KEGG ORTHOLOGY: K16848

ORTHOLOGY: K16848

Entry

K16848                      KO

Symbol

IQGAP1

Name

Ras GTPase-activating-like protein IQGAP1

Pathway

map04520

Adherens junction

map04810

Regulation of actin cytoskeleton

map05205

Proteoglycans in cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K16848  IQGAP1; Ras GTPase-activating-like protein IQGAP1
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K16848  IQGAP1; Ras GTPase-activating-like protein IQGAP1
09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K16848  IQGAP1; Ras GTPase-activating-like protein IQGAP1
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K16848  IQGAP1; Ras GTPase-activating-like protein IQGAP1
   04147 Exosome
    K16848  IQGAP1; Ras GTPase-activating-like protein IQGAP1
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Others
     K16848  IQGAP1; Ras GTPase-activating-like protein IQGAP1
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K16848  IQGAP1; Ras GTPase-activating-like protein IQGAP1
  Exosomal proteins of breast milk
   K16848  IQGAP1; Ras GTPase-activating-like protein IQGAP1
  Exosomal proteins of other body fluids (saliva and urine)
   K16848  IQGAP1; Ras GTPase-activating-like protein IQGAP1
  Exosomal proteins of colorectal cancer cells
   K16848  IQGAP1; Ras GTPase-activating-like protein IQGAP1

Genes

HSA:	8826(IQGAP1)

PTR:	467762(IQGAP1)

PPS:	100985354(IQGAP1)

GGO:	101133145(IQGAP1)

PON:	100174194(IQGAP1)

PPYG:

129013927(IQGAP1)

NLE:	100596536(IQGAP1)

HMH:	116463303 116463643

SSYN:

129482062(IQGAP1)

MCC:	709283(IQGAP1)

MCF:	101926449(IQGAP1)

MTHB:

126959070

MNI:	105488300(IQGAP1)

CSAB:

103231194

CATY:

105601189(IQGAP1)

PANU:

101004913(IQGAP1)

TGE:	112628311(IQGAP1)

MLEU:

105538495(IQGAP1)

RRO:	104679277(IQGAP1)

RBB:	108517209(IQGAP1)

TFN:	117070205(IQGAP1)

PTEH:

111528651(IQGAP1)

CANG:

105515577(IQGAP1)

CJC:	100398711(IQGAP1)

SBQ:	101030045(IQGAP1)

CIMI:

108287595(IQGAP1)

ANAN:

105724931(IQGAP1)

CSYR:

103261946(IQGAP1)

MMUR:

105870594(IQGAP1)

LCAT:

123645104(IQGAP1)

PCOQ:

105809829(IQGAP1)

OGA:	100959408(IQGAP1)

MMU:	29875(Iqgap1)

MCAL:

110299257(Iqgap1)

MPAH:

110333009(Iqgap1)

RNO:	361598(Iqgap1)

MCOC:

116102471(Iqgap1)

ANU:	117694557 117708637(Iqgap1)

ASYL:

127666835(Iqgap1)

MUN:	110566061(Iqgap1)

CGE:	100757264(Iqgap1)

MAUA:

101830531(Iqgap1)

PROB:

127238107(Iqgap1)

PLEU:

114696197(Iqgap1) 114706423

MORG:

121455875(Iqgap1)

MFOT:

126508656

AAMP:

119802785(Iqgap1)

NGI:	103749878(Iqgap1)

HGL:	101720196(Iqgap1)

CPOC:

100732321(Iqgap1)

CCAN:

109696764(Iqgap1)

DORD:

105982470(Iqgap1)

DSP:	122099983(Iqgap1)

PLOP:

125367891(Iqgap1)

NCAR:

124976708

MMMA:

107148405(Iqgap1)

ITI:	101955165(Iqgap1)

OCU:

100344867

OPI:	101524450(IQGAP1)

TUP:	102471568(IQGAP1)

GVR:	103584252(IQGAP1)

CFA:	479050(IQGAP1)

CLUD:

112653075(IQGAP1)

VVP:	112921443(IQGAP1)

VLG:	121489256(IQGAP1)

NPO:	129510250(IQGAP1)

UMR:	103660204(IQGAP1)

UAH:	113263724(IQGAP1)

