KEGG   Homo sapiens (human): 54768
Entry
54768             CDS       T01001                                 
Symbol
HYDIN, CILD5, HYDIN1, HYDIN2, PPP1R31
Name
(RefSeq) HYDIN axonemal central pair apparatus protein
  KO
K17570  hydrocephalus-inducing protein
Organism
hsa  Homo sapiens (human)
Disease
H00564  Primary ciliary dyskinesia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    54768 (HYDIN)
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins [BR:hsa03037]
    54768 (HYDIN)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     54768 (HYDIN)
Cilium and associated proteins [BR:hsa03037]
 Motile cilia and associated proteins
  Sperm associated proteins
   54768 (HYDIN)
SSDB
Motif
Pfam: HYDIN_VesB_CFA65-like_Ig Ig_CFAP65_4th Hydin_ADK ASH Cep192_D3 Cep192_D4 Ig-CFAP74_4th Ig_CFAP65 OCRL-like_ASH PapD-like Ig_CFAP65__9th Motile_Sperm Cep192_D6 Cep192_D7 DUF1573 Cep192_D8 Ig_Dlec1_1 Ig_CFAP74_1st TMEM131_like_N MOV-10_Ig-like Big_2 Ig-CFAP74_2
Other DBs
NCBI-GeneID: 54768
NCBI-ProteinID: NP_001257903
OMIM: 610812
HGNC: 19368
Ensembl: ENSG00000157423
UniProt: Q4G0P3
Structure
LinkDB
Position
16:complement(70802084..71230722)
AA seq 5121 aa
MTSRRLEESMGAVQMGLVNMFKGFQSKVLPPLSPKVVTEEEVNRMLTPSEFLKEMSLTTE
QRLAKTRLMCRPQIIELLDMGETTHQKFSGIDLDQALFQPFPSEIIFQNYTPCEVYEVPL
ILRNNDKIPRLVKVVEESSPYFKVISPKDIGHKVAPGVPSIFRILFTPEENKDYAHTLTC
VTEREKFIVPIKARGARAILDFPDKLNFSTCPVKYSTQKILLVRNIGNKNAVFHIKTCRP
FSIEPAIGTLNVGESMQLEVEFEPQSVGDHSGRLIVCYDTGEKVFVSLYGAAIDMNIRLD
KNSLTIEKTYISLANQRTITIHNRSNIIAHFLWKVFATQQEEDREKYRACDDLIKEEKDE
TDEFFEECITDPLLREHLSVLSRTFANQRRLVQGDSKLFFNNVFTVEPLEGDVWPNSSAE
ITVYFNPLEAKLYQQTIYCDILGREIRLPLRIKGEGMGPKIHFNFELLDIGKVFTGSAHC
YEAILYNKGSIDALFNMTPPTSALGACFVFSPKEGIIEPSGVQAIQISFSSTILGNFEEE
FLVNVNGSPEPVKLTIRGCVIGPTFHFNVPALHFGDVSFGFPHTLICSLNNTSLIPMTYK
LRIPGDGLGHKSISYCEQHVDYKRPSWTKEEISSMKPKEFTISPDCGTIRPQGFAAIRVT
LCSNTVQKYELALVVDVEGIGEEVLALLITARCVVPALHLVNTEVDFGHCFLKYPYEKTL
QLANQDDLPGFYEVQPQVCEEVPTVLFSSPTPSGVISPSSTIHIPLVLETQVTGEHRSTV
YISIFGSQDPPLVCHLKSAGEGPVIYVHPNQVDFGNIYVLKDSSRILNLCNQSFIPAFFQ
AHMAHKKSLWTIEPNEGMVPPETDVQLALTANLNDTLTFKDCVILDIENSSTYRIPVQAS
GTGSTIVSDKPFAPELNLGAHFSLDTHYYHFKLINKGRRIQQLFWMNDSFRPQAKLSKKG
RVKKGHAHVQPQPSGSQEPRDPQSPVFHLHPASMELYPGQAIDVILEGYSATPRIVKEKL
VCHAIIGAQKGKSLVMAVNITCEFVAPLIQLSTKQLIYRLEKKPNSILKPDYQPLAIKNI
STLPVNLLLSTSGPFFICETDKSLLPATPEPIKLEIDEEKNLLIKFDPSYRNDLNNWVAE
EILAIKYVEHPQIDSLDLRGEVHYPNLSFETKELDFGCILNDTELIRYVTITNCSPLVVK
FRWFFLVNDEENQIRFVTLPKKPYSAPVSQMESIPATSEAASPPAILVTVESPEMDLNDF
VKTVLVDEDARPEEKELRKTKASSVISDEIKISSTEIERIYSSQSQVEDQESLQTCEQNE
MLSIGIEEVFDILPLFGVLQPHSSHQISFTFYGHANIIAQAKALCEVEEGPTYEITLKGE
ASLVNYSFDTKDIHYGLQLFDHVTEREITLTNMGKVGFEFKVLTDHQSSPDNLLPGVPLI
LPVSGFISSHQEQVLKVYYLPGVPEVFKRSFQIQIAHLDPENITLSGEGIFPQICLDLPR
NLTANEKYEMFLNQARKNTDKEYNKCEMLDHFDIITEEVPEDEPAEVSAHLQMEVERLIV
