KEGG ORTHOLOGY: K21278

ORTHOLOGY: K21278

Entry

K21278                      KO

Symbol

DUSP1

Name

dual specificity protein phosphatase 1 [EC:3.1.3.16 3.1.3.48]

Pathway

map04010

MAPK signaling pathway

map04726

Serotonergic synapse

map05012

Parkinson disease

map05418

Fluid shear stress and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K21278  DUSP1; dual specificity protein phosphatase 1
09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K21278  DUSP1; dual specificity protein phosphatase 1
09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K21278  DUSP1; dual specificity protein phosphatase 1
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K21278  DUSP1; dual specificity protein phosphatase 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K21278  DUSP1; dual specificity protein phosphatase 1
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     K21278  DUSP1; dual specificity protein phosphatase 1
    3.1.3.48  protein-tyrosine-phosphatase
     K21278  DUSP1; dual specificity protein phosphatase 1
Protein phosphatases and associated proteins [BR:ko01009]
Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   MAPK phosphatases
    K21278  DUSP1; dual specificity protein phosphatase 1

Other DBs

GO:	0017017 0004725

Genes

HSA:	1843(DUSP1)

PTR:	471742(DUSP1)

PPS:	100978783(DUSP1)

GGO:	101145560(DUSP1)

PON:	100435862(DUSP1)

PPYG:

129036959(DUSP1)

NLE:	100591464(DUSP1)

HMH:	116471853(DUSP1)

SSYN:

129486007(DUSP1)

MCC:	702981(DUSP1)

MCF:	102116284(DUSP1)

MTHB:

126956345

MNI:	105480878(DUSP1)

CSAB:

103244980(DUSP1)

CATY:

105581659(DUSP1)

PANU:

100997568(DUSP1)

TGE:	112625873(DUSP1)

MLEU:

105544972(DUSP1)

RRO:	104670131(DUSP1)

RBB:	108520017(DUSP1)

TFN:	117065462(DUSP1)

PTEH:

111547221(DUSP1)

CANG:

105515851(DUSP1)

CJC:	100393730(DUSP1)

SBQ:	101043469(DUSP1)

CIMI:

108317308(DUSP1)

ANAN:

105723244(DUSP1)

CSYR:

103252868(DUSP1)

MMUR:

105871862(DUSP1)

LCAT:

123637948(DUSP1)

ERUF:

138393123(DUSP1)

PCOQ:

105814660(DUSP1)

OGA:	100945193(DUSP1)

MMU:	19252(Dusp1)

MCAL:

110312644(Dusp1)

MPAH:

110337954(Dusp1)

RNO:	114856(Dusp1)

MCOC:

116078286(Dusp1)

ANU:	117711593(Dusp1)

ASYL:

127694747(Dusp1)

MUN:	110547818(Dusp1)

CGE:	100769474(Dusp1)

MAUA:

101831197(Dusp1)

PROB:

127219450(Dusp1)

PLEU:

114709487(Dusp1)

PMAV:

102910983(Dusp1)

MORG:

121464047(Dusp1)

MFOT:

126498056

AAMP:

119812340(Dusp1)

CNL:	130878804(Dusp1)

NGI:	103748194(Dusp1)

HGL:	101701425(Dusp1)

CPOC:

100725668(Dusp1)

CCAN:

109694781(Dusp1)

DORD:

105985414(Dusp1)

DSP:	122099537(Dusp1)

DMER:

138820208(Dusp1) 138838860

PLOP:

125342070(Dusp1)

NCAR:

124987585

MMMA:

107147958(Dusp1)

ITI:	101966058(Dusp1)

OCU:

100340993

OPI:	101531665(DUSP1)

OCZ:	121151072(DUSP1)

TUP:	102481474(DUSP1)

GVR:	103595912(DUSP1)

CFA:	489117(DUSP1)

CLUD:

112651454(DUSP1)

VVP:	112926138(DUSP1)

VLG:	121488137(DUSP1)

NPO:	129509959(DUSP1)

AML:	100483084(DUSP1)

UMR:	103664491(DUSP1)

UAH:	113264095(DUSP1)

UAR:	123788597(DUSP1)

ELK:

111140958

LLV:

125100671

MPUF:

101693585(DUSP1)

MNP:	132028425(DUSP1)

MLK:	131831918(DUSP1)

