KEGG   ORTHOLOGY: K22011
Entry
K22011                      KO                                     
Symbol
cfbA
Name
sirohydrochlorin cobalto/nickelchelatase [EC:4.99.1.3 4.99.1.11]
Pathway
map00860  Porphyrin metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01240  Biosynthesis of cofactors
Module
M00836  Coenzyme F430 biosynthesis, sirohydrochlorin => coenzyme F430
M00924  Cobalamin biosynthesis, anaerobic, uroporphyrinogen III => sirohydrochlorin => cobyrinate a,c-diamide
Reaction
R05807  sirohydrochlorin cobalt-lyase
R11626  Ni-sirohydrochlorin nickel-lyase (sirohydrochlorin-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K22011  cfbA; sirohydrochlorin cobalto/nickelchelatase
Enzymes [BR:ko01000]
 4. Lyases
  4.99  Other lyases
   4.99.1  Sole sub-subclass for lyases that do not belong in the other subclasses
    4.99.1.3  sirohydrochlorin cobaltochelatase
     K22011  cfbA; sirohydrochlorin cobalto/nickelchelatase
    4.99.1.11  sirohydrochlorin nickelchelatase
     K22011  cfbA; sirohydrochlorin cobalto/nickelchelatase
Other DBs
COG: COG2138
GO: 0016852
Genes
AGAR: OAG1_04300
TDU: QJT80_05650
LLH: I41_29610(cbiX)
MJA: MJ_0970
MFE: Mefer_0855
MVU: Metvu_0528
MFS: MFS40622_1021
MIF: Metin_1283
MJH: JH146_1257
MESG: MLAUSG7_0577(cbiX)
MESA: MLASG1_0218(cbiX)
MIG: Metig_0269
MMP: MMP0164(cbiX(s))
MMQ: MmarC5_1511
MMX: MmarC6_0786
MMZ: MmarC7_1164
MMD: GYY_00840
MMAK: MMKA1_01690(cbiX)
MMAO: MMOS7_01950(cbiX)
MMAD: MMJJ_09200(cbiX)
MAE: Maeo_1381
MVN: Mevan_1169
MVO: Mvol_1554
MOK: Metok_0650
METF: CFE53_04845
MTH: MTH_1397
MMG: MTBMA_c17830(cbiX)
MWO: MWSIV6_1777(cbiX)
MTEE: MTTB_15860
METC: MTCT_1270
METE: tca_01350(cbiX)
METZ: METMT2_0062
METK: FVF72_04600(cfbA)
MTHM: FZP57_08700(cfbA)
METJ: FZP68_02025(cfbA)
MST: Msp_1563(cbiX)
METB: AW729_07475
MEIS: PXD04_03550(cfbA)
MSI: Msm_1281
MEB: Abm4_0618(cbiX1)
MMIL: sm9_2307(cbiX1)
MEYE: TL18_00210
MARO: MarbSA_12130
METV: K4897_04930(cfbA)
MEL: Metbo_0181
MEW: MSWAN_2302
METH: MBMB1_1943
MFC: BRM9_0750(cbiX) BRM9_2283
MFI: DSM1535_0709 DSM1535_1217
MCUB: MCBB_2224(cbiX)
MSUB: BK009_08975
METN: BK008_04595
METT: CIT01_05355 CIT01_09230
METO: CIT02_07815 CIT02_10385
MEME: HYG87_06215(cfbA)
MFEG: GCM10025860_05960 GCM10025860_15770
MEER: NKF70_06155(cfbA)
MRID: FGU46_05455(cfbA)
MFV: Mfer_0962
MKA: MK0428
MBA: Mbar_A0344 Mbar_A2400
MBY: MSBRM_0575
MBW: MSBRW_0653 MSBRW_2346
MBAR: MSBR2_1804
MBAK: MSBR3_2859
MAC: MA_3631(cbiX)
MMA: MM_0517
MMAZ: MmTuc01_0537
MMJ: MSMAS_0789
MMAC: MSMAC_0768
MVC: MSVAZ_3049
MEK: MSKOL_2989
MLS: MSLAZ_2302
METM: MSMTP_0889 MSMTP_0890
MEF: MSWH1_2455
MEQ: MSWHS_2588
MSJ: MSSAC_1168 MSSAC_1225
MSZ: MSSIH_1080 MSSIH_2811
MSW: MSSIT_1127 MSSIT_2845
MTHR: MSTHT_2448
MTHE: MSTHC_0834
MHOR: MSHOH_0892
MFZ: AOB57_003185(cfbA)
MHAB: RSJ42_11680(cfbA)
METW: AAY43_06420
MBU: Mbur_1035(cbiXS)