QSYVLEHQKTTTPDPMDDPCFSHRSRRKLAKIQLPEYILDFGYIILGEVRTHIIKIINTS
HFPVSFHADKRVLHETGFSTELDRVKNLPHCETEIFEVRFDPQGANLPVGSKEVILPIKV
VGGPTVHICLQAKVTIPTMTLSRGKVDFATIQCGQCLVETIQLSNHLQVPCEWFVQSQKP
VDKLEKHMPKYLRQKLRAELKPKTRIFEIQPISGVLDPGEKSNVQVKFMPKEEKFYSQTL
VFQIAQSAQKLTLLARGQGLEPRLEFSPSVLDLGPLLLCAPGDEAEVIVKNPCNFPIEFY
SLEFDQQYLIEEKILRKLKGYDSYNTLLLPPRNPGEKLPPELYEYFKEIKKSKEEQMRAK
YLENLAQENEEEDITSSDQGTSNSTKRTSLSRGISVTSNLEEWHALLVESKTYLEEEEDE
ESLEKIIFQTDKLQSIDSHSMEEVGEVENNPVSKAIARHLGIDISAEGRLAKNRKGIAII
IHGTPLSGKSANAVSVAKYYNAACLSIDSIVLEAVANSNNIPGIRARELCIRAAIEQSVK
EGEEAAQEAAVGQNVIGQGRLSTDTLGKLASEMTLVAPEIKPGKSVRGSVVITKSKADSH
GSGSQKQHHSHQSETPQISSSPLPPGPIHRWLSVSPSVGGETGLMSCVLPDELLVQILAE
RIQLSDCYRGVVFDGLDTLFAQNAAAALLCLLKAIGSREHIYILNMAQDYAAMKAQEKAK
KEQEERKHKGALEKEKERLQNMDEEEYDALTEEEKLTFDRGIQQALRERKKREQERLAKE
MQEKKLQQELERQKEEDELKRRVKKGKQGPIKEEPPMKKSQAANKQVPPLTKVDVKMETI
ERKISVREQTMSEKEELNKKKRNMGDVSMHGLPLVQDQEDSEGDNSKDPDKQLAPKFKTY
ELTLKDVQNILMYWDRKQGVQLPPAGMEEAPHEPDDQRQVPLGGRRGRKDRERERLEKER
TEKERLEREKAERERLEKLRALEERSDWEGEGEEDHEGKKEKDLGVPFLDIQTPDFEGLS
WKQALESDKLPKGEQILDILGLGASGPPIPPPALFSIVSYPVKRPPLTMTDDLEHFVFVI
PPSEDISLDEKKEMEIESDFLATTNTTKAQEEQTSSSKGGKQKMKEKIDQVFEIQKDKRH
MALNRKVLSGEPAGTISQLSDTDLDNFNGQHSQEKFTRLNHFRWIVPANGEVTLQVHFSS
DEFGNFDQTFNFEILGTCCQYQLYCRGICTYPYICQDPKVVFPQRKMDMKTNEVIFKKYV
MSTETYYFGPLLCGKSRDKYKSSLFPGNMETLTILNTSLMVVEASFYFQNDVKANTYFLE
PNTMVLKPNEKQILNVWAYPTSVGVFEDSIVCCINDNPEPAIFQLSCQGIRPELELEPRQ
LHFDRLLLHRQESRVVLLRNVTLLPVAWRITSLEHLGDDFTVSLMQGTIPPEAEYGLHLY
FQPTKPVNIKKAIRLEVLDAENLLGVVQIENIMVFAEAYDIALDITFPKGAEGGLDFGIV
RVTEEAKQPLQLKNRGKYEIAFSFSVDSVGISTPNINSMISVQPKKGSLTPTEKPTNVQV
FFHAKKEVKIEHQPVLRCQIIEPNISEGGEIIASIPIKFSANAVYSKYNITPSSVINFGA
LICGTRKSTTFTIENQGVTDFKFALYKLTGESPIHQKKAASHVRHARSRESESFYKTGSS
RAAKFSDTIQKEVTTTGQARFAHGMFTVYPGFGSIPSGGQQVINVDCVADAMGKCEEFIA
IDISGRDPAVHPAGILYTLLAEACLPAFVTENNALIFEEHQICTSANLHHILQTIESGGL
FVEDENKFIFCNVLVGRQAKARFKISNVGKITCDVNIVVRPISNKPFARIVDIFEVEPSK
MCIASHSHAFATVSFTPQIMQNYQCIFEATLDGLPSTLAKSRGLVFDIAGEGNLPRVTVV
RPVLHNQYGNPLLLFKRLLLGHSEKLPLILKNNGVLPAQLHVDLQDELGVFSLKGRPTTA
YIYITEENKPHVKAKKAHTASLVVSPGDTAEFDVVFHSQKVGRMRGIIHLSVINNQYEET
SIHMVGEGYEDDITLDNIHGLVAPTSQEDISISEFTEIIEDNDMEDLVAAALVDHIQFGD
CHIGHSYNASFTVTNHSQVNLIRFEWPVSATIAFSPQMGHLHPGCAKDIVVTMKSDVPIN
LKNMRIRCKLSRIMFQLPADQVPDWDDRMHTVKWVDVPRNMPGTFTTKRKVIETDPEPAH
SVLEENYQELQLQISANVDFASYHCQARDVRFKETLVYQTRVFEFDVINSGRVQLEFSWV
SEDTSKAVSFAKPDHQGSAQKDQLSQGTMHTGSTLDSTMDHWAEGSPQPFSVEPSSGIVP
VGKIQKFKVKFSPLDIGDFESNLFCQIPNLPPGEQGPVLVAKGRSTLPICHFDLKDSDYI
SGHQRNPELRGSSGGALDPNTRVIEFTTVGIGGKNLRTFTILNPTNSTYSFCWISEEIES
LQNPAAFTCLTEKGFIHPEKKAEIVFQFTPFHLGITESSWTFLIPEHNITVPFLLVGKTT
EPLISLNKSHLNFSSLLIGREARETVQIINKEEQGFDFSFQDNSRYSEGFSNSLLVCPME
GWIPPLSRFPIDIFFTPKQEGDVNFNLICNVEKKVHPVTLNVKAEGYTMNVEIKCKDRTG
SITLLTPNQTNIINFYEVELNECVQCEFNFINTGKFTFSFQAQLCGSKTLLQYLEFSPID