NVS:	122892752(DUSP1)

ORO:	101376261(DUSP1)

EJU:	114208648(DUSP1)

ZCA:	113929802(DUSP1)

MLX:	118016761(DUSP1)

NSU:	110588080(DUSP1)

LWW:	102740993(DUSP1)

FCA:	101093416(DUSP1)

PYU:	121011080(DUSP1)

PCOO:

112861350(DUSP1)

PBG:	122492214(DUSP1)

PVIV:

125175007(DUSP1)

LRUF:

124520324

LGF:	123610544(DUSP1)

AJU:

106975373

PTG:	102960774(DUSP1)

PPAD:

109267510(DUSP1)

PUC:

125934994

PLEZ:

122224566(DUSP1)

HHV:	120234102(DUSP1)

BTA:	539175(DUSP1)

BOM:	102266766(DUSP1)

BIU:	109574921(DUSP1)

BBUB:

102410828(DUSP1)

BKE:	129632948(DUSP1)

BBIS:

104996902(DUSP1)

CHX:	102180080(DUSP1)

OAS:	101107632(DUSP1)

BTAX:

128065956(DUSP1)

CSUM:

138094336(DUSP1)

ODA:	120879670(DUSP1)

CCAD:

122454393(DUSP1)

MREE:

136146585(DUSP1)

OVR:	110148228(DUSP1)

MBEZ:

129553152(DUSP1)

SSC:	100522469(DUSP1)

CFR:	102505108(DUSP1)

CBAI:

105082649(DUSP1)

CDK:	105089401(DUSP1)

VPC:	102538892(DUSP1)

BACU:

103004641(DUSP1)

BMUS:

118893064(DUSP1)

LVE:	103073987(DUSP1)

OOR:	101278083(DUSP1)

LALB:

132517291(DUSP1)

GMF:	132597120(DUSP1)

DDP:	132423057(DUSP1)

DLE:	111185473(DUSP1)

PCAD:

102994142(DUSP1)

PSIU:

116751751(DUSP1)

PPHC:

136120493(DUSP1)

NASI:

112405122(DUSP1)

ECB:	100069834(DUSP1)

EPZ:	103542920(DUSP1)

EAI:	106837352(DUSP1)

MYB:	102264079(DUSP1)

MYD:	102760550(DUSP1)

MMYO:

118658302(DUSP1)

MLF:	102434907(DUSP1)

MDT:	132235968(DUSP1)

MYUM:

139010221(DUSP1)

PKL:	118711557(DUSP1)

EFUS:

103291549(DUSP1)

MNA:	107535716(DUSP1)

DRO:	112319677(DUSP1)

SHON:

118994956(DUSP1)

AJM:	119036235(DUSP1)

PDIC:

114510076(DUSP1)

PHAS:

123813204(DUSP1)

MMF:	118615867(DUSP1)

PPAM:

129066477(DUSP1)

HAI:	109379363(DUSP1)

RFQ:	117016981(DUSP1)

PALE:

102894546(DUSP1)

PGIG:

120615021(DUSP1)

PVP:	105299303(DUSP1)

RAY:	107511030(DUSP1)

MJV:	108398732(DUSP1)

TOD:	119235228(DUSP1)

SARA:

101553959(DUSP1)

SFUM:

130021544(DUSP1)

SETR:

126012235(DUSP1)

LAV:	100665180(DUSP1)

TMU:

101352955

ETF:	101661665(DUSP1)

DNM:	101426146(DUSP1)

MDO:	100031265(DUSP1)

GAS:	123237492(DUSP1)

SHR:	100923908(DUSP1)

AFZ:

127550205

PCW:	110196069(DUSP1)

TVP:	118844142(DUSP1)

PBRV:

138172646(DUSP1)

MLAO:

141506019(DUSP1)

OAA:	100076090(DUSP1)

TACU:

119919901(DUSP1)

GGA:	374192(DUSP1)

PCOC:

116232035(DUSP1)

MGP:	100546569(DUSP1)

CJO:	107320475(DUSP1)

TPAI:

128081637(DUSP1)

LMUT:

125700380(DUSP1)

NMEL:

110405394(DUSP1)

APLA:

101802393(DUSP1)

AACU:

137864194(DUSP1)

ACYG:

106042748(DUSP1)

