KEGG   ORTHOLOGY: K21202
Entry
K21202            Tight     KO                                     
Symbol
2-ODD
Name
(-)-deoxypodophyllotoxin synthase [EC:1.14.20.8]
Pathway
map00999  Biosynthesis of various plant secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00902  Podophyllotoxin biosynthesis, coniferyl alcohol => podophyllotoxin
Reaction
R11210  (-)-yatein,2-oxoglutarate:oxygen oxidoreductase (ring-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00999 Biosynthesis of various plant secondary metabolites
    K21202  2-ODD; (-)-deoxypodophyllotoxin synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.20  With 2-oxoglutarate as one donor, and the other dehydrogenated
    1.14.20.8  (-)-deoxypodophyllotoxin synthase
     K21202  2-ODD; (-)-deoxypodophyllotoxin synthase
Genes
AG: ALG05135(2-ODD)
Reference
PMID:26359402
  Authors
Lau W, Sattely ES
  Title
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.
  Journal
Science 349:1224-8 (2015)
DOI:10.1126/science.aac7202
  Sequence
[ag:ALG05135]
LinkDB

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