STVDVGQSVHATLSFQPLKKCVLTDLELIIKISHGPTFMCNISGCAVSPAIHFSFTSYNF
GTCFIYQAGMPPYKQTLVITNKEETPMSIDCLYTNTTHLEVNSRVDVVKPGNTLEIPITF
YPRESINYQELIPFEINGLSQQTVEIKGKGTKMKILVLDPANRIVKLGAVLPGQVVKRTV
SIMNNSLAQLTFNQSILFTIPELQEPKVLTLAPFHNITLKPKEVCKLEVIFAPKKRVPPF
SEEVFMECMGLLRPLFLLSGCCQALEISLDQEHIPFGPVVYQTQATRRILMMNTGDVGAR
FKWDIKKFEPHFSISPEEGYITSGMEVSFEVTYHPTEVGKESLCKNILCYIQGGSPLSLT
LSGVCVGPPAVKEVVNFTCQVRSKHTQTILLSNRTNQTWNLHPIFEGEHWEGPEFITLEA
HQQNKPYEITYRPRTMNLENRKHQGTLFFPLPDGTGWLYALHGTSELPKAVANIYREVPC
KTPYTELLPITNWLNKPQRFRVIVEILKPEKPDLSITMKGLDYIDVLSGSKKDYKLNFFS
HKEGTYAAKVIFRNEVTNEFLYYNVSFRVIPSGIIKTIEMVTPVRQVASASIKLENPLPY
SVTFSTECRMPDIALPSQFVVPANSEGTFSFEFQPLKAGETFGRLTLHNTDLGYYQYELY
LKATPALPEKPVHFQTVLGSSQIILVKFINYTRQRTEYYCRTDCTDFHAEKLINAAPGGQ
GGTEASVEVLFEPSHLGETKGILILSSLAGGEYIIPLFGMALPPKPQGPFSIRAGYSIII
PFKNVFYHMVTFSIIVDNPAFTIRAGESVRPKKINNITVSFEGNPSGSKTPITTKLTVSC
PPGEGSETGVKWVYYLKGITL
NT seq 15366 nt   +upstreamnt  +downstreamnt
atgacaagtagaagacttgaggagtccatgggggctgttcagatgggattggtcaatatg
ttcaaaggatttcaaagcaaggttttgccacccctgagtccaaaggtggttacagaagaa
gaagtaaaccgaatgcttacaccctcagagttcctgaaggaaatgtccctgaccaccgag
cagagactggcaaaaacacgtttgatgtgccgaccacagatcatcgaactcttagatatg
ggggaaacaacacatcagaagttttcaggaattgacctggatcaggcattattccagccc
tttccatcagaaattatatttcagaactacactccctgtgaagtctatgaagttccactg
attttgaggaacaatgacaaaattccaaggttggtgaaagttgtggaagaaagttcgcct
tactttaaagtaatcagccccaaagatattggccacaaagtggctcctggagtgccttcc
atattccgaatcctctttactccagaggagaacaaggattacgcccatacgttgacctgt
gttactgaaagagaaaagtttattgtacccatcaaagctagaggggcacgagccattctc
gattttcctgacaagctgaatttttccacttgtcctgtcaaatacagcacccagaagatt
ctgctggtacgaaacattggcaacaaaaatgctgtatttcacatcaaaacttgtaggcct
ttctctatagaaccagctattggaactcttaatgtgggagagtccatgcaactggaagtg
gagtttgagccacagagtgtgggcgatcacagtggaagacttatcgtgtgttatgacaca
ggtgaaaaggtgtttgtatctctctatggagctgccatagacatgaatataaggctggat
aagaattccttgaccatcgagaaaacctacatatctctggccaatcagcgaactataacc
attcacaatcgcagtaatatcattgcccatttcctgtggaaggtatttgctacccagcaa
gaagaggacagagaaaaatatagggcctgtgatgatctgatcaaagaggagaaggatgag
actgatgagttttttgaagagtgcattactgatcctttactccgagaacatctttctgtt
ctgtcccgaacctttgcgaatcagaggaggctggtgcagggagacagcaagctgttcttc
aataacgttttcactgtggagcccctggaaggtgatgtctggcccaactcatcagctgaa
atcaccgtgtactttaacccactagaagccaagctctatcaacagaccatttactgcgac
attttaggccgagaaatccgtctgcccctccgaatcaaaggggaaggcatgggacctaag
attcacttcaactttgaattgctggatattgggaaagttttcactggatctgcacattgt
tatgaggcgatactgtacaacaaaggcagcatcgatgctctcttcaacatgacccctcca
acttcagctttgggggcctgctttgttttcagtcccaaggaaggcatcattgaaccaagt
ggagtccaagctatccagatctccttcagctctaccatcctgggaaactttgaagaagag
ttcctggtcaatgtcaatgggtcacctgagcctgtgaaactgaccattagaggctgtgtc
attggacctaccttccattttaatgttccagctctgcactttggtgatgtttcctttggg
tttcctcataccttgatatgttccctcaataatacctctttgatccccatgacttacaaa
ctgcgtatccctggggatggccttggccataaaagcatttcatattgtgagcagcatgtg
