KEGG ORTHOLOGY: K17449

ORTHOLOGY: K17449

Entry

K17449                      KO

Symbol

SHC4

Name

SHC-transforming protein 4

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map01522

Endocrine resistance

map04012

ErbB signaling pathway

map04014

Ras signaling pathway

map04062

Chemokine signaling pathway

map04072

Phospholipase D signaling pathway

map04510

Focal adhesion

map04650

Natural killer cell mediated cytotoxicity

map04722

Neurotrophin signaling pathway

map04910

Insulin signaling pathway

map04915

Estrogen signaling pathway

map04917

Prolactin signaling pathway

map04926

Relaxin signaling pathway

map04935

Growth hormone synthesis, secretion and action

map05034

Alcoholism

map05100

Bacterial invasion of epithelial cells

map05206

MicroRNAs in cancer

map05214

Glioma

map05220

Chronic myeloid leukemia

map05224

Breast cancer

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K17449  SHC4; SHC-transforming protein 4
   04014 Ras signaling pathway
    K17449  SHC4; SHC-transforming protein 4
   04072 Phospholipase D signaling pathway
    K17449  SHC4; SHC-transforming protein 4
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K17449  SHC4; SHC-transforming protein 4
09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K17449  SHC4; SHC-transforming protein 4
   04062 Chemokine signaling pathway
    K17449  SHC4; SHC-transforming protein 4
  09152 Endocrine system
   04910 Insulin signaling pathway
    K17449  SHC4; SHC-transforming protein 4
   04915 Estrogen signaling pathway
    K17449  SHC4; SHC-transforming protein 4
   04917 Prolactin signaling pathway
    K17449  SHC4; SHC-transforming protein 4
   04926 Relaxin signaling pathway
    K17449  SHC4; SHC-transforming protein 4
   04935 Growth hormone synthesis, secretion and action
    K17449  SHC4; SHC-transforming protein 4
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K17449  SHC4; SHC-transforming protein 4
09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K17449  SHC4; SHC-transforming protein 4
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K17449  SHC4; SHC-transforming protein 4
   05226 Gastric cancer
    K17449  SHC4; SHC-transforming protein 4
   05214 Glioma
    K17449  SHC4; SHC-transforming protein 4
   05220 Chronic myeloid leukemia
    K17449  SHC4; SHC-transforming protein 4
   05224 Breast cancer
    K17449  SHC4; SHC-transforming protein 4
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    K17449  SHC4; SHC-transforming protein 4
  09165 Substance dependence
   05034 Alcoholism
    K17449  SHC4; SHC-transforming protein 4
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K17449  SHC4; SHC-transforming protein 4
   01522 Endocrine resistance
    K17449  SHC4; SHC-transforming protein 4

Genes

HSA:	399694(SHC4)

PTR:	453414(SHC4)

PPS:	100991042(SHC4)

GGO:	101154420(SHC4)

PON:	100431574(SHC4)

PPYG:

129014141(SHC4)

NLE:	100591644(SHC4)

HMH:	116481523(SHC4)

SSYN:

129482743(SHC4)

MCC:	714611(SHC4)

MCF:	102130383(SHC4)

MTHB:

126958692

MNI:	105490670(SHC4)

CSAB:

103245659(SHC4)

CATY:

105588205(SHC4)

PANU:

101014651 116272720 116272724 116272729 116272733 116272789

TGE:	112627393(SHC4)

MLEU:

105529990(SHC4)

RRO:	104657941(SHC4)

RBB:	108530104(SHC4)

TFN:	117070688(SHC4)

PTEH:

111552722(SHC4)

CANG:

105502189(SHC4)

CJC:	100392220(SHC4)

SBQ:	101032627(SHC4)

CIMI:

108315604(SHC4)

ANAN:

105710105(SHC4)

CSYR:

103272388(SHC4)

MMUR:

105870730(SHC4)

LCAT:

123622389(SHC4)

PCOQ:

105814299(SHC4)

OGA:	100945538(SHC4)

MMU:	271849(Shc4)

MCAL:

110289726(Shc4)