CATA:

118254382(DUSP1)

AFUL:

116495021(DUSP1)

TGU:	100219518(DUSP1)

LSR:	110471461(DUSP1)

SCAN:

103824102(DUSP1)

PMOA:

120498639(DUSP1)

OTC:	121332379(DUSP1)

PRUF:

121365634(DUSP1)

ATRC:

139597844(DUSP1)

GFR:	102033656(DUSP1)

FAB:	101821078(DUSP1)

OMA:	130258899(DUSP1)

PHI:	102114546(DUSP1)

PMAJ:

107210905(DUSP1)

CCAE:

111935377(DUSP1)

CCW:	104689650(DUSP1)

CBRC:

103611569(DUSP1)

ACOE:

138118045(DUSP1)

ETL:	114066568(DUSP1)

ZAB:	102068767(DUSP1)

ZLE:	135453810(DUSP1)

ACHL:

103803993(DUSP1)

SVG:	106853004(DUSP1)

MMEA:

130586910(DUSP1)

HRT:	120759414(DUSP1)

SATI:

136367616(DUSP1)

CFAI:

136297268(DUSP1)

CCIC:

134049541(DUSP1)

FPG:	101917721(DUSP1)

FCH:	102053987(DUSP1)

NNT:	104411934(DUSP1)

SHAB:

115615889(DUSP1)

ACUN:

113485411(DUSP1)

SURA:

141949782(DUSP1)

TALA:

104363136(DUSP1)

ACHC:

115334328(DUSP1)

HALD:

104320040(DUSP1)

HLE:	104838995(DUSP1)

AGEN:

126050842

HHAR:

128134390(DUSP1)

BBUT:

142044304(DUSP1)

GCL:

127022068

CSTI:

104559941(DUSP1)

LDI:	104351976(DUSP1)

MNB:	103778990(DUSP1)

DPUB:

104303946(DUSP1)

PPUS:

135185245(DUSP1)

AVIT:

104280282(DUSP1)

BRHI:

104496350(DUSP1)

EGZ:	104133636(DUSP1)

NNI:	104018968(DUSP1)

PCRI:

104027404(DUSP1)

PCAO:

104045232(DUSP1)

PADL:

103912304(DUSP1)

AFOR:

103904504(DUSP1)

CBOR:

142088747(DUSP1)

GSTE:

104259287(DUSP1)

CBOY:

140656988(DUSP1)

MAME:

142413555(DUSP1)

CLV:	102089263(DUSP1)

CNIC:

135994057(DUSP1)

MUI:	104537598(DUSP1)

PGUU:

104469727(DUSP1)

PLET:

104627753(DUSP1)

CMAC:

104485259(DUSP1)

CUCA:

104065581(DUSP1)

TEO:	104381646(DUSP1)

BREG:

104630447(DUSP1)

GAME:

129212921(DUSP1)

OHA:	104332214(DUSP1)

ACAR:

104530417

CPEA:

104392648(DUSP1)

CVF:	104283862(DUSP1)

RTD:	128916349(DUSP1)

CRID:

134522069(DUSP1)

LMIC:

141749898(DUSP1)

NARQ:

141470042(DUSP1)

AAM:	106497521(DUSP1)

AROW:

112964735(DUSP1)

NPD:	112954502(DUSP1)

TGT:

104572807

DNE:	112996968(DUSP1)

SCAM:

104142462(DUSP1)

ASN:	102375445(DUSP1)

AMJ:	102559641(DUSP1)

CPOO:

109310009(DUSP1)

GGN:	109290041(DUSP1)

PSS:	102463448(DUSP1)

CIZ:	142021260(DUSP1)

CMY:	102948279(DUSP1)

CCAY:

125641952(DUSP1)

LKP:	140915696(DUSP1)

NDS:	141992026(DUSP1)

DCC:	119860669(DUSP1)

CPIC:

101936270(DUSP1)

TST:	117881879(DUSP1)

CABI:

116837244(DUSP1)

MRV:	120370112(DUSP1)

ACS:	100557150(dusp1)

ASAO:

132768815(DUSP1)

PVT:	110086132(DUSP1)

SUND:

121923180(DUSP1)

PBI:	103061052(DUSP1)

PMUR:

107294676(DUSP1)

CTIG:

120311985(DUSP1)

