KEGG ORTHOLOGY: K16816

ORTHOLOGY: K16816

Entry

K16816                      KO

Symbol

PNPLA2, ATGL

Name

patatin-like phospholipase domain-containing protein 2 [EC:3.1.1.3]

Pathway

map00561

Glycerolipid metabolism

map01100

Metabolic pathways

map04714

Thermogenesis

map04923

Regulation of lipolysis in adipocytes

Module

M00098

Acylglycerol degradation

Disease

H01297

Neutral lipid storage disease with myopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00561 Glycerolipid metabolism
    K16816  PNPLA2, ATGL; patatin-like phospholipase domain-containing protein 2
09150 Organismal Systems
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    K16816  PNPLA2, ATGL; patatin-like phospholipase domain-containing protein 2
  09159 Environmental adaptation
   04714 Thermogenesis
    K16816  PNPLA2, ATGL; patatin-like phospholipase domain-containing protein 2
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.3  triacylglycerol lipase
     K16816  PNPLA2, ATGL; patatin-like phospholipase domain-containing protein 2

Other DBs

RN:	R02250 R02687

GO:

0004806

Genes

HSA:	57104(PNPLA2)

PTR:	112207805 450937(PNPLA2)

PPS:	100970121(PNPLA2)

GGO:	101145251(PNPLA2)

PON:	100438169(PNPLA2)

NLE:	100607328(PNPLA2)

MCC:	700824(PNPLA2)

MCF:	102141858(PNPLA2)

MTHB:

126935831

CSAB:

103233992(PNPLA2)

CATY:

105577222(PNPLA2)

PANU:

101013650(PNPLA2)

TGE:	112607117(PNPLA2)

RRO:	104681771(PNPLA2)

RBB:	108513010(PNPLA2)

TFN:	117079862(PNPLA2)

PTEH:

111520551(PNPLA2)

CANG:

105503281(PNPLA2)

CJC:	100408814(PNPLA2)

SBQ:	101033046(PNPLA2)

MMUR:

105874051(PNPLA2)

LCAT:

123642954(PNPLA2)

PCOQ:

105816532(PNPLA2)

OGA:	100947855(PNPLA2)

MMU:	66853(Pnpla2)

MCAL:

110298572(Pnpla2)

MPAH:

110322307(Pnpla2)

RNO:	361676(Pnpla2)

MCOC:

116103223(Pnpla2)

MUN:	110553920(Pnpla2)

CGE:	100753746(Pnpla2)

MAUA:

101835287(Pnpla2)

PLEU:

114693780(Pnpla2)

MORG:

121458007(Pnpla2)

MFOT:

126498761

AAMP:

119816161(Pnpla2)

NGI:	103751092(Pnpla2)

HGL:	101701275(Pnpla2)

CPOC:

100732516(Pnpla2)

CCAN:

109698331(Pnpla2)

DORD:

105998579(Pnpla2)

DSP:	122102587(Pnpla2)

NCAR:

124960604

OPI:	101521600(PNPLA2)

TUP:	102481526(PNPLA2)

GVR:	103604003(PNPLA2)

CFA:	611403(PNPLA2)

CLUD:

112663249(PNPLA2)

VVP:	112924122(PNPLA2)

VLG:	121471418(PNPLA2)

AML:	100463707(PNPLA2)

UMR:	103671100(PNPLA2)

UAH:	113248812(PNPLA2)

UAR:	123775516(PNPLA2)

ELK:

111150106

LLV:

125078242

MPUF:

101692455(PNPLA2)

ORO:	101376822(PNPLA2)

EJU:	114201537(PNPLA2)

ZCA:	113915050(PNPLA2)

MLX:	118016211(PNPLA2)

NSU:	110580667(PNPLA2)

LWW:	102726814(PNPLA2)

FCA:	101082263(PNPLA2)

PYU:	121022827(PNPLA2)

PBG:	122484151(PNPLA2)

LRUF:

124527533

PTG:	102955281(PNPLA2)

PPAD:

109259787(PNPLA2)

AJU:	106988897(PNPLA2)

HHV:	120223431(PNPLA2)

BTA:	508493(PNPLA2)

BOM:	102280861(PNPLA2)

BBUB:

102409429(PNPLA2)

BBIS:

104998825(PNPLA2)

CHX:	100860889(PNPLA2)

OAS:	101123166(PNPLA2)

ODA:	120874195(PNPLA2)

CCAD:

