KEGG   ORTHOLOGY: K21784
Entry
K21784                      KO                                     
Symbol
pigH, redN
Name
4-hydroxy-2,2'-bipyrrole-5-methanol synthase
Pathway
map00333  Prodigiosin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00837  Prodigiosin biosynthesis, L-proline => prodigiosin
M00838  Undecylprodigiosin biosynthesis, L-proline => undecylprodigiosin
Reaction
R11667  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00333 Prodigiosin biosynthesis
    K21784  pigH, redN; 4-hydroxy-2,2'-bipyrrole-5-methanol synthase
Other DBs
COG: COG0156 COG0236
Genes
SMW: SMWW4_v1c10970(pigH)
SRR: SerAS9_1746
SRS: SerAS12_1746
SRA: SerAS13_1747
SERF: L085_23065
SERM: CLM71_22575
SSUR: ATE40_002200
SNEM: NLX84_05470
SERA: Ser39006_020660
SERQ: CWC46_20665
VSR: Vspart_01685(pigH)
PSAZ: PA25_35550
HCH: HCH_06031
SCO: SCO5890(redN)
STRD: NI25_09780
AG: CAH55636(pigH)
 » show all
Reference
  Authors
Williamson NR, Simonsen HT, Ahmed RA, Goldet G, Slater H, Woodley L, Leeper FJ, Salmond GP
  Title
Biosynthesis of the red antibiotic, prodigiosin, in Serratia: identification of a novel 2-methyl-3-n-amyl-pyrrole (MAP) assembly pathway, definition of the terminal condensing enzyme, and implications for undecylprodigiosin biosynthesis in Streptomyces.
  Journal
Mol Microbiol 56:971-89 (2005)
DOI:10.1111/j.1365-2958.2005.04602.x
  Sequence
Reference
  Authors
Harris AK, Williamson NR, Slater H, Cox A, Abbasi S, Foulds I, Simonsen HT, Leeper FJ, Salmond GP
  Title
The Serratia gene cluster encoding biosynthesis of the red antibiotic, prodigiosin, shows species- and strain-dependent genome context variation.
  Journal
Microbiology 150:3547-60 (2004)
DOI:10.1099/mic.0.27222-0
  Sequence
LinkDB

KEGG   REACTION: R11667
Entry
R11667                      Reaction                               
Definition
Pyrrolyl-2-carboxyl-S-[acyl-carrier protein] + Malonyl-CoA + L-Serine <=> 4-Hydroxy-2,2'-bipyrrole-5-methanol + CoA + Acyl-carrier protein + 2 CO2 + H2O
Equation
Pathway
rn00333  Prodigiosin biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00837  Prodigiosin biosynthesis, L-proline => prodigiosin
M00838  Undecylprodigiosin biosynthesis, L-proline => undecylprodigiosin
Orthology
K21784  4-hydroxy-2,2'-bipyrrole-5-methanol synthase
Reference
1  [PMID:15853884]
  Authors
Williamson NR, Simonsen HT, Ahmed RA, Goldet G, Slater H, Woodley L, Leeper FJ, Salmond GP
  Title
Biosynthesis of the red antibiotic, prodigiosin, in Serratia: identification of a novel 2-methyl-3-n-amyl-pyrrole (MAP) assembly pathway, definition of the terminal condensing enzyme, and implications for undecylprodigiosin biosynthesis in Streptomyces.
  Journal
Mol Microbiol 56:971-89 (2005)
DOI:10.1111/j.1365-2958.2005.04602.x
LinkDB

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