MPAH:

110318126(Shc4)

RNO:	679845(Shc4)

MCOC:

116090849(Shc4)

ANU:	117704137(Shc4)

ASYL:

127685843(Shc4)

MUN:	110550937(Shc4)

CGE:	100763505(Shc4)

MAUA:

101841602(Shc4)

PROB:

127221520(Shc4)

PLEU:

114683897(Shc4)

MORG:

121465649(Shc4)

MFOT:

126496689

AAMP:

119815646(Shc4)

NGI:	103733036(Shc4)

HGL:	101717788(Shc4)

CPOC:

100717842(Shc4)

CCAN:

109684252(Shc4)

DORD:

105980977(Shc4)

DSP:	122114464(Shc4)

PLOP:

125340436(Shc4)

NCAR:

124978227

MMMA:

107138120(Shc4)

ITI:	101973095(Shc4)

OCU:

100350676

OPI:	101535980(SHC4)

TUP:	102479734(SHC4)

GVR:	103587215(SHC4)

CFA:	487546(SHC4)

CLUD:

112675960(SHC4)

VVP:	112920045(SHC4)

VLG:	121485135(SHC4)

NPO:	129506392(SHC4)

AML:	100475137(SHC4)

UMR:	103676722(SHC4)

UAH:	113269597(SHC4)

UAR:	123801854(SHC4)

ELK:

111162137

LLV:

125105042

MPUF:

101689202(SHC4)

MNP:	131999737(SHC4)

MLK:	131836254(SHC4)

NVS:	122893234(SHC4)

ORO:	101375729(SHC4)

EJU:	114206514(SHC4)

ZCA:	113909494(SHC4)

MLX:	118002971(SHC4)

NSU:	110584023(SHC4)

LWW:	102732584(SHC4)

FCA:	101099050(SHC4)

PYU:	121041673(SHC4)

PCOO:

112856265(SHC4)

PBG:	122468671(SHC4)

PVIV:

125168731(SHC4)

LRUF:

124508608

LGF:	123583052(SHC4)

AJU:

106967221

PTG:	102955115(SHC4)

PPAD:

109263016(SHC4)

PUC:

125909988

PLEZ:

122222065(SHC4)

HHV:	120220858(SHC4)

BTA:	524734(SHC4)

BOM:	102284488(SHC4)

BIU:	109565147(SHC4)

BBUB:

102406154(SHC4)

BBIS:

104988263(SHC4)

CHX:	102179773(SHC4)

OAS:	101110241(SHC4)

BTAX:

128054009(SHC4)

CSUM:

138073913(SHC4)

ODA:	120852962(SHC4)

CCAD:

122443633(SHC4)

MREE:

136171655(SHC4)

OVR:	110135943(SHC4)

MBEZ:

129562932(SHC4)

SSC:	100526147(SHC4)

CFR:	102517753(SHC4)

CBAI:

105077007(SHC4)

CDK:	105104832(SHC4)

VPC:	102528702(SHC4)

BACU:

102999132(SHC4)

BMUS:

118890587(SHC4)

LVE:	103088900(SHC4)

OOR:	101289594(SHC4)

LALB:

132520784(SHC4)

DLE:	111181617(SHC4)

PCAD:

102988652(SHC4)

PSIU:

116749591(SHC4)

NASI:

112402165(SHC4)

ECB:	100055699(SHC4)

EPZ:	103551857(SHC4)

EAI:	106838625(SHC4)

MYB:	102239285(SHC4)

MYD:	102762219(SHC4)

MMYO:

118651538(SHC4)

MLF:	102431548(SHC4)

MDT:	132237519(SHC4)

MYUM:

139015564(SHC4)

PKL:	118721624(SHC4)

EFUS:

103287410(SHC4)

MNA:	107535558(SHC4)

DRO:	112311774(SHC4)

SHON:

118992600(SHC4)

AJM:	119057612(SHC4)

PDIC:

114492960(SHC4)

PHAS:

123808639(SHC4)

MMF:	118631532(SHC4)

PPAM:

129064266(SHC4)

HAI:	109394486(SHC4)

