KEGG   ORTHOLOGY: K16378
Entry
K16378                      KO                                     
Symbol
rapP, fkbP
Name
pipecolate-incorporating enzyme
Pathway
map01052  Type I polyketide structures
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K16378  rapP, fkbP; pipecolate-incorporating enzyme
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K16378  rapP, fkbP; pipecolate-incorporating enzyme
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Others
   K16378  rapP, fkbP; pipecolate-incorporating enzyme
Genes
SRC: M271_40705
SMAL: SMALA_8317
SSOI: I1A49_45325
SANT: QR300_38485
SQZ: FQU76_32185
SKA: CP970_02285
STSU: B7R87_01755
SLUO: PS467_39440
ACTN: L083_2962(rapP)
AG: AAC68816(fkbP) AAF86395(fkbP) ADU56324(fkbP) CAA60461(rapP)
Reference
PMID:9266694
  Authors
Konig A, Schwecke T, Molnar I, Bohm GA, Lowden PA, Staunton J, Leadlay PF
  Title
The pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin--nucleotide sequence analysis, disruption and heterologous expression of rapP from Streptomyces hygroscopicus.
  Journal
Eur J Biochem 247:526-34 (1997)
DOI:10.1111/j.1432-1033.1997.00526.x
Reference
PMID:8635730 (rapP)
  Authors
Molnar I, Aparicio JF, Haydock SF, Khaw LE, Schwecke T, Konig A, Staunton J, Leadlay PF
  Title
Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase.
  Journal
Gene 169:1-7 (1996)
DOI:10.1016/0378-1119(95)00799-7
  Sequence
Reference
  Authors
Gatto GJ Jr, McLoughlin SM, Kelleher NL, Walsh CT
  Title
Elucidating the substrate specificity and condensation domain activity of FkbP, the FK520 pipecolate-incorporating enzyme.
  Journal
Biochemistry 44:5993-6002 (2005)
DOI:10.1021/bi050230w
Reference
PMID:10863099 (fkbP)
  Authors
Wu K, Chung L, Revill WP, Katz L, Reeves CD
  Title
The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.
  Journal
Gene 251:81-90 (2000)
DOI:10.1016/S0378-1119(00)00171-2
  Sequence
Reference
PMID:9780228 (fkbP)
  Authors
Motamedi H, Shafiee A
  Title
The biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506.
  Journal
Eur J Biochem 256:528-34 (1998)
DOI:10.1046/j.1432-1327.1998.2560528.x
  Sequence
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