TSR:	106540028(DUSP1)

PGUT:

117657383(DUSP1)

PCAE:

139312511(DUSP1)

APRI:

131189813(DUSP1)

PTEX:

113433686(DUSP1)

NSS:	113425923(DUSP1)

VKO:	123035828(DUSP1)

PMUA:

114591047(DUSP1)

PRAF:

128407789(DUSP1)

ZVI:	118080296(DUSP1)

HCG:	128347342(DUSP1)

GJA:	107124748(DUSP1)

STOW:

125429842(DUSP1)

EMC:	129328422(DUSP1)

XLA:	380262(dusp1.L) 398254(dusp1.S)

XTR:	448043(dusp1)

NPR:	108788764(DUSP1)

RTEM:

120932271(DUSP1)

ACAT:

141132319(DUSP1)

PADS:

140323671(DUSP1)

BBUF:

120978125(DUSP1)

BGAR:

122928163(DUSP1)

DTC:	141088962(DUSP1)

PWL:	138304513(DUSP1)

MUO:	115476326(DUSP1)

GSH:	117351557(DUSP1)

DRE:	406340(dusp1)

SRX:	107706733 107712309

SANH:

107660428 107679114

SGH:	107558048 107577187

CCAR:

109074644(dusp1) 122147390

CAUA:

113113377 113113503

CGIB:

127970913 128026918

PTET:

122357325(dusp1)

LROH:

127161711(dusp1)

GRF:	141288337(dusp1)

OMC:	131553421(dusp1)

PPRM:

120464368(dusp1)

RKG:	130102854(dusp1)

MAMB:

125259015(dusp1)

CIDE:

127494586

CERY:

137019374(dusp1)

MASI:

127412852 127418396

TROS:

130564183(dusp1)

TDW:	130438409(dusp1)

MANU:

129421845(dusp1)

PDAB:

135749388(dusp1)

IPU:

108268678

IFU:	128611097(dusp1)

PHYP:

113542903(dusp1)

SMEO:

124386498(dusp1)

TFD:	113647798(dusp1)

TVC:	132855519(dusp1)

CGAR:

128531560(dusp1)

NGRA:

132890524(dusp1)

TRN:	134319587(dusp1)

AMEX:

103038437(dusp1)

CMAO:

118807327(dusp1)

EEE:

113576529

CHAR:

105906318(dusp1)

SPIL:

134068755(dusp1)

ASAD:

121694597(dusp1)

TRU:	101074284(dusp1)

TFS:	130531020(dusp1)

TNG:	GSTEN00017097G001

LCO:	104936101(dusp1)

NCC:	104959297(dusp1)

TBEN:

117475204(dusp1)

CGOB:

115014913(dusp1)

PGEO:

117454177(dusp1)

GACU:

117557009(dusp1)

EMAC:

134859632(dusp1)

ELY:	117261229(dusp1)

EFO:	125894304(dusp1)

PLEP:

121948033(dusp1)

SLUC:

116064228(dusp1)

ECRA:

117951932(dusp1)

ESP:	116697230(dusp1)

PFLV:

114562612(dusp1)

GAT:	120818003(dusp1)

PPUG:

119211338(dusp1)

AFB:	129089957(dusp1)

CLUM:

117737683(dusp1)

PSWI:

130209503(dusp1)

CANA:

137795939(dusp1)

CVE:	137875344(dusp1)

MSAM:

119889382(dusp1)

SCHU:

122879987(dusp1)

EARM:

139291124(dusp1)

CUD:	121516018(dusp1)

SPUL:

138597982(dusp1)

LMIX:

132982271(dusp1)

HTC:	141793971(dusp1)

ALAT:

119007720(dusp1)

ASTR:

137602511(dusp1)

PKLU:

139206964(dusp1)

MZE:	101487702(dusp1)

ONL:	100694058(dusp1)

OAU:	116324554(dusp1)

OLA:	101173794(dusp1)

OML:	112153347(dusp1)

CSAI:

133446865(dusp1)

XMA:	102232508(dusp1)

XCO:	114139363(dusp1)

XHE:	116714079(dusp1)

PRET:

103471107(dusp1)

PFOR:

103144546(dusp1)

PLAI:

106947098(dusp1)

PMEI:

106929685(dusp1)

GAF:	122837415(dusp1)

