KEGG   ORTHOLOGY: K16056
Entry
K16056                      KO                                     

Name
ORAI1
Definition
calcium release-activated calcium channel protein 1
Pathway
map04020  Calcium signaling pathway
map04024  cAMP signaling pathway
map04611  Platelet activation
map04924  Renin secretion
map04925  Aldosterone synthesis and secretion
map04927  Cortisol synthesis and secretion
map04934  Cushing syndrome
map05340  Primary immunodeficiency
Disease
H00093  Combined immunodeficiency
H02258  Tubular aggregate myopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K16056  ORAI1; calcium release-activated calcium channel protein 1
   04024 cAMP signaling pathway
    K16056  ORAI1; calcium release-activated calcium channel protein 1
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K16056  ORAI1; calcium release-activated calcium channel protein 1
  09152 Endocrine system
   04924 Renin secretion
    K16056  ORAI1; calcium release-activated calcium channel protein 1
   04925 Aldosterone synthesis and secretion
    K16056  ORAI1; calcium release-activated calcium channel protein 1
   04927 Cortisol synthesis and secretion
    K16056  ORAI1; calcium release-activated calcium channel protein 1
 09160 Human Diseases
  09163 Immune disease
   05340 Primary immunodeficiency
    K16056  ORAI1; calcium release-activated calcium channel protein 1
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K16056  ORAI1; calcium release-activated calcium channel protein 1
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K16056  ORAI1; calcium release-activated calcium channel protein 1
Ion channels [BR:ko04040]
 Other channels
  Calcium channel, calcium release-activated (Orai)
   K16056  ORAI1; calcium release-activated calcium channel protein 1
Other DBs
GO: 0015279
TC: 1.A.52.1.1 1.A.52.2 1.A.52.3
Genes
HSA: 84876(ORAI1)
PTR: 473293(ORAI1)
PPS: 100987781(ORAI1)
GGO: 101149689(ORAI1)
PON: 100432306(ORAI1)
NLE: 100591849(ORAI1)
MCC: 700190(ORAI1)
MCF: 102129315(ORAI1)
CSAB: 103239286(ORAI1)
CATY: 105590966(ORAI1)
PANU: 101023431(ORAI1)
RRO: 104666279(ORAI1)
RBB: 108529632(ORAI1)
TFN: 117089273(ORAI1)
CJC: 100400670(ORAI1)
SBQ: 101044294(ORAI1)
MMUR: 105880911(ORAI1)
MMU: 109305(Orai1)
MCAL: 110294733(Orai1)
MPAH: 110312963(Orai1)
RNO: 304496(Orai1)
MCOC: 116068382(Orai1)
MUN: 110545302(Orai1)
CGE: 100752394(Orai1)
PLEU: 114704549(Orai1)
NGI: 103739067(Orai1)
HGL: 101699660(Orai1)
CCAN: 109686395(Orai1)
OCU: 100349347(ORAI1)
TUP: 102475070(ORAI1)
CFA: 486261(ORAI1)
VVP: 112935218(ORAI1)
VLG: 121475602(ORAI1)
AML: 100477778(ORAI1)
UMR: 103661271(ORAI1)
UAH: 113266942(ORAI1)
ORO: 101368790(ORAI1)
ELK: 111156453
MPUF: 101689903(ORAI1)
EJU: 114219084(ORAI1)
MLX: 118018437(ORAI1)
FCA: 101096922(ORAI1)
PTG: 102972831(ORAI1)
PPAD: 109277687(ORAI1)
AJU: 106967590(ORAI1)
HHV: 120242940(ORAI1)
BTA: 517688(ORAI1)
BOM: 102274230(ORAI1)
BIU: 109571127(ORAI1)
BBUB: 102398422(ORAI1)
CHX: 102171809(ORAI1)
OAS: 101102013(ORAI1)
ODA: 120871068(ORAI1)
SSC: 100154923(ORAI1)
CFR: 102503461(ORAI1)
CDK: 105102512(ORAI1)
BACU: 103004835(ORAI1)
LVE: 103088422(ORAI1)
OOR: 101279655(ORAI1)
DLE: 111186877(ORAI1)
PCAD: 102975350(ORAI1)
ECB: 100059726(ORAI1)
EPZ: 103541373(ORAI1)
EAI: 106842218(ORAI1)
MYB: 102253522(ORAI1)
MYD: 102775355(ORAI1)
MMYO: 118678320(ORAI1)
MNA: 107529588(ORAI1)
HAI: 109386109(ORAI1)
DRO: 112310607(ORAI1)
SHON: 118991071(ORAI1)
AJM: 119048683(ORAI1)
MMF: 118639809(ORAI1)
