KEGG ORTHOLOGY: K17570

ORTHOLOGY: K17570

Entry

K17570                      KO

Symbol

HYDIN

Name

hydrocephalus-inducing protein

Disease

H00564

Primary ciliary dyskinesia

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K17570  HYDIN; hydrocephalus-inducing protein
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins
    K17570  HYDIN; hydrocephalus-inducing protein
Protein phosphatases and associated proteins [BR:ko01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K17570  HYDIN; hydrocephalus-inducing protein
Cilium and associated proteins [BR:ko03037]
Motile cilia and associated proteins
  Sperm associated proteins
   K17570  HYDIN; hydrocephalus-inducing protein

Genes

HSA:	54768(HYDIN)

PTR:	454221(HYDIN)

PPS:	100970183(HYDIN)

GGO:	101139295(HYDIN)

PON:	100456091(HYDIN)

PPYG:

129015565(HYDIN)

NLE:	100583141(HYDIN)

HMH:	116471478(HYDIN)

SSYN:

129493002(HYDIN)

MCC:	708629(HYDIN)

MCF:	102121751(HYDIN)

MTHB:

126943698

MNI:	105491299(HYDIN)

CSAB:

103233167(HYDIN)

CATY:

105576716(HYDIN)

PANU:

101004679(HYDIN)

TGE:	112614116(HYDIN)

MLEU:

105537214(HYDIN)

RRO:	104677812(HYDIN)

RBB:	108527450(HYDIN)

TFN:	117088025(HYDIN)

PTEH:

111541437(HYDIN)

CANG:

105526178(HYDIN)

CJC:	100396866(HYDIN)

SBQ:	101045008(HYDIN)

CIMI:

108294393

ANAN:

105706742(HYDIN)

CSYR:

103265684

MMUR:

105875420(HYDIN)

PCOQ:

105807968(HYDIN)

OGA:	100945998(HYDIN)

MMU:	244653(Hydin)

MCAL:

110300911(Hydin)

MPAH:

110337353(Hydin)

RNO:	292017(Hydin)

MCOC:

116070168(Hydin)

ANU:	117723157(Hydin)

ASYL:

127671644(Hydin)

MUN:	110546011(Hydin)

CGE:	100758841(Hydin)

MAUA:

101834812(Hydin)

PROB:

127234425(Hydin)

PLEU:

114708071(Hydin)

MORG:

121447022(Hydin)

MFOT:

126502941

AAMP:

119801781(Hydin)

NGI:	103735648(Hydin)

HGL:	101696339(Hydin)

CPOC:

100718497(Hydin)

CCAN:

109678264 109697819

DORD:

105983049(Hydin)

DSP:	122126161(Hydin)

DMER:

138829739(Hydin)

PLOP:

125358207(Hydin)

NCAR:

124967160

MMMA:

107150921(Hydin)

ITI:	101966084(Hydin)

OCU:

100347308

OPI:	101519602(HYDIN)

OCZ:	121157934(HYDIN)

TUP:	102481975(HYDIN)

CFA:	100683062(HYDIN)

CLUD:

112646612(HYDIN)

VVP:	112929534(HYDIN)

VLG:	121500983(HYDIN)

NPO:	129496562(HYDIN)

AML:	100479593(HYDIN)

UMR:	103673581(HYDIN)

UAH:	113252465(HYDIN)

UAR:	123800529(HYDIN)

ELK:

111152905

LLV:

125089288

MPUF:

101693557(HYDIN)

MNP:	132004778(HYDIN)

MLK:	131817517(HYDIN)

NVS:	122911263(HYDIN)

ORO:	101377354(HYDIN)

EJU:	114198918(HYDIN)

ZCA:	113935700(HYDIN)

MLX:	118023593(HYDIN)

LWW:

102749204

FCA:	101093658(HYDIN)

PYU:

121009765

PBG:	122494437(HYDIN)

PVIV:

125153192(HYDIN)

LRUF:

124511860

LGF:	123579422(HYDIN)

AJU:

106984357

PTG:	102968801(HYDIN)

PPAD:

109270655(HYDIN)

PUC:	125916950 125917342

PLEZ:

122207588(HYDIN)

HHV:	120225334(HYDIN)

BTA:	504406(HYDIN)

BOM:	102271818(HYDIN)

BIU:	109572882(HYDIN)

BBUB:

102414575(HYDIN)

BBIS:

