KEGG   ORTHOLOGY: K15992
Entry
K15992            Tight     KO                                     
Symbol
tylI, CYP113B
Name
cytochrome P450 TylI
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00773  Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
Reaction
R06449  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K15992  tylI, CYP113B; cytochrome P450 TylI
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K15992  tylI, CYP113B; cytochrome P450 TylI
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15992  tylI, CYP113B; cytochrome P450 TylI
   00199 Cytochrome P450
    K15992  tylI, CYP113B; cytochrome P450 TylI
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Oxygenase
   K15992  tylI, CYP113B; cytochrome P450 TylI
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, bacteria type
  CYP113 family
   K15992  tylI, CYP113B; cytochrome P450 TylI
Other DBs
COG: COG2124
Genes
AG: AAA21341(tylI)
Reference
PMID:11476481
  Authors
Rawlings BJ.
  Title
Type I polyketide biosynthesis in bacteria (part B).
  Journal
Nat Prod Rep 18:231-81 (2001)
DOI:10.1039/B100191O
Reference
PMID:7984112
  Authors
Merson-Davies LA, Cundliffe E
  Title
Analysis of five tylosin biosynthetic genes from the tyllBA region of the Streptomyces fradiae genome.
  Journal
Mol Microbiol 13:349-55 (1994)
DOI:10.1111/j.1365-2958.1994.tb00428.x
  Sequence
[ag:AAA21341]
LinkDB

KEGG   REACTION: R06449
Entry
R06449                      Reaction                               
Definition
5-O-beta-D-Mycaminosyltylactone + 2 NADPH + 2 Oxygen + 2 H+ <=> 20-Oxo-5-O-beta-mycaminosyltylactone + 2 NADP+ + 3 H2O
Equation
C12001 + 2 C00005 + 2 C00007 + 2 C00080 <=> C20760 + 2 C00006 + 3 C00001
Comment
cytochrome P450,TylI
multi-step reaction
Reaction class
RC00001  C00005_C00006
RC03223  C12001_C20760
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00773  Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
Orthology
K15992  cytochrome P450 TylI
LinkDB

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