PALE: 102883130(ORAI1)
RAY: 107515241(ORAI1)
MJV: 108390400(ORAI1)
LAV: 100669326(ORAI1)
TMU: 101348360
MDO: 100015978(ORAI1)
SHR: 111719559(ORAI1)
PCW: 110196793(ORAI1)
OAA: 100079447(ORAI1)
GGA: 416845(ORAI1)
PCOC: 116228615(ORAI1)
MGP: 100542708(ORAI1)
CJO: 107321339(ORAI1)
NMEL: 110406589(ORAI1)
APLA: 101802702(ORAI1)
ACYG: 106031142(ORAI1)
TGU: 100218031(ORAI1)
LSR: 110471754(ORAI1)
SCAN: 103818164(ORAI1)
PMOA: 120509628(ORAI1)
GFR: 102045243(ORAI1)
FAB: 101813302(ORAI1)
PHI: 102113680(ORAI1)
PMAJ: 107211567(ORAI1)
CCAE: 111936395(ORAI1)
CCW: 104688700(ORAI1)
ETL: 114054974(ORAI1)
FPG: 101912221(ORAI1)
FCH: 102050948(ORAI1)
CLV: 102084504(ORAI1)
EGZ: 104130104(ORAI1)
NNI: 104019483(ORAI1)
ACUN: 113486098(ORAI1)
PADL: 103914529(ORAI1)
AAM: 106495677(ORAI1)
ASN: 102379313(ORAI1)
AMJ: 102565923(ORAI1)
CPOO: 109312628(ORAI1)
GGN: 109290597(ORAI1)
PSS: 102446257(ORAI1)
CMY: 102933783(ORAI1)
CPIC: 101940211(ORAI1)
TST: 117887905(ORAI1)
CABI: 116836801(ORAI1)
ACS: 100556544(orai1)
PBI: 103061493(ORAI1)
PMUR: 107286984
TSR: 106547442(ORAI1)
PGUT: 117672217(ORAI1)
PMUA: 114586206(ORAI1)
ZVI: 118075638(ORAI1)
GJA: 107115887(ORAI1)
XLA: 108716807(orai2.L) 734537(orai2.S)
XTR: 100380109(orai2)
NPR: 108787479(ORAI1)
DRE: 402892(orai1b) 566671(orai1a)
IPU: 108264930(orai1) 108276842(orai1)
AMEX: 103031227 103036052(orai1)
EEE: 113567671(orai1) 113586910
TRU: 101064627(orai1) 101071466
ELY: 117253138 117269664(orai1b)
PLEP: 121944888 121959873(orai1b)
SLUC: 116034963(orai1b) 116062327
GAT: 120830329 120832131(orai1b)
MSAM: 119891958 119914585(orai1b)
CUD: 121509706 121524961(orai1b)
ONL: 100693342 100703835(orai1)
OAU: 116322549(orai1b) 116323649
OML: 112148274 112163130(orai1b)
XMA: 102221509(orai1) 102228317
XCO: 114149284(orai1) 114155074
XHE: 116724169(orai1) 116729592
CVG: 107091275(orai1) 107092763
NFU: 107373313(orai1) 107393664
KMR: 108232614(orai1b) 108236518
ALIM: 106514480(orai1) 106516709
POV: 109626191(orai1) 109641090
LCF: 108878716 108879826(orai1)
SDU: 111230954 111234147(orai1)
SLAL: 111645055 111655175(orai1)
XGL: 120805097 120805983(orai1b)
MALB: 109951308(orai1) 109954899
ELS: 105014888 105024851(orai1)
SFM: 108921846(orai1) 108935040
PKI: 111839328(orai1) 111842172
LOC: 102690767(orai1)
LCM: 102365455(ORAI1)
CMK: 103184306(orai1)
RTP: 109923315(orai1)
BFO: 118425456
CIN: 100180182
SCLV: 120342346
SKO: 100371578
DME: Dmel_CG11430(olf186-F)
DER: 6546716
DSI: Dsimw501_GD11325(Dsim_GD11325)
DSR: 110177916
DPE: 6592236
DAZ: 108616475
DNV: 108654172
DHE: 111605369
MDE: 101900497
LCQ: 111679473
ACOZ: 120949243
AARA: 120893938
AAG: 5579438
BMOR: 100188931(Orai1) 101739927
BMAN: 114248852
PXY: 105381117
DCI: 103505211
CLEC: 106664899
NLU: 111062307
PVM: 113818970
EAF: 111701483
DSV: 119446593
VDE: 111253030
VJA: 111271895
DPTE: 113788521
CSCU: 111637948
CEL: CELE_C09F5.2(orai-1)
CBR: CBG15255(Cbr-orai-1)
TSP: Tsp_01599
PCAN: 112563136
BGT: 106056210
GAE: 121367981
CRG: 105328659
OBI: 106870551
NVE: 5512883
EPA: 110241367
ATEN: 116296363
ADF: 107332597
AMIL: 114952745
PDAM: 113676130
SPIS: 111322177
DGT: 114520469
HMG: 100213417
VCN: VOLCADRAFT_127367(ssa12)
MNG: MNEG_2934
 » show all
Reference
  Authors
Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A
  Title
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.
  Journal
Nature 441:179-85 (2006)
DOI:10.1038/nature04702
  Sequence
[hsa:84876] [dme:Dmel_CG11430]
LinkDB

DBGET integrated database retrieval system