KEGG ORTHOLOGY: K18364

ORTHOLOGY: K18364

Entry

K18364                      KO

Symbol

bphH, xylJ, tesE

Name

2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase [EC:4.2.1.80 4.2.1.132]

Pathway

map00362

Benzoate degradation

map00621

Dioxin degradation

map00622

Xylene degradation

map00984

Steroid degradation

map01100

Metabolic pathways

map01120

Microbial metabolism in diverse environments

map01220

Degradation of aromatic compounds

Module

M00569

Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA

Reaction

R02601

4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming)

R05864

4-hydroxy-2-oxohexanoate hydro-lyase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K18364  bphH, xylJ, tesE; 2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase
   00622 Xylene degradation
    K18364  bphH, xylJ, tesE; 2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase
   00621 Dioxin degradation
    K18364  bphH, xylJ, tesE; 2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase
   00984 Steroid degradation
    K18364  bphH, xylJ, tesE; 2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase
Enzymes [BR:ko01000]
4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.80  2-oxopent-4-enoate hydratase
     K18364  bphH, xylJ, tesE; 2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase
    4.2.1.132  2-hydroxyhexa-2,4-dienoate hydratase
     K18364  bphH, xylJ, tesE; 2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase
Dioxygenases [br01602.html]
Dioxygenases in aromatic ring cleavage
  K18364

Other DBs

GO:	0008684 0034856

Genes

PGE:	LG71_12240

PLUM:

A4R40_11035

PAKH:

B0X70_11350

PLUI:

CE143_11265

PSD:	DSC_09160 DSC_09365

LSY:	H8L67_00470(dmpE)

RGL:	CS053_01760

RTH:	LRK53_10275(dmpE)

RBD:

ALSL_1080

VAF:	D1115_22450

PATE:

NNL38_21635(dmpE)

PRE:	PCA10_13820 PCA10_p0350(carD)

PFUW:

KF707C_12170 KF707C_15560(bzaF) KF707C_16070(salF) KF707C_16250(bphX1)

PLAL:

FXN65_06420

PCQ:	PcP3B5_25700(tesE_1)

PNT:	G5B91_07425(dmpE)

PPI:	ND086(nahL)

PPUT:

L483_14065

PPUN:

PP4_27260

PPJ:	RK21_04237

PZA:	HU749_013350

PVR:	PverR02_11595 PverR02_14690

PMED:

E3Z27_14780

PPUU:

PputUW4_01660(mhpD)

PKC:	PKB_4239(xylJ)

PFZ:	AV641_10535

PLQ:	AA042_19765

PALK:

PSAKL28_05940

PPSY:

AOC04_07835

PFK:	PFAS1_28775

PSET:

THL1_1433

PSIL:

PMA3_11735 PMA3_18070

PKE:	DLD99_14750

PUM:	HGP31_20760

PPSH:

G5J76_13490

PAZE:

KSS91_19295

PALV:

KSS97_16725

PTAE:

NCTC10697_02057(xylJ)

PCAV:

D3880_02345(dmpE) D3880_11810(dmpE) D3880_17505

PPHN:

HU825_04980(dmpE) HU825_14755

PIZ:	LAB08_R28780(dmpE) LAB08_R40970

PKM:	PZ739_11545

PSHS:

JJN09_05425

PLAU:

I0D68_00650(dmpE) I0D68_06180 I0D68_15095(dmpE)

PFOU:

PBEJ:

PSKP:

PDEU:

PBUB:

PSML:

PSMZ:

PSIV:

PSWO:

PMOR:

PPSE:

BN5_3620(nahL)

PALL:

UYA_06720 UYA_06980 UYA_07060 UYA_20155

PSC:	A458_06520

PSTU:

UIB01_22740

PBM:	CL52_14710

SDEG:

GOM96_01760

AVN:	Avin_08670(xylJ) Avin_30610(lapE)

AVL:	AvCA_08670(xylJ) AvCA_30610(lapE)

AVD:	AvCA6_08670(xylJ) AvCA6_30610(lapE)

ACX:	Achr_32780

HPEG:

EAO82_00555(dmpE) EAO82_09425(dmpE)

HAES:

LO767_17670(dmpE)

HARR:

HV822_17975

PPHA:

BVH74_06155 BVH74_16350 BVH74_17960

HASM:

QAO71_12430

MAD:	HP15_1113 HP15_4034

MSR:	AU15_21080

MLQ:	ASQ50_09215

MSQ:	BKP64_13850

MARJ:

MARI_05440(xylJ)

MALL:

PBN92_01670(dmpE)

MSHE:

MAALD49_03410 MAALD49_03860

MANP:

EHN06_02445(dmpE)

MAMM:

ABNF92_03750(dmpE) ABNF92_09340(dmpE)

KAK:	Kalk_07855

SPL:

SHL:

SWD:

SHEM:

COLW:

CBER:

THT:	E2K93_11200

PHA:	PSHAa2141(xylJ)

PTN:	PTRA_a2594(bphH)

PNG:	PNIG_a2788(bphH)

HARO:

R50071_02970 R50071_12460

SPOI:

IMCC21906_00389 IMCC21906_02710

SNAN:

