KEGG   ORTHOLOGY: K20680
Entry
K20680            Tight     KO                                     
Symbol
fdtB
Name
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase [EC:2.6.1.90]
Pathway
map00523  Polyketide sugar unit biosynthesis
map00541  Biosynthesis of various nucleotide sugars
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01250  Biosynthesis of nucleotide sugars
Reaction
R09824  dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose:2-oxoglutarate aminotransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00541 Biosynthesis of various nucleotide sugars
    K20680  fdtB; dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K20680  fdtB; dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.90  dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase
     K20680  fdtB; dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase
Other DBs
COG: COG0399
Genes
AG: AAS55722(fdtB)
Reference
PMID:12740380
  Authors
Pfoestl A, Hofinger A, Kosma P, Messner P
  Title
Biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose in Aneurinibacillus thermoaerophilus L420-91T.
  Journal
J Biol Chem 278:26410-7 (2003)
DOI:10.1074/jbc.M300858200
  Sequence
[ag:AAS55722]
LinkDB

KEGG   ENZYME: 2.6.1.90
Entry
EC 2.6.1.90                 Enzyme                                 
Name
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase;
dTDP-6-deoxy-D-xylohex-3-uloseaminase;
FdtB;
TDP-3-keto-6-deoxy-D-galactose-3-aminotransferase;
RavAMT;
TDP-3-keto-6-deoxy-D-galactose 3-aminotransferase;
TDP-3-dehydro-6-deoxy-D-galactose 3-aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose:2-oxoglutarate aminotransferase
Reaction(IUBMB)
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2-oxoglutarate = dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose + L-glutamate [RN:R09824]
Reaction(KEGG)
R09824
Substrate
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose [CPD:C19947];
2-oxoglutarate [CPD:C00026]
Product
dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose [CPD:C19960];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. The enzyme is involved in the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose. The reaction occurs in the reverse direction.
History
EC 2.6.1.90 created 2011
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec00541  Biosynthesis of various nucleotide sugars
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K20680  dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase
Reference
1  [PMID:12740380]
  Authors
Pfoestl A, Hofinger A, Kosma P, Messner P
  Title
Biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose in Aneurinibacillus thermoaerophilus L420-91T.
  Journal
J Biol Chem 278:26410-7 (2003)
DOI:10.1074/jbc.M300858200
  Sequence
[ag:AAS55722]
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.90
IUBMB Enzyme Nomenclature: 2.6.1.90
ExPASy - ENZYME nomenclature database: 2.6.1.90
BRENDA, the Enzyme Database: 2.6.1.90
LinkDB

KEGG   REACTION: R09824
Entry
R09824                      Reaction                               
Name
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose:2-oxoglutarate aminotransferase
Definition
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2-Oxoglutarate <=> dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose + L-Glutamate
Equation
C19947 + C00026 <=> C19960 + C00025
Reaction class
RC00006  C00025_C00026
RC00781  C19947_C19960
Enzyme
2.6.1.90
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn00541  Biosynthesis of various nucleotide sugars
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01250  Biosynthesis of nucleotide sugars
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.90
     R09824  dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2-Oxoglutarate <=> dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose + L-Glutamate
Orthology
K20680  dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase [EC:2.6.1.90]
Other DBs
RHEA: 31622
LinkDB

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