KEGG ORTHOLOGY: K18018

ORTHOLOGY: K18018

Entry

K18018                      KO

Symbol

PTPN5

Name

tyrosine-protein phosphatase non-receptor type 5 [EC:3.1.3.48]

Pathway

map04010

MAPK signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K18018  PTPN5; tyrosine-protein phosphatase non-receptor type 5
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K18018  PTPN5; tyrosine-protein phosphatase non-receptor type 5
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     K18018  PTPN5; tyrosine-protein phosphatase non-receptor type 5
Protein phosphatases and associated proteins [BR:ko01009]
Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Non-receptor PTPs
    K18018  PTPN5; tyrosine-protein phosphatase non-receptor type 5

Other DBs

GO:

0004725

Genes

HSA:	84867(PTPN5)

PTR:	466462(PTPN5)

PPS:	100973047(PTPN5)

GGO:	101143525(PTPN5)

PPYG:

129008337(PTPN5)

NLE:	100607052(PTPN5)

HMH:	116476440(PTPN5)

SSYN:

129484340(PTPN5)

MCC:	708151(PTPN5)

MCF:	102128329(PTPN5)

MTHB:

126934652

MNI:	105486992(PTPN5)

CSAB:

103239069(PTPN5)

CATY:

105598862(PTPN5)

PANU:

100999160(PTPN5)

TGE:	112606343(PTPN5)

MLEU:

105537665(PTPN5)

RRO:	104667659(PTPN5)

RBB:	108519292(PTPN5)

TFN:	117081288(PTPN5)

PTEH:

111555061(PTPN5)

CANG:

105508595(PTPN5)

CJC:	100408421(PTPN5)

SBQ:	101051113(PTPN5)

CIMI:

108302298(PTPN5)

ANAN:

105720190(PTPN5)

CSYR:

103272872(PTPN5)

MMUR:

105879952(PTPN5)

LCAT:

123641667(PTPN5)

PCOQ:

105818292(PTPN5)

OGA:	100946875(PTPN5)

MMU:	19259(Ptpn5)

MCAL:

110298575(Ptpn5)

MPAH:

110317657(Ptpn5)

RNO:	29644(Ptpn5)

MCOC:

116102258(Ptpn5)

ANU:	117716152(Ptpn5)

ASYL:

127682290(Ptpn5)

MUN:	110559663(Ptpn5)

CGE:	100753442(Ptpn5)

MAUA:

101840162(Ptpn5)

PROB:

127213792(Ptpn5)

PLEU:

114685631(Ptpn5)

MORG:

121450546(Ptpn5)

MFOT:

126493734

AAMP:

119802794(Ptpn5)

NGI:	103732971(Ptpn5)

HGL:	101718223(Ptpn5)

CPOC:

100716019(Ptpn5)

CCAN:

109696898(Ptpn5)

DORD:

105988126(Ptpn5)

DSP:	122117718(Ptpn5)

PLOP:

125362670(Ptpn5)

NCAR:

124959485

MMMA:

107158188(Ptpn5)

ITI:	101961347(Ptpn5)

OCU:	100359020 127484946

OPI:	101535486(PTPN5)

TUP:	102479366(PTPN5)

GVR:	103598115(PTPN5)

CFA:	485409(PTPN5)

CLUD:

112667741(PTPN5)

VVP:	112911553(PTPN5)

VLG:	121475911(PTPN5)

NPO:	129504933(PTPN5)

AML:	100473902(PTPN5)

UMR:	103659448(PTPN5)

UAH:	113265116(PTPN5)

UAR:	123799493(PTPN5)

ELK:

111149763

LLV:

125079969

MPUF:

101691212(PTPN5)

MNP:	132022037(PTPN5)

MLK:	131810284(PTPN5)

NVS:	122912774(PTPN5)

ORO:	101371264(PTPN5)

EJU:	114220043(PTPN5)

ZCA:	113915522(PTPN5)

MLX:	118015542(PTPN5)

NSU:	110576632(PTPN5)

LWW:	102736211(PTPN5)

FCA:	101081668(PTPN5)

PYU:	121043676(PTPN5)

PCOO:

112865627(PTPN5)

PBG:	122483606(PTPN5)

PVIV:

125177155(PTPN5)

LRUF:

124506316

LGF:	123601470(PTPN5)

AJU:

106987478

PTG:	102950078(PTPN5)

PPAD:

109271233(PTPN5)

PUC:

125913124

PLEZ:

122200780(PTPN5)

HHV:	120234805(PTPN5)

BTA:	615850(PTPN5)

