KEGG   ORTHOLOGY: K22011
Entry
K22011                      KO                                     
Symbol
cfbA
Name
sirohydrochlorin cobalto/nickelchelatase [EC:4.99.1.3 4.99.1.11]
Pathway
map00860  Porphyrin metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01240  Biosynthesis of cofactors
Module
M00836  Coenzyme F430 biosynthesis, sirohydrochlorin => coenzyme F430
M00924  Cobalamin biosynthesis, anaerobic, uroporphyrinogen III => sirohydrochlorin => cobyrinate a,c-diamide
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K22011  cfbA; sirohydrochlorin cobalto/nickelchelatase
Enzymes [BR:ko01000]
 4. Lyases
  4.99  Other lyases
   4.99.1  Sole sub-subclass for lyases that do not belong in the other subclasses
    4.99.1.3  sirohydrochlorin cobaltochelatase
     K22011  cfbA; sirohydrochlorin cobalto/nickelchelatase
    4.99.1.11  sirohydrochlorin nickelchelatase
     K22011  cfbA; sirohydrochlorin cobalto/nickelchelatase
Other DBs
RN: R05807 R11626
COG: COG2138
GO: 0016852
Genes
MJA: MJ_0970
MFE: Mefer_0855
MVU: Metvu_0528
MFS: MFS40622_1021
MIF: Metin_1283
MJH: JH146_1257
MESG: MLAUSG7_0577(cbiX)
MESA: MLASG1_0218(cbiX)
MIG: Metig_0269
MMP: MMP0164(cbiX(s))
MMD: GYY_00840
MMAK: MMKA1_01690(cbiX)
MMAO: MMOS7_01950(cbiX)
MMAD: MMJJ_09200(cbiX)
MAE: Maeo_1381
MVO: Mvol_1554
MTH: MTH_1397
MMG: MTBMA_c17830(cbiX)
METC: MTCT_1270
MWO: MWSIV6_1777(cbiX)
METE: tca_01350(cbiX)
METK: FVF72_04600(cfbA)
MTHM: FZP57_08700(cfbA)
METJ: FZP68_02025(cfbA)
MST: Msp_1563(cbiX)
MSI: Msm_1281
MEB: Abm4_0618(cbiX1)
MMIL: sm9_2307(cbiX1)
MEYE: TL18_00210
METH: MBMB1_1943
MFC: BRM9_0750(cbiX) BRM9_2283
MCUB: MCBB_2224(cbiX)
MEME: HYG87_06215(cfbA)
MFV: Mfer_0962
MKA: MK0428
MBAR: MSBR2_1804
MBAK: MSBR3_2859
MAC: MA_3631(cbiX)
MMA: MM_0517
MMAC: MSMAC_0768
MTHR: MSTHT_2448
MTHE: MSTHC_0834
MHOR: MSHOH_0892
MFZ: AOB57_003185(cfbA)
MBU: Mbur_1035(cbiXS)
MMET: MCMEM_1517
MELO: J7W08_06395(cfbA)
MMH: Mmah_1410
MPY: Mpsy_2755
MZI: HWN40_08895(cfbA)
MTP: Mthe_0104
MCJ: MCON_1928(cbiX)
MHI: Mhar_2389
MHU: Mhun_0668
MRTJ: KHC33_10030(cfbA)
MBG: BN140_0720(cbiX)
MPI: Mpet_1000
MBN: Mboo_1417
MPL: Mpal_0681
MPD: MCP_0361(cbiX-1)
MEZ: Mtc_0061(cbiX)
RCI: RCIX2006(cbiX-1)
MELU: MTLP_03870
MEAM: MU439_05090(cfbA)
MEAR: Mpt1_c07010(cbiX1) Mpt1_c08040(cbiX2)
 » show all
Reference
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
[mac:MA_3631]
LinkDB