122430658(PNPLA2)

SSC:	100049704(PNPLA2)

CFR:	102522737(PNPLA2)

CBAI:

105069757(PNPLA2)

CDK:	105105445(PNPLA2)

VPC:	102545377(PNPLA2)

BACU:

102997570(PNPLA2)

LVE:	103080064(PNPLA2)

OOR:	101283683(PNPLA2)

DLE:	111170300(PNPLA2)

PCAD:

102980462(PNPLA2)

PSIU:

116758204(PNPLA2)

ECB:	100146758(PNPLA2)

EPZ:	103544296(PNPLA2)

EAI:	106824961(PNPLA2)

MYB:	102242697(PNPLA2)

MYD:	102764823(PNPLA2)

MMYO:

118648996(PNPLA2)

MNA:	107542321(PNPLA2)

PKL:	118717946(PNPLA2)

HAI:	109375650(PNPLA2)

DRO:	112317241(PNPLA2)

SHON:

118982231(PNPLA2)

AJM:	119062187(PNPLA2)

PDIC:

114499336(PNPLA2)

PHAS:

123807331(PNPLA2)

MMF:	118643197(PNPLA2)

RFQ:	117029952(PNPLA2)

PALE:

102878066(PNPLA2)

PGIG:

120584680(PNPLA2)

PVP:	105305945(PNPLA2)

RAY:	107507296(PNPLA2)

MJV:	108408640(PNPLA2)

TOD:	119249833(PNPLA2)

SARA:

101547288(PNPLA2)

LAV:	100657987(PNPLA2)

TMU:

101353614

ETF:	101649578(PNPLA2)

DNM:	101411289(PNPLA2)

MDO:	100031359(PNPLA2)

SHR:	100925043(PNPLA2)

PCW:	110202950(PNPLA2)

OAA:	103168938(PNPLA2)

GGA:	418233(PNPLA3) 431066(PNPLA2)

PCOC:

116231444 116239020(PNPLA2)

MGP:	100294555(PNPLA2)

CJO:	107314514(PNPLA2) 107317383

NMEL:

110396835 110401530(PNPLA2)

APLA:

101796497(PNPLA2) 101802708

ACYG:

106031781(PNPLA2) 106038244

AFUL:

116489179 116489933(PNPLA2)

TGU:	100219060(PNPLA2) 100231669

LSR:	110473186 110484489(PNPLA2)

SCAN:

103819680 103824075(PNPLA2)

PMOA:

120507696 120511422(PNPLA2)

OTC:	121344884(PNPLA2) 121347853

PRUF:

121351902 121360899(PNPLA2)

GFR:	102044651 102044787(PNPLA2)

FAB:	101805858(PNPLA2) 101820592

PHI:	102100353(PNPLA2) 102102532

PMAJ:

107205005 107205543(PNPLA2)

CCAE:

111923366 111930735(PNPLA2)

CCW:	104688026(PNPLA2) 104696128

CBRC:

103619970 103620898(PNPLA2)

ETL:	114064564 114068481(PNPLA2)

ZAB:	102068522(PNPLA2) 102072203

ACHL:

103801310 103808279(PNPLA2)

FPG:	101917296 101922710(PNPLA2)

FCH:	102055351 102059870(PNPLA2)

CLV:	102085397 102093271(PNPLA2)

EGZ:	104127095(PNPLA2) 104135158

NNI:	104012676(PNPLA5) 104017312(PNPLA2)

PLET:

104614711 104626945

PCRI:

104024032 104024972(PNPLA2)

PCAO:

104047097 104048124(PNPLA1)

ACUN:

113480980(PNPLA2) 113490465

TALA:

104363487 104366877(PNPLA2)

PADL:

103916456(PNPLA2) 103924466

AFOR:

103896228(PNPLA2) 103898753

ACHC:

115351746(PNPLA2) 115352620

HALD:

104315696(PNPLA2) 104321468

HLE:	104828694(PNPLA2) 104829392(PNPLA5)

AGEN:

126046894 126047801

GCL:	127016675 127021437

CCRI:

104166270(PNPLA2) 104169570

CSTI:

104556172 104563559(PNPLA2)

EHS:	104506485(PNPLA2) 104507978

CMAC:

104483937(PNPLA2) 104486759

MUI:	104541793 104546955

FGA:	104074271 104076872(PNPLA2)

GSTE:

104251186 104257470(PNPLA2)

LDI:	104354916(PNPLA2)