I6N98_10800

STAW:

NCG89_14300

ZAL:	AZF00_03890 AZF00_11430 AZF00_17820

MSPN:

M8T91_14350

HJA:	BST95_09505

HALC:

EY643_13295

AFUS:

EYZ66_02605(dmpE) EYZ66_12965

PAQM:

E0F26_07475

CYQ:

Q91_0508

CZA:	CYCME_2103

CYY:	CPC19_10515(dmpE)

BLEP:

AL038_01300(dmpE)

THIS:

AEH:

TBN:

APAC:

MGEO:

CFI10_00425(dmpE) CFI10_04960(dmpE)

MSEC:

LN244_04775 LN244_11330(dmpE)

MRZ:	KDW95_00770

NCU:	F0U83_03045(dmpE)

NJP:	NEJAP_0671(mhpD)

NIK:	F5I99_10105(dmpE) F5I99_10520(dmpE)

AJP:	AMJAP_2999(mhpD)

EMP:	EZMO1_1317(tesE)

ASIM:

FE240_03500(dmpE)

ZDF:	AN401_14585

SOK:	D0B54_06200

SINI:

GT972_13730(dmpE) GT972_14670

FCE:	JN531_005830

GBI:	PG2T_02230

GPB:	HDN1F_27090(tesE)

NZO:	SAMEA4504057_0450(xylJ)

NCI:	NCTC10296_00911(xylJ_1)

NWD:	H3L96_04745(dmpE)

NDU:	LVJ88_00610(dmpE)

VFF:	VITFI_CDS1370

PTES:

JQU52_04880(dmpE)

USU:	LVJ78_03680(dmpE)

CHRO:

CXB49_03840

AQL:	BXU06_16875

RPI:

Rpic_4620

RPF:	Rpic12D_3544

RPJ:	N234_08150 N234_12215

RIN:	ACS15_4354(dmpE)

REH:	H16_B0548(mhpD1) H16_B0597(bphH)

CNC:	CNE_2c04940(mhpD) CNE_2c05420(xylJ2) CNE_BB1p11990(xylJ1) CNE_BB1p13280(xylJ2)

CUH:	BJN34_30960

REU:	Reut_A1510 Reut_B5691

RME:	Rmet_1321(xylJ)

CTI:	RALTA_B0401(mhpD)

CBW:	RR42_s2313 RR42_s2484

CCUP:

BKK81_19910 BKK81_27090

CUP:	BKK80_21900 BKK80_29230

CUU:	BKK79_35180

COX:	E0W60_07775(dmpE) E0W60_08025(dmpE)

CCAX:

KZ686_09995(dmpE)

CUK:	KB879_20190(dmpE) KB879_20425(dmpE)

CNAN:

A2G96_22770

CUPP:

CTP10_R37960(dmpE) CTP10_R38470(dmpE)

BVI:	Bcep1808_7603

BUR:	Bcep18194_B1459 Bcep18194_B2961

BCJ:

BCAM1613

BCEN:

DM39_3383(dmpE) DM39_4834(dmpE)

BCEO:

I35_5473

BCT:	GEM_4111 GEM_5403

BCED:

DM42_4993(dmpE) DM42_6345(dmpE)

BCEP:

APZ15_31155

BPYR:

ABD05_27820

BCON:

NL30_04140 NL30_24600

BDF:	WI26_15985 WI26_21145

BTEI:

WS51_00560 WS51_05695

BPSL:

WS57_06045 WS57_12165

BMEC:

WJ16_26790

BSTL:

BBJ41_10510 BBJ41_21340

BANN:

JFN94_19125(dmpE) JFN94_25650(dmpE)

BARI:

NLX30_30185(dmpE)

BAEN:

L3V59_21740(dmpE) L3V59_30395(dmpE)

BUQ:	AC233_11195

BURK:

DM992_32625(dmpE)

BURT:

BTHE68_57030

BXE:	Bxe_C1189(bphH)

BXB:	DR64_8616(dmpE)

BUZ:	AYM40_21220

BFN:	OI25_4589(dmpE)

PARB:

CJU94_37870(dmpE) CJU94_38115(dmpE)

PCAF:

DSC91_003291

PMEG:

FNZ07_21165(dmpE)

PBRY:

NDK50_32875(dmpE)

PPAI:

E1956_37240(dmpE) E1956_45885

PHUN:

U0042_26770(dmpE)

PPK:	U875_01900

PRB:	X636_07570

PVE:	UC34_07065

CABA:

SBC2_49020(tesE)

LIMN:

HKT17_03820(dmpE)

BOJ:	CBF45_01490 CBF45_04500 CBF45_06955

APES:

FOC84_00320(dmpE)

AVH:	WHX56_04395

CDN:	BN940_01166 BN940_04316

KGY:	EHF36_01675(dmpE) EHF36_04885(dmpE)

RLH:	MIZ03_0646 MIZ03_1022

PNA:

AJS:

ACID:

ACIP:

ACIN:

ACIS:

AMON:

H9L24_14185(dmpE)

VEI:

Veis_2785

VBO:	CKY39_28505(dmpE)