UAR:	123802462(IQGAP1)

ELK:

111152707

LLV:

125103843

MPUF:

101673618(IQGAP1)

MNP:	131999019(IQGAP1)

MLK:	131835568(IQGAP1)

NVS:	122893075(IQGAP1)

ORO:	101369803(IQGAP1)

EJU:	114223251(IQGAP1)

ZCA:	113908944(IQGAP1)

MLX:	118023079(IQGAP1)

NSU:	110572388(IQGAP1)

LWW:	102730889(IQGAP1)

FCA:	101087841(IQGAP1)

PYU:	121042350(IQGAP1)

PCOO:

112855178(IQGAP1)

PBG:	122467525(IQGAP1)

PVIV:

125167700(IQGAP1)

LRUF:

124517266

LGF:	123584438(IQGAP1)

AJU:

106965891

PTG:	102957368(IQGAP1)

PPAD:

109273484(IQGAP1)

PUC:

125910729

PLEZ:

122221581(IQGAP1)

HHV:	120248522(IQGAP1)

BTA:	104968536(IQGAP1)

BOM:	102281381(IQGAP1)

BIU:	109575386(IQGAP1)

BBUB:

102397947(IQGAP1)

BBIS:

104989404(IQGAP1)

CHX:	102172668(IQGAP1)

OAS:	101104610(IQGAP1)

BTAX:

128066364(IQGAP1)

CSUM:

138095516(IQGAP1)

ODA:	120875579(IQGAP1)

CCAD:

122419814(IQGAP1)

MREE:

136147140(IQGAP1)

OVR:	110148969(IQGAP1)

MBEZ:

129550312(IQGAP1)

SSC:	100157656(IQGAP1)

CFR:	102513791(IQGAP1)

CBAI:

105069087(IQGAP1)

CDK:	105094701(IQGAP1)

VPC:	102540357(IQGAP1)

BACU:

103019637(IQGAP1)

BMUS:

118889758(IQGAP1)

LVE:	103077891(IQGAP1)

OOR:	101273971(IQGAP1)

LALB:

132525485(IQGAP1)

DLE:	111169686(IQGAP1)

PCAD:

102993570(IQGAP1)

PSIU:

116748836(IQGAP1)

PPHC:

136118760(IQGAP1)

NASI:

112414157(IQGAP1)

ECB:	100068724(IQGAP1)

EPZ:	103546217(IQGAP1)

EAI:	106832054(IQGAP1)

MYB:	102263858(IQGAP1)

MYD:	102766452(IQGAP1)

MMYO:

118679268(IQGAP1)

MLF:	102420198 102422362

MDT:	132222859(IQGAP1)

MYUM:

138998416(IQGAP1)

PKL:	118706353(IQGAP1)

EFUS:

103303003(IQGAP1)

MNA:	107540385(IQGAP1)

DRO:	112306063(IQGAP1)

SHON:

118991938(IQGAP1)

AJM:	119052120(IQGAP1)

PDIC:

114488513(IQGAP1)

PHAS:

123809603(IQGAP1)

MMF:	118640887(IQGAP1)

PPAM:

129083457(IQGAP1)

HAI:	109381492(IQGAP1)

RFQ:	117018820(IQGAP1)

PALE:

102888464(IQGAP1)

PGIG:

120599264(IQGAP1)

PVP:	105302874(IQGAP1)

RAY:	107514129(IQGAP1)

MJV:	108403848(IQGAP1)

TOD:	119244245(IQGAP1)

SARA:

101539282(IQGAP1)

SFUM:

130032900(IQGAP1)

SETR:

126022399(IQGAP1)

LAV:	100660209(IQGAP1)

TMU:

101356521

ETF:	101651283(IQGAP1)

DNM:	101434613(IQGAP1)

MDO:	100014032(IQGAP1)

GAS:	123232996(IQGAP1)

SHR:	100933251(IQGAP1)

PCW:	110214079(IQGAP1)

TVP:	118828016(IQGAP1)

PBRV:

138148577(IQGAP1)

OAA:	100085128(IQGAP1)

TACU:

119931327(IQGAP1)

GGA:	415591(IQGAP3)

PCOC:

116225543(IQGAP1)

MGP:	100550295(IQGAP1)

