KEGG   ORTHOLOGY: K16343
Entry
K16343                      KO                                     

Symbol
PLA2G6, IPLA2
Name
calcium-independent phospholipase A2 [EC:3.1.1.4]
Pathway
map00564  Glycerophospholipid metabolism
map00565  Ether lipid metabolism
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00592  alpha-Linolenic acid metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map04014  Ras signaling pathway
map04270  Vascular smooth muscle contraction
map04666  Fc gamma R-mediated phagocytosis
map04750  Inflammatory mediator regulation of TRP channels
Disease
H00057  Parkinson disease
H00833  Neurodegeneration with brain iron accumulation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00564 Glycerophospholipid metabolism
    K16343  PLA2G6, IPLA2; calcium-independent phospholipase A2
   00565 Ether lipid metabolism
    K16343  PLA2G6, IPLA2; calcium-independent phospholipase A2
   00590 Arachidonic acid metabolism
    K16343  PLA2G6, IPLA2; calcium-independent phospholipase A2
   00591 Linoleic acid metabolism
    K16343  PLA2G6, IPLA2; calcium-independent phospholipase A2
   00592 alpha-Linolenic acid metabolism
    K16343  PLA2G6, IPLA2; calcium-independent phospholipase A2
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K16343  PLA2G6, IPLA2; calcium-independent phospholipase A2
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    K16343  PLA2G6, IPLA2; calcium-independent phospholipase A2
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K16343  PLA2G6, IPLA2; calcium-independent phospholipase A2
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K16343  PLA2G6, IPLA2; calcium-independent phospholipase A2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K16343  PLA2G6, IPLA2; calcium-independent phospholipase A2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.4  phospholipase A2
     K16343  PLA2G6, IPLA2; calcium-independent phospholipase A2
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Other mitophagy factors
    K16343  PLA2G6, IPLA2; calcium-independent phospholipase A2
Other DBs
RN: R01315 R01317 R02053 R07064 R07379 R07387 R07859
GO: 0047499
Genes
HSA: 8398(PLA2G6)
PTR: 470208(PLA2G6)
PPS: 100973899(PLA2G6)
GGO: 101154603(PLA2G6)
PON: 100445065(PLA2G6)
NLE: 100605211(PLA2G6)
MCC: 700184(PLA2G6)
MCF: 101926332(PLA2G6)
CSAB: 103223308(PLA2G6)
CATY: 105575872(PLA2G6)
PANU: 100999243(PLA2G6)
RRO: 104682532(PLA2G6)
RBB: 108521470(PLA2G6)
TFN: 117070299(PLA2G6)
PTEH: 111549021(PLA2G6)
CJC: 100415535(PLA2G6)
SBQ: 101038559(PLA2G6)
MMUR: 105858610(PLA2G6)
MMU: 53357(Pla2g6)
MCAL: 110310640(Pla2g6)
MPAH: 110334864(Pla2g6)
RNO: 360426(Pla2g6)
MCOC: 116075844(Pla2g6)
MUN: 110566433(Pla2g6)
CGE: 100751421(Pla2g6)
PLEU: 114694258(Pla2g6)
NGI: 103748592(Pla2g6)
HGL: 101710669(Pla2g6)
CCAN: 109692765(Pla2g6)
OCU: 100008961(PLA2G6)
OPI: 101526582(PLA2G6)
TUP: 102488703(PLA2G6)
CFA: 481256(PLA2G6)
VVP: 112908689(PLA2G6)
VLG: 121491290(PLA2G6)
AML: 100472577(PLA2G6)
UMR: 103676531(PLA2G6)
UAH: 113241785(PLA2G6)
ORO: 101377812(PLA2G6)
ELK: 111157482
MPUF: 101687081(PLA2G6)
EJU: 114218422(PLA2G6)
MLX: 117998687(PLA2G6)
FCA: 101095350(PLA2G6)
PYU: 121040357(PLA2G6)
PBG: 122472747(PLA2G6)
PTG: 102968751(PLA2G6)
AJU: 106981012(PLA2G6)
HHV: 120241143(PLA2G6)
BTA: 535381(PLA2G6)
BOM: 102285524(PLA2G6)
BIU: 109559808(PLA2G6)
BBUB: 102411334(PLA2G6)
CHX: 102182111(PLA2G6)
OAS: 101103799(PLA2G6)
ODA: 120857629(PLA2G6)
CCAD: 122423634(PLA2G6)
SSC: 100514711(PLA2G6)
CFR: 102514758(PLA2G6)
CBAI: 105073128(PLA2G6)
CDK: 105091954(PLA2G6)
BACU: 103005121(PLA2G6)
LVE: 103091644(PLA2G6)
OOR: 101277123(PLA2G6)
DLE: 111186263(PLA2G6)