gactacaaaagaccatcttggaccaaggaagaaatatcctcaatgaaaccaaaagaattc
accatctctcctgactgtggcaccattcgcccccagggatttgctgctatcagggtgaca
ttatgctccaacactgtgcagaaatacgagctggcactcgtggtggacgtggagggcatc
ggagaagaggtgctggcgctcttaattacagcaaggtgtgttgtacctgccctccacctg
gtcaatacagaggtggactttgggcactgcttcctgaagtacccgtatgagaaaacactc
cagcttgccaatcaagatgacctcccaggattctatgaggtccagcctcaggtgtgtgag
gaggtgcctactgtgctgttttccagccccacccccagcggggtcatctccccaagcagc
accatccacataccactggtcctggagacccaggtcactggagaacacagatccacggtt
tacatctcaatctttgggagccaggacccccctttggtatgtcacttaaagagcgctgga
gaaggcccagttatctacgtccatcccaatcaagtggacttcgggaatatctacgtccta
aaagactcttccaggattctcaacctatgcaaccagtccttcattcccgcatttttccag
gcacacatggcacacaaaaaatccctttggacgattgaacccaatgaaggcatggttcct
ccagaaactgatgttcaactggcactgaccgccaacctgaatgacacactgacattcaag
gactgtgttattttggacattgaaaatagcagtacctatcggattcctgttcaggcttcc
ggaactggttccactattgtttcagataagccctttgctccagaactcaatttgggggca
cattttagcctggatacccactattaccactttaagttgatcaacaagggacgtcggatc
caacagttgttctggatgaatgatagcttccgaccccaggccaagctgagtaagaagggc
cgggttaagaagggacatgctcatgtccaaccccagcccagtggctctcaggagcccagg
gatccacagagccccgtgtttcatctccaccccgccagcatggagctgtacccaggccag
gcaattgatgtgatactcgaaggctattctgctactcccaggatagtgaaagagaagctg
gtgtgccacgccatcatcggggcacagaaggggaagagcttggtgatggctgtgaacatc
acctgtgagttcgtcgcacctctcatccagctctccaccaagcagctcatctaccgactg
gagaagaaacctaacagtatcctgaaacctgattaccagcccttggccataaagaacatt
tccaccctgcccgtgaacttgttgctgtcaacatctggacccttctttatatgtgagact
gataaatccctgctgccggcaactcctgagcctattaaactggaaattgatgaagaaaaa
aacctgctgatcaagtttgacccttcctacagaaacgatctgaacaactgggtggcagaa
gaaattctagcaattaagtatgtggaacaccctcagatagacagcctggacctgcgcgga
gaagtgcattaccccaacctcagctttgagacaaaggagctggattttggctgcatcctg
aacgatactgagctcattcgctacgttaccatcaccaactgcagtccgttggttgtgaag
tttcgctggttcttcttggtgaatgatgaggaaaatcagataaggtttgtgacattgccg
aagaagccctacagtgccccagtgtcccagatggagtccatcccagcaacctcagaggct
gccagcccaccagcaatcctagttacagtagagtcccccgagatggatttaaatgatttt
gttaagactgtccttgtggatgaagatgccaggcctgaagaaaaagaactaagaaaaacg
aaagcttccagtgtgatctcagatgaaataaaaattagctctactgaaatagaaagaata
tactcaagccagagccaggtggaggatcaggaatccctacagacctgtgaacagaatgag
atgctttccattgggatagaagaagtgtttgatattttgcccctgtttggagtgttgcag
ccacacagtagccaccaaatatcgttcaccttctatggacacgctaacatcattgcacaa
gctaaagctctgtgtgaagtggaagaaggacccacctacgaaataacactgaagggagag
gcgtccctggtcaactattcctttgacaccaaggatattcactacggattacagctgttt
gaccatgtcacagagagggaaatcacgctgacgaacatggggaaagttggctttgagttc
aaggttctgactgaccaccagtcttctccagacaaccttctccctggagtgccactaatc
ctgcctgtgtctggctttatcagttcacatcaagagcaggtattaaaagtttactaccta
cctggagtacctgaggtctttaaaaggagtttccagatacagatcgcccacctggaccca
gaaaatatcactctgagcggagagggaatctttccccaaatctgcctcgatctccccagg
aacctcacagcaaatgaaaagtatgaaatgttcttgaatcaagccaggaaaaacacagac
