KEGG   ORTHOLOGY: K17746
Entry
K17746                      KO                                     
Symbol
ChaDH
Name
chanoclavine-I dehydrogenase [EC:1.1.1.332]
Pathway
map00901  Indole alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00963  Chanoclavine aldehyde biosynthesis, tryptophan => chanoclavine-I aldehyde
Reaction
R10128  chanoclavine-I:NAD+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00901 Indole alkaloid biosynthesis
    K17746  ChaDH; chanoclavine-I dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.332  chanoclavine-I dehydrogenase
     K17746  ChaDH; chanoclavine-I dehydrogenase
Genes
MGR: MGG_02225 MGG_09087
PPEI: PpBr36_06906
PGRI: PgNI_05463
NHE: NECHADRAFT_80607
FFC: NCS54_00718400
FKR: NCS57_00758700
MAW: 19251296(J3458_016181)
MAJ: MAA_06739
MBRN: 26246261(easD)
CFJ: CFIO01_09989
GLZ: GLAREA_05925
AFM: AFUA_2G18000
ABE: ARB_04646
TVE: TRV_01860
 » show all
Reference
PMID:20039019
  Authors
Wallwey C, Matuschek M, Li SM
  Title
Ergot alkaloid biosynthesis in Aspergillus fumigatus: conversion of chanoclavine-I to chanoclavine-I aldehyde catalyzed by a short-chain alcohol dehydrogenase FgaDH.
  Journal
Arch Microbiol 192:127-34 (2010)
DOI:10.1007/s00203-009-0536-1
  Sequence
[afm:AFUA_2G18000]
Reference
PMID:22403186
  Authors
Wallwey C, Heddergott C, Xie X, Brakhage AA, Li SM
  Title
Genome mining reveals the presence of a conserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal family Arthrodermataceae.
  Journal
Microbiology 158:1634-44 (2012)
DOI:10.1099/mic.0.056796-0
  Sequence
[abe:ARB_04646]
LinkDB

KEGG   ENZYME: 1.1.1.332
Entry
EC 1.1.1.332                Enzyme                                 
Name
chanoclavine-I dehydrogenase;
easD (gene name);
fgaDH (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
chanoclavine-I:NAD+ oxidoreductase
Reaction(IUBMB)
chanoclavine-I + NAD+ = chanoclavine-I aldehyde + NADH + H+ [RN:R10128]
Reaction(KEGG)
R10128
Substrate
chanoclavine-I [CPD:C09131];
NAD+ [CPD:C00003]
Product
chanoclavine-I aldehyde [CPD:C20379];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme catalyses a step in the pathway of ergot alkaloid biosynthesis in certain fungi.
History
EC 1.1.1.332 created 2012
Pathway
ec00901  Indole alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17746  chanoclavine-I dehydrogenase
Genes
MGR: MGG_02225 MGG_09087
PPEI: PpBr36_06906
PGRI: PgNI_05463
NHE: NECHADRAFT_80607
FFC: NCS54_00718400
FKR: NCS57_00758700
MAW: 19251296(J3458_016181)
MAJ: MAA_06739
MBRN: 26246261(easD)
CFJ: CFIO01_09989
GLZ: GLAREA_05925
AFM: AFUA_2G18000
ABE: ARB_04646
TVE: TRV_01860
 » show all
Reference
1  [PMID:20039019]
  Authors
Wallwey C, Matuschek M, Li SM
  Title
Ergot alkaloid biosynthesis in Aspergillus fumigatus: conversion of chanoclavine-I to chanoclavine-I aldehyde catalyzed by a short-chain alcohol dehydrogenase FgaDH.
  Journal
Arch Microbiol 192:127-34 (2010)
DOI:10.1007/s00203-009-0536-1
  Sequence
[afm:AFUA_2G18000]
Reference
2  [PMID:22403186]
  Authors
Wallwey C, Heddergott C, Xie X, Brakhage AA, Li SM
  Title
Genome mining reveals the presence of a conserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal family Arthrodermataceae.
  Journal
Microbiology 158:1634-44 (2012)
DOI:10.1099/mic.0.056796-0
  Sequence
[abe:ARB_04646]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.332
IUBMB Enzyme Nomenclature: 1.1.1.332
ExPASy - ENZYME nomenclature database: 1.1.1.332
BRENDA, the Enzyme Database: 1.1.1.332
LinkDB

KEGG   REACTION: R10128
Entry
R10128                      Reaction                               
Name
chanoclavine-I:NAD+ oxidoreductase
Definition
Chanoclavine-I + NAD+ <=> Chanoclavine-I aldehyde + NADH + H+
Equation
C09131 + C00003 <=> C20379 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC02561  C09131_C20379
Enzyme
1.1.1.332
Pathway
rn00901  Indole alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00963  Chanoclavine aldehyde biosynthesis, tryptophan => chanoclavine-I aldehyde
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.332
     R10128  Chanoclavine-I + NAD+ <=> Chanoclavine-I aldehyde + NADH + H+
Orthology
K17746  chanoclavine-I dehydrogenase [EC:1.1.1.332]
Other DBs
RHEA: 33894
LinkDB

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