KEGG ORTHOLOGY: K18262

ORTHOLOGY: K18262

Entry

K18262                      KO

Symbol

EFEMP1, FBLN3

Name

EGF-containing fibulin-like extracellular matrix protein 1

Disease

H00557

Cutis laxa

H00825

Familial flecked retina syndrome

H02110

Doyne honeycomb retinal dystrophy

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K18262  EFEMP1, FBLN3; EGF-containing fibulin-like extracellular matrix protein 1
   04990 Domain-containing proteins not elsewhere classified
    K18262  EFEMP1, FBLN3; EGF-containing fibulin-like extracellular matrix protein 1
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K18262  EFEMP1, FBLN3; EGF-containing fibulin-like extracellular matrix protein 1
Domain-containing proteins not elsewhere classified [BR:ko04990]
EGF-like domain-containing proteins
  hEGF / cEGF domain-containing proteins
   K18262  EFEMP1, FBLN3; EGF-containing fibulin-like extracellular matrix protein 1

Genes

HSA:	2202(EFEMP1)

PTR:	455416(EFEMP1)

PPS:	100989008(EFEMP1)

GGO:	101142079(EFEMP1)

PON:	100442979(EFEMP1)

NLE:	100594795(EFEMP1)

HMH:	116482979(EFEMP1)

MCC:	718984(EFEMP1)

MCF:	102119251(EFEMP1)

MTHB:

126934150

MNI:	105465062(EFEMP1)

CSAB:

103220232(EFEMP1)

CATY:

105576409(EFEMP1)

PANU:

101024495(EFEMP1)

TGE:	112636916(EFEMP1)

MLEU:

105551322(EFEMP1)

RRO:	104672418(EFEMP1)

RBB:	108531285(EFEMP1)

TFN:	117099666(EFEMP1)

PTEH:

111553457(EFEMP1)

CANG:

105522847(EFEMP1)

CJC:	100392620(EFEMP1)

SBQ:	101053911(EFEMP1)

CIMI:

108313804(EFEMP1)

CSYR:

103273178(EFEMP1)

MMUR:

105878435(EFEMP1)

LCAT:

123636934(EFEMP1)

PCOQ:

105814774(EFEMP1)

OGA:	100961842(EFEMP1)

MMU:	216616(Efemp1)

MCAL:

110304847(Efemp1)

MPAH:

110330451(Efemp1)

RNO:	305604(Efemp1)

MCOC:

116068811(Efemp1)

ANU:	117712769(Efemp1)

MUN:	110562944(Efemp1)

CGE:	100750809(Efemp1)

MAUA:

101825131(Efemp1)

PROB:

127234016(Efemp1)

PLEU:

114708300(Efemp1)

MORG:

121459427(Efemp1)

MFOT:

126489530

AAMP:

119820048(Efemp1)

NGI:	103725699(Efemp1)

HGL:	101705517(Efemp1)

CPOC:

100713549(Efemp1)

CCAN:

109698247(Efemp1)

DORD:

105986883(Efemp1)

DSP:	122117487(Efemp1)

PLOP:

125356427(Efemp1)

NCAR:

124962969

MMMA:

107137271(Efemp1)

OCU:

100345739

OPI:	101525578(EFEMP1)

TUP:	102470773(EFEMP1)

GVR:	103589251(EFEMP1)

CFA:	474604(EFEMP1)

CLUD:

112672487(EFEMP1)

VVP:	112915265(EFEMP1)

VLG:	121491072(EFEMP1)

NPO:	129511412(EFEMP1)

AML:	100474434(EFEMP1)

UMR:	103671277(EFEMP1)

UAH:	113245479(EFEMP1)

UAR:	123785945(EFEMP1)

ELK:

111148014

LLV:

125109067

MPUF:

101671746(EFEMP1)

MNP:	132021536(EFEMP1)

MLK:	131840150(EFEMP1)

NVS:	122916495(EFEMP1)

ORO:	101381277(EFEMP1)

EJU:	114198535(EFEMP1)

ZCA:	113937061(EFEMP1)

MLX:	118008106(EFEMP1)

NSU:	110590365(EFEMP1)

LWW:	102749860(EFEMP1)

FCA:	101094585(EFEMP1)

PYU:	121016270(EFEMP1)

PCOO:

112869103(EFEMP1)

PBG:	122496864(EFEMP1)

PVIV:

125162612(EFEMP1)

LRUF:

124504236

PTG:	102960968(EFEMP1)

PPAD:

109253392(EFEMP1)

PUC:

125937010

AJU:

106976772

HHV:	120220927(EFEMP1)

BTA:	511566(EFEMP1)

BOM:	102279418(EFEMP1)

BIU:	109566089(EFEMP1)

BBUB:

102413534(EFEMP1)

BBIS:

104989857(EFEMP1)

CHX:	102190700(EFEMP1)

OAS:	101120648(EFEMP1)

BTAX:

128056071(EFEMP1)

ODA:	120851832(EFEMP1)

CCAD:

122441690(EFEMP1)

MBEZ:

129539221(EFEMP1)

SSC:	100512046(EFEMP1)

CFR:	102523276(EFEMP1)

CBAI:

105066520(EFEMP1)

CDK:	105097229(EFEMP1)

VPC:	102530424(EFEMP1)

BACU:

103005768(EFEMP1)

BMUS:

118905738(EFEMP1)

LVE:	103085923(EFEMP1)

OOR:	101275053(EFEMP1)

DLE:	111186514(EFEMP1)

PCAD:

102984069(EFEMP1)

PSIU:

116764255(EFEMP1)

NASI:

112404857(EFEMP1)

ECB:	100066175(EFEMP1)

EPZ:	103546252(EFEMP1)

EAI:	106832304(EFEMP1)

MYB:	102262786(EFEMP1)

MYD:	102768718(EFEMP1)

MMYO:

118668983(EFEMP1)

MLF:	102440443(EFEMP1)

PKL:	118717381(EFEMP1)

EFUS:

103305386(EFEMP1)

MNA:	107544302(EFEMP1)

DRO:	112297906(EFEMP1)

SHON:

118988394(EFEMP1)

AJM:	119047960(EFEMP1)

PDIC:

114499876(EFEMP1)

PHAS:

123811508(EFEMP1)

MMF:	118631181(EFEMP1)

PPAM:

129072040(EFEMP1)

HAI:	109371935(EFEMP1)

RFQ:	117033101(EFEMP1)

PALE:

102885164(EFEMP1)

PGIG:

120621633(EFEMP1)

PVP:	105294647(EFEMP1)

RAY:	107519675(EFEMP1)

MJV:	108394416(EFEMP1)

TOD:	119258966(EFEMP1)

SARA:

101559137(EFEMP1)

SETR:

126024379(EFEMP1)

LAV:	100655858(EFEMP1)

TMU:

101359676

ETF:	101648691(EFEMP1)

DNM:	101421512(EFEMP1)

MDO:	100033335(EFEMP1)

GAS:	123236866(EFEMP1)

SHR:	100933362(EFEMP1)

AFZ:

127548100

PCW:	110215072(EFEMP1)

OAA:	100079495(EFEMP1)

GGA:	428543(EFEMP1)

PCOC:

116231877(EFEMP1)

MGP:	100541136(EFEMP1)

CJO:	107310813(EFEMP1)

TPAI:

128077659(EFEMP1)

LMUT:

125690141(EFEMP1)

NMEL:

110396077(EFEMP1)

APLA:

101795399(EFEMP1)

ACYG:

106042282(EFEMP1)

CATA:

118257441(EFEMP1)

AFUL:

116487363(EFEMP1)

TGU:	100226873(EFEMP1)

LSR:	110469089(EFEMP1)

SCAN:

103819243(EFEMP1)

PMOA:

120506029(EFEMP1)

OTC:	121342678(EFEMP1)

PRUF:

121357104(EFEMP1)

GFR:	102032716(EFEMP1)

FAB:	101808846(EFEMP1)

OMA:	130250707(EFEMP1)

PHI:	102103619(EFEMP1)

PMAJ:

107201376(EFEMP1)

CCAE:

111926409(EFEMP1)

CCW:	104691501(EFEMP1)

CBRC:

103622997(EFEMP1)

ETL:	114066733(EFEMP1)

ZAB:	102065643(EFEMP1)

ACHL:

103797490

SVG:	106865201(EFEMP1)

MMEA:

130583157(EFEMP1)

HRT:	120750571(EFEMP1)

FPG:	101914631(EFEMP1)

FCH:	102056344(EFEMP1)

CLV:	102085471(EFEMP1)

EGZ:	104127855(EFEMP1)

NNI:	104022419(EFEMP1)

PCRI:

104027249(EFEMP1)

PLET:

104622500(EFEMP1)

EHS:	104503665(EFEMP1)

PCAO:

104043136(EFEMP1)

ACUN:

113478651(EFEMP1)

TALA:

104361943(EFEMP1)

PADL:

103913137(EFEMP1)

AFOR:

103906533(EFEMP1)

ACHC:

115344672(EFEMP1)

HALD:

104311999

HLE:	104836326(EFEMP1)

AGEN:

126038805

GCL:

127014293

CSTI:

104558114(EFEMP1)

CMAC:

104473919(EFEMP1)

MUI:

104540542

BREG:

104630073(EFEMP1)

GSTE:

104254844(EFEMP1)

LDI:	104351402(EFEMP1)

MNB:	103780083(EFEMP1)

OHA:	104326537(EFEMP1)

NNT:	104412549(EFEMP1)

SHAB:

115609807(EFEMP1)

DPUB:

104301643(EFEMP1)

PGUU:

104468925(EFEMP1)

ACAR:

104523274(EFEMP1)

CPEA:

104394882(EFEMP1)

AVIT:

104268490(EFEMP1)

CVF:	104287326(EFEMP1)

RTD:	128907590(EFEMP1)

CUCA:

104055365(EFEMP1)

TEO:	104370284(EFEMP1)

BRHI:

104501262(EFEMP1)

AAM:	106490456(EFEMP1)

AROW:

112966456(EFEMP1)

NPD:	112942796(EFEMP1)

TGT:	104571121(EFEMP1)

DNE:	112988026(EFEMP1)

SCAM:

104140319(EFEMP1)

ASN:	102378127(EFEMP1)

AMJ:	102563522(EFEMP1)

CPOO:

109319585(EFEMP1)

GGN:	109296989(EFEMP1)

PSS:	102455232(EFEMP1)

CMY:	102947049(EFEMP1)

CCAY:

125633490(EFEMP1)

DCC:	119853099(EFEMP1)

CPIC:

101932197(EFEMP1)

TST:	117874315(EFEMP1)

CABI:

116824928(EFEMP1)

MRV:	120402429(EFEMP1)

ACS:	100565417(efemp1)

ASAO:

132761594(EFEMP1)

PVT:	110070848(EFEMP1)

SUND:

121935391(EFEMP1)

PBI:	103050061(EFEMP1)

PMUR:

107302260(EFEMP1)

CTIG:

120308378(EFEMP1)

TSR:	106543258(EFEMP1)

PGUT:

117671497(EFEMP1)

APRI:

131189083(EFEMP1)

PTEX:

113433438(EFEMP1)

NSS:	113418059(EFEMP1)

VKO:	123022695(EFEMP1)

PMUA:

114594890(EFEMP1)

PRAF:

128411374(EFEMP1)

ZVI:	118083003(EFEMP1)

HCG:	128323385(EFEMP1)

GJA:	107123642(EFEMP1)

STOW:

125445262(EFEMP1)

EMC:	129334576(EFEMP1)

XLA:	108716598(efemp1.L) 108717761(efemp1.S)

XTR:	100495975(efemp1)

NPR:	108804764(EFEMP1)

RTEM:

120937719(EFEMP1)

BBUF:

120998856(EFEMP1)

BGAR:

122934075(EFEMP1)

MUO:	115465606(EFEMP1)

GSH:	117357388(EFEMP1)

DRE:	100332567(efemp1) 563864(si:ch73-173h19.3)

SRX:	107706109 107720391 107742815 107753722

SANH:

107657491 107679068 107699135 107701580

SGH:	107551359 107558226 107565914(efemp1) 107588455

CCAR:

109058193 109071541 109085398 109112899

CAUA:

113039751 113065160 113113117(efemp1)

CGIB:

127943043 127987517 128026529

PTET:

122356455(efemp1)

LROH:

127162498(si:ch73-173h19.3) 127175154(efemp1)

OMC:	131530263(si:ch73-173h19.3) 131552263(efemp1)

PPRM:

120491872(si:ch73-173h19.3) 120492247(efemp1)

RKG:	130093385(si:ch73-173h19.3) 130103810(efemp1)

MAMB:

125254538(si:ch73-173h19.3) 125277575(efemp1)

CIDE:

127520513(si:ch73-173h19.3) 127524391

MASI:

127438456 127438716

TROS:

130548901(si:ch73-173h19.3)

TDW:	130430775(si:ch73-173h19.3)