RFQ:	117023566(SHC4)

PALE:

102888926(SHC4)

PGIG:

120622672(SHC4)

PVP:	105288811(SHC4)

RAY:	107519965(SHC4)

MJV:	108402352(SHC4)

TOD:	119238599(SHC4)

SARA:

101537303(SHC4)

SFUM:

130043108(SHC4)

SETR:

126020007(SHC4)

LAV:	100654827(SHC4)

TMU:

101355900

ETF:	101654517(SHC4)

DNM:	101422617(SHC4)

MDO:	100031128(SHC4)

GAS:	123234105(SHC4)

SHR:	100927458(SHC4)

AFZ:

127551137

PCW:	110201503(SHC4)

TVP:	118828960(SHC4)

PBRV:

138168967(SHC4)

GGA:	426482(SHC4)

PCOC:

116225316(SHC4)

MGP:	100541111(SHC4)

CJO:	107318783(SHC4)

TPAI:

128075375(SHC4)

LMUT:

125698401(SHC4)

NMEL:

110403695(SHC4)

APLA:

101797165(SHC4)

ACYG:

106033799(SHC4)

CATA:

118251605(SHC4)

AFUL:

116493314(SHC4)

TGU:	100226451(SHC4)

LSR:	110474245(SHC4)

SCAN:

103816021(SHC4)

PMOA:

120509194(SHC4)

OTC:	121343474(SHC4)

PRUF:

121354436(SHC4)

ATRC:

139596858(SHC4)

GFR:	102037367(SHC4)

FAB:	101809679(SHC4)

OMA:	130257341(SHC4)

PHI:	102103363(SHC4)

PMAJ:

107209575(SHC4)

CCAE:

111934113(SHC4)

CCW:	104683990(SHC4)

CBRC:

103621260(SHC4)

ACOE:

138116540(SHC4)

ETL:	114059944(SHC4)

ZAB:	102067308(SHC4)

ZLE:	135452305(SHC4)

ACHL:

103798302(SHC4)

SVG:	106860078(SHC4)

MMEA:

130575771(SHC4)

HRT:	120758926(SHC4)

SATI:

136367052(SHC4)

CCIC:

134049091(SHC4)

FPG:	101914295(SHC4)

FCH:	102053624(SHC4)

CCRI:

104161587(SHC4)

NNT:	104411986(SHC4)

SHAB:

115613139(SHC4)

ACUN:

113484090(SHC4)

TALA:

104357518(SHC4)

ACHC:

115341918(SHC4)

HALD:

104315604(SHC4)

HLE:	104834500(SHC4)

AGEN:

126043703

HHAR:

128151192(SHC4)

GCL:

127020528

CSTI:

104556641(SHC4)

LDI:	104346282(SHC4)

MNB:	103776604(SHC4)

DPUB:

104297382(SHC4)

PPUS:

135182980(SHC4)

AVIT:

104274922(SHC4)

BRHI:

104500250(SHC4)

EGZ:	104130918(SHC4)

NNI:	104017130(SHC4)

PCRI:

104035380

PADL:

103922748(SHC4)

AFOR:

103896621(SHC4)

FGA:	104082118(SHC4)

GSTE:

104264988(SHC4)

CLV:	102088829(SHC4)

MUI:	104546219(SHC4)

PGUU:

104464437(SHC4)

PLET:

104614810(SHC4)

EHS:	104516719(SHC4)

CMAC:

104487484(SHC4)

CUCA:

104055747(SHC4)

TEO:	104382566(SHC4)

BREG:

104637341(SHC4)

OHA:	104334595(SHC4)

ACAR:

104522621(SHC4)

CPEA:

104386019(SHC4)

CVF:	104287431(SHC4)

RTD:	128915243(SHC4)

CRID:

134520956(SHC4)

AAM:	106496580(SHC4)

AROW:

112963474(SHC4)

NPD:	112952858(SHC4)

TGT:	104569525(SHC4)

DNE:	112981447(SHC4)

SCAM:

104148257(SHC4)

ASN:	102383468(SHC4)

