KEGG   ORTHOLOGY: K16007
Entry
K16007            Tight     KO                                     
Symbol
oleAI
Name
8,8a-deoxyoleandolide synthase 1
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00775  Oleandomycin biosynthesis, malonyl-CoA + methylmalonyl-CoA => 8,8a-deoxyoleandolide => oleandomycin
Reaction
R06453  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K16007  oleAI; 8,8a-deoxyoleandolide synthase 1
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K16007  oleAI; 8,8a-deoxyoleandolide synthase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K16007  oleAI; 8,8a-deoxyoleandolide synthase 1
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Oleandomycin synthase
     K16007  oleAI; 8,8a-deoxyoleandolide synthase 1
Genes
AG: AAF82408(oleAI)
Reference
PMID:10908114
  Authors
Shah S, Xue Q, Tang L, Carney JR, Betlach M, McDaniel R
  Title
Cloning, characterization and heterologous expression of a polyketide synthase and P-450 oxidase involved in the biosynthesis of the antibiotic oleandomycin.
  Journal
J Antibiot (Tokyo) 53:502-8 (2000)
DOI:10.7164/antibiotics.53.502
  Sequence
[ag:AAF82408]
LinkDB

KEGG   ORTHOLOGY: K24565
Entry
K24565                      KO                                     
Symbol
oleAII
Name
8,8a-deoxyoleandolide synthase 2
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
Module
M00775  Oleandomycin biosynthesis, malonyl-CoA + methylmalonyl-CoA => 8,8a-deoxyoleandolide => oleandomycin
Reaction
R06453  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K24565  oleAII; 8,8a-deoxyoleandolide synthase 2
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K24565  oleAII; 8,8a-deoxyoleandolide synthase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K24565  oleAII; 8,8a-deoxyoleandolide synthase 2
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Oleandomycin synthase
     K24565  oleAII; 8,8a-deoxyoleandolide synthase 2
Genes
SLIA: HA039_05740
SMAO: CAG99_26295
SYUN: MOV08_16420
AG: AAF82409(oleAII)
Reference
PMID:10908114
  Authors
Shah S, Xue Q, Tang L, Carney JR, Betlach M, McDaniel R
  Title
Cloning, characterization and heterologous expression of a polyketide synthase and P-450 oxidase involved in the biosynthesis of the antibiotic oleandomycin.
  Journal
J Antibiot (Tokyo) 53:502-8 (2000)
DOI:10.7164/antibiotics.53.502
  Sequence
[ag:AAF82409]
LinkDB

KEGG   ORTHOLOGY: K24566
Entry
K24566                      KO                                     
Symbol
oleAIII
Name
8,8a-deoxyoleandolide synthase 3
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
Module
M00775  Oleandomycin biosynthesis, malonyl-CoA + methylmalonyl-CoA => 8,8a-deoxyoleandolide => oleandomycin
Reaction
R06453  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K24566  oleAIII; 8,8a-deoxyoleandolide synthase 3
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K24566  oleAIII; 8,8a-deoxyoleandolide synthase 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K24566  oleAIII; 8,8a-deoxyoleandolide synthase 3
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Oleandomycin synthase
     K24566  oleAIII; 8,8a-deoxyoleandolide synthase 3
Genes
AG: AAA19695(oleAIII)
Reference
PMID:10908114
  Authors
Shah S, Xue Q, Tang L, Carney JR, Betlach M, McDaniel R
  Title
Cloning, characterization and heterologous expression of a polyketide synthase and P-450 oxidase involved in the biosynthesis of the antibiotic oleandomycin.
  Journal
J Antibiot (Tokyo) 53:502-8 (2000)
DOI:10.7164/antibiotics.53.502
Reference
PMID:8107683
  Authors
Swan DG, Rodriguez AM, Vilches C, Mendez C, Salas JA
  Title
Characterisation of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence.
  Journal
Mol Gen Genet 242:358-62 (1994)
DOI:10.1007/BF00280426
  Sequence
[ag:AAA19695]
LinkDB

KEGG   REACTION: R06453
Entry
R06453                      Reaction                               
Definition
Malonyl-CoA + 6 Methylmalonyl-CoA + 6 NADPH + 6 H+ <=> 8,8a-Deoxyoleandolide + 7 CoA + 7 CO2 + H2O + 6 NADP+
Equation
C00083 + 6 C02557 + 6 C00005 + 6 C00080 <=> C11989 + 7 C00010 + 7 C00011 + C00001 + 6 C00006
Comment
8,8a-deoxyoleandolide synthase,OleA1-3
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00083  C00010_C02557
RC02826  C02557_C11989
RC02828  C02557_C11989
RC02829  C02557_C11989
RC02830  C02557_C11989
RC02831  C02557_C11989
RC02918  C00083_C11989
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00775  Oleandomycin biosynthesis, malonyl-CoA + methylmalonyl-CoA => 8,8a-deoxyoleandolide => oleandomycin
Orthology
K16007  8,8a-deoxyoleandolide synthase 1
K24565  8,8a-deoxyoleandolide synthase 2
K24566  8,8a-deoxyoleandolide synthase 3
LinkDB

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