KEGG   ORTHOLOGY: K20429
Entry
K20429                      KO                                     
Symbol
vioA
Name
dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33]
Pathway
map00541  Biosynthesis of various nucleotide sugars
map01100  Metabolic pathways
map01250  Biosynthesis of nucleotide sugars
Reaction
R02773  dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00541 Biosynthesis of various nucleotide sugars
    K20429  vioA; dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.33  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
     K20429  vioA; dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
Other DBs
COG: COG0399
GO: 0019179
Genes
ECT: ECIAI39_0979(vioA)
EOC: CE10_2353(vioA)
EBR: ECB_01942(vioA)
ECOB: C3029_14350
EBL: ECD_01942(vioA)
EBE: B21_01931(ybl97)
EBD: ECBD_1619
SHQ: A0259_14015
ESH: C1N69_14925
PDZ: HHA33_11055
TOE: QMG90_13825
EBB: F652_1773
SMAF: D781_3917
SERT: TAN611_4078(vioA)
PCV: BCS7_12855
PPEU: DUT67_21235
PAY: PAU_04327(vioA)
HAV: AT03_13955
HPAR: AL518_12410
PFUW: KF707C_17310
PFV: Psefu_4173
PSV: PVLB_06575
PKC: PKB_2543(arnb1)
PFZ: AV641_08190
PSEJ: HNQ25_14985
PWY: HU734_007720
PSSX: DCC84_09200
AJO: RZ95_16600
ATG: J4G44_00260
ABOU: ACBO_05730
MBAH: HYN46_11415
SHE: Shewmr4_1321
SHW: Sputw3181_1468
SCHK: GII14_07745
MEEP: JWZ98_14515
MEEC: PL263_06500
MLAU: ACEPPP_06495(vioA)
TSJ: L3K52_17760(vioA)
NWR: E3U44_08215
THIP: N838_01675
THIM: KFB96_06625
HHU: AR456_16635
HASO: B2G49_21050
HABD: OM794_18145
SAJS: QO259_09020
MARS: A8C75_04390
MRZ: KDW95_11735
AHI: VU14_07300
ASAA: KXJ75_15915(vioA)
CHIC: N8I74_14320(vioA)
RME: Rmet_5236(vioA)
BMA: BMA2877
BMV: BMASAVP1_A3452
BML: BMA10229_A1667
BMN: BMA10247_3098
BMAZ: BM44_262
BMAL: DM55_916
BMAE: DM78_805
BMAQ: DM76_893
BMAI: DM57_1630
BMAF: DM51_2494
BMAB: BM45_3026
BPS: BPSL3323
BPM: BURPS1710b_0095(vioA)
BPL: BURPS1106A_3956
BPD: BURPS668_3874
BPR: GBP346_A4061
BPSE: BDL_2052
BPSM: BBQ_3510
BPSU: BBN_96
BPSD: BBX_444
BPZ: BP1026B_I3559
BPQ: BPC006_I3997
BPK: BBK_1541
BPSH: DR55_1178
BPSA: BBU_2216
BPSO: X996_791
BUT: X994_2810
BSAV: WS86_01370
BCM: Bcenmc03_0219
BCH: Bcen2424_0237
BCJ: BCAL0110
BCEO: I35_0117
BMK: DM80_1540
BMUL: NP80_280
BCED: DM42_1591
BCEP: APZ15_04740
BPYR: ABD05_06810
BSTL: BBJ41_10350
BARI: NLX30_00910(vioA)
BGL: bglu_1g01670
BGU: KS03_1082
BGD: bgla_1g01800
BGO: BM43_1576
BYI: BYI23_A001000
BGP: BGL_1c01430
BPLA: bpln_1g01440
BURT: BTHE68_01050
BXE: Bxe_A0099 Bxe_A3719