CJO:	107318890(IQGAP1)

TPAI:

128075542(IQGAP1) 128088710

LMUT:

125698497(IQGAP1)

NMEL:

110403663(IQGAP1)

APLA:

101789617(IQGAP1)

ACYG:

106049780(IQGAP1)

CATA:

118259406(IQGAP1)

AFUL:

116493615(IQGAP1)

TGU:	100220311(IQGAP1)

LSR:	110476683(IQGAP1)

SCAN:

103816139(IQGAP1)

PMOA:

120508899(IQGAP1)

OTC:	121343431(IQGAP1)

PRUF:

121352233(IQGAP1)

ATRC:

139596634(IQGAP1)

GFR:	102042572(IQGAP1)

FAB:	101809992(IQGAP1)

OMA:	130257258(IQGAP1)

PHI:	102103186(IQGAP1)

PMAJ:

107209265(IQGAP1)

CCAE:

111933926(IQGAP1)

CCW:	104683841(IQGAP1)

CBRC:

103618774(IQGAP1)

ACOE:

138116728(IQGAP1)

ETL:	114064288(IQGAP1)

ZAB:	102068656(IQGAP1)

ZLE:	135452121(IQGAP1)

ACHL:

103810137(IQGAP1)

SVG:

106860120

MMEA:

130585131(IQGAP1)

HRT:	120758594(IQGAP1)

SATI:

136366837(IQGAP1)

CCIC:

134049392(IQGAP1)

FPG:	101912284(IQGAP1)

FCH:	102054787(IQGAP1)

CCRI:

104159744(IQGAP1)

SHAB:

115612920(IQGAP1)

ACUN:

113483871(IQGAP1)

TALA:

104361560(IQGAP1)

ACHC:

115341071(IQGAP1)

HALD:

104318295(IQGAP1)

HLE:	104834664(IQGAP1)

AGEN:

126043982

HHAR:

128150799(IQGAP1)

GCL:

127020875

CSTI:

104562169(IQGAP1)

LDI:	104350235(IQGAP1)

MNB:	103781392(IQGAP1)

DPUB:

104297361(IQGAP1)

PPUS:

135183022(IQGAP1)

AVIT:

104279008(IQGAP1)

BRHI:

104495335(IQGAP1)

EGZ:	104125986(IQGAP1)

PCRI:

104037231(IQGAP1)

PADL:

103914866(IQGAP1)

AFOR:

103899818(IQGAP1)

FGA:	104080089(IQGAP1)

GSTE:

104257171(IQGAP1)

CBOY:

140656210(IQGAP1)

CLV:	102089584(IQGAP1)

CNIC:

135992737(IQGAP1)

MUI:	104533573(IQGAP1)

PGUU:

104469259(IQGAP1)

EHS:	104515337(IQGAP1)

CMAC:

104473420(IQGAP1)

CUCA:

104056427(IQGAP1)

BREG:

104635111(IQGAP1)

OHA:	104336898(IQGAP1)

ACAR:

104521894(IQGAP1)

CPEA:

104385784(IQGAP1)

CVF:	104285685(IQGAP1)

RTD:	128914568(IQGAP1)

CRID:

134520287(IQGAP1)

AROW:

112976285(IQGAP1)

NPD:	112954147(IQGAP1)

TGT:	104578500(IQGAP1)

DNE:	112992463(IQGAP1)

SCAM:

104141032(IQGAP1)

ASN:	102381745(IQGAP1)

AMJ:	102569599(IQGAP1)

CPOO:

109308796(IQGAP1)

GGN:	109288382(IQGAP1)

PSS:	102458593(IQGAP1)

CMY:	102935527(IQGAP1)

CCAY:

125643419(IQGAP1)

DCC:	119862488(IQGAP1)

CPIC:

101949591(IQGAP1)

TST:	117883548(IQGAP1)

CABI:

116818044(IQGAP1)

MRV:	120373830(IQGAP1)

ACS:	100551905(iqgap1)

ASAO:

132762469(IQGAP1)

PVT:	110077222(IQGAP1)

SUND:

121932994

PBI:	103059858(IQGAP1)

PMUR:

107289788(IQGAP1)

CTIG:

120316409(IQGAP1)

