KEGG ORTHOLOGY: K21412

ORTHOLOGY: K21412

Entry

K21412                      KO

Symbol

ANKLE2, LEM4

Name

ankyrin repeat and LEM domain-containing protein 2

Disease

H00269

Primary microcephaly

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K21412  ANKLE2, LEM4; ankyrin repeat and LEM domain-containing protein 2
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Chromatin remodeling factors
   Other chromatin remodeling factors
    K21412  ANKLE2, LEM4; ankyrin repeat and LEM domain-containing protein 2

Genes

HSA:	23141(ANKLE2)

PTR:	452390(ANKLE2)

PPS:	100996209(ANKLE2)

GGO:	101125042(ANKLE2)

PON:	100172101(ANKLE2)

NLE:	100587345(ANKLE2) 115834272

HMH:	116477653(ANKLE2)

MCC:	698529(ANKLE2)

MCF:	101926552(ANKLE2)

MTHB:

126930563

MNI:	105490571(ANKLE2)

CSAB:

103239456

CATY:

105600737(ANKLE2)

PANU:

101015170(ANKLE2)

TGE:	112634014(ANKLE2)

MLEU:

105541270(ANKLE2)

RRO:	104674307(ANKLE2)

RBB:	108544510(ANKLE2)

TFN:	117089143(ANKLE2)

PTEH:

111529826(ANKLE2)

CANG:

105525394(ANKLE2)

CJC:	100406622(ANKLE2)

SBQ:	101054102(ANKLE2)

CIMI:

108292661(ANKLE2)

CSYR:

103251123(ANKLE2)

MMUR:

105861816(ANKLE2)

LCAT:

123625606(ANKLE2)

PCOQ:

105820721(ANKLE2)

OGA:	100958083(ANKLE2)

MMU:	71782(Ankle2)

MCAL:

110294747(Ankle2)

MPAH:

110312806(Ankle2)

RNO:	360829(Ankle2)

MCOC:

116068119(Ankle2)

ANU:	117697877(Ankle2)

MUN:	110553169(Ankle2)

CGE:	100750769(Ankle2)

MAUA:

101841307(Ankle2)

PROB:

127215912(Ankle2)

PLEU:

114682902(Ankle2)

MORG:

121445732(Ankle2)

MFOT:

126511665

AAMP:

119825680(Ankle2)

NGI:	103750599(Ankle2)

HGL:	101721686(Ankle2)

CPOC:

100728743(Ankle2)

CCAN:

109686264 109686268

DORD:

105990587(Ankle2)

DSP:	122096669(Ankle2)

PLOP:

125349244(Ankle2)

NCAR:

124990931

MMMA:

107159060(Ankle2)

OCU:

100338448

OPI:	101524430(ANKLE2)

TUP:	102472658(ANKLE2)

GVR:	103585272(ANKLE2)

CFA:	609795(ANKLE2)

CLUD:

112676380(ANKLE2)

VVP:	112911587(ANKLE2)

VLG:	121475818(ANKLE2)

NPO:	129507513(ANKLE2)

AML:	100467500(ANKLE2)

UMR:	103678884(ANKLE2)

UAH:	113266836(ANKLE2)

UAR:	123803878(ANKLE2)

ELK:

111139775

LLV:

125081928

MPUF:

101691419(ANKLE2)

MNP:	132023043(ANKLE2)

MLK:	131811912(ANKLE2)

NVS:	122903113(ANKLE2)

ORO:	101369693(ANKLE2)

EJU:	114202365(ANKLE2)

ZCA:	113913161(ANKLE2)

MLX:	118018349(ANKLE2)

NSU:	110582300(ANKLE2)

LWW:	102736000(ANKLE2)

FCA:	101093717(ANKLE2)

PYU:	121022741(ANKLE2)

PCOO:

112855088(ANKLE2)

PBG:	122470084(ANKLE2)

PVIV:

125149255(ANKLE2)

LRUF:

124527812

PTG:	102962472(ANKLE2)

PPAD:

109260669(ANKLE2)

PUC:

125915073

AJU:

106985895

HHV:	120224522(ANKLE2)

BTA:	540159(ANKLE2)

BOM:	102279536(ANKLE2)

BIU:	109571144(ANKLE2)

BBUB:

102403013(ANKLE2)

BBIS:

104997608(ANKLE2)

CHX:	102174325(ANKLE2)

OAS:	101115403(ANKLE2)

BTAX:

128062654(ANKLE2)

ODA:	120871532(ANKLE2)

CCAD:

122453950(ANKLE2)

MBEZ:

129542308(ANKLE2)

SSC:	100624394(ANKLE2)

CFR:	102510486(ANKLE2)

CBAI:

105063725(ANKLE2)

CDK:	105104090(ANKLE2)

VPC:	102535924(ANKLE2)

