KEGG   ORTHOLOGY: K18074
Entry
K18074                      KO                                     
Symbol
tphA2
Name
terephthalate 1,2-dioxygenase oxygenase component alpha subunit [EC:1.14.12.15]
Pathway
map00624  Polycyclic aromatic hydrocarbon degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00624  Terephthalate degradation, terephthalate => 3,4-dihydroxybenzoate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00624 Polycyclic aromatic hydrocarbon degradation
    K18074  tphA2; terephthalate 1,2-dioxygenase oxygenase component alpha subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.12  With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
    1.14.12.15  terephthalate 1,2-dioxygenase
     K18074  tphA2; terephthalate 1,2-dioxygenase oxygenase component alpha subunit
Dioxygenases [br01602.html]
 Dioxygenases in aromatic ring cleavage
  K18074
Other DBs
RN: R05148
GO: 0018628
Genes
VPD: VAPA_2c09660
CTT: CtCNB1_1493
CTES: O987_22455
RTA: Rta_16750
HYB: Q5W_19735
HTN: KI616_03585
Reference
PMID:7961417
  Authors
Schlafli HR, Weiss MA, Leisinger T, Cook AM
  Title
Terephthalate 1,2-dioxygenase system from Comamonas testosteroni T-2: purification and some properties of the oxygenase component.
  Journal
J Bacteriol 176:6644-52 (1994)
DOI:10.1128/JB.176.21.6644-6652.1994
  Sequence
Reference
  Authors
Fukuhara Y, Kasai D, Katayama Y, Fukuda M, Masai E
  Title
Enzymatic properties of terephthalate 1,2-dioxygenase of Comamonas sp. strain E6.
  Journal
Biosci Biotechnol Biochem 72:2335-41 (2008)
DOI:10.1271/bbb.80236
LinkDB

KEGG   ORTHOLOGY: K18075
Entry
K18075                      KO                                     
Symbol
tphA3
Name
terephthalate 1,2-dioxygenase oxygenase component beta subunit [EC:1.14.12.15]
Pathway
map00624  Polycyclic aromatic hydrocarbon degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00624  Terephthalate degradation, terephthalate => 3,4-dihydroxybenzoate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00624 Polycyclic aromatic hydrocarbon degradation
    K18075  tphA3; terephthalate 1,2-dioxygenase oxygenase component beta subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.12  With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
    1.14.12.15  terephthalate 1,2-dioxygenase
     K18075  tphA3; terephthalate 1,2-dioxygenase oxygenase component beta subunit
Dioxygenases [br01602.html]
 Dioxygenases in aromatic ring cleavage
  K18075
Other DBs
RN: R05148
GO: 0018628
Genes
PARK: LSG25_11505
VPD: VAPA_2c09670
CTT: CtCNB1_1494
CTES: O987_22460
RTA: Rta_16740
HYB: Q5W_19730
Reference
PMID:7961417
  Authors
Schlafli HR, Weiss MA, Leisinger T, Cook AM
  Title
Terephthalate 1,2-dioxygenase system from Comamonas testosteroni T-2: purification and some properties of the oxygenase component.
  Journal
J Bacteriol 176:6644-52 (1994)
DOI:10.1128/JB.176.21.6644-6652.1994
  Sequence
Reference
  Authors
Fukuhara Y, Kasai D, Katayama Y, Fukuda M, Masai E
  Title
Enzymatic properties of terephthalate 1,2-dioxygenase of Comamonas sp. strain E6.
  Journal
Biosci Biotechnol Biochem 72:2335-41 (2008)
DOI:10.1271/bbb.80236
LinkDB

KEGG   ORTHOLOGY: K18077
Entry
K18077                      KO                                     
Symbol
tphA1
Name
terephthalate 1,2-dioxygenase reductase component [EC:1.18.1.-]
Pathway
map00624  Polycyclic aromatic hydrocarbon degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00624  Terephthalate degradation, terephthalate => 3,4-dihydroxybenzoate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00624 Polycyclic aromatic hydrocarbon degradation
    K18077  tphA1; terephthalate 1,2-dioxygenase reductase component
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.18  Acting on iron-sulfur proteins as donors
   1.18.1  With NAD+ or NADP+ as acceptor
    1.18.1.-
     K18077  tphA1; terephthalate 1,2-dioxygenase reductase component
Dioxygenases [br01602.html]
 Dioxygenases in aromatic ring cleavage
  K18077
Other DBs
RN: R05148
Genes
VPD: VAPA_2c09690
CTT: CtCNB1_1496
CTES: O987_22470
RTA: Rta_16720
HYB: Q5W_19720
Reference
  Authors
Fukuhara Y, Kasai D, Katayama Y, Fukuda M, Masai E
  Title
Enzymatic properties of terephthalate 1,2-dioxygenase of Comamonas sp. strain E6.
  Journal
Biosci Biotechnol Biochem 72:2335-41 (2008)
DOI:10.1271/bbb.80236
LinkDB

KEGG   REACTION: R05148
Entry
R05148                      Reaction                               
Name
benzene-1,4-dicarboxylate, NADH:oxygen oxidoreductase (1,2-hydroxylating)
Definition
Terephthalate + Oxygen + NADH + H+ <=> (3S,4R)-3,4-Dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+
Equation
Reaction class
RC00001  C00003_C00004
RC00270  C06318_C06337
Enzyme
Pathway
rn00624  Polycyclic aromatic hydrocarbon degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00624  Terephthalate degradation, terephthalate => 3,4-dihydroxybenzoate
Orthology
K18074  terephthalate 1,2-dioxygenase oxygenase component alpha subunit [EC:1.14.12.15]
K18075  terephthalate 1,2-dioxygenase oxygenase component beta subunit [EC:1.14.12.15]
K18077  terephthalate 1,2-dioxygenase reductase component [EC:1.18.1.-]
Other DBs
RHEA: 10315
LinkDB

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