KEGG ENZYME: 1.14.20.8

ENZYME: 1.14.20.8

Entry

EC 1.14.20.8                Enzyme

Name

(-)-deoxypodophyllotoxin synthase;
2-ODD (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and the other dehydrogenated

Sysname

(-)-yatein,2-oxoglutarate:oxygen oxidoreductase (ring-forming)

Reaction(IUBMB)

(-)-yatein + 2-oxoglutarate + O2 = (-)-deoxypodophyllotoxin + succinate + CO2 + H2O [RN:R11210]

Reaction(KEGG)

R11210

Substrate

(-)-yatein [CPD:C10557];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]

Product

(-)-deoxypodophyllotoxin [CPD:C10556];
succinate [CPD:C00042];
CO2 [CPD:C00011];
H2O [CPD:C00001]

Comment

The enzyme, characterized from the plant Sinopodophyllum hexandrum (mayapple), is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs. It catalyses the closure of the central six-membered ring in the aryltetralin scaffold.

History

EC 1.14.20.8 created 2016 as EC 1.14.11.50, transferred 2018 to EC 1.14.20.8

Pathway

ec00999

Biosynthesis of various plant secondary metabolites

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K21202

(-)-deoxypodophyllotoxin synthase