MMET: MCMEM_1517
MELO: J7W08_06395(cfbA)
MMH: Mmah_1410
MHAZ: BHR79_06625
MPOT: BKM01_02870
MEV: Metev_0558
MZH: Mzhil_0471
MPY: Mpsy_2755
MZI: HWN40_08895(cfbA)
MMAV: RE476_01290(cfbA)
MSEB: RE474_10980(cfbA)
MHZ: Metho_0734
MEHF: MmiHf6_00840
MEES: MmiEs2_09210
MTP: Mthe_0104
MCJ: MCON_1928(cbiX)
MHI: Mhar_2389
MHU: Mhun_0668
MRTJ: KHC33_10030(cfbA)
MLA: Mlab_0518 Mlab_1086
MEM: Memar_1731
MBG: BN140_0720(cbiX)
MCHK: MchiMG62_19330
MSUM: OH143_02885(cfbA)
MRC: R6Y96_04915(cfbA)
MPI: Mpet_1000
MEND: L6E24_12105(cfbA)
MEFW: F1737_06060(cfbA)
MAQE: RJ40_03905(cfbA)
MFK: E2N92_04060(cfbA)
MOU: OU421_12225(cfbA)
MESB: L1S32_04105(cfbA)
MANQ: L1994_05920(cfbA)
MBN: Mboo_1417
MFO: Metfor_1750
MESK: METHP_01902
MPL: Mpal_0681
MPD: MCP_0361(cbiX-1)
MEZ: Mtc_0061(cbiX)
RCI: RCIX2006(cbiX-1)
MELU: MTLP_03870
MEAM: MU439_05090(cfbA)
MEAE: QEN48_05065(cfbA)
MER: MMINT_17250
MEAR: Mpt1_c07010(cbiX1) Mpt1_c08040(cbiX2)
MVJ: ACO0C9_00900(cfbA)
 » show all
Reference
PMID:27846569
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
[mac:MA_3631]
LinkDB

KEGG   ENZYME: 4.99.1.11
Entry
EC 4.99.1.11                Enzyme                                 
Name
sirohydrochlorin nickelchelatase;
cfbA (gene name)
Class
Lyases;
Other lyases;
Sole sub-subclass for lyases that do not belong in the other subclasses
Sysname
Ni-sirohydrochlorin nickel-lyase (sirohydrochlorin-forming)
Reaction(IUBMB)
Ni-sirohydrochlorin + 2 H+ = sirohydrochlorin + Ni2+ [RN:R11626]
Reaction(KEGG)
R11626
Substrate
Ni-sirohydrochlorin [CPD:C21510];
H+ [CPD:C00080]
Product
sirohydrochlorin [CPD:C05778];
Ni2+ [CPD:C19609]
Comment
The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase. It catalyses the insertion of the nickel ion into sirohydrochlorin.
History
EC 4.99.1.11 created 2017
Pathway
ec00860  Porphyrin metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K22011  sirohydrochlorin cobalto/nickelchelatase
Genes
AGAR: OAG1_04300
TDU: QJT80_05650
LLH: I41_29610(cbiX)
MJA: MJ_0970
MFE: Mefer_0855
MVU: Metvu_0528
MFS: MFS40622_1021
MIF: Metin_1283
MJH: JH146_1257
MESG: MLAUSG7_0577(cbiX)
MESA: MLASG1_0218(cbiX)
MIG: Metig_0269
MMP: MMP0164(cbiX(s))
MMQ: MmarC5_1511
MMX: MmarC6_0786
MMZ: MmarC7_1164
MMD: GYY_00840
MMAK: MMKA1_01690(cbiX)
MMAO: MMOS7_01950(cbiX)
MMAD: MMJJ_09200(cbiX)
MAE: Maeo_1381
MVN: Mevan_1169
MVO: Mvol_1554
MOK: Metok_0650
METF: CFE53_04845
MTH: MTH_1397
MMG: MTBMA_c17830(cbiX)
MWO: MWSIV6_1777(cbiX)
MTEE: MTTB_15860
METC: MTCT_1270
METE: tca_01350(cbiX)
METZ: METMT2_0062
METK: FVF72_04600(cfbA)
MTHM: FZP57_08700(cfbA)
METJ: FZP68_02025(cfbA)
MST: Msp_1563(cbiX)
METB: AW729_07475
MEIS: PXD04_03550(cfbA)
MSI: Msm_1281
MEB: Abm4_0618(cbiX1)
MMIL: sm9_2307(cbiX1)
MEYE: TL18_00210
MARO: MarbSA_12130
METV: K4897_04930(cfbA)
MEL: Metbo_0181
MEW: MSWAN_2302
METH: MBMB1_1943
MFC: BRM9_0750(cbiX) BRM9_2283