KEGG   ENZYME: 4.99.1.11
Entry
EC 4.99.1.11                Enzyme                                 
Name
sirohydrochlorin nickelchelatase;
cfbA (gene name)
Class
Lyases;
Other lyases;
Sole sub-subclass for lyases that do not belong in the other subclasses
Sysname
Ni-sirohydrochlorin nickel-lyase (sirohydrochlorin-forming)
Reaction(IUBMB)
Ni-sirohydrochlorin + 2 H+ = sirohydrochlorin + Ni2+ [RN:R11626]
Reaction(KEGG)
R11626
Substrate
Ni-sirohydrochlorin [CPD:C21510];
H+ [CPD:C00080]
Product
sirohydrochlorin [CPD:C05778];
Ni2+ [CPD:C19609]
Comment
The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase. It catalyses the insertion of the nickel ion into sirohydrochlorin.
History
EC 4.99.1.11 created 2017
Pathway
ec00860  Porphyrin metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K22011  sirohydrochlorin cobalto/nickelchelatase
Genes
MJAMJ_0970
MFEMefer_0855
MVUMetvu_0528
MFSMFS40622_1021
MIFMetin_1283
MJHJH146_1257
MESGMLAUSG7_0577(cbiX)
MESAMLASG1_0218(cbiX)
MIGMetig_0269
MMPMMP0164(cbiX(s))
MMQMmarC5_1511
MMXMmarC6_0786
MMZMmarC7_1164
MMDGYY_00840
MMAKMMKA1_01690(cbiX)
MMAOMMOS7_01950(cbiX)
MMADMMJJ_09200(cbiX)
MAEMaeo_1381
MVNMevan_1169
MVOMvol_1554
MOKMetok_0650
METFCFE53_04845
MTHMTH_1397
MMGMTBMA_c17830(cbiX)
METCMTCT_1270
MWOMWSIV6_1777(cbiX)
METEtca_01350(cbiX)
METZMETMT2_0062
METKFVF72_04600(cfbA)
MTHMFZP57_08700(cfbA)
METJFZP68_02025(cfbA)
MSTMsp_1563(cbiX)
METBAW729_07475
MSIMsm_1281
MEBAbm4_0618(cbiX1)
MMILsm9_2307(cbiX1)
MEYETL18_00210
MAROMarbSA_12130
MELMetbo_0181
MEWMSWAN_2302
METHMBMB1_1943
MFCBRM9_0750(cbiX) BRM9_2283
MFIDSM1535_0709 DSM1535_1217
MCUBMCBB_2224(cbiX)
MSUBBK009_08975
METNBK008_04595
METTCIT01_05355 CIT01_09230
METOCIT02_07815 CIT02_10385
MEMEHYG87_06215(cfbA)
MFVMfer_0962
MKAMK0428
MBAMbar_A0344 Mbar_A2400
MBYMSBRM_0575
MBWMSBRW_0653 MSBRW_2346
MBARMSBR2_1804
MBAKMSBR3_2859
MACMA_3631(cbiX)
MMAMM_0517
MMAZMmTuc01_0537
MMJMSMAS_0789
MMACMSMAC_0768
MVCMSVAZ_3049
MEKMSKOL_2989
MLSMSLAZ_2302
METMMSMTP_0889 MSMTP_0890
MEFMSWH1_2455
MEQMSWHS_2588
MSJMSSAC_1168 MSSAC_1225
MSZMSSIH_1080 MSSIH_2811
MSWMSSIT_1127 MSSIT_2845
MTHRMSTHT_2448
MTHEMSTHC_0834
MHORMSHOH_0892
MFZAOB57_003185(cfbA)
MBUMbur_1035(cbiXS)
MMETMCMEM_1517
MELOJ7W08_06395(cfbA)
MMHMmah_1410
MHAZBHR79_06625
MEVMetev_0558
MZHMzhil_0471
MPYMpsy_2755
MZIHWN40_08895(cfbA)
MHZMetho_0734
MTPMthe_0104
MCJMCON_1928(cbiX)
MHIMhar_2389
MHUMhun_0668
MRTJKHC33_10030(cfbA)
MLAMlab_0518 Mlab_1086
MEMMemar_1731
MBGBN140_0720(cbiX)
MCHKMchiMG62_19330
MPIMpet_1000
MBNMboo_1417
MFOMetfor_1750
MPLMpal_0681
MPDMCP_0361(cbiX-1)
MEZMtc_0061(cbiX)
RCIRCIX2006(cbiX-1)
MELUMTLP_03870
MEAMMU439_05090(cfbA)
MERMMINT_17250
MEARMpt1_c07010(cbiX1) Mpt1_c08040(cbiX2)
 » show all
Reference
1  [PMID:27846569]
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
[mac:MA_3631]
Other DBs
ExplorEnz - The Enzyme Database: 4.99.1.11
IUBMB Enzyme Nomenclature: 4.99.1.11
ExPASy - ENZYME nomenclature database: 4.99.1.11
BRENDA, the Enzyme Database: 4.99.1.11
LinkDB

KEGG   REACTION: R11626
Entry
R11626                      Reaction                               
Name
Ni-sirohydrochlorin nickel-lyase (sirohydrochlorin-forming)
Definition
Sirohydrochlorin + Nickel(2+) <=> Nickel-sirohydrochlorin + 2 H+
Equation
Comment
nickel chelatase
Reaction class
RC01012  C05778_C21510
Enzyme
Pathway
rn00860  Porphyrin metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01240  Biosynthesis of cofactors
Module
M00836  Coenzyme F430 biosynthesis, sirohydrochlorin => coenzyme F430
Orthology
K22011  sirohydrochlorin cobalto/nickelchelatase [EC:4.99.1.3 4.99.1.11]
Other DBs
RHEA: 52799
LinkDB

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