KEGG   ORTHOLOGY: K19183
Entry
K19183                      KO                                     
Symbol
FGAFS
Name
festuclavine dehydrogenase [EC:1.5.1.44]
Pathway
map00901  Indole alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00964  Fumigaclavine biosynthesis, chanoclavine-I aldehyde => fumigaclavine C
Reaction
R10163  festuclavine:NAD+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00901 Indole alkaloid biosynthesis
    K19183  FGAFS; festuclavine dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.44  festuclavine dehydrogenase
     K19183  FGAFS; festuclavine dehydrogenase
Genes
MAJ: MAA_06737
GLZ: GLAREA_05927
AFM: AFUA_2G17970
PBL: PAAG_05656
PBN: PADG_07739
BGH: BDBG_04508
CBET: CB0940_09201
Reference
PMID:20526482
  Authors
Wallwey C, Matuschek M, Xie XL, Li SM
  Title
Ergot alkaloid biosynthesis in Aspergillus fumigatus: Conversion of chanoclavine-I aldehyde to festuclavine by the festuclavine synthase FgaFS in the presence of the old yellow enzyme FgaOx3.
  Journal
Org Biomol Chem 8:3500-8 (2010)
DOI:10.1039/c003823g
  Sequence
[afm:AFUA_2G17970]
LinkDB

KEGG   ENZYME: 1.5.1.44
Entry
EC 1.5.1.44                 Enzyme                                 
Name
festuclavine dehydrogenase;
FgaFS;
festuclavine synthase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
festuclavine:NAD+ oxidoreductase
Reaction(IUBMB)
festuclavine + NAD+ = 6,8-dimethyl-6,7-didehydroergoline + NADH + H+ [RN:R10163]
Reaction(KEGG)
R10163
Substrate
festuclavine [CPD:C20408];
NAD+ [CPD:C00003]
Product
6,8-dimethyl-6,7-didehydroergoline [CPD:C20409];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family. The reaction proceeds in vivo in the opposite direction to the one shown here.
History
EC 1.5.1.44 created 2012
Pathway
ec00901  Indole alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19183  festuclavine dehydrogenase
Genes
MAJ: MAA_06737
GLZ: GLAREA_05927
AFM: AFUA_2G17970
PBL: PAAG_05656
PBN: PADG_07739
BGH: BDBG_04508
CBET: CB0940_09201
Reference
1  [PMID:20526482]
  Authors
Wallwey C, Matuschek M, Xie XL, Li SM
  Title
Ergot alkaloid biosynthesis in Aspergillus fumigatus: Conversion of chanoclavine-I aldehyde to festuclavine by the festuclavine synthase FgaFS in the presence of the old yellow enzyme FgaOx3.
  Journal
Org Biomol Chem 8:3500-8 (2010)
DOI:10.1039/c003823g
  Sequence
[afm:AFUA_2G17970]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.44
IUBMB Enzyme Nomenclature: 1.5.1.44
ExPASy - ENZYME nomenclature database: 1.5.1.44
BRENDA, the Enzyme Database: 1.5.1.44
LinkDB

KEGG   REACTION: R10163
Entry
R10163                      Reaction                               
Name
festuclavine:NAD+ oxidoreductase
Definition
Festuclavine + NAD+ <=> 6,8-Dimethyl-6,7-didehydroergoline + NADH + H+
Equation
C20408 + C00003 <=> C20409 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC03068  C20408_C20409
Enzyme
1.5.1.44
Pathway
rn00901  Indole alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00964  Fumigaclavine biosynthesis, chanoclavine-I aldehyde => fumigaclavine C
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.44
     R10163  Festuclavine + NAD+ <=> 6,8-Dimethyl-6,7-didehydroergoline + NADH + H+
Orthology
K19183  festuclavine dehydrogenase [EC:1.5.1.44]
Other DBs
RHEA: 34058
LinkDB

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