KEGG   ORTHOLOGY: K20680
Entry
K20680            Tight     KO                                     
Symbol
fdtB
Name
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase [EC:2.6.1.90]
Pathway
map00523  Polyketide sugar unit biosynthesis
map00541  O-Antigen nucleotide sugar biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01250  Biosynthesis of nucleotide sugars
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00541 O-Antigen nucleotide sugar biosynthesis
    K20680  fdtB; dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K20680  fdtB; dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.90  dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase
     K20680  fdtB; dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase
Other DBs
RN: R09824
COG: COG0399
Genes
AG: AAS55722(fdtB)
Reference
PMID:12740380
  Authors
Pfoestl A, Hofinger A, Kosma P, Messner P
  Title
Biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose in Aneurinibacillus thermoaerophilus L420-91T.
  Journal
J Biol Chem 278:26410-7 (2003)
DOI:10.1074/jbc.M300858200
  Sequence
[ag:AAS55722]
LinkDB

KEGG   ENZYME: 2.6.1.90
Entry
EC 2.6.1.90                 Enzyme                                 
Name
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase;
dTDP-6-deoxy-D-xylohex-3-uloseaminase;
FdtB;
TDP-3-keto-6-deoxy-D-galactose-3-aminotransferase;
RavAMT;
TDP-3-keto-6-deoxy-D-galactose 3-aminotransferase;
TDP-3-dehydro-6-deoxy-D-galactose 3-aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose:2-oxoglutarate aminotransferase
Reaction(IUBMB)
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2-oxoglutarate = dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose + L-glutamate [RN:R09824]
Reaction(KEGG)
R09824
Substrate
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose [CPD:C19947];
2-oxoglutarate [CPD:C00026]
Product
dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose [CPD:C19960];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. The enzyme is involved in the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose. The reaction occurs in the reverse direction.
History
EC 2.6.1.90 created 2011
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec00541  O-Antigen nucleotide sugar biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K20680  dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase
Reference
1  [PMID:12740380]
  Authors
Pfoestl A, Hofinger A, Kosma P, Messner P
  Title
Biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose in Aneurinibacillus thermoaerophilus L420-91T.
  Journal
J Biol Chem 278:26410-7 (2003)
DOI:10.1074/jbc.M300858200
  Sequence
[ag:AAS55722]
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.90
IUBMB Enzyme Nomenclature: 2.6.1.90
ExPASy - ENZYME nomenclature database: 2.6.1.90
BRENDA, the Enzyme Database: 2.6.1.90
LinkDB

KEGG   REACTION: R09824
Entry
R09824                      Reaction                               
Name
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose:2-oxoglutarate aminotransferase
Definition
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2-Oxoglutarate <=> dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose + L-Glutamate
Equation
C19947 + C00026 <=> C19960 + C00025
Reaction class
RC00006  C00025_C00026
RC00781  C19947_C19960
Enzyme
2.6.1.90
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn00541  O-Antigen nucleotide sugar biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01250  Biosynthesis of nucleotide sugars
Orthology
K20680  dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase [EC:2.6.1.90]
Other DBs
RHEA: 31622
LinkDB

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