KEGG ORTHOLOGY: K20199

ORTHOLOGY: K20199

Entry

K20199                      KO

Symbol

pchA

Name

4-hydroxybenzaldehyde dehydrogenase (NADP+) [EC:1.2.1.96]

Pathway

map00623

Toluene degradation

map01120

Microbial metabolism in diverse environments

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00623 Toluene degradation
    K20199  pchA; 4-hydroxybenzaldehyde dehydrogenase (NADP+)
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.96  4-hydroxybenzaldehyde dehydrogenase (NADP+)
     K20199  pchA; 4-hydroxybenzaldehyde dehydrogenase (NADP+)

Other DBs

RN:	R01294 R11195

COG:

COG1012

Genes

KPAS:

LUW96_27875

KLC:	K7H21_07315

RTH:	LRK53_00385

LAEO:

L2Y97_07285

PFUW:

KF707C_49540

PCQ:	PcP3B5_13480(yfmT_1)

PPUT:

L483_22005

PALD:

LU682_010465

PDR:	H681_14070

PALK:

PSAKL28_20220 PSAKL28_31420

PSOS:

POS17_5138(pcuC)

PSET:

THL1_648

PSIL:

PMA3_18555

PUM:	HGP31_12070

PLAL:

PASG:

ACIU:

CAMH:

COBE:

OCE:

VST:	LVJ81_12800

VMS:	LVJ82_08995

EBA:	ebA3161(pchA)

AVV:	RvVAT039_12790 RvVAT039_37260

AVF:	RvVAR031_32700 RvVAR031_40300

TMD:	KUV46_09890

SQO:	NMP03_09275

HNZ:	P9989_02030

PCHU:

PSUA:

EACE:

EAUR:

EMM:	PTI97_13080

EPF:	OE059_01180

PMAH:

PTQ21_17060

AACO:

K1I37_11200

MSEN:

K3U95_02165

CCOE:

CETAM_10235(yfmT)

CPOY:

GP475_11710

SMAO:

CAG99_11870

AJG:	KKR91_02090

ASUN:

KG104_01890

ASUF:

MNQ99_18755

ACAO:

NF551_02055

AZH:	MUK71_02130

AGEG:

MUG94_01800

GPR:	JQN66_03880

GMY:

XH9_04975

GNC:	QQS42_03975

MPOR:

THAO:

NAKE:

SNAH:

CALN:

MROB:

SFOL:

HTS:	HMJ29_04580

SABU:

MBM09_12560

AG:	AGO01127(pchA)

» show all

Reference

PMID:23736872

Authors

Chen YF, Chao H, Zhou NY

Title

The catabolism of 2,4-xylenol and p-cresol share the enzymes for the oxidation of para-methyl group in Pseudomonas putida NCIMB 9866.

Journal

Appl Microbiol Biotechnol 98:1349-56 (2014)
DOI:10.1007/s00253-013-5001-z

Sequence

[ag:AGO01127]

LinkDB

ENZYME: 1.2.1.96

Entry

EC 1.2.1.96                 Enzyme

Name

4-hydroxybenzaldehyde dehydrogenase (NADP+);
p-hydroxybenzaldehyde dehydrogenase (ambiguous);
pchA (gene name)

Class

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor

Sysname

4-hydroxybenzaldehyde:NADP+ oxidoreductase

Reaction(IUBMB)

4-hydroxybenzaldehyde + NADP+ + H2O = 4-hydroxybenzoate + NADPH + 2 H+ [RN:R01294]

Reaction(KEGG)

R01294;
(other) R11195

Substrate

4-hydroxybenzaldehyde [CPD:C00633];
NADP+ [CPD:C00006];
H2O [CPD:C00001]

Product

4-hydroxybenzoate [CPD:C00156];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Involved in the aerobic pathway for degradation of toluene, 4-methylphenol, and 2,4-xylenol by several Pseudomonas strains. The enzyme is also active with 4-hydroxy-3-methylbenzaldehyde. cf. EC 1.2.1.64, 4-hydroxybenzaldehyde dehydrogenase (NAD+).