VAV:	IG196_08130(dmpE)

VAE:	RZE79_18250(dmpE)

CTT:	CtCNB1_1353 CtCNB1_3149

CTES:

O987_07740

COF:	FOZ74_08305(dmpE)

CRJ:	QMY55_07020

ADN:	Alide_0337

ADK:	Alide2_0282

OTD:	J1M35_00055(dmpE)

HYL:	LPB072_18180

HPSE:

HPF_01870(xylJ)

HYN:	F9K07_02750(dmpE)

HTN:	KI616_01965(dmpE)

DIH:	G7047_01670(dmpE) G7047_09705

DRG:	H9K76_11645(dmpE)

DIM:	K2L43_01275(dmpE)

DIS:	I3K84_11925(dmpE)

SIMP:

C6571_13615(dmpE)

MELA:

C6568_07860(dmpE)

MJE:	LVC68_01005(dmpE)

STHM:

IS481_10530(dmpE)

SAQA:

OMP39_09110(dmpE)

MPT:	Mpe_A2273 Mpe_A3325

METP:

C1M51_06460(dmpE) C1M51_15400(dmpE)

SNN:	EWH46_19325

SMIO:

CATMQ487_04110 CATMQ487_17560 CATMQ487_31610

IDC:	LRM40_19570(dmpE)

LCH:

Lcho_3343

JAG:	GJA_236(xylJ)

JAJ:	EKL02_01815(dmpE)

HEW:	HBDW_03980

MASW:

AM586_18650

TMJ:	P0M04_30675(dmpE)

ACTB:

RHM62_03640

RBU:	PG1C_14105

ABRE:

pbN1_20560(mhpD)

DAR:	Daro_2774 Daro_3785

DEY:	HYN24_14130(dmpE) HYN24_14215(dmpE)

DDEN:

KI615_16885(dmpE)

FLE:	KI610_08575(dmpE) KI610_13420(dmpE) KI610_15465(dmpE)

AZO:	azo1853(lapE) azo2434(nahL)

AOA:	dqs_2006 dqs_2578

AZI:	AzCIB_1507 AzCIB_4411

AZD:	CDA09_09955 CDA09_10325(dmpE) CDA09_10440(dmpE) CDA09_21440(dmpE)

AZR:	CJ010_12250(dmpE) CJ010_15220(dmpE)

TMZ:	Tmz1t_2077 Tmz1t_3091

THU:	AC731_001810 AC731_008895

THAU:

C4PIVTH_2807(mhpD) C4PIVTH_4321(mhpD) C4PIVTH_4380(mhpD)

THK:	CCZ27_10770(dmpE) CCZ27_16275(dmpE)

THAG:

CKCBHOJB_02379(tesE_1) CKCBHOJB_03304(tesE_2)

AZQ:	G3580_00535(dmpE) G3580_08270(dmpE)

MFUJ:

MENS:

RPOP:

PAQT:

TEC:	AKL02_008255

FRB:	AB6B37_08185

NAR:

Saro_3689

NPP:	PP1Y_AT32745 PP1Y_Mpl3103

NPN:	JI59_22525

NOV:	TQ38_027295

NOT:	C7W88_20925

NOVO:

IM701_15590

SGI:	SGRAN_1581(mhpD)

SPOG:

SPHM:

SSAN:

SPKC:

SPHA:

SLAN:

SBIN:

SPCL:

SJP:	SJA_C1-11870(mhpD)

SINB:

SIDU_08330

SYB:	TZ53_09010 TZ53_23455

SPHB:

EP837_03394(bphH)

SHYD:

SUFL:

SBAR:

SPCA:

SPJS:

SFLA:

SPHFLASMR4Y_02368(tesE)

SPHJ:

PALG:

PHAO:

ALTN:

PMAS:

TFV:	IDJ81_04970

PHZ:	CHX26_05320

NTD:	EGO55_13680

CAEN:

K5X80_14735

PEG:	E5R92_01705

HTL:

HPTL_0050

ACIB:

ACBT_0261(dmpE)

AFC:	AFAEC_1846(dmpE)

AAQI:

AAQM_0980(dmpE)

ACLO:

ACLO_a0141(dmpE)

ADZ:	ADFLV_2553(dmpE)

ARC:

ABLL_2444

AROS:

NJU99_01640(dmpE)

ALK:	ALEK_0381(dmpE)

AANA:

AANAER_1258(dmpE)

PRUE:

LVJ94_28770

AMOB:

HG15A2_23830(tesE)

BHUI:

BAYD:

BBOR:

ASED:

AFAS:

FFE:	LSG31_21095

MHAP:

JFY71_09925

CFEU:

CFELI_13980(mhpD)

AFUV:

ACTR:

CWO:

PARN:

NAY:	HYG81_22605

AG:	BAC67694(tesE)

» show all

Reference

PMID:16151114

Authors

Horinouchi M, Hayashi T, Koshino H, Kurita T, Kudo T

Title

Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441.

Journal

Appl Environ Microbiol 71:5275-81 (2005)
DOI:10.1128/AEM.71.9.5275-5281.2005

Sequence

[ag:BAC67694]

LinkDB

DBGET integrated database retrieval system