BXB: DR64_1407 DR64_2274
BPX: BUPH_03788
BPY: Bphyt_3836
BFN: OI25_1588
PARB: CJU94_05880
PTS: CUJ90_17635
PDIO: PDMSB3_4262(vioA)
PBRY: NDK50_20380(vioA)
PKF: RW095_34655
PAPI: SG18_07890
CABK: NK8_01070(vioA)
BUE: BRPE67_ACDS01080
TVL: FAZ95_00235
PARK: LSG25_05110
RHY: RD110_04345
RHF: EUB48_18920
RHG: EXZ61_05640
RHOA: HZ993_12150
RLH: MIZ03_3793
RHOF: AB3G31_06830(vioA)
POS: DT070_07685
POO: F7R28_01735
VBO: CKY39_03805
CAQT: KAQ61_18330
JAG: GJA_1947
JAZ: YQ44_15035
JAL: BZG29_12855
JSV: CNX70_13255
JAS: FJQ89_01865
JLV: G3257_13390
JAH: JAB4_027320(vioA_1)
JAE: OPV09_12970
MNR: ACZ75_03140
MENY: LSQ66_03930
MPLI: E1742_05400
DUG: HH213_04860
UNY: UNDYM_4038
NOK: FAY22_13335
TSW: VA613_13155
MPAU: ZMTM_15060
SLT: Slit_0603
FAM: OYT1_ch0387
DEY: HYN24_10250
FLE: KI610_04150
APP: CAP2UW1_0846
RET: RHE_CH01517
REC: RHECIAT_CH0001587
REL: REMIM1_CH01532
RLB: RLEG3_16760
RGA: RGR602_CH01758
RPHA: AMC79_CH01542
RHK: Kim5_CH01646
RBQ: J2J99_07805
RSUL: N2599_09455
RCT: PYR68_05895
RBW: RLCC275e_06425
RIF: U5G49_001713 U5G49_006971
SEOH: ACMUJL_04670
MAES: Ga0123461_1879
DPS: DP0043
RLC: K227x_19190(vioA)
PRS: B9H02_08770
AG: AAD44154(vioA) AAR97958(vioA)
 » show all
Reference
PMID:17905981
  Authors
Wang Y, Xu Y, Perepelov AV, Qi Y, Knirel YA, Wang L, Feng L
  Title
Biochemical characterization of dTDP-D-Qui4N and dTDP-D-Qui4NAc biosynthetic pathways in Shigella dysenteriae type 7 and Escherichia coli O7.
  Journal
J Bacteriol 189:8626-35 (2007)
DOI:10.1128/JB.00777-07
  Sequence
[ag:AAD44154 AAR97958]
LinkDB

KEGG   ENZYME: 2.6.1.33
Entry
EC 2.6.1.33                 Enzyme                                 
Name
dTDP-4-amino-4,6-dideoxy-D-glucose transaminase;
thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase;
thymidine diphospho-4-amino-6-deoxyglucose aminotransferase;
thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase;
thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase;
TDP-4-keto-6-deoxy-D-glucose transaminase;
VioA;
dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
dTDP-4-amino-4,6-dideoxy-alpha-D-glucose:2-oxoglutarate aminotransferase
Reaction(IUBMB)
dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate [RN:R02773]
Reaction(KEGG)
R02773;
(other) R02772
Substrate
dTDP-4-amino-4,6-dideoxy-alpha-D-glucose [CPD:C04268];
2-oxoglutarate [CPD:C00026]
Product
dTDP-4-dehydro-6-deoxy-alpha-D-glucose [CPD:C11907];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein.
