KEGG ORTHOLOGY: K19884

ORTHOLOGY: K19884

Entry

K19884            Tight     KO

Symbol

rebO

Name

7-chloro-L-tryptophan oxidase [EC:1.4.3.23]

Pathway

map00404

Staurosporine biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00789

Rebeccamycin biosynthesis, tryptophan => rebeccamycin

Reaction

R09560

7-chloro-L-tryptophan:oxygen oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K19884  rebO; 7-chloro-L-tryptophan oxidase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.4  Acting on the CH-NH2 group of donors
   1.4.3  With oxygen as acceptor
    1.4.3.23  7-chloro-L-tryptophan oxidase
     K19884  rebO; 7-chloro-L-tryptophan oxidase

Other DBs

COG:

COG1231

Genes

AG:	BAC10674(rebO)

Reference

PMID:15743957

Authors

Nishizawa T, Aldrich CC, Sherman DH

Title

Molecular analysis of the rebeccamycin L-amino acid oxidase from Lechevalieria aerocolonigenes ATCC 39243.

Journal

J Bacteriol 187:2084-92 (2005)
DOI:10.1128/JB.187.6.2084-2092.2005

Sequence

[ag:BAC10674]

Reference

PMID:16313168

Authors

Howard-Jones AR, Walsh CT

Title

Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD.

Journal

Biochemistry 44:15652-63 (2005)
DOI:10.1021/bi051706e

LinkDB

ENZYME: 1.4.3.23

Entry

EC 1.4.3.23                 Enzyme

Name

7-chloro-L-tryptophan oxidase;
RebO

Class

Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor

Sysname

7-chloro-L-tryptophan:oxygen oxidoreductase

Reaction(IUBMB)

7-chloro-L-tryptophan + O2 = 2-imino-3-(7-chloroindol-3-yl)propanoate + H2O2 [RN:R09560]

Reaction(KEGG)

R09560

Substrate

7-chloro-L-tryptophan [CPD:C19687];
O2 [CPD:C00007]

Product

2-imino-3-(7-chloroindol-3-yl)propanoate [CPD:C19688];
H2O2 [CPD:C00027]

Comment

Contains a noncovalently bound FAD [1,2]. This enzyme catalyses a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. During catalysis, the bound FAD is reoxidized at the expense of molecular oxygen, producing one molecule of hydrogen peroxide. The enzyme shows significant preference for 7-chloro-L-tryptophan over L-tryptophan [1].

History

EC 1.4.3.23 created 2010

Pathway

ec00404

Staurosporine biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K19884

7-chloro-L-tryptophan oxidase

Reference

1 [PMID:15743957]

Authors

Nishizawa T, Aldrich CC, Sherman DH

Title

Molecular analysis of the rebeccamycin L-amino acid oxidase from Lechevalieria aerocolonigenes ATCC 39243.

Journal

J Bacteriol 187:2084-92 (2005)
DOI:10.1128/JB.187.6.2084-2092.2005

Sequence

[ag:BAC10674]

Reference

2 [PMID:16313168]

Authors

Howard-Jones AR, Walsh CT

Title

Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD.

Journal

Biochemistry 44:15652-63 (2005)
DOI:10.1021/bi051706e

Sequence

[ag:BAC10674]

Other DBs

ExplorEnz - The Enzyme Database:

1.4.3.23

IUBMB Enzyme Nomenclature:

1.4.3.23

ExPASy - ENZYME nomenclature database:

1.4.3.23

BRENDA, the Enzyme Database:

1.4.3.23

LinkDB

REACTION: R09560

Entry

R09560                      Reaction

Name

7-chloro-L-tryptophan:oxygen oxidoreductase

Definition

7-Chloro-L-tryptophan + Oxygen <=> 2-Imino-3-(7-chloroindol-3-yl)propanoate + Hydrogen peroxide

Equation

C19687 + C00007 <=> C19688 + C00027

Reaction class

RC02566

C19687_C19688

RC02755

C00007_C00027

Enzyme

1.4.3.23

Pathway

rn00404

Staurosporine biosynthesis

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

Module

M00789

Rebeccamycin biosynthesis, tryptophan => rebeccamycin

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.4  Acting on the CH-NH2 group of donors
   1.4.3  With oxygen as acceptor
    1.4.3.23
     R09560  7-Chloro-L-tryptophan + Oxygen <=> 2-Imino-3-(7-chloroindol-3-yl)propanoate + Hydrogen peroxide

Orthology

K19884

7-chloro-L-tryptophan oxidase [EC:1.4.3.23]

Other DBs

RHEA:

27305

LinkDB

DBGET integrated database retrieval system