AMJ:	102568049(SHC4)

CPOO:

109309042(SHC4)

GGN:	109288589(SHC4)

PSS:	102455357(SHC4)

CMY:	102934651(SHC4)

CCAY:

125644095(SHC4)

DCC:	119862189(SHC4)

CPIC:

101946426(SHC4)

TST:	117884252(SHC4)

CABI:

116814983(SHC4)

MRV:	120372994(SHC4)

ACS:	100560740(shc4)

ASAO:

132762381(SHC4)

PVT:	110077281(SHC4)

SUND:

121933468(SHC4)

PBI:	103055438(SHC4)

PMUR:

107287682(SHC4)

CTIG:

120315185(SHC4)

PGUT:

117675742(SHC4)

APRI:

131184796(SHC4)

PTEX:

113442312(SHC4)

NSS:	113418294(SHC4)

VKO:	123027782(SHC4)

PMUA:

114584523(SHC4)

PRAF:

128401621(SHC4)

ZVI:	118092793(SHC4)

HCG:	128335158(SHC4)

GJA:	107124453(SHC4)

EMC:	129345563(SHC4)

XLA:	108711398(shc4.L) 108712318(shc4.S)

XTR:	100490718(shc4)

NPR:	108792188(SHC4)

RTEM:

120931328(SHC4)

BBUF:

120985832(SHC4)

BGAR:

122927622(SHC4)

PWL:	138284084(SHC4)

MUO:	115460653(SHC4)

GSH:	117348271(SHC4)

CHAR:

105889012

SPIL:

134095531

TRU:	105417270(shc4)

TFS:

130516637

LCO:	109136640(shc4)

TBEN:

117471585

CGOB:

115023683(shc4)

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116703619(shc4)

PFLV:

114556819(shc4)

GAT:

PPUG:

AFB:

CLUM:

CANA:

CVE:	137887045 137888633

MSAM:

SCHU:

CUD:

SPUL:

LMIX:

ALAT:

ASTR:

MZE:	101474172(shc4)

ONL:	100701320(shc4)

OAU:

116311729

OLA:	101170912(shc4)

OML:

112160361

CSAI:

133420018

XMA:	102222349(shc4)

XCO:	114142814(shc4)

XHE:	116719254(shc4)

PRET:

103462081(shc4)

PFOR:

103146152(shc4)

PLAI:

106935451(shc4)

PMEI:

106904493(shc4)

GAF:

122841451

PPRL:

129369591

CVG:	107085339(shc4)

CTUL:

119782435

GMU:

124867254

NFU:	107381724(shc4)

AOCE:

EJA:

BFRE:

MCEP:

CSEM:

103379110(shc4)

POV:	109637245(shc4)

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:	111238681(shc4)

SLAL:

111661140(shc4)

XGL:

120792101

HCQ:	109525729(shc4)

SSCV:

SBIA:

PEE:

PTAO:

ENY:

SJO:

SSCO:

GMH:	115559155(shc4)

OEP:

134028002

SFM:

108940860

PKI:	111844965(shc4)

AANG:

118227959

AROT:

135255391

CCOG:

133130613

LOC:	102684593(shc4)

PSPA:

121294465 121298902

ARUT:

117428494 117429071

PSEX:

120539955

LCM:	102354432(SHC4)

CMK:

CPLA:

HOC:

LERI:

MMER:

Reference

PMID:17409413

Authors

Fagiani E, Giardina G, Luzi L, Cesaroni M, Quarto M, Capra M, Germano G, Bono M, Capillo M, Pelicci P, Lanfrancone L

Title

RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas.

Journal

Cancer Res 67:3064-73 (2007)
DOI:10.1158/0008-5472.CAN-06-2301

Sequence

[hsa:399694]

Reference

PMID:17452444

Authors

Jones N, Hardy WR, Friese MB, Jorgensen C, Smith MJ, Woody NM, Burden SJ, Pawson T

Title

Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase.

Journal

Mol Cell Biol 27:4759-73 (2007)
DOI:10.1128/MCB.00184-07

Sequence

[hsa:399694]

LinkDB

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