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00781  Nogalavinone/aklavinone biosynthesis, deoxynogalonate/deoxyaklanonate => nogalavinone/aklavinone
Reaction
R06679  12-deoxyaklanonic-acid:oxygen oxidoreductase
R09327  deoxynogalonate:oxygen oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15941  snoaB, dnrG, aknX; deoxynogalonate / 12-deoxyaklanonic acid monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15941  snoaB, dnrG, aknX; deoxynogalonate / 12-deoxyaklanonic acid monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.12  With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
    1.13.12.22  deoxynogalonate monooxygenase
     K15941  snoaB, dnrG, aknX; deoxynogalonate / 12-deoxyaklanonic acid monooxygenase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Oxygenase
   K15941  snoaB, dnrG, aknX; deoxynogalonate / 12-deoxyaklanonic acid monooxygenase
Genes
SPRI: SPRI_0238
SRW: TUE45_01321
STIR: DDW44_27785
SGAL: CP966_29065
SCIN: CP977_28060
STSU: B7R87_22030
SCOE: CP976_32920
SLIA: HA039_05630
SPEU: CGZ69_24320
SXN: IAG42_36735
SDD: D9753_08545
SNIG: HEK616_47560
SJN: RI060_18285
SHAU: K9S39_40670
SKG: KJK29_16080
SINN: ABB07_18395
STPB: QR97_38665
TCU: Tcur_2800
PMAD: BAY61_07690
MAU: Micau_3995
MIL: ML5_4426
MFEU: H1D33_25705
AG: AAA65205(dnrG) AAF70105(aknX) CAA12015(snoaB)
 » show all
Reference
PMID:8668120
  Authors
Ylihonko K, Tuikkanen J, Jussila S, Cong L, Mantsala P
  Title
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.
  Journal
Mol Gen Genet 251:113-20 (1996)
DOI:10.1007/BF02172908
  Sequence
[ag:CAA12015]
Reference
PMID:20052967
  Authors
Grocholski T, Koskiniemi H, Lindqvist Y, Mantsala P, Niemi J, Schneider G
  Title
Crystal structure of the cofactor-independent monooxygenase SnoaB from Streptomyces nogalater: implications for the reaction mechanism.
  Journal
Biochemistry 49:934-44 (2010)
DOI:10.1021/bi901985b
Reference
PMID:12399480
  Authors
Chung JY, Fujii I, Harada S, Sankawa U, Ebizuka Y
  Title
Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.
  Journal
J Bacteriol 184:6115-22 (2002)
DOI:10.1128/JB.184.22.6115-6122.2002
  Sequence
[ag:AAF70105]
LinkDB

KEGG   REACTION: R06679
Entry
R06679                      Reaction                               
Name
12-deoxyaklanonic-acid:oxygen oxidoreductase
Definition
12-Deoxyaklanonic acid + Oxygen <=> Aklanonate + H2O
Equation
C12420 + C00007 <=> C12421 + C00001
Comment
monooxygenase, aknX, dnr/dauG
Reaction class
RC01658  C12420_C12421
Enzyme
1.13.12.-
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00781  Nogalavinone/aklavinone biosynthesis, deoxynogalonate/deoxyaklanonate => nogalavinone/aklavinone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.12  With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
    1.13.12.-
     R06679  12-Deoxyaklanonic acid + Oxygen <=> Aklanonate + H2O
Orthology
K15941  deoxynogalonate / 12-deoxyaklanonic acid monooxygenase [EC:1.13.12.22 1.13.12.-]
LinkDB

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