aaagagtataacaaatgtgaaatgctcgatcactttgacataataactgaggaagtgcca
gaagacgagcctgctgaggtaagtgctcatctccagatggaggtagaaagacttatagtc
caaagctatgtcctagaacatcagaaaacaaccacccctgatcctatggatgacccctgc
ttcagccatcggagtcgccgcaaactggccaaaatccagctaccagagtacatcctggac
tttggctacatcatccttggcgaagtccgaacccacatcatcaagatcatcaacaccagt
cactttccagtgtcattccatgcagacaagcgtgtccttcatgagacaggattcagtact
gagctagatcgtgtaaagaatctacctcattgtgaaacggaaatatttgaagtgagattt
gacccacagggggccaatcttcctgttggaagcaaagaagtcattctgcccatcaaggtg
gttggagggccaacagttcacatctgtctccaagccaaggtgaccattccaaccatgact
ctctctcgtggaaaagtggactttgccacaattcagtgtggacagtgcctggtggaaact
attcagctttccaatcatctccaagtcccttgtgaatggttcgtccagagccaaaagcct
gttgacaagctggagaaacacatgccgaagtacttaagacagaaactacgcgctgaatta
aagccaaagacacggatcttcgaaatccagcccatttctggagtcttggatcctggtgag
aagtccaacgtgcaagtgaaattcatgccaaaagaagagaaattctacagccaaaccctg
gtgtttcagattgcccagagtgctcaaaagcttaccctcctggcacgtgggcaaggtcta
gagccacgcctggaatttagtccttcagtcctggatctggggccactgctactttgtgca
cctggagacgaggccgaggtgatagtgaagaatccctgcaacttccccattgagttttat
tccttagaatttgatcagcagtatctcatagaagaaaagatcttgcggaagctgaagggc
tatgattcctacaacaccctgctgctgcctccccgcaaccctggggagaagctgccccca
gaactgtacgagtacttcaaagagataaagaagtcaaaagaggagcagatgagggcgaaa
tatctggagaatctggcacaggagaatgaagaggaagatataacctcatcagatcaggga
acctccaatagcacaaagaggacatcgctgagccgagggatctctgtcacatccaacctg
gaagaatggcacgccctgttggtcgagtccaaaacctacctagaggaagaggaggatgag
gaaagcctggaaaaaatcattttccaaactgacaagcttcagagcattgacagccactcc
atggaggaagttggagaggtggaaaacaacccagtgagcaaagcaatcgctcgccacctg
ggcattgacatttctgcagaaggccgcctggccaagaaccggaaaggcatcgccattatc
attcatgggacacccttgtcaggaaagtcagccaatgccgttagcgtggccaagtactac
aacgcagcctgcctgagcatcgactccattgtgctggaagctgtggccaacagcaacaac
atcccagggatccgggcccgtgagctctgcatcagggctgccatagagcagtccgtgaag
gaaggagaggaggctgcccaggaggcagctgtgggtcaaaacgtcatagggcaaggacga
ctgagcactgacaccttgggcaagttagcctccgagatgactctggtggccccagaaatt
aaacctggaaagagtgttcgtgggagcgtggtgatcaccaaaagcaaggcagacagccat
ggctccgggtcacagaagcagcatcactcacaccagtctgaaacaccacagatttcctcc
agccctctccccccggggcccatccaccgctggctcagtgttagtcccagtgtcggaggc
gagaccgggctgatgagctgtgtgctcccggatgaacttctcgtgcagatcctggcagag
cggatacagctgagtgactgctaccgaggagtggtgtttgatggcctcgacactctcttt
gctcagaatgctgcagccgccctcctctgcctgctgaaggccattggcagccgggagcat
atatacattctcaacatggcccaggattacgcagccatgaaggcccaggagaaagccaaa
aaggagcaagaagaacgcaagcacaagggagctcttgagaaagagaaggagcgtctccaa
aacatggatgaggaagaatatgatgccctgactgaggaggagaaactcacattcgatcgg
gggattcagcaggcgctccgcgagcggaagaagagggagcaggagaggctggcaaaggaa
atgcaagaaaagaagctacagcaggagctggagcgacaaaaggaagaggatgagctgaaa
cggagggtcaaaaaaggaaagcagggacccattaaggaggagccccccatgaagaaatct
caagcagcaaacaagcaggttcctccgctcaccaaagtggatgtcaagatggagacaatc
gaaaggaaaatatctgttagggaacaaacaatgtctgagaaggaagagctaaataagaag