BOM:	102277977(PTPN5)

BIU:	109554692(PTPN5)

BBUB:

102406742(PTPN5)

BBIS:

105001985(PTPN5)

CHX:	102186279(PTPN5)

OAS:	101121131(PTPN5)

BTAX:

128069107(PTPN5)

CSUM:

138083508(PTPN5)

ODA:	120874867(PTPN5)

CCAD:

122430989(PTPN5)

MREE:

136168855(PTPN5)

OVR:	110137285(PTPN5)

MBEZ:

129549013(PTPN5)

SSC:	100524422(PTPN5)

CFR:	102517612(PTPN5)

CBAI:

105076573(PTPN5)

CDK:	105095337(PTPN5)

VPC:	102528189(PTPN5)

BACU:

103005705(PTPN5)

BMUS:

118899544(PTPN5)

LVE:	103089479(PTPN5)

OOR:	101274390(PTPN5)

LALB:

132525221(PTPN5)

DLE:	111179848(PTPN5)

PCAD:

102979381(PTPN5)

PSIU:

116757973(PTPN5)

NASI:

112412869(PTPN5)

ECB:	100071930(PTPN5)

EPZ:	103557827(PTPN5)

EAI:	106845283(PTPN5)

MYB:	102249900(PTPN5)

MYD:	102765900(PTPN5)

MMYO:

118664913(PTPN5)

MLF:	102438731(PTPN5)

MDT:	132241904(PTPN5)

MYUM:

139019024(PTPN5)

PKL:	118712899(PTPN5)

EFUS:

103292722(PTPN5)

MNA:	107542187(PTPN5)

DRO:	112303383(PTPN5)

SHON:

118983091(PTPN5)

AJM:	119053103(PTPN5)

PDIC:

114500541(PTPN5)

PHAS:

123810216(PTPN5)

MMF:	118628632(PTPN5)

PPAM:

129080757(PTPN5)

HAI:	109387487(PTPN5)

RFQ:	117030866(PTPN5)

PALE:

102888396(PTPN5)

PGIG:

120604581(PTPN5)

PVP:	105303912(PTPN5)

RAY:	107520776(PTPN5)

MJV:	108404049(PTPN5)

TOD:	119254953(PTPN5)

SARA:

101547310(PTPN5)

SFUM:

130039063(PTPN5)

SETR:

126018917(PTPN5)

LAV:	100657728(PTPN5)

TMU:

101353972

ETF:	101657639(PTPN5)

DNM:	101428889(PTPN5)

MDO:	100028129(PTPN5)

GAS:	123250911(PTPN5)

SHR:	100921633(PTPN5)

AFZ:

127539693

PCW:	110221105(PTPN5)

TVP:	118853484(PTPN5)

PBRV:

138149725(PTPN5)

OAA:	103166704(PTPN5)

TACU:

119943351(PTPN5)

GGA:	423085(PTPN5)

PCOC:

116242959(PTPN5)

MGP:	100550438(PTPN5)

CJO:	107314697(PTPN5)

TPAI:

128085996(PTPN5)

LMUT:

125694573(PTPN5)

NMEL:

110400991(PTPN5)

APLA:

101800659(PTPN5)

ACYG:

106042588(PTPN5)

CATA:

118244774(PTPN5)

AFUL:

116490382(PTPN5)

TGU:	100230601(PTPN5)

LSR:	110468078(PTPN5)

SCAN:

103826765(PTPN5)

PMOA:

120501422(PTPN5)

OTC:	121341525(PTPN5)

PRUF:

121360909(PTPN5)

ATRC:

139590313(PTPN5)

GFR:	102042583(PTPN5)

FAB:	101807075(PTPN5)

OMA:	130254312(PTPN5)

PHI:	102108508(PTPN5)

PMAJ:

107205708(PTPN5)

CCAE:

111930793(PTPN5)

CCW:	104686125(PTPN5)

CBRC:

103624953(PTPN5)

ACOE:

138111334(PTPN5)

ETL:

114066601

ZAB:	102060748(PTPN5)

ZLE:	135448637(PTPN5)

ACHL:

103805604(PTPN5)

SVG:	106859801(PTPN5)

MMEA:

130575387(PTPN5)

HRT:	120754502(PTPN5)

SATI:

136362409(PTPN5)

CCIC:

134045018(PTPN5)

FPG:	101910414(PTPN5)

FCH:	102056607(PTPN5)

CCRI:

104160760(PTPN5)

NNT:	104407080(PTPN5)

SHAB:

115606852(PTPN5)

ACUN:

113481142(PTPN5)

TALA:

