KEGG   ORTHOLOGY: K16816
Entry
K16816                      KO                                     
Symbol
PNPLA2, ATGL
Name
patatin-like phospholipase domain-containing protein 2 [EC:3.1.1.3]
Pathway
map00561  Glycerolipid metabolism
map01100  Metabolic pathways
map04714  Thermogenesis
map04923  Regulation of lipolysis in adipocytes
Module
M00098  Acylglycerol degradation
Disease
H01297  Neutral lipid storage disease with myopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00561 Glycerolipid metabolism
    K16816  PNPLA2, ATGL; patatin-like phospholipase domain-containing protein 2
 09150 Organismal Systems
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    K16816  PNPLA2, ATGL; patatin-like phospholipase domain-containing protein 2
  09159 Environmental adaptation
   04714 Thermogenesis
    K16816  PNPLA2, ATGL; patatin-like phospholipase domain-containing protein 2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.3  triacylglycerol lipase
     K16816  PNPLA2, ATGL; patatin-like phospholipase domain-containing protein 2
Other DBs
RN: R02250 R02687
GO: 0004806
Genes
HSA: 57104(PNPLA2)
PTR: 112207805 450937(PNPLA2)
PPS: 100970121(PNPLA2)
GGO: 101145251(PNPLA2)
PON: 100438169(PNPLA2)
NLE: 100607328(PNPLA2)
MCC: 700824(PNPLA2)
MCF: 102141858(PNPLA2)
MTHB: 126935831
CSAB: 103233992(PNPLA2)
CATY: 105577222(PNPLA2)
PANU: 101013650(PNPLA2)
TGE: 112607117(PNPLA2)
RRO: 104681771(PNPLA2)
RBB: 108513010(PNPLA2)
TFN: 117079862(PNPLA2)
PTEH: 111520551(PNPLA2)
CANG: 105503281(PNPLA2)
CJC: 100408814(PNPLA2)
SBQ: 101033046(PNPLA2)
MMUR: 105874051(PNPLA2)
LCAT: 123642954(PNPLA2)
PCOQ: 105816532(PNPLA2)
OGA: 100947855(PNPLA2)
MMU: 66853(Pnpla2)
MCAL: 110298572(Pnpla2)
MPAH: 110322307(Pnpla2)
RNO: 361676(Pnpla2)
MCOC: 116103223(Pnpla2)
MUN: 110553920(Pnpla2)
CGE: 100753746(Pnpla2)
MAUA: 101835287(Pnpla2)
PLEU: 114693780(Pnpla2)
MORG: 121458007(Pnpla2)
MFOT: 126498761
AAMP: 119816161(Pnpla2)
NGI: 103751092(Pnpla2)
HGL: 101701275(Pnpla2)
CPOC: 100732516(Pnpla2)
CCAN: 109698331(Pnpla2)
DORD: 105998579(Pnpla2)
DSP: 122102587(Pnpla2)
NCAR: 124960604
OPI: 101521600(PNPLA2)
TUP: 102481526(PNPLA2)
GVR: 103604003(PNPLA2)
CFA: 611403(PNPLA2)
CLUD: 112663249(PNPLA2)
VVP: 112924122(PNPLA2)
VLG: 121471418(PNPLA2)
AML: 100463707(PNPLA2)
UMR: 103671100(PNPLA2)
UAH: 113248812(PNPLA2)
UAR: 123775516(PNPLA2)
ELK: 111150106
LLV: 125078242
MPUF: 101692455(PNPLA2)
ORO: 101376822(PNPLA2)
EJU: 114201537(PNPLA2)
ZCA: 113915050(PNPLA2)
MLX: 118016211(PNPLA2)
NSU: 110580667(PNPLA2)
LWW: 102726814(PNPLA2)
FCA: 101082263(PNPLA2)
PYU: 121022827(PNPLA2)
PBG: 122484151(PNPLA2)
LRUF: 124527533
PTG: 102955281(PNPLA2)
PPAD: 109259787(PNPLA2)
AJU: 106988897(PNPLA2)
HHV: 120223431(PNPLA2)
BTA: 508493(PNPLA2)
BOM: 102280861(PNPLA2)
BBUB: 102409429(PNPLA2)
BBIS: 104998825(PNPLA2)
CHX: 100860889(PNPLA2)
OAS: 101123166(PNPLA2)
ODA: 120874195(PNPLA2)
CCAD: 122430658(PNPLA2)
SSC: 100049704(PNPLA2)
CFR: 102522737(PNPLA2)
CBAI: 105069757(PNPLA2)
CDK: 105105445(PNPLA2)
VPC: 102545377(PNPLA2)
BACU: 102997570(PNPLA2)
LVE: 103080064(PNPLA2)
OOR: 101283683(PNPLA2)
DLE: 111170300(PNPLA2)
