KEGG   ORTHOLOGY: K20571
Entry
K20571            Tight     KO                                     
Symbol
kanC
Name
dehydrogenase [EC:1.1.1.-]
Pathway
map00524  Neomycin, kanamycin and gentamicin biosynthesis
map01110  Biosynthesis of secondary metabolites
map01250  Biosynthesis of nucleotide sugars
Reaction
R06594  UDP-glucose:NAD+ 3-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K20571  kanC; dehydrogenase
Other DBs
COG: COG0673
Genes
SKA: CP970_06675
AG: CAE46940(kanC)
Reference
  Authors
Kharel MK, Subba B, Basnet DB, Woo JS, Lee HC, Liou K, Sohng JK
  Title
A gene cluster for biosynthesis of kanamycin from Streptomyces kanamyceticus: comparison with gentamicin biosynthetic gene cluster.
  Journal
Arch Biochem Biophys 429:204-14 (2004)
DOI:10.1016/j.abb.2004.06.009
  Sequence
Reference
  Authors
Park JW, Park SR, Nepal KK, Han AR, Ban YH, Yoo YJ, Kim EJ, Kim EM, Kim D, Sohng JK, Yoon YJ
  Title
Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation.
  Journal
Nat Chem Biol 7:843-52 (2011)
DOI:10.1038/nchembio.671
LinkDB

KEGG   REACTION: R06594
Entry
R06594                      Reaction                               
Name
UDP-glucose:NAD+ 3-oxidoreductase
Definition
UDP-glucose + NAD+ <=> UDP-3-ketoglucose + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00182  C00029_C12210
Enzyme
1.1.1.-
Pathway
rn00524  Neomycin, kanamycin and gentamicin biosynthesis
rn01051  Biosynthesis of ansamycins
rn01110  Biosynthesis of secondary metabolites
rn01250  Biosynthesis of nucleotide sugars
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-
     R06594  UDP-glucose + NAD+ <=> UDP-3-ketoglucose + NADH + H+
Orthology
K16015  oxidoreductase [EC:1.1.1.-]
K20571  dehydrogenase [EC:1.1.1.-]
Other DBs
RHEA: 35758
LinkDB

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