104368975(PTPN5)

ACHC:

115352047(PTPN5)

HALD:

104310827(PTPN5)

HLE:	104829551(PTPN5)

AGEN:

126047372

HHAR:

128152852(PTPN5)

GCL:

127017179

CSTI:

104557785(PTPN5)

LDI:	104345449(PTPN5)

MNB:	103777499(PTPN5)

DPUB:

104299776(PTPN5)

PPUS:

135185963(PTPN5)

AVIT:

104271242(PTPN5)

BRHI:

104489373(PTPN5)

EGZ:	104123215(PTPN5)

NNI:	104010500(PTPN5)

PCRI:

104034516(PTPN5)

PCAO:

104047280

PADL:

103920704(PTPN5)

AFOR:

103906727(PTPN5)

FGA:	104073840(PTPN5)

GSTE:

104256654(PTPN5)

CLV:	102094464(PTPN5)

MUI:	104545608(PTPN5)

PGUU:

104466194(PTPN5)

PLET:

104621540(PTPN5)

EHS:	104514527(PTPN5)

CMAC:

104480756(PTPN5)

CUCA:

104068893(PTPN5)

TEO:	104380570(PTPN5)

BREG:

104638495(PTPN5)

OHA:	104330111(PTPN5)

ACAR:

104521054(PTPN5)

CPEA:

104389098(PTPN5)

CVF:	104292597(PTPN5)

RTD:	128908526(PTPN5)

CRID:

134514316(PTPN5)

AAM:	106497121(PTPN5)

AROW:

112972421(PTPN5)

NPD:	112951449(PTPN5)

TGT:	104575391(PTPN5)

DNE:	112978967(PTPN5)

SCAM:

104143763(PTPN5)

ASN:	102384432(PTPN5)

AMJ:	102557921(PTPN5)

CPOO:

109321500(PTPN5)

GGN:	109299151(PTPN5)

CCAY:

125639206(PTPN5)

DCC:	119857972(PTPN5)

TST:

117877276

ACS:	100559376(ptpn5)

ASAO:

132770848(PTPN5)

PVT:	110088555(PTPN5)

SUND:

121919243(PTPN5)

PBI:

103048272

PMUR:

107290720(PTPN5)

CTIG:

120311368(PTPN5)

TSR:	106542427(PTPN5)

PGUT:

117665251(PTPN5)

APRI:

131185614(PTPN5)

PTEX:

113440211(PTPN5)

NSS:	113412564(PTPN5)

VKO:	123021234(PTPN5)

PMUA:

114598878(PTPN5)

PRAF:

128416129(PTPN5)

ZVI:	118092954(PTPN5)

HCG:	128332752(PTPN5)

GJA:	107111851(PTPN5)

STOW:

125426933(PTPN5)

EMC:	129325191(PTPN5)

XLA:	108713695 108715327

XTR:	116410221(ptpn5)

NPR:	108785951(PTPN5)

RTEM:

120917022(PTPN5)

BBUF:

120980593(PTPN5)

BGAR:

122921088(PTPN5)

PWL:	138284337(PTPN5)

MUO:	115468933(PTPN5)

GSH:	117352374(PTPN5)

DRE:	559524(ptpn5)

SRX:	107722354 107739473

SANH:

107656192 107703306

SGH:	107554596 107590990(ptpn5)

CCAR:

109093367(ptpn5) 109105154

CAUA:

113051631 113106124

CGIB:

127961028 128016789

PTET:

122349695(ptpn5)

LROH:

127168439(ptpn5)

OMC:	131543591(ptpn5)

PPRM:

120491066(ptpn5)

RKG:	130103613(ptpn5)

MAMB:

125264984(ptpn5)

CIDE:

127516339

CERY:

137030719(ptpn5)

MASI:

127415325 127446470

TROS:

130559420(ptpn5)

TDW:	130427565(ptpn5)

MANU:

129445842(ptpn5)

PDAB:

135778832(ptpn5)

IPU:	108259119(ptpn5)

IFU:	128602944(ptpn5)

PHYP:

113546699(ptpn5)

SMEO:

124380023(ptpn5)

TFD:	113634254(ptpn5)

TVC:	132839027(ptpn5)

CGAR:

128518300(ptpn5)

NGRA:

132875149(ptpn5)

TRN:	134304098(ptpn5)

AMEX:

103023150(ptpn5)

CMAO:

118817644(ptpn5)

EEE:	113577702(ptpn5)

CHAR:

105906457(ptpn5)

SPIL:

134095622(ptpn5)

TRU:	101065894(ptpn5)