History

EC 1.2.1.96 created 2015

Pathway

ec00623

Toluene degradation

ec01120

Microbial metabolism in diverse environments

Orthology

K20199

4-hydroxybenzaldehyde dehydrogenase (NADP+)

Genes

KPAS:

LUW96_27875

KLC:	K7H21_07315

RTH:	LRK53_00385

LAEO:

L2Y97_07285

PFUW:

KF707C_49540

PCQ:	PcP3B5_13480(yfmT_1)

PPUT:

L483_22005

PALD:

LU682_010465

PDR:	H681_14070

PALK:

PSAKL28_20220 PSAKL28_31420

PSOS:

POS17_5138(pcuC)

PSET:

THL1_648

PSIL:

PMA3_18555

PUM:	HGP31_12070

PLAL:

FXN65_13830

PASG:

KSS96_11230

ACIU:

A3K93_06980

CAMH:

LCW13_08055

COBE:

CLAM6_15430

OCE:

GU3_14325

VST:	LVJ81_12800

VMS:	LVJ82_08995

EBA:	ebA3161(pchA)

AVV:	RvVAT039_12790 RvVAT039_37260

AVF:	RvVAR031_32700 RvVAR031_40300

TMD:	KUV46_09890

SQO:	NMP03_09275

HNZ:	P9989_02030

PCHU:

QNI29_11975

PSUA:

FLK61_38060

EACE:

KKI46_02990

EAUR:

NMQ00_01220

EMM:	PTI97_13080

EPF:	OE059_01180

PMAH:

PTQ21_17060

AACO:

K1I37_11200

MSEN:

K3U95_02165

CCOE:

CETAM_10235(yfmT)

CPOY:

GP475_11710

SMAO:

CAG99_11870

AJG:	KKR91_02090

ASUN:

KG104_01890

ASUF:

MNQ99_18755

ACAO:

NF551_02055

AZH:	MUK71_02130

AGEG:

MUG94_01800

GPR:	JQN66_03880

GMY:

XH9_04975

GNC:	QQS42_03975

MPOR:

KW076_03745

THAO:

NI17_020775

NAKE:

KGD83_24515

SNAH:

OUQ99_26040

CALN:

NIES2098_22770

MROB:

HH214_16945

SFOL:

H3H32_04235

HTS:	HMJ29_04580

SABU:

MBM09_12560

» show all

Reference

1 [PMID:2019564]

Authors

Whited GM, Gibson DT.

Title

Separation and partial characterization of the enzymes of the toluene-4-monooxygenase catabolic pathway in Pseudomonas mendocina KR1.

Journal

J Bacteriol 173:3017-20 (1991)
DOI:10.1128/JB.173.9.3017-3020.1991

Reference

2 [PMID:23736872]

Authors

Chen YF, Chao H, Zhou NY

Title

The catabolism of 2,4-xylenol and p-cresol share the enzymes for the oxidation of para-methyl group in Pseudomonas putida NCIMB 9866.

Journal

Appl Microbiol Biotechnol 98:1349-56 (2014)
DOI:10.1007/s00253-013-5001-z

Sequence

[ag:AGO01127]

Other DBs

ExplorEnz - The Enzyme Database:

1.2.1.96

IUBMB Enzyme Nomenclature:

1.2.1.96

ExPASy - ENZYME nomenclature database:

1.2.1.96

BRENDA, the Enzyme Database:

1.2.1.96

CAS:	61229-72-9

LinkDB

REACTION: R11195

Entry

R11195                      Reaction

Name

4-hydroxy-3-methylbenzaldehyde:NADP+ oxidoreductase

Definition

4-Hydroxy-3-methylbenzaldehyde + NADP+ + H2O <=> 4-Hydroxy-3-methylbenzoate + NADPH + H+

Equation

C21166 + C00006 + C00001 <=> C21167 + C00005 + C00080

Reaction class

RC00075

C21166_C21167

Enzyme

1.2.1.96

Pathway

rn00623

Toluene degradation

rn01120

Microbial metabolism in diverse environments

Orthology

K20199

4-hydroxybenzaldehyde dehydrogenase (NADP+) [EC:1.2.1.96]

LinkDB

DBGET integrated database retrieval system