History
EC 2.6.1.33 created 1972
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec00525  Acarbose and validamycin biosynthesis
ec00541  Biosynthesis of various nucleotide sugars
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13308  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
K20428  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
K20429  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
K21328  dTDP-4-amino-4,6-dideoxy-D-glucose/dTDP-4-amino-2,4-dideoxy-beta-L-xylose transaminase
Genes
ECT: ECIAI39_0979(vioA)
EOC: CE10_2353(vioA)
EBR: ECB_01942(vioA)
ECOB: C3029_14350
EBL: ECD_01942(vioA)
EBE: B21_01931(ybl97)
EBD: ECBD_1619
SHQ: A0259_14015
ESH: C1N69_14925
PDZ: HHA33_11055
TOE: QMG90_13825
EBB: F652_1773
SMAF: D781_3917
SERT: TAN611_4078(vioA)
PCV: BCS7_12855
PPEU: DUT67_21235
PAY: PAU_04327(vioA)
HAV: AT03_13955
HPAR: AL518_12410
PFUW: KF707C_17310
PFV: Psefu_4173
PSV: PVLB_06575
PKC: PKB_2543(arnb1)
PFZ: AV641_08190
PSEJ: HNQ25_14985
PWY: HU734_007720
PSSX: DCC84_09200
AJO: RZ95_16600
ATG: J4G44_00260
ABOU: ACBO_05730
MBAH: HYN46_11415
SHE: Shewmr4_1321
SHW: Sputw3181_1468
SCHK: GII14_07745
THAT: H3N35_23260
TVD: SG34_025420
PAEW: KIH87_05075
CJA: CJA_3257
MEEP: JWZ98_14515
MEEC: PL263_06500
MLAU: ACEPPP_06495(vioA)
TSJ: L3K52_17760(vioA)
NWR: E3U44_08215
THIP: N838_01675
THIM: KFB96_06625
HHU: AR456_16635
HASO: B2G49_21050
HABD: OM794_18145
SAJS: QO259_09020
MARS: A8C75_04390
MRZ: KDW95_11735
AHI: VU14_07300
ASAA: KXJ75_15915(vioA)
CHIC: N8I74_14320(vioA)
RME: Rmet_5236(vioA)
BMA: BMA2877
BMV: BMASAVP1_A3452
BML: BMA10229_A1667
BMN: BMA10247_3098
BMAZ: BM44_262
BMAL: DM55_916
BMAE: DM78_805
BMAQ: DM76_893
BMAI: DM57_1630
BMAF: DM51_2494
BMAB: BM45_3026
BPS: BPSL3323
BPM: BURPS1710b_0095(vioA)
BPL: BURPS1106A_3956
BPD: BURPS668_3874
BPR: GBP346_A4061
BPSE: BDL_2052
BPSM: BBQ_3510
BPSU: BBN_96
BPSD: BBX_444
BPZ: BP1026B_I3559
BPQ: BPC006_I3997
BPK: BBK_1541
BPSH: DR55_1178
BPSA: BBU_2216
BPSO: X996_791
BUT: X994_2810
BSAV: WS86_01370
BCM: Bcenmc03_0219
BCH: Bcen2424_0237
BCJ: BCAL0110
BCEO: I35_0117
BMK: DM80_1540
BMUL: NP80_280
BCED: DM42_1591
BCEP: APZ15_04740
BPYR: ABD05_06810
BSTL: BBJ41_10350
BARI: NLX30_00910(vioA)
BGL: bglu_1g01670
BGU: KS03_1082
BGD: bgla_1g01800
BGO: BM43_1576
BYI: BYI23_A001000
BGP: BGL_1c01430
BPLA: bpln_1g01440
BURT: BTHE68_01050
BXE: Bxe_A0099 Bxe_A3719
BXB: DR64_1407 DR64_2274
BPX: BUPH_03788
BPY: Bphyt_3836
BFN: OI25_1588
PARB: CJU94_05880
PTS: CUJ90_17635
PDIO: PDMSB3_4262(vioA)
PBRY: NDK50_20380(vioA)
PKF: RW095_34655
PAPI: SG18_07890
CABK: NK8_01070(vioA)
BUE: BRPE67_ACDS01080
TVL: FAZ95_00235
PARK: LSG25_05110
RHY: RD110_04345
RHF: EUB48_18920
RHG: EXZ61_05640
RHOA: HZ993_12150
RLH: MIZ03_3793
RHOF: AB3G31_06830(vioA)
POS: DT070_07685
POO: F7R28_01735
VBO: CKY39_03805
CAQT: KAQ61_18330
JAG: GJA_1947
JAZ: YQ44_15035
JAL: BZG29_12855
JSV: CNX70_13255
JAS: FJQ89_01865
JLV: G3257_13390
JAH: JAB4_027320(vioA_1)
JAE: OPV09_12970
MNR: ACZ75_03140
MENY: LSQ66_03930
MPLI: E1742_05400
DUG: HH213_04860
UNY: UNDYM_4038
NOK: FAY22_13335
TSW: VA613_13155
MPAU: ZMTM_15060
SLT: Slit_0603
FAM: OYT1_ch0387
DEY: HYN24_10250