BACU:

103019027(ANKLE2)

BMUS:

118906698(ANKLE2)

LVE:	103076821(ANKLE2)

OOR:	101274128(ANKLE2)

DLE:	111186984(ANKLE2)

PCAD:

102985234(ANKLE2)

PSIU:

116765200(ANKLE2)

NASI:

112396231(ANKLE2)

ECB:	100061570(ANKLE2)

EPZ:	103561637(ANKLE2)

EAI:	106843876(ANKLE2)

MYB:	102261595(ANKLE2)

MYD:	102755396(ANKLE2)

MMYO:

118653027(ANKLE2)

MLF:	102439840(ANKLE2)

PKL:	118716861(ANKLE2)

EFUS:

103300355(ANKLE2)

MNA:	107529671(ANKLE2)

DRO:	112310665(ANKLE2)

SHON:

118990974(ANKLE2)

AJM:	119060739(ANKLE2)

PDIC:

114489720(ANKLE2)

PHAS:

123822205(ANKLE2)

MMF:	118639816(ANKLE2)

PPAM:

129087334(ANKLE2)

HAI:	109376155(ANKLE2)

RFQ:	117017624(ANKLE2)

PALE:

102892003(ANKLE2)

PGIG:

120615962(ANKLE2)

PVP:	105299553(ANKLE2)

RAY:	107511553(ANKLE2)

MJV:	108409906(ANKLE2)

TOD:	119244222 119245097

SARA:

101552639(ANKLE2)

SETR:

126002009(ANKLE2)

LAV:	100657966(ANKLE2)

TMU:

101346943

ETF:	101655058(ANKLE2)

DNM:	101424428(ANKLE2)

MDO:	100027608(ANKLE2)

GAS:	123232307(ANKLE2)

SHR:	100931024(ANKLE2)

AFZ:

127545344

PCW:	110220327(ANKLE2)

OAA:	100080049(ANKLE2)

GGA:	416790(ANKLE2)

PCOC:

116228300(ANKLE2)

MGP:	100546770(ANKLE2)

CJO:	107321065(ANKLE2)

TPAI:

128084623(ANKLE2)

LMUT:

125701588(ANKLE2)

NMEL:

110406416(ANKLE2)

APLA:

101801643(ANKLE2)

ACYG:

106031229(ANKLE2)

CATA:

118253025(ANKLE2)

AFUL:

116495959(ANKLE2)

TGU:	100219926(ANKLE2)

LSR:	110478087(ANKLE2)

SCAN:

103818093(ANKLE2)

PMOA:

120509564(ANKLE2)

OTC:	121338802(ANKLE2)

PRUF:

121364792(ANKLE2)

GFR:	102040608(ANKLE2)

FAB:	101821545(ANKLE2)

OMA:	130259882(ANKLE2)

PHI:	102113750(ANKLE2)

PMAJ:

107211669(ANKLE2)

CCAE:

111936507(ANKLE2)

CCW:	104688624(ANKLE2)

CBRC:

103615969(ANKLE2)

ETL:	114061828(ANKLE2)

ZAB:	102071236(ANKLE2)

ACHL:

103803252(ANKLE2)

SVG:	106864829(ANKLE2)

MMEA:

130575289(ANKLE2)

HRT:	120760438(ANKLE2)

FPG:	101917562(ANKLE2)

FCH:	102060275(ANKLE2)

CLV:	102094024(ANKLE2)

EGZ:	104127197(ANKLE2)

NNI:	104019954(ANKLE2)

PCRI:

104024305(ANKLE2)

PLET:

104624978(ANKLE2)

EHS:	104503183(ANKLE2)

PCAO:

104045731(ANKLE2)

ACUN:

113486227(ANKLE2)

TALA:

104355704(ANKLE2)

PADL:

103912178(ANKLE2)

AFOR:

103894869(ANKLE2)

ACHC:

115346649(ANKLE2)

HALD:

104311028(ANKLE2)

HLE:	104840625(ANKLE2)

AGEN:

126040266

GCL:

127022856

CCRI:

104167407(ANKLE2)

CSTI:

104556655(ANKLE2)

CMAC:

104473380(ANKLE2)

MUI:	104547798(ANKLE2)

BREG:

104638296(ANKLE2)

FGA:	104076087(ANKLE2)

GSTE:

104250672(ANKLE2)

LDI:	104347141(ANKLE2)

MNB:	103769825(ANKLE2)

OHA:	104327550(ANKLE2)

NNT:	104403021(ANKLE2)

SHAB:

115614335(ANKLE2)

DPUB:

104309663(ANKLE2)

PGUU:

104457983(ANKLE2)

ACAR:

104517927(ANKLE2)

CPEA:

104388775(ANKLE2)

AVIT:

104267578(ANKLE2)