104996621(HYDIN)

CHX:	102186513(HYDIN)

OAS:	101115477(HYDIN)

BTAX:

128063921(HYDIN)

CSUM:

138096769

ODA:	120873000(HYDIN)

CCAD:

122420565(HYDIN)

MREE:

136157473

OVR:	110149275(HYDIN)

MBEZ:

129546924(HYDIN)

SSC:	100513208(HYDIN)

CFR:	102512023(HYDIN)

CBAI:

105073573(HYDIN)

CDK:

105104275

VPC:	102540118(HYDIN)

BACU:

103017441(HYDIN)

BMUS:

118885524(HYDIN)

LVE:	103086195(HYDIN)

OOR:	101278244(HYDIN)

LALB:

132509220(HYDIN)

GMF:	115856839(HYDIN)

DDP:	132416868(HYDIN)

DLE:	111179543(HYDIN)

PCAD:

102985291

PSIU:

116743994(HYDIN)

NASI:

112393370(HYDIN)

ECB:	102150351(HYDIN)

EPZ:	103552415(HYDIN)

EAI:	106823432(HYDIN)

MYB:	102243406 102254555(HYDIN)

MYD:	102772638(HYDIN)

MMYO:

118674761(HYDIN)

MLF:	102420237(HYDIN)

MDT:	132216273(HYDIN)

MYUM:

138996707(HYDIN)

PKL:	118720775(HYDIN)

EFUS:

103284845(HYDIN)

MNA:	107524405(HYDIN)

DRO:	112300600(HYDIN)

SHON:

118999239(HYDIN)

AJM:	119055881(HYDIN)

PDIC:

114488389(HYDIN)

PHAS:

123806117(HYDIN)

MMF:	118638438(HYDIN)

PPAM:

129075212(HYDIN)

HAI:	109388732(HYDIN)

RFQ:	117035044(HYDIN)

PALE:

102894227(HYDIN)

PGIG:

120593961(HYDIN)

PVP:	105305860(HYDIN)

RAY:	107520518(HYDIN)

MJV:	108397082(HYDIN)

TOD:	119249044(HYDIN)

SFUM:

130044343(HYDIN)

SETR:

126027328(HYDIN)

LAV:	100671686(HYDIN)

TMU:

101350350

ETF:	101654290(HYDIN)

DNM:

101426676

MDO:	100024722 103102138(HYDIN)

GAS:	123233210(HYDIN)

SHR:	100914259(HYDIN)

PCW:	110192464(HYDIN)

TVP:	118842689(HYDIN)

PBRV:

138160765(HYDIN)

MLAO:

141496608(HYDIN)

OAA:	100075365(HYDIN)

TACU:

119934227(HYDIN)

GGA:	427538(HYDIN)

PCOC:

116243993(HYDIN)

MGP:	100547126(HYDIN)

CJO:	107319192(HYDIN)

TPAI:

128081807(HYDIN)

LMUT:

125699199(HYDIN)

NMEL:

110404399(HYDIN)

APLA:

101798776(HYDIN)

ACYG:

106033173(HYDIN)

CATA:

118246580(HYDIN)

AFUL:

116493960(HYDIN)

TGU:	100218634 100230051 105760079 105760502 115490885 115491697 115496814 116807028 116807034 116807036

LSR:	110479561 110482787 110483528

SCAN:

103821197(HYDIN)

PMOA:

120497211 120497215

OTC:	121338535 121347744

PRUF:

121358501

ATRC:

139596578 139604446 139604470

GFR:	102043817(HYDIN)

FAB:	101805799 101805801 101814042

OMA:

130258038

PHI:	102107443(HYDIN)

CCAE:

111934786 111934787 111942295 111943177 111943647

CCW:

104687538

CBRC:

103620336

ACOE:

138112188 138112757 138112759 138117197

ETL:	114062280 114069555 114070219

ZLE:	135452647 135452980

HRT:

120757950

CCIC:

134048140 134048146 134048147 134048150 134048152 134048153 134048155 134048156 134048157 134048158 134048161 134048162 134048163 134048164 134048165 134048166 134048167 134048169

FPG:	101911161 101913348(HYDIN)

FCH:	102047281 102049977

NNT:	104403692(HYDIN)

SHAB:

115604907

ACUN:

113480132 113484557(HYDIN) 113484652 113490565 113490582 113490592

TALA:

104363547(HYDIN)

ACHC:

115346324(HYDIN)

HALD:

104313092

HLE:

104842692

AGEN:

126040311

HHAR:

128146128(HYDIN)

GCL:

127020990

PPUS:

135184255(HYDIN) 135186408 135186411

BRHI:

104500761

EGZ:

104130293

NNI:	104017493(HYDIN)

PCRI:

104031707

PCAO:

104050026(HYDIN)

PADL:

103922274(HYDIN)

AFOR:

103908466

FGA:

104075549

CBOR:

142087130(HYDIN)

CBOY:

140656477(HYDIN)

MAME:

142414136(HYDIN)

CLV:	102084901(HYDIN)

CNIC:

135991826(HYDIN)

PLET:

104621648(HYDIN)

CMAC:

104481601

CUCA:

104063205 104068383 128850760

BREG:

104636550

CPEA:

104389053(HYDIN)

CVF:	104284887(HYDIN)

RTD:	128908579(HYDIN)

CRID:

134515307(HYDIN)

LMIC:

141742020(HYDIN)

AAM:	106489386(HYDIN)

AROW:

112975162

NPD:	112943205(HYDIN)

TGT:	104578227(HYDIN)

DNE:	112987472(HYDIN)

SCAM:

104147275(HYDIN)

ASN:	102388673(HYDIN)

AMJ:	102565501(HYDIN)

CPOO:

109310446(HYDIN)

GGN:	109289675(HYDIN)

PSS:

102463468

CIZ:	142020526(HYDIN)

CMY:	102942855(HYDIN)

CCAY:

125620741(HYDIN)

DCC:	119841410(HYDIN)

CPIC:

101935042

TST:	117886764(HYDIN)

CABI:

116833711(HYDIN)

MRV:	120384424(HYDIN)

ACS:	100559292(hydin)

ASAO:

132783133(HYDIN)

PVT:	110081287(HYDIN)

SUND:

121920312

PBI:	103061703 103061778 103062831

PMUR:

107284162(HYDIN)

CTIG:

120312608(HYDIN)

TSR:	106548718 106555971

PGUT:

117670480(HYDIN)

PCAE:

139323404(HYDIN)

PTEX:

113445295(HYDIN)

NSS:	113422995(HYDIN)

VKO:	123025342(HYDIN)

PMUA:

114601859(HYDIN)

PRAF:

128419079(HYDIN)

ZVI:	118086773(HYDIN)

HCG:	128334407(HYDIN)

GJA:	107114842 107124600

STOW:

125443320(HYDIN)

EMC:	129344273(HYDIN)

XLA:	108715467(hydin.S)

XTR:	100145658(hydin)

NPR:

108803285

RTEM:

120917774(HYDIN)

ACAT:

141112659(HYDIN)

BBUF:

120980745(HYDIN)

BGAR:

122920895(HYDIN)

PWL:	138268098(HYDIN)

MUO:	115471301(HYDIN)

GSH:	117359874(HYDIN)

DRE:	557988(hydin)

SRX:	107738674(hydin)

SANH:

107694921(hydin)

SGH:	107596987(hydin)

CCAR:

109090251(hydin)

CAUA:

113073593 113118408

CGIB:

127977818

PTET:

122362538(hydin)

LROH:

127181090(hydin)

GRF:	141345758(hydin)

OMC:	131524331(hydin)

PPRM:

120487805(hydin)

RKG:	130088288(hydin)

MAMB:

125254200(hydin)

CIDE:

127500172

CERY:

137022927(hydin)

MASI:

127417085

TROS:

130563252(hydin)

TDW:	130435568(hydin)

MANU:

129419374(hydin)

PDAB:

135769419(hydin)

IPU:

124626069

IFU:	128606753 128606758

PHYP:

113534528(hydin)

SMEO:

124396136(hydin)

TFD:	113652377 113652474

TVC:	132851104 132851105

CGAR:

128527483

NGRA:

132888030(hydin) 132888301

TRN:	134322782(hydin)

AMEX:

103041600(hydin)

CMAO:

118818556(hydin)

EEE:	113573594 113573623

CHAR:

105904476(hydin)

SPIL:

134094418(hydin)

ASAD:

121723217(hydin)

TRU:	101065100 101067071

TFS:	130536381(hydin)

TNG:	GSTEN00026625G001

LCO:	104929137(hydin)

NCC:

104951381

TBEN:

117491543(hydin)