TFS:	130535718(ptpn5)

TNG:	GSTEN00038501G001

LCO:

104920490

NCC:

104940848

TBEN:

117491954(ptpn5)

CGOB:

115010056

PGEO:

117447538(ptpn5)

GACU:

117545919(ptpn5)

EMAC:

134874499

ELY:	117262592(ptpn5)

EFO:	125888078(ptpn5)

PLEP:

121950813

SLUC:

116038377(ptpn5)

ECRA:

117949248(ptpn5)

ESP:

116694286

PFLV:

114559684(ptpn5)

GAT:	120809403(ptpn5) 120812667

PPUG:

119196303(ptpn5)

AFB:	129108718(ptpn5)

CLUM:

117731943(ptpn5)

PSWI:

130195249(ptpn5)

CANA:

137804129

CVE:	137881492(ptpn5)

MSAM:

119893264

SCHU:

122874264(ptpn5)

CUD:	121514670(ptpn5)

SPUL:

138613467

LMIX:

132973186(ptpn5)

ALAT:

119023684(ptpn5)

ASTR:

137594298

MZE:	101473792(ptpn5)

ONL:	100703346(ptpn5)

OAU:

116327613

OLA:

101163224

OML:	112152074(ptpn5)

CSAI:

133444026

XMA:	102238211(ptpn5)

XCO:	114161670(ptpn5)

XHE:	116734207(ptpn5)

PRET:

103466167(ptpn5)

PFOR:

103144422(ptpn5)

PLAI:

PMEI:

GAF:

PPRL:

CVG:	107089488(ptpn5)

CTUL:

119796815(ptpn5)

GMU:	124857975(ptpn5)

NFU:

107389033

KMR:	108237439(ptpn5)

ALIM:

106515673(ptpn5)

NWH:	119415589(ptpn5)

AOCE:

111570650(ptpn5)

EJA:

138206015

BFRE:

138634679

MCEP:

125015208(ptpn5)

CSEM:

103380360

POV:

109638926

SSEN:

122764948(ptpn5)

SSOE:

131470447(ptpn5)

HHIP:

117762628(ptpn5)

HSP:	118109097(ptpn5)

PPLT:

128445139(ptpn5)

SMAU:

118315892(ptpn5)

LCF:

108875380

SDU:	111228477(ptpn5)

SLAL:

111661793

XGL:	120793415(ptpn5)

HCQ:

109530503

SSCV:

125971167

SBIA:

133502662(ptpn5)

PEE:

133403064

PTAO:

133477657

BPEC:

110165954(ptpn5)

ENY:	140348689(ptpn5)

MALB:

109967912

BSPL:

114857399(ptpn5)

SJO:	128358556(ptpn5)

SSCO:

133982050(ptpn5)

SASA:

106561045(ptpn5) 106584593

STRU:

115192770 115197045

OTW:	112217302(ptpn5) 112218233

OMY:	110492572 110521305

OGO:	124010526 124037575

ONE:	115134483 115144763

OKI:	109867255 109897758

OKE:	118358784 118396109

OMM:	135509580 135556637

OCLA:

139369496 139407566

SALP:

111962156 111972030

SNH:	120051694 120066574

CCLU:

121532053 121540701

ELS:	105007395(ptpn5)

OEP:	134021665(ptpn5)

SFM:	108934665 108942176

PKI:	111840143 111859517

AANG:

118215237 118226898(ptpn5)

AROT:

135242147 135255623(ptpn5)

CCOG:

133111925 133130577(ptpn5)

LOC:	102687397(ptpn5)

PSPA:

121294414(ptpn5) 121329595

ARUT:

117431960 117434719 117969233

PSEX:

120515534(ptpn5)

LCM:	102348627(PTPN5)

RTP:	109930335(ptpn5)

CPLA:

122557917(ptpn5)

HOC:	132824164(ptpn5)

LERI:

129705827(ptpn5)

RES:

135695283

» show all

Reference

PMID:18923032

Authors

Zhang Y, Venkitaramani DV, Gladding CM, Zhang Y, Kurup P, Molnar E, Collingridge GL, Lombroso PJ

Title

The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation.

Journal

J Neurosci 28:10561-6 (2008)
DOI:10.1523/JNEUROSCI.2666-08.2008

Sequence

[mmu:19259]

Reference

PMID:12483215

Authors

Paul S, Nairn AC, Wang P, Lombroso PJ

Title

NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling.

Journal

Nat Neurosci 6:34-42 (2003)
DOI:10.1038/nn989

Sequence

[hsa:84867]

LinkDB

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