aaaaggaacatgggcgatgtcagcatgcatgggcttcctcttgtccaggaccaagaggac
agtgaaggggacaactcaaaggaccccgacaagcaactggccccgaagtttaagacctat
gaattgacactgaaggatgtccagaacatcctcatgtactgggaccggaagcaaggagtc
cagctgcctcctgcagggatggaggaagcgccccatgagcccgacgaccagcgccaggtc
cccttgggtgggcgcaggggccgcaaggaccgggagagagagcgcctggagaaggagcgc
acggagaaggagcgcctggagagggagaaggcggagcgggagcgcctggagaagctgcga
gccctggaggagcggagcgactgggagggggaaggggaggaggaccacgaagggaagaag
gagaaggacctgggcgtacccttcctagacatccagacaccagactttgaaggcttgagc
tggaagcaggccctagagagcgacaagcttcccaaaggagagcagatcctagacatcttg
ggtctgggtgcctccggaccacccatcccgcctcccgccttattctcaatcgtctcctac
ccggtgaagcggccacctttgaccatgacagacgacctggagcattttgtatttgtgatc
ccaccatccgaagatatatctctggatgaaaaaaaagaaatggaaatagaatcagacttt
ttggccaccacaaacactacaaaggctcaagaggagcagaccagctcatctaaggggggc
aaacagaaaatgaaagaaaagatagaccaagtcttcgagattcagaaagacaagcgtcac
atggccttaaacaggaaggtcctttctggggaacctgctggaaccatttcccagctgtca
gatacagacctggacaacttcaacgggcagcactcccaggagaaattcaccagactgaat
cacttccggtggatcgtgccagccaatggcgaggtaacgttgcaggtgcacttctcttct
gatgagttcgggaactttgaccaaacctttaactttgagatcctaggaacttgctgccag
taccagctctactgccgaggcatctgcacttacccatacatttgccaagacccaaaagtg
gtatttcctcagcggaagatggacatgaagacaaatgaggtcatctttaagaagtatgtt
atgagcacggagacgtactactttgggccactactttgtggaaaatcaagagataagtac
aagtcatccttattcccaggcaacatggagacgctaacaatcctgaacacttccttaatg
gtggtggaggcatccttctattttcagaatgatgtcaaagcaaacacgtacttcctggaa
cccaacaccatggtcctgaaacccaatgagaagcagatattaaacgtatgggcctaccct
acttcagttggtgtctttgaagacagcattgtctgctgcatcaatgacaacccagagcca
gccatcttccaattaagctgccaggggatccgcccggaactagagctggaacccaggcaa
ttacattttgaccggctcttgctgcacagacaggaatccagggtagttcttctccgcaat
gtcacgctcctgcctgtggcctggcggatcaccagcctggagcacttgggtgatgatttc
actgtatccctgatgcaggggaccatcccccctgaggctgagtacggcctgcacctgtac
tttcagcccaccaagcctgtcaacatcaagaaggctattcggttggaggttttagatgca
gaaaatcttcttggtgttgttcagattgaaaatatcatggtctttgcagaggcatacgac
atcgccttggacatcaccttccccaaaggagctgaagggggactggattttgggattgtc
agggtcacagaggaggcgaagcagcccctgcaattgaagaaccgtgggaaatatgagatc
gcgttcagcttttccgtggactctgtagggatttcaacacctaatataaattccatgatc
tcagtccaacccaaaaagggttcactgaccccaacagaaaaacccacaaatgtccaagtt
ttcttccatgcaaaaaaggaagtgaagattgagcaccagcctgttctgcgctgtcagatt
attgagcccaatatttcagaaggaggtgagatcattgccagcatcccaattaagttttcc
gcgaatgcagtatattccaaatacaacatcaccccctcctctgtcatcaactttggagct
ttgatctgtggcactcgtaaaagcaccaccttcaccatagaaaatcaaggtgttactgac
ttcaagttcgccctttataagctgacaggggagagccccattcatcaaaagaaagcagcc
agccacgtcagacatgcaagatcccgagaaagtgagagcttctacaaaactggctcttcc
agagcagccaagttctctgacacgattcagaaagaagtaaccaccacaggccaggcccgc
ttcgcccatggcatgttcaccgtgtaccctgggtttggctccattccttccggaggacag
caggtcatcaacgttgactgtgtggctgacgccatgggaaagtgtgaggagtttatagcc
atcgatatctccggccgagaccctgcagtccaccctgccggcattctttacactttgcta