ECB: 100055064(PLA2G6)
EPZ: 103565810(PLA2G6)
EAI: 106837612(PLA2G6)
MYB: 102258983(PLA2G6)
MYD: 102763469(PLA2G6)
MMYO: 118651011(PLA2G6)
MNA: 107544563(PLA2G6)
DRO: 112321643(PLA2G6)
SHON: 119002165(PLA2G6)
AJM: 119060262(PLA2G6)
MMF: 118623893(PLA2G6)
PALE: 102880597(PLA2G6)
PGIG: 120614822(PLA2G6)
RAY: 107519256(PLA2G6)
MJV: 108392650(PLA2G6)
TOD: 119247271(PLA2G6)
LAV: 100665160(PLA2G6)
TMU: 101345872
MDO: 100016178(PLA2G6)
OAA: 100090638(PLA2G6)
GGA: 418028(PLA2G6)
PCOC: 116233337(PLA2G6)
MGP: 100549498(PLA2G6)
CJO: 107314075(PLA2G6)
NMEL: 110392785(PLA2G6)
APLA: 101797588(PLA2G6)
ACYG: 106035895(PLA2G6)
TGU: 100222459(PLA2G6)
LSR: 110483821(PLA2G6)
SCAN: 103813604(PLA2G6)
PMOA: 120510023(PLA2G6)
OTC: 121342342(PLA2G6)
PRUF: 121361131(PLA2G6)
GFR: 102035453(PLA2G6)
FAB: 101818570(PLA2G6)
PHI: 102111464(PLA2G6)
PMAJ: 107205116(PLA2G6)
CCAE: 111931233(PLA2G6)
CCW: 104696522(PLA2G6)
ETL: 114055386(PLA2G6)
FPG: 101918608(PLA2G6)
FCH: 102054654(PLA2G6)
CLV: 102095923(PLA2G6)
EGZ: 104134317(PLA2G6)
NNI: 104021606(PLA2G6)
ACUN: 113491295(PLA2G6)
PADL: 103924163(PLA2G6)
AAM: 106488934(PLA2G6)
AROW: 112969341(PLA2G6)
NPD: 112947717(PLA2G6)
DNE: 112984354(PLA2G6)
CPOO: 109315942(PLA2G6)
GGN: 109296014(PLA2G6)
TST: 117880458(PLA2G6)
CABI: 116831656(PLA2G6)
XLA: 108714545(pla2g6.L) 446689(pla2g6.S)
XTR: 780118(pla2g6)
NPR: 108799210(PLA2G6)
DRE: 406370(pla2g6)
SRX: 107717654 107720373(pla2g6)
IPU: 108259399(pla2g6)
PHYP: 113547636
AMEX: 103024703(pla2g6)
EEE: 113585736(pla2g6)
AANG: 118220923(pla2g6)
LOC: 102693567(pla2g6)
PSPA: 121306129(pla2g6)
ARUT: 117433087(pla2g6) 117965683
BFO: 118429598
BBEL: 109483454
CIN: 100181039
SCLV: 120347936
SPU: 576520
DME: Dmel_CG6718(iPLA2-VIA)
DER: 6546011
DSE: 6605112
DSI: Dsimw501_GD12885(Dsim_GD12885)
DAN: 6507312
DSR: 110190566
DPE: 6602813
DMN: 108152862
DWI: 6645213
DGR: 6557342
DAZ: 108613870
DNV: 108651333
DHE: 111598208
DVI: 6622506
CCAT: 101457315
BOD: 106617612
MDE: 101898986
SCAC: 106085447
LCQ: 111675088
ACOZ: 120948318
AARA: 120908823
AAG: 5576852
CPII: 120413215
AME: 410570
ACER: 107999863
BIM: 100745755
BBIF: 117209224
BVK: 117231011
BVAN: 117155003
BTER: 105666437
CCAL: 108627808
OBB: 114875563
MGEN: 117226073
NMEA: 116428671
CGIG: 122397377
AEC: 105151653
ACEP: 105621014
PBAR: 105428233
FEX: 115240740
NVI: 100121363
TPRE: 106656972
FAS: 105266211
DAM: 107045182
CCIN: 107264649
TCA: 659843
LDC: 111507625
APLN: 108735382
PPYR: 116173186
BMOR: 101741228
MSEX: 115441201
BANY: 112048385
PPOT: 106109842
PXU: 106121474
ZCE: 119828291
API: 100164748
DNX: 107165067
AGS: 114132376
RMD: 113560473
HHAL: 106686156
NLU: 111060992
CSEC: 111875780
DMK: 116925314
EAF: 111710089
RSAN: 119400521
SDM: 118202602
CEL: CELE_F47A4.5(ipla-2) CELE_W07A8.2(ipla-3)
CBR: CBG01902
BMY: BM_BM6221(Bm6221)
TSP: Tsp_02795
BGT: 106073292
PMAX: 117325741
OSN: 115215664
NVE: 5516683
ATEN: 116302370
 » show all
Reference
PMID:9417066
  Authors
Larsson PK, Claesson HE, Kennedy BP
  Title
Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity.
  Journal
J Biol Chem 273:207-14 (1998)
DOI:10.1074/jbc.273.1.207
  Sequence
[hsa:8398]
Reference
  Authors
Schaloske RH, Dennis EA
  Title
The phospholipase A2 superfamily and its group numbering system.
  Journal
Biochim Biophys Acta 1761:1246-59 (2006)
DOI:10.1016/j.bbalip.2006.07.011
Reference
  Authors
Lv Z, Guo J, Sun Q, Li K, Yu R, Tian J, Yan X, Tang B
  Title
Association between PLA2G6 gene polymorphisms and Parkinson's disease in the Chinese Han population.
  Journal
Parkinsonism Relat Disord 18:641-4 (2012)
DOI:10.1016/j.parkreldis.2012.02.015
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