Entry
Symbol
rapP, fkbP
Name
pipecolate-incorporating enzyme
Pathway
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09109 Metabolism of terpenoids and polyketides
01052 Type I polyketide structures
K16378 rapP, fkbP; pipecolate-incorporating enzyme
09180 Brite Hierarchies
09181 Protein families: metabolism
01008 Polyketide biosynthesis proteins
K16378 rapP, fkbP; pipecolate-incorporating enzyme
Polyketide biosynthesis proteins [BR:ko01008 ]
Polyketide tailoring proteins
Others
K16378 rapP, fkbP; pipecolate-incorporating enzyme
BRITE hierarchy
Genes
Taxonomy UniProt
Reference
Authors
Konig A, Schwecke T, Molnar I, Bohm GA, Lowden PA, Staunton J, Leadlay PF
Title
The pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin--nucleotide sequence analysis, disruption and heterologous expression of rapP from Streptomyces hygroscopicus.
Journal
Reference
Authors
Molnar I, Aparicio JF, Haydock SF, Khaw LE, Schwecke T, Konig A, Staunton J, Leadlay PF
Title
Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase.
Journal
Sequence
Reference
Authors
Gatto GJ Jr, McLoughlin SM, Kelleher NL, Walsh CT
Title
Elucidating the substrate specificity and condensation domain activity of FkbP, the FK520 pipecolate-incorporating enzyme.
Journal
Reference
Authors
Wu K, Chung L, Revill WP, Katz L, Reeves CD
Title
The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.
Journal
Sequence
Reference
Authors
Motamedi H, Shafiee A
Title
The biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506.
Journal
Sequence
LinkDB
All DBs