KEGG   ORTHOLOGY: K20429
Entry
K20429                      KO                                     
Symbol
vioA
Name
dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33]
Pathway
map00541  O-Antigen nucleotide sugar biosynthesis
map01100  Metabolic pathways
map01250  Biosynthesis of nucleotide sugars
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00541 O-Antigen nucleotide sugar biosynthesis
    K20429  vioA; dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.33  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
     K20429  vioA; dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
Other DBs
RN: R02773
COG: COG0399
GO: 0019179
Genes
ECT: ECIAI39_0979(vioA)
EOC: CE10_2353(vioA)
EBR: ECB_01942(vioA)
EBL: ECD_01942(vioA)
EBE: B21_01931(ybl97)
EBD: ECBD_1619
SHQ: A0259_14015
ESH: C1N69_14925
PDZ: HHA33_11055
PAY: PAU_04327(vioA)
AG: AAD44154(vioA) AAR97958(vioA)
 » show all
Reference
  Authors
Wang Y, Xu Y, Perepelov AV, Qi Y, Knirel YA, Wang L, Feng L
  Title
Biochemical characterization of dTDP-D-Qui4N and dTDP-D-Qui4NAc biosynthetic pathways in Shigella dysenteriae type 7 and Escherichia coli O7.
  Journal
J Bacteriol 189:8626-35 (2007)
DOI:10.1128/JB.00777-07
  Sequence
LinkDB

KEGG   ENZYME: 2.6.1.33
Entry
EC 2.6.1.33                 Enzyme                                 
Name
dTDP-4-amino-4,6-dideoxy-D-glucose transaminase;
thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase;
thymidine diphospho-4-amino-6-deoxyglucose aminotransferase;
thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase;
thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase;
TDP-4-keto-6-deoxy-D-glucose transaminase;
VioA;
dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
dTDP-4-amino-4,6-dideoxy-alpha-D-glucose:2-oxoglutarate aminotransferase
Reaction(IUBMB)
dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate [RN:R02773]
Reaction(KEGG)
R02773;
(other) R02772
Substrate
dTDP-4-amino-4,6-dideoxy-alpha-D-glucose [CPD:C04268];
2-oxoglutarate [CPD:C00026]
Product
dTDP-4-dehydro-6-deoxy-alpha-D-glucose [CPD:C11907];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein.
History
EC 2.6.1.33 created 1972
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec00525  Acarbose and validamycin biosynthesis
ec00541  O-Antigen nucleotide sugar biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13308  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
K20428  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
K20429  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
K21328  dTDP-4-amino-4,6-dideoxy-D-glucose/dTDP-4-amino-2,4-dideoxy-beta-L-xylose transaminase
Genes
ECTECIAI39_0979(vioA)
EOCCE10_2353(vioA)
EBRECB_01942(vioA)
EBLECD_01942(vioA)
EBEB21_01931(ybl97)
EBDECBD_1619
SHQA0259_14015
ESHC1N69_14925
PDZHHA33_11055
PAYPAU_04327(vioA)
HAVAT03_13955
SHEShewmr4_1321
SHWSputw3181_1468
PAEWKIH87_05075
CJACJA_3257
AHIVU14_07300
SURSTAUR_1378(gacV)
CSUAIM538_21580 IM538_21585
SGUSGLAU_00985(gacV)
STREGZL_03714
SXISXIM_35940
STRMM444_29855
SCADDN051_13755
SNRSNOUR_10120(eryCIV)
SGFHEP81_07915
SGXH4W23_25490
SATAC5746_38530
SROIIAG44_16020
SHKJ2N69_01045
AERAERYTH_15840
SENSACE_0716(eryCIV)
KALKALB_4714 KALB_6578(acuN2)
STPStrop_2221
SAQSare_2034 Sare_2945
MCABHXZ27_06180(rosQ)
ASEACPL_3667(acbV)
AEYCDG81_13210
HMTMTP16_12000
MOXDAMO_2610
 » show all
Reference
1  [PMID:5332731]
  Authors
Matsuhashi M, Strominger JL.
  Title
Thymidine diphosphate 4-acetamido-2,6-dideoxyhexoses. 3. Purification and properties of thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase from Escherichia coli strain B.
  Journal
J Biol Chem 241:4738-44 (1966)
Reference
2  [PMID:17905981]
  Authors
Wang Y, Xu Y, Perepelov AV, Qi Y, Knirel YA, Wang L, Feng L
  Title
Biochemical characterization of dTDP-D-Qui4N and dTDP-D-Qui4NAc biosynthetic pathways in Shigella dysenteriae type 7 and Escherichia coli O7.
  Journal
J Bacteriol 189:8626-35 (2007)
DOI:10.1128/JB.00777-07
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.33
IUBMB Enzyme Nomenclature: 2.6.1.33
ExPASy - ENZYME nomenclature database: 2.6.1.33
BRENDA, the Enzyme Database: 2.6.1.33
CAS: 9023-19-2
LinkDB

KEGG   REACTION: R02773
Entry
R02773                      Reaction                               
Name
dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase
Definition
dTDP-4-amino-4,6-dideoxy-D-glucose + 2-Oxoglutarate <=> dTDP-4-oxo-6-deoxy-D-glucose + L-Glutamate
Equation
Reaction class
RC00006  C00025_C00026
RC00781  C04268_C11907
Enzyme
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn00525  Acarbose and validamycin biosynthesis
rn00541  O-Antigen nucleotide sugar biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01250  Biosynthesis of nucleotide sugars
Module
M00797  dTDP-D-desosamine biosynthesis
Orthology
K13308  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33]
K20428  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33]
K20429  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33]
K21328  dTDP-4-amino-4,6-dideoxy-D-glucose/dTDP-4-amino-2,4-dideoxy-beta-L-xylose transaminase [EC:2.6.1.33 2.6.1.-]
Other DBs
RHEA: 19088
LinkDB

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