KEGG   ORTHOLOGY: K20859
Entry
K20859                      KO                                     
Symbol
phnPP
Name
phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase [EC:3.1.4.57]
Pathway
map00440  Phosphonate and phosphinate metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00440 Phosphonate and phosphinate metabolism
    K20859  phnPP; phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.57  phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase
     K20859  phnPP; phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase
Other DBs
RN: R10972 R10973
COG: COG0613
Genes
PMR: PMI2225
PMIB: BB2000_2358
PVL: AOB99_13045
ORB: IPMB12_08225
BON: A361_16710
BKO: CKF48_11535
OIH: OB0975
OCN: CUC15_18900
OCB: CV093_20380
LGY: T479_13155
BTS: Btus_3094
EMU: EMQU_2192
CBA: CLB_0694
CBH: CLC_0709
CBY: CLM_0769
CBL: CLK_0057
CBB: CLD_0101
CBI: CLJ_B0727
CBF: CLI_0732
CBM: CBF_0700
ESR: ES1_20910
ESU: EUS_09310
CCEL: CCDG5_0088
RCH: RUM_21690
FPR: FP2_18910
PDC: CDIF630_03845(phnPP)
APR: Apre_0404
ELE: Elen_0235
AEQ: AEQU_1669
 » show all
Reference
  Authors
Ghodge SV, Cummings JA, Williams HJ, Raushel FM
  Title
Discovery of a cyclic phosphodiesterase that catalyzes the sequential hydrolysis of both ester bonds to phosphorus.
  Journal
J Am Chem Soc 135:16360-3 (2013)
DOI:10.1021/ja409376k
  Sequence
[ele:Elen_0235]
LinkDB

KEGG   ENZYME: 3.1.4.57
Entry
EC 3.1.4.57                 Enzyme                                 
Name
phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase;
cyclic phosphate dihydrolase;
phnPP (gene name)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
Sysname
5-phospho-alpha-D-ribose 1,2-cyclic phosphate 1,2-diphosphophosphohydrolase
Reaction(IUBMB)
(1) 5-phospho-alpha-D-ribose 1,2-cyclic phosphate + H2O = D-ribofuranose 2,5-bisphosphate [RN:R10972];
(2) D-ribofuranose 2,5-bisphosphate + H2O = D-ribofuranose 5-phosphate + phosphate [RN:R10973]
Reaction(KEGG)
R10972 R10973
Substrate
5-phospho-alpha-D-ribose 1,2-cyclic phosphate [CPD:C20440];
H2O [CPD:C00001];
D-ribofuranose 2,5-bisphosphate
Product
D-ribofuranose 2,5-bisphosphate;
D-ribofuranose 5-phosphate;
phosphate [CPD:C00009]
Comment
The enzyme, characterized from the bacterium Eggerthella lenta, is involed in degradation of methylphosphonate.
History
EC 3.1.4.57 created 2014
Pathway
ec00440  Phosphonate and phosphinate metabolism
Orthology
K20859  phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase
Genes
PMRPMI2225
PMIBBB2000_2358
PVLAOB99_13045
ORBIPMB12_08225
BONA361_16710
BKOCKF48_11535
OIHOB0975
OCNCUC15_18900
OCBCV093_20380
LGYT479_13155
VHLBME96_18175
VIGBKP57_09550
VNECFK40_19470
VPNA21D_01679
VPTKBP50_21000
LAOAOX59_16425
GRCGI584_22750
MEKUHUW50_12535
MSEMGMB29_03820
MDGK8L98_07815
STEAC0679_00925
SHVAAT16_04630
JEAJEM45_10180
BCHSJNE38_07990
PTAHPL003_21630
PVOPVOR_21494
PPSCEHS13_07605
PLYCGXP70_25175
COHNKCTCHS21_53240
BTSBtus_3094
KYRCVV65_15305
EFFskT53_05480
PKUAUO94_01265
PANABBH88_04250
PFAEAJGP001_16440
NTRB0W44_15275
EFTM395_05000
EMUEMQU_2192
VPIBW732_08205
CRNCAR_c04960
CBACLB_0694
CBHCLC_0709
CBYCLM_0769
CBLCLK_0057
CBBCLD_0101
CBICLJ_B0727
CBFCLI_0732
CBMCBF_0700
CBJH04402_00728
CPASClopa_3535 Clopa_4267
CPATCLPA_c34290
CPAECPAST_c34290
CLDCLSPO_c06830
FSAC5Q98_00455
RUKA4V00_03930
RBPB6259_05855
ESRES1_20910
ESUEUS_09310
CCELCCDG5_0088
EHAEthha_2741
RALRumal_0453
RCHRUM_21690
RUSRBI_I01096
FPRFP2_18910
FPRACG447_02550
CAPREQM14_08565
CAMLH6X83_07695
CLFGJQ69_04680
SMANC12CBH8_01850
CFEMHCR03_01790
ACOLK5I23_14945
ARFAR1Y2_3080
ACACEYQ97_02465
CDFCD630_35310
PDCCDIF630_03845(phnPP)
CDCCD196_3320
CDLCDR20291_3366
PDFCD630DERM_35310
FAAHMPREF0389_01627
DAIDesaci_1741
TFRBR63_00785
FWADCMF_19485
APRApre_0404
PFACPFJ30894_00322
AARGAargi30884_26100
ABSIA9CBEGH2_23420
CIUG4D55_14195
ERMEYR00_04625
ERBA4V01_17290
TURAT726_10395
TSGHLK68_10410
ELEElen_0235
EGDGS424_001325
AEQAEQU_1669
RTSCE91St31_31500
 » show all
Reference
1  [PMID:24147537]
  Authors
Ghodge SV, Cummings JA, Williams HJ, Raushel FM
  Title
Discovery of a cyclic phosphodiesterase that catalyzes the sequential hydrolysis of both ester bonds to phosphorus.
  Journal
J Am Chem Soc 135:16360-3 (2013)
DOI:10.1021/ja409376k
  Sequence
[ele:Elen_0235]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.4.57
IUBMB Enzyme Nomenclature: 3.1.4.57
ExPASy - ENZYME nomenclature database: 3.1.4.57
BRENDA, the Enzyme Database: 3.1.4.57
LinkDB

KEGG   REACTION: R10972
Entry
R10972                      Reaction                               
Name
5-phospho-alpha-D-ribose 1,2-cyclic phosphate 1-phosphohydrolase (D-ribose 2,5-bisphosphate-forming)
Definition
alpha-D-Ribose 1,2-cyclic phosphate 5-phosphate + H2O <=> D-Ribose 2,5-bisphosphate
Equation
Reaction class
RC00296  C20440_C20986
Enzyme
Pathway
rn00440  Phosphonate and phosphinate metabolism
Orthology
K20859  phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase [EC:3.1.4.57]
LinkDB

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