KEGG   ORTHOLOGY: K19853
Entry
K19853            Tight     KO                                     
Symbol
tyl1a
Name
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase [EC:5.3.2.4]
Pathway
map00523  Polyketide sugar unit biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01250  Biosynthesis of nucleotide sugars
Module
M00796  dTDP-D-mycaminose biosynthesis
Reaction
R06424  dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose:dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose isomerase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K19853  tyl1a; TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase
Enzymes [BR:ko01000]
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.2  Interconverting keto- and enol-groups
    5.3.2.4  TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose-forming)
     K19853  tyl1a; TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase
Genes
SAMB: SAM23877_5623(srm14)
SCAE: IHE65_08870
Reference
PMID:17209568
  Authors
Melancon CE 3rd, Hong L, White JA, Liu YN, Liu HW
  Title
Characterization of TDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase from the D-mycaminose biosynthetic pathway of Streptomyces fradiae: in vitro activity and substrate specificity studies.
  Journal
Biochemistry 46:577-90 (2007)
DOI:10.1021/bi061907y
Reference
PMID:18048924
  Authors
Karray F, Darbon E, Oestreicher N, Dominguez H, Tuphile K, Gagnat J, Blondelet-Rouault MH, Gerbaud C, Pernodet JL
  Title
Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens.
  Journal
Microbiology 153:4111-22 (2007)
DOI:10.1099/mic.0.2007/009746-0
  Sequence
[samb:SAM23877_5623]
LinkDB

KEGG   ORTHOLOGY: K24249
Entry
K24249                      KO                                     
Symbol
qdtA
Name
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase [EC:5.3.2.4]
Pathway
map00541  Biosynthesis of various nucleotide sugars
map01100  Metabolic pathways
map01250  Biosynthesis of nucleotide sugars
Module
M01024  dTDP-Qui3NAc biosynthesis, Glc-1P => dTDP-Qui3NAc
Reaction
R06424  dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose:dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose isomerase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00541 Biosynthesis of various nucleotide sugars
    K24249  qdtA; TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase
Enzymes [BR:ko01000]
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.2  Interconverting keto- and enol-groups
    5.3.2.4  TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose-forming)
     K24249  qdtA; TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase
Genes
TVAI: T19A02B_0700(fdtA)
CBE: Cbei_2596
CBZ: Cbs_2596
CSR: Cspa_c19620
CAH: CAETHG_2608
CCK: Ccar_14195
CEU: A7L45_16800
CDY: F3K33_13280
CRW: CROST_039220(fdtA)
CGEL: psyc5s11_31550
CLOM: AXY43_01095
CRAS: KVH43_11465
ELM: ELI_1977
ELIM: B2M23_19440
AWO: Awo_c20960
AMIC: Ami3637_06300
THYR: P4S50_04730
AG: AAR85518(qdtA)
 » show all
Reference
PMID:17941826
  Authors
Pfostl A, Zayni S, Hofinger A, Kosma P, Schaffer C, Messner P
  Title
Biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose.
  Journal
Biochem J 410:187-94 (2008)
DOI:10.1042/BJ20071044
  Sequence
[ag:AAR85518]
LinkDB

KEGG   REACTION: R06424
Entry
R06424                      Reaction                               
Name
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose:dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose isomerase
Definition
dTDP-4-oxo-6-deoxy-D-glucose <=> dTDP-3-oxo-6-deoxy-D-glucose
Equation
C11907 <=> C11908
Reaction class
RC01513  C11907_C11908
Enzyme
5.3.2.4
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn00541  Biosynthesis of various nucleotide sugars
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01250  Biosynthesis of nucleotide sugars
Module
M00796  dTDP-D-mycaminose biosynthesis
M01024  dTDP-Qui3NAc biosynthesis, Glc-1P => dTDP-Qui3NAc
Brite
Enzymatic reactions [BR:br08201]
 5. Isomerase reactions
  5.3  Intramolecular oxidoreductases
   5.3.2  Interconverting keto- and enol-groups
    5.3.2.4
     R06424  dTDP-4-oxo-6-deoxy-D-glucose <=> dTDP-3-oxo-6-deoxy-D-glucose
Orthology
K19853  TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase [EC:5.3.2.4]
K24249  TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase [EC:5.3.2.4]
Other DBs
RHEA: 31842
LinkDB

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