TSR:

106546133

PGUT:

117676245(IQGAP1)

APRI:

131184550(IQGAP1)

PTEX:

113442104(IQGAP1)

NSS:	113423314(IQGAP1)

VKO:	123030710(IQGAP1)

PMUA:

114584440

PRAF:

128401686(IQGAP1)

ZVI:	118092659(IQGAP1)

HCG:	128334800(IQGAP1)

GJA:	107109718(IQGAP1)

STOW:

125424474(IQGAP1)

EMC:	129345157(IQGAP1)

XLA:	398589(iqgap1.L) 445857

XTR:	100127767(iqgap1)

NPR:	108795256(IQGAP1)

RTEM:

120931267(IQGAP1)

ACAT:

141131375(IQGAP1)

BBUF:

120985880(IQGAP1)

BGAR:

122927588(IQGAP1)

DTC:	141084122(IQGAP1)

PWL:	138284136(IQGAP1)

MUO:	115459836(IQGAP1)

GSH:	117348277(IQGAP1)

DRE:	100002928(iqgap1)

SRX:	107730269 107757707

SANH:

107695311 107701276

SGH:	107596412(iqgap1) 107600473

CCAR:

109067713 109096645

CAUA:

113051359 113106269

CGIB:

127961601 128017762

PTET:

122349753(iqgap1)

LROH:

127168354(iqgap1)

GRF:	141331076(iqgap1)

OMC:	131543943(iqgap1)

PPRM:

120464781

RKG:	130091215(iqgap1)

MAMB:

125265100(iqgap1)

CIDE:

127515802

CERY:

137031207(iqgap1)

MASI:

127414464 127447175

TROS:

130555930(iqgap1)

TDW:	130421011(iqgap1)

MANU:

129447670(iqgap1)

PDAB:

135778686(iqgap1)

IPU:

108259258

IFU:	128602716(iqgap1)

PHYP:

113540859(iqgap1)

SMEO:

124379705(iqgap1)

TFD:	113636729(iqgap1)

TVC:	132839045(iqgap1)

CGAR:

128518626(iqgap1)

NGRA:

132875027(iqgap1)

TRN:	134303931(iqgap1)

AMEX:

103043074(iqgap1)

CMAO:

118817559(iqgap1)

CHAR:

105908116(iqgap1)

SPIL:

134095235(iqgap1)

TRU:	101061053(iqgap1)

TFS:	130518532(iqgap1)

TNG:	GSTEN00018653G001

LCO:	104927249(iqgap1)

NCC:	104948912(iqgap1)

TBEN:

117471315(iqgap1)

CGOB:

115025471(iqgap1)

PGEO:

117463408(iqgap1)

GACU:

117533641(iqgap1)

EMAC:

134863184(iqgap1)

ELY:	117254124(iqgap1)

EFO:	125904958(iqgap1)

PLEP:

121942071(iqgap1)

SLUC:

116067267(iqgap1)

ECRA:

117961642(iqgap1)

ESP:	116686679(iqgap1)

PFLV:

114552405(iqgap1)

GAT:	120830671(iqgap1)

PPUG:

119195977(iqgap1)

AFB:	129099136(iqgap1)

CLUM:

117728809(iqgap1)

PSWI:

130192989(iqgap1)

CANA:

137786559(iqgap1)

CVE:	137882211(iqgap1)

MSAM:

119890288(iqgap1)

SCHU:

122880059(iqgap1)

CUD:	121510907(iqgap1)

SPUL:

138606794(iqgap1)

LMIX:

132978330(iqgap1)

ALAT:

119017880(iqgap1)

ASTR:

137604028(iqgap1)

MZE:	101469891(iqgap1)

ONL:	100707758(iqgap1)

OAU:	116333021(iqgap1)

OLA:	101162510(iqgap1)

OML:	112160729(iqgap1)

CSAI:

133458532(iqgap1)

XMA:	102219414(iqgap1)

XCO:	114142790(iqgap1)

XHE:	116718704(iqgap1)

PRET:

103462973(iqgap1)

PFOR:

103131721

PLAI:

106937661(iqgap1)

PMEI:

106932907(iqgap1)

GAF:	122824919(iqgap1)

PPRL:

129354066(iqgap1)