CGOB:

115009322(hydin)

PGEO:

117448452(hydin)

GACU:

117539678(hydin)

EMAC:

134880293(hydin)

ELY:	117261679(hydin)

EFO:	125887268(hydin)

PLEP:

121954904(hydin)

SLUC:

116057480(hydin)

ECRA:

117948490(hydin)

ESP:	116693535(hydin)

PFLV:

114559652(hydin)

PPUG:

119209213(hydin)

AFB:	129107931(hydin)

CLUM:

117732057(hydin)

PSWI:

130195691(hydin)

CANA:

137803622(hydin)

CVE:	137888531(hydin)

MSAM:

119894044(hydin)

CUD:	121514826(hydin)

SPUL:

138613383(hydin)

LMIX:

132973506(hydin)

HTC:	141796482(hydin)

ALAT:

119024384(hydin)

ASTR:

137593390

MZE:	106674582(hydin)

ONL:

100692506

OAU:	116331609(hydin)

OLA:	101165480(hydin)

OML:	112152869(hydin)

CSAI:

133444915(hydin)

XMA:	102219463(hydin)

XCO:	114150975(hydin)

XHE:	116734684(hydin)

PRET:

103466222(hydin)

PFOR:

103145508

PLAI:

106937647

PMEI:

106926058

GAF:	122834990(hydin)

PPRL:

129361325(hydin)

CVG:	107103075(hydin)

CTUL:

119791614(hydin)

GMU:	124857744(hydin)

NFU:	107374178 107383621

KMR:	108246893(hydin)

ALIM:

106520170(hydin)

NWH:	119415977(hydin)

AOCE:

111570817(hydin)

EJA:	138212389(hydin)

BFRE:

138636688(hydin)

MCEP:

125014612(hydin)

CSEM:

103379508(hydin)

POV:	109641872(hydin)

SSEN:

122775674(hydin)

SSOE:

131470332(hydin)

HHIP:

117763243(hydin)

HSP:	118109497(hydin)

PPLT:

128444069(hydin)

SMAU:

118315136(hydin)

LCF:

108901846

SDU:	111225159(hydin)

SLAL:

111655734(hydin)

XGL:	120792838(hydin)

HCQ:	109523815 109530321

SSCV:

125971313(hydin)

SBIA:

133501937(hydin)

PEE:	133403021(hydin)

PTAO:

133478183(hydin)

BPEC:

110169501(hydin)

ENY:	140348483(hydin) 140348484

MALB:

109952930 109952933

BSPL:

114857093(hydin)

SJO:	128359485(hydin)

SSCO:

133982526(hydin)

TTY:	137182541(hydin)

GMH:	115550799(hydin)

SASA:

106573752(hydin)

STRU:

115151966(hydin)

OTW:	112252367(hydin)

OMY:	110520526(hydin)

OGO:	124000692(hydin)

ONE:	115109392(hydin)

OKI:	109889338(hydin)

OKE:	118401254(hydin)

OMM:	135524416(hydin)

OCLA:

139401276

SALP:

111952737 111952738 111953014

SNH:	120053218(hydin)

SFON:

129867083(hydin)

CCLU:

121577462 123491989

ELS:	105023480 106024788

OEP:	134020620(hydin)

SFM:	108918964 108923397 108926217

PKI:	111851834 111851835

AANG:

118228196(hydin)

AROT:

135256185(hydin)

CCOG:

133131557(hydin)

LOC:	102682674(hydin)

PSPA:

121325837 121325838(hydin)

ARUT:

117424076 117425956

PSEX:

120534857(hydin) 120534858

LCM:	102362270(HYDIN)

RTP:	109911317(hydin)

CPLA:

122558600(hydin)

HOC:	132823601(hydin)

SCAU:

119971522(hydin)

LERI:

129705249(hydin)

HAKA:

140740438

PMRN:

116944173(HYDIN)

LRJ:	133350890(HYDIN)

BFO:

BBEL:

CIN:

SCLV:

SPU:	576233 580280

LVG:	121407280 121407342

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG15824(CG15824)

DER:

6541119

DSE:

6617315

DSI:	Dsimw501_GD28300(Dsim_GD28300)

DYA:	Dyak_GE15843

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI18006

DAZ:

DNV:

DHE:

BDR:

AOQ:

ALUD:

TDA:

MDE:

LCQ:

CVJ:

GFS:

AME:	100578512 113219012

ACER:

ALAB:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:	114875362 114875364

OLG:

NMEA:

CGIG:

SOC:

AEC:

ACEP:

CCOA:

TCZ:

TSEP:

PBAR:

VEM:	105568708 105568711

TLN:

139820663

HST:	105182009 105182012

DQU:	106745993 106745994

CFO:

FEX:

LHU:

OBO:

PCF:	106789577 106789579

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

DAM:

VCAN:

CCIN:

DPA:

SOY:

AGB:

APLN:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_211175

BANY:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

ZCE:

CCRC:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

LGLY:

CSTB:

CFUM:

CLEC:

HHAL:

NLU:	111051311 111051318

PHU:	Phum_PHUM363890

PAME:

138709986

BROR:

134537853

LGI:	LOTGIDRAFT_122343

PVUL:

PCAN:

LSAX:

BGT:

GAE:	121388299 121388868

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

YBA:

MCAF:

MMER:

RPHI:

MAEA:

OBI:

LJP:

LAK:

SMM:	Smp_175450

OVI:	T265_10961

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_30117

AQU:	100633719 100638274

SMO:	SELMODRAFT_425615 SELMODRAFT_450466(HY3)

CRE:	CHLRE_01g025400v5

VCN:	VOLCADRAFT_67248

MNG:

MNEG_2452

MIS:	MICPUN_63074(HYDIN)

MPP:	MICPUCDRAFT_48266

MBR:	MONBRDRAFT_18473

SRE:	PTSG_09699

PFA:	PF3D7_1444100

PREI:

PRSY57_1443400

PLAG:

39744378(PADL01_1444100)

PYO:	PY17X_1311800

PCB:	PCHAS_1311200

PBE:	PBANKA_1308000

PVV:	PVVCY_1300970

PKN:	PKNH_1238200

PVX:	PVX_118290

PCY:	PCYB_127100

TGO:	TGME49_206550

TET:	TTHERM_00551040

PTM:	GSPATT00029426001 GSPATT00035604001 GSPATT00035607001

AAF:	AURANDRAFT_62593

PIF:	PITG_19203 PITG_21017

PSOJ:

PHYSODRAFT_470288

SPAR:

SPRG_10008

TBR:	Tb927.6.3150

TBG:	TbgDal_VI2940

TCR:	507023.220

LMA:	LMJF_30_1810

LIF:	LINJ_30_1810

LDO:	LDBPK_301810

LMI:	LMXM_29_1810

LMAT:

92513843(LSCM1_03798)

LBZ:	LBRM_17_0870

LPAN:

LPMP_301780

LOI:	92358070(LSCM4_02100)

LEIS:

94178241(GH5_02737)

LENR:

94170331(CUR178_03084)

LEIN:

94187143(JIQ42_03465)

PHET:

94289067(JKF63_02967)

NGR:	NAEGRDRAFT_78704

TVA:	4748323(TVAGG3_0892870) 4753136(TVAGG3_0618090) 4761292(TVAGG3_0936020) 4764456(TVAGG3_0004330) 4767143(TVAGG3_0944940) 4767853(TVAGG3_0588320) 4775696(TVAGG3_0681090) 5465402(TVAGG3_0712350) 5465431(TVAGG3_0711910) 5467674(TVAGG3_0262410)

GTT:	GUITHDRAFT_78541

» show all

Reference

PMID:23022101

Authors

Olbrich H, Schmidts M, Werner C, Onoufriadis A, Loges NT, Raidt J, Banki NF, Shoemark A, Burgoyne T, Al Turki S, Hurles ME, Kohler G, Schroeder J, Nurnberg G, Nurnberg P, Chung EM, Reinhardt R, Marthin JK, Nielsen KG, Mitchison HM, Omran H

Title

Recessive HYDIN mutations cause primary ciliary dyskinesia without randomization of left-right body asymmetry.

Journal

Am J Hum Genet 91:672-84 (2012)
DOI:10.1016/j.ajhg.2012.08.016

Sequence

[hsa:54768]

Reference

PMID:18250199

Authors

Lechtreck KF, Delmotte P, Robinson ML, Sanderson MJ, Witman GB

Title

Mutations in Hydin impair ciliary motility in mice.

Journal

J Cell Biol 180:633-43 (2008)
DOI:10.1083/jcb.200710162

Sequence

[mmu:244653]

LinkDB

DBGET integrated database retrieval system