KEGG   ORTHOLOGY: K18385
Entry
K18385                      KO                                     
Symbol
PAXC, ATMC, LTMC
Name
geranylgeranyldiphosphate transferase
Pathway
map00403  Indole diterpene alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00661  Paspaline biosynthesis, geranylgeranyl-PP + indoleglycerol phosphate => paspaline
Reaction
R10349  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00403 Indole diterpene alkaloid biosynthesis
    K18385  PAXC, ATMC, LTMC; geranylgeranyldiphosphate transferase
Genes
MAW: 19251250(J3458_002674)
MAJ: MAA_00080
MBRN: 26245742(ltmC)
BFU: BCIN_05g05670(Bcpax1)
ACT: ACLA_008500
AOR: AO090113000171
ANG: An03g00850 An11g02500
AFV: AFLA_009878
ALUC: AKAW2_10058S AKAW2_80220S
APUU: APUU_21148A
PCS: N7525_008636
 » show all
Reference
PMID:19801473
  Authors
Nicholson MJ, Koulman A, Monahan BJ, Pritchard BL, Payne GA, Scott B
  Title
Identification of two aflatrem biosynthesis gene loci in Aspergillus flavus and metabolic engineering of Penicillium paxilli to elucidate their function.
  Journal
Appl Environ Microbiol 75:7469-81 (2009)
DOI:10.1128/AEM.02146-08
  Sequence
[afv:AFLA_009878]
Reference
PMID:11169115
  Authors
Young C, McMillan L, Telfer E, Scott B
  Title
Molecular cloning and genetic analysis of an indole-diterpene gene cluster from Penicillium paxilli.
  Journal
Mol Microbiol 39:754-64 (2001)
DOI:10.1046/j.1365-2958.2001.02265.x
Reference
PMID:23311903
  Authors
Tagami K, Liu C, Minami A, Noike M, Isaka T, Fueki S, Shichijo Y, Toshima H, Gomi K, Dairi T, Oikawa H
  Title
Reconstitution of biosynthetic machinery for indole-diterpene paxilline in Aspergillus oryzae.
  Journal
J Am Chem Soc 135:1260-3 (2013)
DOI:10.1021/ja3116636
LinkDB

KEGG   REACTION: R10349
Entry
R10349                      Reaction                               
Definition
Geranylgeranyl diphosphate + Indoleglycerol phosphate <=> 3-Geranylgeranylindole + D-Glyceraldehyde 3-phosphate + Diphosphate
Equation
C00353 + C03506 <=> C20525 + C00118 + C00013
Reaction class
RC00700  C00118_C03506
Pathway
rn00403  Indole diterpene alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00661  Paspaline biosynthesis, geranylgeranyl-PP + indoleglycerol phosphate => paspaline
Orthology
K18385  geranylgeranyldiphosphate transferase
LinkDB

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