CVF:	104289198(ANKLE2)

RTD:	128916892(ANKLE2)

CUCA:

104054662(ANKLE2)

TEO:	104369913(ANKLE2)

BRHI:

104488039(ANKLE2)

AAM:	106486878(ANKLE2)

AROW:

112978408(ANKLE2)

NPD:	112945981(ANKLE2)

TGT:	104577594(ANKLE2)

DNE:	112987131(ANKLE2)

SCAM:

104138852(ANKLE2)

ASN:	102387367(ANKLE2)

AMJ:	102562419(ANKLE2)

CPOO:

109312755(ANKLE2)

GGN:	109290468(ANKLE2)

PSS:	102459347(ANKLE2)

CMY:	102947573(ANKLE2)

CCAY:

125623021(ANKLE2)

DCC:	119843674(ANKLE2)

CPIC:

101947297(ANKLE2)

TST:	117888320(ANKLE2)

CABI:

116819449(ANKLE2)

MRV:	120386453(ANKLE2)

ACS:	100564079(ankle2)

ASAO:

132781431(ANKLE2)

PVT:	110087924(ANKLE2)

SUND:

121916420(ANKLE2)

PBI:	103056147(ANKLE2)

PMUR:

107295448(ANKLE2)

CTIG:

120303150(ANKLE2)

TSR:	106551641(ANKLE2)

PGUT:

117676385(ANKLE2)

APRI:

131185881(ANKLE2)

PTEX:

113446482(ANKLE2)

NSS:	113423498(ANKLE2)

VKO:	123028762(ANKLE2)

PMUA:

114587017(ANKLE2)

PRAF:

128404120(ANKLE2)

ZVI:	118076511(ANKLE2)

HCG:	128337952(ANKLE2)

GJA:	107120986(ANKLE2)

STOW:

125442374(ANKLE2)

EMC:	129341414(ANKLE2)

XLA:	108705155(ankle2.S) 108716081(ankle2.L)

XTR:	100380184(ankle2)

NPR:	108787926(ANKLE2)

RTEM:

120935740(ANKLE2)

BBUF:

120988668(ANKLE2)

BGAR:

122924480(ANKLE2)

MUO:	115481166(ANKLE2)

GSH:	117365105(ANKLE2)

DRE:	559297(ankle2) 569920

SRX:	107741250 107752143

SANH:

107665457 107672626 107684979

SGH:	107573467 107595914 107597302

CCAR:

109079231(ankle2) 109109457

CAUA:

113048941 113048973 113075826 113109496 113110121

CGIB:

127958114 128013297

PTET:

122333899 122345038(ankle2)

LROH:

127166043(ankle2) 127171632

OMC:	131540764(ankle2) 131548641

PPRM:

120469496(ankle2) 120478441

RKG:	130075928 130097152(ankle2)

MAMB:

125262560 125267221(ankle2)

CIDE:

127512064 127521943

MASI:

127418557 127432335 127433067 127433812

TROS:

130546073 130548725(ankle2)

TDW:	130412118 130419385(ankle2)

MANU:

129439806(ankle2) 129446375

IPU:	108255613 108277272

IFU:	128620727 128625442(ankle2)

PHYP:

113528149(ankle2) 113544909

SMEO:

124380606(ankle2) 124393788

TFD:	113638471 113656754(ankle2)

TVC:	132854887(ankle2) 132863352

AMEX:

103031719 111193770(ankle2)

CMAO:

118825145 118827464(ankle2)

EEE:	113573337 113586792(ankle2)

CHAR:

105889893(ankle2) 105911736

TRU:	101066454(ankle2)

TFS:	130526214(ankle2)

TNG:	GSTEN00031071G001 GSTEN00031072G001

LCO:	104920896(ankle2)

NCC:

104953040

TBEN:

117498726(ankle2)

CGOB:

115013949(ankle2)

PGEO:

117452094(ankle2)

GACU:

117555019(ankle2)

EMAC:

134874066(ankle2)

ELY:	117252390(ankle2)

EFO:	125889866(ankle2)

PLEP:

121943997(ankle2)

SLUC:

116050467(ankle2)

ECRA:

117944219(ankle2)

ESP:	116688919(ankle2)

PFLV:

114555051(ankle2)

GAT:	120831252(ankle2)

PPUG:

119224408(ankle2)

AFB:	129101659(ankle2)

CLUM:

117736852(ankle2)

PSWI:

130196513(ankle2)

MSAM:

119891641(ankle2)

SCHU:

122876380(ankle2)

CUD:	121509589(ankle2)

ALAT:

119019887(ankle2)

MZE:	101483395(ankle2)

ONL:	100704688(ankle2)

OAU:	116323346(ankle2)

OLA:	101163336(ankle2)

OML:	112148136(ankle2)

CSAI:

133451378(ankle2)