CVG:	107091091(iqgap1)

CTUL:

119798839(iqgap1)

GMU:	124866901(iqgap1)

NFU:	107382018(iqgap1)

KMR:	108247124(iqgap1)

ALIM:

106533090

NWH:	119424724(iqgap1)

AOCE:

111578513(iqgap1)

EJA:	138213831(iqgap1)

BFRE:

138631177(iqgap1)

MCEP:

125005073(iqgap1)

CSEM:

103398470(iqgap1)

SSEN:

122772238(iqgap1)

SSOE:

131459787(iqgap1)

HHIP:

117757025(iqgap1)

HSP:

118105716

PPLT:

128445772(iqgap1)

SMAU:

118302710(iqgap1)

LCF:

108894212

SDU:	111222899(iqgap1)

SLAL:

111656615(iqgap1)

XGL:	120796491(iqgap1)

HCQ:	109514308(iqgap1)

SSCV:

125967067(iqgap1)

SBIA:

133498637(iqgap1)

PEE:	133395470(iqgap1)

PTAO:

133473259(iqgap1)

BPEC:

110168840(iqgap1)

ENY:	140350603(iqgap1)

MALB:

109954516(iqgap1)

BSPL:

114851805(iqgap1)

SJO:	128363378(iqgap1)

SSCO:

133978232(iqgap1)

GMH:	115559111(iqgap1)

SASA:

100380768(iqga1) 106562619

STRU:

115166923 115203385

OTW:	112237930(iqgap1)

OMY:	110506160 110514283

OGO:	124017809(iqgap1)

OKI:	109881629(iqgap1) 109895205

OKE:	118373336(iqgap1)

OMM:	135556464(iqgap1)

OCLA:

139385062

SNH:	120048448(iqgap1)

CCLU:

121582996(iqgap1)

ELS:	105014938(iqgap1)

OEP:	134027740(iqgap1)

SFM:	108941147(iqgap1)

PKI:	111844997(iqgap1)

AANG:

118227398(iqgap1)

AROT:

135255468(iqgap1)

CCOG:

133130224(iqgap1)

LOC:	102698473(iqgap1)

PSPA:

121294507(iqgap1) 121299295

ARUT:

117427590 117429953

PSEX:

120541601(iqgap1)

LCM:	102355177(IQGAP1)

CMK:	103188605(iqgap1)

RTP:	109916564(iqgap1)

CPLA:

122542580(iqgap1)

HOC:	132834848(iqgap1)

LERI:

129713655(iqgap1)

HAKA:

140714062(iqgap1)

PMRN:

116939017 116941875(IQGAP1)

LRJ:	133343868(IQGAP1) 133346574

BFO:

BBEL:

SCLV:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

PFLL:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

MSEX:

DPL:	KGM_203792

BANY:

MJU:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

OFU:

PGW:

ACOO:

DVT:

DCI:

NLU:

HVI:

MQU:	128997445 128997484

FOC:

TPAL:

PAME:

BROR:

IEL:

HAMR:

AFRA:

PCHN:

PMOO:

MNZ:

MRJ:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

LPOL:

LGI:	LOTGIDRAFT_216980

PVUL:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LLON:

NVE:

ATEN:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

HMG:

HSY:

TAD:	TRIADDRAFT_37304

AQU:

100634031

MBR:	MONBRDRAFT_14583

» show all

Reference

PMID:15890984

Authors

Noritake J, Watanabe T, Sato K, Wang S, Kaibuchi K

Title

IQGAP1: a key regulator of adhesion and migration.

Journal

J Cell Sci 118:2085-92 (2005)
DOI:10.1242/jcs.02379

Reference

PMID:16595175

Authors

Brown MD, Sacks DB

Title

IQGAP1 in cellular signaling: bridging the GAP.

Journal

Trends Cell Biol 16:242-9 (2006)
DOI:10.1016/j.tcb.2006.03.002

Reference

PMID:15695813

Authors

Li Z, McNulty DE, Marler KJ, Lim L, Hall C, Annan RS, Sacks DB

Title

IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner.

Journal

J Biol Chem 280:13871-8 (2005)
DOI:10.1074/jbc.M413482200

Sequence

[hsa:8826]

LinkDB

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