PCAD: 102980462(PNPLA2)
PSIU: 116758204(PNPLA2)
ECB: 100146758(PNPLA2)
EPZ: 103544296(PNPLA2)
EAI: 106824961(PNPLA2)
MYB: 102242697(PNPLA2)
MYD: 102764823(PNPLA2)
MMYO: 118648996(PNPLA2)
MNA: 107542321(PNPLA2)
PKL: 118717946(PNPLA2)
HAI: 109375650(PNPLA2)
DRO: 112317241(PNPLA2)
SHON: 118982231(PNPLA2)
AJM: 119062187(PNPLA2)
PDIC: 114499336(PNPLA2)
PHAS: 123807331(PNPLA2)
MMF: 118643197(PNPLA2)
RFQ: 117029952(PNPLA2)
PALE: 102878066(PNPLA2)
PGIG: 120584680(PNPLA2)
PVP: 105305945(PNPLA2)
RAY: 107507296(PNPLA2)
MJV: 108408640(PNPLA2)
TOD: 119249833(PNPLA2)
SARA: 101547288(PNPLA2)
LAV: 100657987(PNPLA2)
TMU: 101353614
ETF: 101649578(PNPLA2)
DNM: 101411289(PNPLA2)
MDO: 100031359(PNPLA2)
SHR: 100925043(PNPLA2)
PCW: 110202950(PNPLA2)
OAA: 103168938(PNPLA2)
GGA: 418233(PNPLA3) 431066(PNPLA2)
PCOC: 116231444 116239020(PNPLA2)
MGP: 100294555(PNPLA2)
CJO: 107314514(PNPLA2) 107317383
NMEL: 110396835 110401530(PNPLA2)
APLA: 101796497(PNPLA2) 101802708
ACYG: 106031781(PNPLA2) 106038244
AFUL: 116489179 116489933(PNPLA2)
TGU: 100219060(PNPLA2) 100231669
LSR: 110473186 110484489(PNPLA2)
SCAN: 103819680 103824075(PNPLA2)
PMOA: 120507696 120511422(PNPLA2)
OTC: 121344884(PNPLA2) 121347853
PRUF: 121351902 121360899(PNPLA2)
GFR: 102044651 102044787(PNPLA2)
FAB: 101805858(PNPLA2) 101820592
PHI: 102100353(PNPLA2) 102102532
PMAJ: 107205005 107205543(PNPLA2)
CCAE: 111923366 111930735(PNPLA2)
CCW: 104688026(PNPLA2) 104696128
CBRC: 103619970 103620898(PNPLA2)
ETL: 114064564 114068481(PNPLA2)
ZAB: 102068522(PNPLA2) 102072203
ACHL: 103801310 103808279(PNPLA2)
FPG: 101917296 101922710(PNPLA2)
FCH: 102055351 102059870(PNPLA2)
CLV: 102085397 102093271(PNPLA2)
EGZ: 104127095(PNPLA2) 104135158
NNI: 104012676(PNPLA5) 104017312(PNPLA2)
PCRI: 104024032 104024972(PNPLA2)
PCAO: 104047097 104048124(PNPLA1)
ACUN: 113480980(PNPLA2) 113490465
TALA: 104363487 104366877(PNPLA2)
PADL: 103916456(PNPLA2) 103924466
AFOR: 103896228(PNPLA2) 103898753
ACHC: 115351746(PNPLA2) 115352620
HALD: 104315696(PNPLA2) 104321468
HLE: 104828694(PNPLA2) 104829392(PNPLA5)
CCRI: 104166270(PNPLA2) 104169570
CSTI: 104556172 104563559(PNPLA2)
EHS: 104506485(PNPLA2) 104507978
CMAC: 104483937(PNPLA2) 104486759
FGA: 104074271 104076872(PNPLA2)
GSTE: 104251186 104257470(PNPLA2)
LDI: 104354916(PNPLA2)
OHA: 104326726(PNPLA2) 104326998
NNT: 104406957(PNPLA2) 104410541
DPUB: 104296337 104299845(PNPLA2)
PGUU: 104459071(PNPLA2) 104462038
ACAR: 104518832(PNPLA2) 104522273
CPEA: 104387655(PNPLA2) 104395097
AVIT: 104276410 104278299(PNPLA2)
CVF: 104281671 104290297(PNPLA2)
CUCA: 104067327(PNPLA5) 104068918(PNPLA2)
TEO: 104379771 104381342(PNPLA2)
BRHI: 104500532 104502313(PNPLA2)
AAM: 106488311 106490004(PNPLA2)
AROW: 112962696(PNPLA2) 112967076
NPD: 112943580(PNPLA2) 112956866
TGT: 104569230 104575011(PNPLA2)
DNE: 112988036(PNPLA2) 112991526
SCAM: 104143770(PNPLA2) 104146640
ASN: 102381486(PNPLA2)
AMJ: 102569620(PNPLA2)
CPOO: 109316348 109321166(PNPLA2)
GGN: 109296345 109299202(PNPLA2)
PSS: 102443833 102450379(PNPLA2)
CMY: 102931307(PNPLA2) 102938324
CPIC: 101936184 101948343(PNPLA2)
TST: 117871694 117877337(PNPLA2)