XMA:	102219826(ankle2)

XCO:	114154229(ankle2)

XHE:	116729495(ankle2)

PRET:

103469733(ankle2)

PFOR:

103141344(ankle2)

PLAI:

106947323(ankle2)

PMEI:

106917197(ankle2)

GAF:	122828353(ankle2)

PPRL:

129372932(ankle2)

CVG:	107089951(ankle2)

CTUL:

119775579(ankle2)

GMU:	124877771(ankle2)

NFU:	107393545(ankle2)

KMR:	108234946(ankle2)

ALIM:

106524331(ankle2)

NWH:	119414119(ankle2)

AOCE:

111569419(ankle2)

MCEP:

125012885(ankle2)

CSEM:

103398082(ankle2)

POV:	109633751(ankle2)

SSEN:

122769801(ankle2)

HHIP:

117753427 117767969(ankle2)

HSP:	118101094 118114633(ankle2)

SMAU:

118314394(ankle2)

LCF:

108878111

SDU:	111227642(ankle2)

SLAL:

111647885(ankle2)

XGL:	120804824(ankle2)

HCQ:	109524954(ankle2)

SSCV:

125993887

SBIA:

133499665(ankle2)

PEE:	133400390(ankle2)

PTAO:

133474669(ankle2)

BPEC:

110163359(ankle2)

MALB:

109954774(ankle2)

BSPL:

114862974(ankle2)

SJO:	128365143(ankle2)

SASA:

106564143 106568248 106580463 106585087

STRU:

115148323 115159374 115164316 115200337

OTW:	112219481 112248632 112262714

OMY:	110523762 110525846 110536229 110537159

OGO:	124034181 124036465 124048771

ONE:	115111755 115125319 115140220

OKI:	109868028 109881753 109896061

OKE:	118358456 118387708 118393372

SALP:

111958079 111961443 111973811 111981657

SNH:	120025726 120035926 120044824 120063268

CCLU:

121530635 121573832 121582338 121585006

ELS:	105014338(ankle2) 105027053

SFM:	108932815 108940295(ankle2)

PKI:	111844181(ankle2) 111849988

AANG:

118206165(ankle2)

LOC:	102693582(ankle2)

PSPA:

121297623 121300053

ARUT:

117427169 117428221

PSEX:

120540592(ankle2)

LCM:	102366492(ANKLE2)

CMK:	103183987(ankle2)

RTP:	109935636(ankle2)

CPLA:

122562532(ankle2)

HOC:	132827023(ankle2)

LERI:

129709267(ankle2)

PMRN:

116958101(ANKLE2)

BFO:

118409528

CIN:	100182883 113475729

SCLV:

SPU:

APLC:

SKO:

DME:	Dmel_CG8465(Ankle2)

DER:

6549841

DSE:

6618092

DSI:	Dsimw501_GD28485(Dsim_GD28485)

DYA:	Dyak_GE15586

DAN:

6505265

DSR:	110177088 110184429 110187462

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI14635

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:	119633337 119639881

ECOE:

129947193

CLON:

129613153

AGA:	133393933 4576014

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ017579

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:	111415421 111422187

BMOR:

101744789

BMAN:

114242727

MSEX:

115452243

DPL:	KGM_205968

BANY:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105383500 105384173 105384540

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM122510

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_200043

DMK:

PVM:

PJA:

PCHN:

HAME:

CQD:

PTRU:

MNZ:

HAZT:

EAF:

LSM:

DSV:

RSAN:

RMP:

VDE:	111252292 111255233

VJA:	111260740 111268505

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

CEL:	CELE_Y55F3BR.8(lem-4)

CBR:

CBG_13985

CRQ:	GCK72_015749

NAI:	NECAME_02109

LOA:	LOAG_06265

TSP:

Tsp_09223

HRO:	HELRODRAFT_89576

LGI:	LOTGIDRAFT_138560

PVUL:

126829528

PCAN:

112559418

BGT:	106052430 106061453

GAE:

HRF:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MMER:

RPHI:

OBI:

OSN:

LAK:	106164256 106164257

SMM:	Smp_036090

OVI:	T265_09839

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:	114533067 114534167

XEN:

124445126

HMG:

101238853

HSY:

130621798

TAD:	TRIADDRAFT_61691

AQU:

100641836

MBR:	MONBRDRAFT_22717

» show all

Reference

PMID:22770216

Authors

Asencio C, Davidson IF, Santarella-Mellwig R, Ly-Hartig TB, Mall M, Wallenfang MR, Mattaj IW, Gorjanacz M

Title

Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis.

Journal

Cell 150:122-35 (2012)
DOI:10.1016/j.cell.2012.04.043

Sequence

[hsa:23141] [cel:CELE_Y55F3BR.8]

LinkDB

DBGET integrated database retrieval system