gctgaagcctgtctaccagccttcgtgaccgaaaacaatgccttgatatttgaagagcac
cagatatgtaccagtgccaacctgcaccacatcctgcagaccatagagagcggggggctg
ttcgtcgaggatgagaacaagttcatcttctgcaatgtcctggtgggccgccaagccaag
gctcgtttcaagatcagcaacgtgggaaagatcacctgtgatgtcaacattgtagtcagg
cctatctccaataagccctttgcccgcatcgtcgacatttttgaagtggaacccagcaag
atgtgcattgccagtcattcccatgcctttgccacggtgtccttcaccccgcagatcatg
cagaactaccagtgcatctttgaggctaccttggatggcttgcccagcaccctggccaag
agccgaggcctcgtgtttgacatcgctggtgaggggaacctccctcgagtgacggttgtg
cggccagttcttcataaccaatatggaaaccccttgctcctctttaagaggcttctcctt
ggtcattcagagaagctgcctctcatcctcaagaacaatggtgtcctccctgcccagctg
catgttgacctgcaggatgagctaggagtcttctccctgaaagggaggcccaccaccgcg
tatatctacatcacagaggaaaataaaccacatgtaaaagcaaagaaagctcacacagcc
tccttggttgtttctcctggagatacagctgaatttgatgtcgttttccactcccagaag
gttgggaggatgagaggtatcatccacttgtcagtgatcaacaaccaatatgaggagacc
tccatccacatggtgggagagggctatgaggatgacatcaccttggacaacatccatgga
ctggtggcccccaccagccaggaagacataagtatctctgagttcacagagatcatcgag
gacaatgatatggaagacttggtggcagctgctctggtggaccacatccaatttggggac
tgccacattggacacagctataatgcgagcttcacagtcacaaatcacagccaagtgaac
ttgatacggtttgaatggcctgtttcagctacaattgctttctccccacagatgggccac
ctccaccctgggtgtgccaaggacatagtggtgaccatgaagtcagatgtacccatcaac
ctaaagaatatgcggatcaggtgcaagctctccaggattatgtttcagctccctgcagac
caggtccccgactgggatgaccgcatgcacacagtcaagtgggtggacgtacccagaaac
atgcctgggactttcactacaaaacgaaaagtgatagagacggatccggaacctgctcac
tcagtactagaagaaaactaccaagaactgcagcttcaaatcagtgccaatgtggatttc
gcttcataccattgccaagcaagagatgtgcgctttaaggaaaccttggtttaccagacc
cgagtgtttgagttcgatgtgattaattcaggacgtgtccagctggaattcagctgggtc
tcagaagatacctcaaaggcagtcagctttgcaaaaccagatcaccaaggttcagctcaa
aaagatcagcttagtcagggcacgatgcatacaggcagcaccctggacagcaccatggac
cactgggccgagggttccccacagcccttctctgtggagccctcttcgggaatcgtgccg
gtggggaagattcagaagttcaaagtaaaattctccccgttggacattggagacttcgag
agcaaccttttctgccagattcccaacctgccacctggagagcaaggtccggtcctggta
gcaaaagggcggagcaccttgcccatctgccattttgatctgaaagactcggactacata
agtggccatcagcgcaacccagagctccgagggtccagtgggggagctctggatccaaac
acccgggtgattgagttcaccactgtgggcataggagggaagaatctccggacctttacc
atcctaaacccaaccaatagcacctactccttctgctggatctctgaagaaattgaaagt
ctccagaaccctgcagcattcacatgccttacagaaaagggcttcatccaccctgaaaag
aaagccgagatcgtgttccagttcacacctttccatctgggcatcactgagtcatcatgg
accttcctaattcccgagcacaacatcacagtccctttcctgctggtaggcaaaactacc
gaacctctcatctctctgaacaagtcacacctcaacttcagctctctcctcattggcaga
gaagccagggagactgtgcagatcattaacaaggaggagcaggggttcgatttttccttc
caggacaactcccgctattctgaaggtttcagcaacagcctgcttgtatgtcccatggaa
ggctggatcccaccactgtccaggttcccaattgatattttcttcacaccaaagcaggaa
ggagatgtgaactttaatttgatctgcaatgtggaaaagaaagtccaccctgtgacatta
aatgtcaaggccgagggctacactatgaatgtggagatcaagtgcaaggacaggacaggc
tccatcactctgttgactcccaaccagactaacatcatcaacttctatgaggtggagtta
aatgaatgtgtccagtgtgaattcaactttatcaacactggaaagttcaccttcagcttc