OHA:	104326726(PNPLA2) 104326998

NNT:	104406957(PNPLA2) 104410541

DPUB:

104296337 104299845(PNPLA2)

PGUU:

104459071(PNPLA2) 104462038

ACAR:

104518832(PNPLA2) 104522273

CPEA:

104387655(PNPLA2) 104395097

AVIT:

104276410 104278299(PNPLA2)

CVF:	104281671 104290297(PNPLA2)

CUCA:

104067327(PNPLA5) 104068918(PNPLA2)

TEO:	104379771 104381342(PNPLA2)

BRHI:

104500532 104502313(PNPLA2)

AAM:	106488311 106490004(PNPLA2)

AROW:

112962696(PNPLA2) 112967076

NPD:	112943580(PNPLA2) 112956866

TGT:	104569230 104575011(PNPLA2)

DNE:	112988036(PNPLA2) 112991526

SCAM:

104143770(PNPLA2) 104146640

ASN:	102381486(PNPLA2)

AMJ:	102569620(PNPLA2)

CPOO:

109316348 109321166(PNPLA2)

GGN:	109296345 109299202(PNPLA2)

PSS:	102443833 102450379(PNPLA2)

CMY:	102931307(PNPLA2) 102938324

CPIC:

101936184 101948343(PNPLA2)

TST:	117871694 117877337(PNPLA2)

CABI:

116825742 116838665(PNPLA2)

MRV:	120392979 120403898(PNPLA2)

ACS:	100551847(pnpla2)

PVT:	110074181(PNPLA2)

SUND:

121930050(PNPLA2) 121931193

PBI:	103048393(PNPLA2)

PMUR:

107283959(PNPLA2)

CTIG:

120298306(PNPLA2)

TSR:	106542070(PNPLA2)

PGUT:

117665196(PNPLA2)

VKO:	123021115(PNPLA2) 123033938

PMUA:

114599534(PNPLA2)

ZVI:	118088392(PNPLA2)

GJA:	107116418(PNPLA2)

STOW:

125426968(PNPLA2) 125435637(PNPLA3)

XLA:	108713865(pnpla2.L) 108715180(pnpla2.S)

XTR:	780152(pnpla2)

NPR:	108794583(PNPLA2)

RTEM:

120917311(PNPLA2)

BBUF:

120981001(PNPLA2)

BGAR:

122920167(PNPLA2)

DRE:	101887155(pnpla2)

SRX:	107716673 107726855

SANH:

107665735 107674849 107679605

SGH:	107551437 107577070

CCAR:

109051066 109065140

CAUA:

113041015 113042895 113043026 113094068

MAMB:

125246844(pnpla2)

IPU:	108269288 108274701(pnpla2)

PHYP:

113529505(pnpla2) 113546554

SMEO:

124392162(pnpla2)

TFD:	113654047(pnpla2)

AMEX:

103023613 103029861(pnpla2)

EEE:

113588195

TRU:	101061643(pnpla2) 101066653 101066877 101077770

TNG:	GSTEN00004542G001 GSTEN00004543G001 GSTEN00029863G001

LCO:	104928846(pnpla2) 104929551 104931885 104937568

NCC:	104941548 104956192(pnpla2) 104967347

CGOB:

115009445 115009967 115010160(pnpla2) 115010995

ELY:	117258923 117261910 117262194 117262738(pnpla2)

EFO:	125886905 125887442 125887874(pnpla2) 125891590(pnpla1)

PLEP:

121947371 121950525 121950590(pnpla2) 121950639

SLUC:

116046811 116046813 116058550

ECRA:

117947636 117948724(pnpla2) 117948731 117948735

ESP:	116692440 116693591 116693596 116694270

PFLV:

114558527 114559722 114560038 114560097

GAT:	120808694(pnpla2) 120809531 120829597

PPUG:

119195725(pnpla2) 119196411 119223144

MSAM:

119893301(pnpla2) 119905147

CUD:	121515003(pnpla2) 121515174 121515211 121517178

ALAT:

119023544 119023958 119023963 119024376(pnpla2)

MZE:	101470022 101482270 101483520

ONL:	100690902 100692445 100697369 100697903

OAU:	116313958 116314001 116326215(pnpla2) 116330832

OLA:	101155345 101155596 101156893 101168619

OML:	112151928 112151964 112152880(pnpla2) 112159858

XMA:	102226589 102228835 102237891

XCO:	114151724 114153411(pnpla2) 114156880 114156892

XHE:	116721947 116730918 116730988 116732186

PRET:

103465704 103465705 103466503(pnpla2) 103467428

PFOR:

103141311(pnpla2) 103149658 103156562 103156563

PLAI:

106938997 106939005 106942002(pnpla2) 106946660

PMEI:

106925505 106930769(pnpla2) 106933962 106933968

GAF:	122828025 122831272 122835711(pnpla2) 122835866

CVG:	107092186 107101198

CTUL:

119784346 119787400(pnpla2) 119798185

GMU:	124855728 124856623(pnpla2) 124865635(pnpla1)

NFU:	107388365 107388367 107388678 107390959

KMR:	108229859(pnpla2) 108235201 108245711 108245735

ALIM:

106521184 106522640 106522811

NWH:	119415787(pnpla2) 119416090 119417263

AOCE:

111573854 111577265 111580511

MCEP:

125011729(pnpla1) 125014442 125014443 125015534(pnpla2)

CSEM:

103379814 103379815 103380279(pnpla2)

POV:	109624276 109624498 109635035 109648188(pnpla2)

SSEN:

122775535 122776372 122776514(pnpla2) 122777289(pnpla1)

HHIP:

117762912(pnpla2) 117763670 117764010

HSP:	118109338 118109375(pnpla2) 118110631(pnpla1)

LCF:	108877866 108886921(pnpla2) 108889297 108889299

SDU:	111229787 111229788 111229822(pnpla2)

SLAL:

111650403 111650476 111667036 111669001

XGL:	120793349 120793552(pnpla2) 120803292

HCQ:	109507635(pnpla2) 109528676 109530843

BPEC:

110160334 110160347 110164878 110169305(pnpla2)

MALB:

109951167 109956420 109968666 109972349

BSPL:

114857222 114857223 114857781(pnpla2) 114858894

SASA:

106572965 106584779 106590753 106596546 106612943

STRU:

115165257 115192928 115197722 115206838

OTW:	112238871 112242251(pnpla2)

OMY:	110503375 110512506 110522695

OGO:	124004937 124018191 124032000 124036978(pnpla2)

ONE:	115122496 115125484 115141301

SALP:

111957907 112070263

SNH:	120052317(pnpla2) 120066504

CCLU:

121531591 121540758 121587368

ELS:	105006487 105009990 105018061

SFM:	108939144 108941267(pnpla2)

PKI:	111848020(pnpla2)

AANG:

118207390 118227161(pnpla2)

LOC:	102689456 102693732

PSPA:

121294827(pnpla2) 121329755

ARUT:

117434920

PSEX:

120535878(pnpla2)

LCM:	102349054(PNPLA2) 102364578(PNPLA1)

CMK:	103186006(pnpla2)

RTP:

SPU:

APLC:

SKO:

ACOZ:

CPII:

AME:

ACER:

ALAB:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BPYO:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

NVI:

CSOL:

CCIN:

TCA:	659311(bmm)

DPA:

ATD:

NVL:

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

NLU:

PHU:	Phum_PHUM457610

ZNE:

110829229

FCD:

110857045

DPX:	DAPPUDRAFT_199604 DAPPUDRAFT_40590

PCHN:

125045619 125045642

HAZT:

108671161

EAF:

111712249

ISC:	IscW_ISCW017608

VJA:

DPTE:

CSCU:

PTEP:

SDM:

LGI:	LOTGIDRAFT_104376

CRG:

MYI:

PMAX:

OSN:

LAK:

SMM:	Smp_124390

OVI:	T265_08820

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

TAD:	TRIADDRAFT_18195

AQU:

100642049

EHX:	EMIHUDRAFT_432975

» show all

Reference

PMID:16239926

Authors

Smirnova E, Goldberg EB, Makarova KS, Lin L, Brown WJ, Jackson CL

Title

ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells.

Journal

EMBO Rep 7:106-13 (2006)
DOI:10.1038/sj.embor.7400559

Reference

PMID:15550674

Authors

Zimmermann R, Strauss JG, Haemmerle G, Schoiswohl G, Birner-Gruenberger R, Riederer M, Lass A, Neuberger G, Eisenhaber F, Hermetter A, Zechner R

Title

Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase.

Journal

Science 306:1383-6 (2004)
DOI:10.1126/science.1100747

Sequence

[hsa:57104]

LinkDB

DBGET integrated database retrieval system