MANU:

129416460 129416750 129453737(si:ch73-173h19.3)

IPU:

108260945

IFU:	128604241(efemp1)

PHYP:

113544369(efemp1)

SMEO:

124381259(efemp1)

TFD:	113660768(efemp1)

TVC:	132841821(efemp1)

AMEX:

103023569

CMAO:

118816734(efemp1)

EEE:

113586676

CHAR:

105906762(si:ch73-173h19.3) 105910169(efemp1)

TRU:	101062681(efemp1)

TFS:	130534110(efemp1)

TNG:	GSTEN00016470G001

LCO:	104930910 104938122

NCC:	104943160(efemp1)

TBEN:

117499808(efemp1)

CGOB:

115020515(efemp1)

PGEO:

117460112(efemp1)

GACU:

117538166(efemp1)

EMAC:

134859086(efemp1)

ELY:	117247833(efemp1)

EFO:	125903385(efemp1)

PLEP:

121954938(efemp1)

SLUC:

116054375(efemp1)

ECRA:

117960782(efemp1)

ESP:

116704858

PFLV:

114571948(efemp1)

GAT:	120820980(efemp1)

PPUG:

119214518(efemp1)

AFB:	129092334(efemp1)

CLUM:

117744504(efemp1)

PSWI:

130207090(efemp1)

MSAM:

119899893 119917336(efemp1)

SCHU:

122873762(si:ch73-173h19.3) 122884202(efemp1)

CUD:	121510863(efemp1)

ALAT:

119022865(si:ch73-173h19.3) 119034200(efemp1)

MZE:	101474115(efemp1)

ONL:	100711494(efemp1)

OAU:	116316594(efemp1)

OLA:

101159128

OML:	112161738(efemp1)

CSAI:

133463522

XMA:	102226234(efemp1)

XCO:	114137917(efemp1)

XHE:	116713211(efemp1)

PRET:

103476862(efemp1)

PFOR:

103147731(efemp1)

PLAI:

106959655(efemp1)

PMEI:

106918085(efemp1)

GAF:	122843038(efemp1)

PPRL:

129359762(efemp1)

CVG:	107094931(efemp1)

CTUL:

119788565

GMU:

124859155

NFU:	107375721(efemp1)

KMR:

108245568

ALIM:

106532327(efemp1)

NWH:	119418555(efemp1)

AOCE:

111564391(efemp1)

MCEP:

125019163(efemp1)

CSEM:

103387206

POV:

109629867

SSEN:

122782088(efemp1)

HHIP:

117775662(efemp1)

HSP:	118119283(efemp1)

SMAU:

118284022(efemp1)

LCF:	108880394(efemp1) 108882303(si:ch73-173h19.3)

SDU:	111235383 111237593

SLAL:

111651351 111654674 111670572

XGL:	120796041(efemp1) 120800510(si:ch73-173h19.3)

HCQ:	109509934(efemp1)

SSCV:

125978826

SBIA:

133510121(efemp1)

PEE:

133409515

PTAO:

133485618(efemp1)

BPEC:

110159143

MALB:

109961986(efemp1) 109971827

BSPL:

114841810(efemp1)

SJO:

128373159

SASA:

106564782 106584872

STRU:

115177941 115208478

OTW:	112230414 112266170

OMY:	110486086 110493800

OGO:	124003784 124016531

ONE:	115103986 115142677

OKI:	109875530 109890464

OKE:	118365058 118389093

SALP:

111961238 111982266

SNH:	120022411 120032767

CCLU:

121572660 123485530

ELS:

105030762

SFM:	108927162 108933630

PKI:	111835757(efemp1) 111853475

AANG:

118217842(efemp1) 118219535(si:ch73-173h19.3)

LOC:	102689216(efemp1)

PSPA:

121316146 121317277

ARUT:

117402550 117410367

PSEX:

120516335(efemp1)

LCM:	102354884(EFEMP1)

CMK:

CPLA:

HOC:

LERI:

NVE:

EPA:

Reference

PMID:20005202

Authors

Wakabayashi T, Matsumine A, Nakazora S, Hasegawa M, Iino T, Ota H, Sonoda H, Sudo A, Uchida A

Title

Fibulin-3 negatively regulates chondrocyte differentiation.

Journal

Biochem Biophys Res Commun 391:1116-21 (2010)
DOI:10.1016/j.bbrc.2009.12.034

Sequence

[hsa:2202]

LinkDB

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