KEGG   ORTHOLOGY: K17718
Entry
K17718                      KO                                     
Symbol
CYP2C8
Name
cytochrome P450 family 2 subfamily C8 [EC:1.14.14.1]
Pathway
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map04726  Serotonergic synapse
map05204  Chemical carcinogenesis - DNA adducts
map05417  Lipid and atherosclerosis
Reaction
R07042  
R07043  
R07048  
R07050  
R07055  
R07056  
R08312  
R08390  
R08392  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
   00591 Linoleic acid metabolism
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
  09111 Xenobiotics biodegradation and metabolism
   00982 Drug metabolism - cytochrome P450
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
Genes
HSA: 1558(CYP2C8)
PTR: 450909(CYP2C8)
PPS: 100967379(CYP2C8)
GGO: 101127173
PON: 100447840(CYP2C8)
PPYG: 129006200
NLE: 100602226
HMH: 116457254
SSYN: 129462752
MCC: 100534648(CYP2C93) 678683(CYP2C8) 702239
MCF: 102116849 102117212(CYP2C8) 102119308(CYP2C93)
MTHB: 126962030 126962037
MNI: 105470206 105470207 105481168
CSAB: 103216303(CYP2C8) 103216308
CATY: 105576140 105576141 105587200
PANU: 101022842(CYP2C8) 101023648
TGE: 112631270 112631271
MLEU: 105535381 105553656 105553690
RRO: 104665592
RBB: 108541196
TFN: 117069764
PTEH: 111529253
CANG: 105504518 105527573
CJC: 100390915(CYP2C8) 100402764
SBQ: 101041387
CIMI: 108281688(CYP2C8)
ANAN: 105708272(CYP2C8)
CSYR: 103260641
LCAT: 123650043 123650045 123650047 123650048
PCOQ: 105822696
OGA: 100941864 100942590
GVR: 103597628 103609276 103609277 103610831 103610943
ASAO: 132781291
SUND: 121921666
CTIG: 120296912 120296913 120298508 120317800 120317801
APRI: 131192456
PRAF: 128407606
GSH: 117365670
HOC: 132836750
RMP: 119168129
CRG: 105344043
CANU: 128177588
CVN: 111128571
 » show all
Reference
PMID:3500169
  Authors
Okino ST, Quattrochi LC, Pendurthi UR, McBride OW, Tukey RH
  Title
Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing.
  Journal
J Biol Chem 262:16072-9 (1987)
  Sequence
[hsa:1558]
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