CABI: 116825742 116838665(PNPLA2)
MRV: 120392979 120403898(PNPLA2)
ACS: 100551847(pnpla2)
PVT: 110074181(PNPLA2)
SUND: 121930050(PNPLA2) 121931193
PBI: 103048393(PNPLA2)
PMUR: 107283959(PNPLA2)
CTIG: 120298306(PNPLA2)
TSR: 106542070(PNPLA2)
PGUT: 117665196(PNPLA2)
VKO: 123021115(PNPLA2) 123033938
PMUA: 114599534(PNPLA2)
ZVI: 118088392(PNPLA2)
GJA: 107116418(PNPLA2)
STOW: 125426968(PNPLA2) 125435637(PNPLA3)
XLA: 108713865(pnpla2.L) 108715180(pnpla2.S)
XTR: 780152(pnpla2)
NPR: 108794583(PNPLA2)
RTEM: 120917311(PNPLA2)
BBUF: 120981001(PNPLA2)
BGAR: 122920167(PNPLA2)
DRE: 101887155(pnpla2)
MAMB: 125246844(pnpla2)
IPU: 108269288 108274701(pnpla2)
PHYP: 113529505(pnpla2) 113546554
SMEO: 124392162(pnpla2)
TFD: 113654047(pnpla2)
AMEX: 103023613 103029861(pnpla2)
EEE: 113588195
EFO: 125886905 125887442 125887874(pnpla2) 125891590(pnpla1)
MSAM: 119893301(pnpla2) 119905147
GMU: 124855728 124856623(pnpla2) 124865635(pnpla1)
MCEP: 125011729(pnpla1) 125014442 125014443 125015534(pnpla2)
SSEN: 122775535 122776372 122776514(pnpla2) 122777289(pnpla1)
HSP: 118109338 118109375(pnpla2) 118110631(pnpla1)
OTW: 112238871 112242251(pnpla2)
SNH: 120052317(pnpla2) 120066504
SFM: 108939144 108941267(pnpla2)
PKI: 111848020(pnpla2)
AANG: 118207390 118227161(pnpla2)
PSPA: 121294827(pnpla2) 121329755
ARUT: 117434920
PSEX: 120535878(pnpla2)
LCM: 102349054(PNPLA2) 102364578(PNPLA1)
CMK: 103186006(pnpla2)
RTP: 109926498
SPU: 582648
APLC: 110975490
SKO: 100374988
ACOZ: 120955150
CPII: 120428645
AME: 551055
ACER: 107993792
ALAB: 122719328
BIM: 100747930
BBIF: 117213842
BVK: 117234400
BVAN: 117163341
BTER: 100651324
BPYO: 122568718
CCAL: 108629084
OBB: 114878435
MGEN: 117217515
NMEA: 116430358
CGIG: 122399516
SOC: 105207573
MPHA: 105831282
AEC: 105144242
ACEP: 105619246
PBAR: 105432178
VEM: 105565342
HST: 105181728
DQU: 106746566
CFO: 105250235
FEX: 115236395
LHU: 105676997
PGC: 109852332
OBO: 105284717
PCF: 106786103
PFUC: 122514765
VPS: 122636730
NVI: 100118986
CSOL: 105365411
CCIN: 107268531
TCA: 659311(bmm)
DPA: 109534185
ATD: 109598159
NVL: 108562167
API: 100162729
DNX: 107163238
AGS: 114131901
RMD: 113548305
NLU: 111053138
ZNE: 110829229
FCD: 110857045
HAZT: 108671161
EAF: 111712249
VJA: 111269670
DPTE: 113795201
PTEP: 107455774
SDM: 118192788
CRG: 105328357
MYI: 110445973
PMAX: 117335822
OSN: 115228520
LAK: 106181783
ATEN: 116304047
ADF: 107346163
AMIL: 114958515
PDAM: 113669342
SPIS: 111325998
DGT: 114527358
XEN: 124455523
HMG: 100205181
AQU: 100642049
 » show all
Reference
  Authors
Smirnova E, Goldberg EB, Makarova KS, Lin L, Brown WJ, Jackson CL
  Title
ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells.
  Journal
EMBO Rep 7:106-13 (2006)
DOI:10.1038/sj.embor.7400559
Reference
  Authors
Zimmermann R, Strauss JG, Haemmerle G, Schoiswohl G, Birner-Gruenberger R, Riederer M, Lass A, Neuberger G, Eisenhaber F, Hermetter A, Zechner R
  Title
Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase.
  Journal
Science 306:1383-6 (2004)
DOI:10.1126/science.1100747
  Sequence
[hsa:57104]
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