Entry
Symbol
tylF
Name
Pathway
map00522 Biosynthesis of 12-, 14- and 16-membered macrolides
map01110 Biosynthesis of secondary metabolites
Module
M00773 Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
Reaction
R02858 S-adenosyl-L-methionine:macrocin 3'''-O-methyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09109 Metabolism of terpenoids and polyketides
00522 Biosynthesis of 12-, 14- and 16-membered macrolides
K15996 tylF; macrocin O-methyltransferase
09180 Brite Hierarchies
09181 Protein families: metabolism
01008 Polyketide biosynthesis proteins
K15996 tylF; macrocin O-methyltransferase
Enzymes [BR:ko01000 ]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.101 macrocin O-methyltransferase
K15996 tylF; macrocin O-methyltransferase
Polyketide biosynthesis proteins [BR:ko01008 ]
Polyketide tailoring proteins
Methylase
K15996 tylF; macrocin O-methyltransferase
BRITE hierarchy
Other DBs
Genes
Taxonomy UniProt
Reference
Authors
Fouces R, Mellado E, Diez B, Barredo JL
Title
The tylosin biosynthetic cluster from Streptomyces fradiae: genetic organization of the left region.
Journal
Reference
Authors
Kreuzman AJ, Turner JR, Yeh WK
Title
Two distinctive O-methyltransferases catalyzing penultimate and terminal reactions of macrolide antibiotic (tylosin) biosynthesis. Substrate specificity, enzyme inhibition, and kinetic mechanism.
Journal
J Biol Chem 263:15626-33 (1988)
Sequence
LinkDB
All DBs