PPRL:

129362495(dusp1)

CVG:	107093461(dusp1)

CTUL:

119783207(dusp1)

GMU:	124859767(dusp1)

NFU:	107394133(dusp1)

KMR:	108242066(dusp1)

ALIM:

106510863(dusp1)

NWH:	119409059(dusp1)

AOCE:

111578781(dusp1)

EJA:	138211653(dusp1)

BFRE:

138620057(dusp1)

MCEP:

125008164(dusp1)

CSEM:

103391114(dusp1)

POV:	109647322(dusp1)

SSEN:

122778966(dusp1)

SSOE:

131472993(dusp1)

HHIP:

117768814(dusp1)

HSP:	118112328(dusp1)

PPLT:

128446110(dusp1)

SMAU:

118319688(dusp1)

LCF:

108882864

SDU:	111226686(dusp1)

SLAL:

111652061(dusp1)

XGL:	120785624(dusp1)

HCQ:	109515925(dusp1)

SSCV:

125977095(dusp1)

SBIA:

133509042(dusp1)

PEE:	133408031(dusp1)

PTAO:

133484927(dusp1)

BPEC:

110163462(dusp1)

ENY:	140353494(dusp1)

MALB:

109968408(dusp1)

BSPL:

114864794(dusp1)

SJO:	128363308(dusp1)

SSCO:

133985816(dusp1)

TTY:	137189193(dusp1)

GMH:	115552483(dusp1)

SASA:

106604105 106611914

STRU:

115166291 115205790

OTW:	112241347 112241498(dusp1)

OMY:	110487960 110504465(dusp1)

OGO:	123994218(dusp1) 124011447

ONE:	115123656(dusp1)

OKI:	109880139 109883429

OKE:	118380385 127929767(dusp1)

OMM:	135526803 135545413(dusp1)

OCLA:

139366596 139390700

SALP:

112076474 112077166

SNH:	120047837 120062585(dusp1)

SFON:

129827307(dusp1) 129858551

CCLU:

121555999(dusp1) 121556112 121556118

ELS:	105026777(dusp1)

OEP:	134032506(dusp1)

SFM:	108931840(dusp1)

PKI:	111857699(dusp1)

AANG:

118224188(dusp1)

AROT:

135250311(dusp1)

CCOG:

133124999(dusp1)

LOC:	102688449(dusp1)

PSPA:

121297145 121324461

ARUT:

117412756 117431064

PSEX:

120542340(dusp1)

LCM:	102364866(DUSP1)

CMK:	103190804(dusp1)

RTP:	109914245(dusp1) 109924522

CPLA:

122543238 122556719(dusp1)

CPUN:

140459779(dusp2) 140492140(dusp1)

HOC:	132823180(dusp1) 132836846(dusp2)

SCAU:

119957457(dusp2) 119965168(dusp1)

LERI:

129701673(dusp1)

HAKA:

140739390(dusp1)

PMRN:

116940690 116941284(DUSP1)

LRJ:	133343516 133345571

BFO:

118413453

BBEL:

109485283

CIN:	778913(dusp1.2.4.5)

LVG:

AFIL:

SKO:

PFLL:

PTRU:

MNZ:

MRJ:

OOT:

VDE:

VJA:

GOE:

CSCU:

CVS:	136977752 136979875

UDV:

129222434

LPOL:

106461504

LGI:	LOTGIDRAFT_54372

PVUL:

126814776 126816197

PCAN:

112564659

LSAX:

138954370 138983081

BARL:

143279377 143279471 143293590

BGT:

106050206

GAE:

121383351

HRF:

124149166

HRJ:	124267559 124271659

HASI:

HCRA:

CVN:

MYI:

PMAX:

AIRR:

YBA:

MCAF:

OSN:

LJP:	135466694 135468715

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

RES:

TAD:	TRIADDRAFT_14780

PCO:	PHACADRAFT_54994

SRE:	PTSG_10981

DFA:

DFA_09473

EIV:	EIN_488240

PIF:	PITG_13732

PSOJ:

PHYSODRAFT_315023

» show all

Reference

PMID:1406996

Authors

Keyse SM, Emslie EA

Title

Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase.

Journal

Nature 359:644-7 (1992)
DOI:10.1038/359644a0

Sequence

[hsa:1843]

LinkDB

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