caggcacagctgtgtggctccaaaaccttgctgcagtacttggaattttcacccatcgac
agcactgtggatgtaggacagagtgtacatgccaccctgtcttttcaaccattaaagaag
tgtgtcttgacagacctggaactcataatcaagatcagccatggtccaacatttatgtgc
aacatctcaggctgtgctgtgagcccggctatccatttctccttcaccagctacaacttt
gggacctgctttatctatcaagctgggatgcccccatacaaacaaaccctggtaattacc
aacaaggaagaaacacctatgagcatagattgtctgtacaccaacaccactcacctcgag
gtgaactcccgtgttgatgtggtaaagccaggaaacacattggagattccaataactttt
tatcctcgagaaagtatcaactatcaagaactcattccctttgaaatcaatgggctctca
caacaaacagtcgaaatcaaagggaagggtaccaaaatgaagattttagtcctagatcca
gccaacaggattgtgaagttgggagctgtcctaccagggcaggttgtgaaaagaacagtt
tccatcatgaacaacagcctggcccagctcacatttaatcagtccattctgttcacaatt
ccagaactccaggaacccaaggtccttaccctggcgcccttccacaacatcacactgaag
cccaaagaagtctgtaaactggaagtcatctttgccccgaagaagcgtgtccctcccttc
tctgaggaagtgttcatggaatgcatggggctcctgcgccccctcttcctccttagcggc
tgctgccaggccctggagatctcactggaccaggaacatattccctttggacccgtggtg
tatcagacgcaagccacacgtcgcatcctcatgatgaacacaggcgatgtgggtgcaagg
tttaaatgggacatcaaaaaatttgagcctcatttctccattagcccagaagaaggctat
attacctcaggcatggaggtttcttttgaagtgacctaccatcccaccgaggtgggaaag
gagagcctttgtaaaaacattctctgctacatccagggaggcagtcctctgagtctaacc
ctgtctggagtctgcgtgggaccacctgcggtaaaagaggtagtgaatttcacgtgccag
gtgcgctccaagcacacgcagaccatcctgctgtcaaaccgcaccaaccagacctggaat
ctgcaccccatctttgagggcgagcactgggaggggcctgagttcatcaccctggaggcc
caccagcaaaacaagccctatgagatcacctacaggccccgcaccatgaacttggagaac
cgcaagcaccagggcaccctcttcttccccctcccagatgggaccggctggctgtatgct
ctgcatgggacttctgagctccccaaagctgtagccaatatctatcgtgaagtgccatgt
aagaccccctacactgagcttctgccaatcaccaactggctgaacaagccccagagattc
cgggtcatcgtggaaatactgaaaccagagaagccggacctaagcatcactatgaagggc
cttgattacattgatgtactgtctggctctaagaaagactacaagctgaacttcttttcc
cacaaggagggaacgtacgctgcaaaggtgatcttccgaaacgaggtgacaaatgagttc
ttgtactacaatgtgagtttcagggtcatcccttcaggcatcatcaaaaccatcgagatg
gtgaccccagtccggcaagttgcgtcagcctccatcaagttggagaaccctctgccctac
tcggtgaccttctccacggaatgccggatgcccgacatcgccctgccctcccagtttgtg
gtgcctgccaactccgagggcacgttctcatttgaatttcagcccctgaaagctggagaa
accttcggaagactaactttgcacaacactgacttgggttactaccaatatgagctctat
ctgaaagccacgccagcacttccggaaaagcctgttcacttccagactgtccttggcagc
agccaaatcatccttgtgaagttcatcaattacacacggcagaggacagaatactactgc
aggaccgactgtacagacttccacgcagaaaaactcattaatgcagccccaggaggccag
ggaggcactgaagccagtgtggaagtcttattcgagcccagccacctgggtgagaccaag
ggcatcctgatcctatcatcgctcgcaggtggagagtatatcatccccctctttggaatg
gctctgcctcccaagccccaaggtcccttctcgatccgagccgggtacagcataatcatc
cccttcaagaatgtcttctatcacatggtgaccttctccatcatcgtggataacccagcc
ttcaccattcgcgctggagagtctgtgcggcccaagaagatcaacaacatcacagtctcc
tttgaaggaaacccatctggcagcaaaacccccatcaccaccaagctgactgtgagctgc
cctcctggtgaagggagtgagactggagttaaatgggtttattatctgaaggggatcacc
ctttag

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