FLE: KI610_04150
APP: CAP2UW1_0846
RET: RHE_CH01517
REC: RHECIAT_CH0001587
REL: REMIM1_CH01532
RLB: RLEG3_16760
RGA: RGR602_CH01758
RPHA: AMC79_CH01542
RHK: Kim5_CH01646
RBQ: J2J99_07805
RSUL: N2599_09455
RCT: PYR68_05895
RBW: RLCC275e_06425
RIF: U5G49_001713 U5G49_006971
SEOH: ACMUJL_04670
MAES: Ga0123461_1879
DPS: DP0043
SUR: STAUR_1378(gacV)
RLC: K227x_19190(vioA)
PRS: B9H02_08770
SCYE: R2B67_24620
SGU: SGLAU_00985(gacV)
STRE: GZL_03714
SXI: SXIM_35940
STRM: M444_29855
SCAD: DN051_13755
SNR: SNOUR_10120(eryCIV)
SSIA: A7J05_03450
SRJ: SRO_6644
SSPO: DDQ41_30825
SGF: HEP81_06987 HEP81_07915
SPAC: B1H29_04375
SGX: H4W23_25490
SATA: C5746_38530
SROI: IAG44_16020
SHK: J2N69_01045
SGK: PET44_28275
SYUN: MOV08_16445
SCAT: P8A18_33700
STRJ: H7827_09970
STRH: GXP74_26620
AER: AERYTH_15840
ACIR: OG979_40450
AWS: ACN3XK_69380
SEN: SACE_0716(eryCIV)
AMOG: QRX60_49190
KAL: KALB_4714 KALB_6578(acuN2)
STP: Strop_2221
SAQ: Sare_2034 Sare_2945
MCAB: HXZ27_06180(rosQ)
ASE: ACPL_3667(acbV)
ACTS: ACWT_3539
PRY: Prubr_33310
AEY: CDG81_13210
 » show all
Reference
1  [PMID:5332731]
  Authors
Matsuhashi M, Strominger JL.
  Title
Thymidine diphosphate 4-acetamido-2,6-dideoxyhexoses. 3. Purification and properties of thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase from Escherichia coli strain B.
  Journal
J Biol Chem 241:4738-44 (1966)
Reference
2  [PMID:17905981]
  Authors
Wang Y, Xu Y, Perepelov AV, Qi Y, Knirel YA, Wang L, Feng L
  Title
Biochemical characterization of dTDP-D-Qui4N and dTDP-D-Qui4NAc biosynthetic pathways in Shigella dysenteriae type 7 and Escherichia coli O7.
  Journal
J Bacteriol 189:8626-35 (2007)
DOI:10.1128/JB.00777-07
  Sequence
[ag:AAD44154 AAR97958]
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.33
IUBMB Enzyme Nomenclature: 2.6.1.33
ExPASy - ENZYME nomenclature database: 2.6.1.33
BRENDA, the Enzyme Database: 2.6.1.33
CAS: 9023-19-2
LinkDB

KEGG   REACTION: R02773
Entry
R02773                      Reaction                               
Name
dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase
Definition
dTDP-4-amino-4,6-dideoxy-D-glucose + 2-Oxoglutarate <=> dTDP-4-oxo-6-deoxy-D-glucose + L-Glutamate
Equation
C04268 + C00026 <=> C11907 + C00025
Reaction class
RC00006  C00025_C00026
RC00781  C04268_C11907
Enzyme
2.6.1.33
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn00525  Acarbose and validamycin biosynthesis
rn00541  Biosynthesis of various nucleotide sugars
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01250  Biosynthesis of nucleotide sugars
Module
M00797  dTDP-D-desosamine biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.33
     R02773  dTDP-4-amino-4,6-dideoxy-D-glucose + 2-Oxoglutarate <=> dTDP-4-oxo-6-deoxy-D-glucose + L-Glutamate
Orthology
K13308  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33]
K20428  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33]
K20429  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33]
K21328  dTDP-4-amino-4,6-dideoxy-D-glucose/dTDP-4-amino-2,4-dideoxy-beta-L-xylose transaminase [EC:2.6.1.33 2.6.1.-]
Other DBs
RHEA: 19088
LinkDB

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