MFI: DSM1535_0709 DSM1535_1217
MCUB: MCBB_2224(cbiX)
MSUB: BK009_08975
METN: BK008_04595
METT: CIT01_05355 CIT01_09230
METO: CIT02_07815 CIT02_10385
MEME: HYG87_06215(cfbA)
MFEG: GCM10025860_05960 GCM10025860_15770
MEER: NKF70_06155(cfbA)
MRID: FGU46_05455(cfbA)
MFV: Mfer_0962
MKA: MK0428
MBA: Mbar_A0344 Mbar_A2400
MBY: MSBRM_0575
MBW: MSBRW_0653 MSBRW_2346
MBAR: MSBR2_1804
MBAK: MSBR3_2859
MAC: MA_3631(cbiX)
MMA: MM_0517
MMAZ: MmTuc01_0537
MMJ: MSMAS_0789
MMAC: MSMAC_0768
MVC: MSVAZ_3049
MEK: MSKOL_2989
MLS: MSLAZ_2302
METM: MSMTP_0889 MSMTP_0890
MEF: MSWH1_2455
MEQ: MSWHS_2588
MSJ: MSSAC_1168 MSSAC_1225
MSZ: MSSIH_1080 MSSIH_2811
MSW: MSSIT_1127 MSSIT_2845
MTHR: MSTHT_2448
MTHE: MSTHC_0834
MHOR: MSHOH_0892
MFZ: AOB57_003185(cfbA)
MHAB: RSJ42_11680(cfbA)
METW: AAY43_06420
MBU: Mbur_1035(cbiXS)
MMET: MCMEM_1517
MELO: J7W08_06395(cfbA)
MMH: Mmah_1410
MHAZ: BHR79_06625
MPOT: BKM01_02870
MEV: Metev_0558
MZH: Mzhil_0471
MPY: Mpsy_2755
MZI: HWN40_08895(cfbA)
MMAV: RE476_01290(cfbA)
MSEB: RE474_10980(cfbA)
MHZ: Metho_0734
MEHF: MmiHf6_00840
MEES: MmiEs2_09210
MTP: Mthe_0104
MCJ: MCON_1928(cbiX)
MHI: Mhar_2389
MHU: Mhun_0668
MRTJ: KHC33_10030(cfbA)
MLA: Mlab_0518 Mlab_1086
MEM: Memar_1731
MBG: BN140_0720(cbiX)
MCHK: MchiMG62_19330
MSUM: OH143_02885(cfbA)
MRC: R6Y96_04915(cfbA)
MPI: Mpet_1000
MEND: L6E24_12105(cfbA)
MEFW: F1737_06060(cfbA)
MAQE: RJ40_03905(cfbA)
MFK: E2N92_04060(cfbA)
MOU: OU421_12225(cfbA)
MESB: L1S32_04105(cfbA)
MANQ: L1994_05920(cfbA)
MBN: Mboo_1417
MFO: Metfor_1750
MESK: METHP_01902
MPL: Mpal_0681
MPD: MCP_0361(cbiX-1)
MEZ: Mtc_0061(cbiX)
RCI: RCIX2006(cbiX-1)
MELU: MTLP_03870
MEAM: MU439_05090(cfbA)
MEAE: QEN48_05065(cfbA)
MER: MMINT_17250
MEAR: Mpt1_c07010(cbiX1) Mpt1_c08040(cbiX2)
MVJ: ACO0C9_00900(cfbA)
 » show all
Reference
1  [PMID:27846569]
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
[mac:MA_3631]
Other DBs
ExplorEnz - The Enzyme Database: 4.99.1.11
IUBMB Enzyme Nomenclature: 4.99.1.11
ExPASy - ENZYME nomenclature database: 4.99.1.11
BRENDA, the Enzyme Database: 4.99.1.11
LinkDB

KEGG   REACTION: R11626
Entry
R11626                      Reaction                               
Name
Ni-sirohydrochlorin nickel-lyase (sirohydrochlorin-forming)
Definition
Sirohydrochlorin + Nickel(2+) <=> Nickel-sirohydrochlorin + 2 H+
Equation
C05778 + C19609 <=> C21510 + 2 C00080
Comment
nickel chelatase
Reaction class
RC01012  C05778_C21510
Enzyme
4.99.1.11
Pathway
rn00860  Porphyrin metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01240  Biosynthesis of cofactors
Module
M00836  Coenzyme F430 biosynthesis, sirohydrochlorin => coenzyme F430
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.99  Other lyases
   4.99.1  Sole sub-subclass for lyases that do not belong in the other subclasses
    4.99.1.11
     R11626  Sirohydrochlorin + Nickel(2+) <=> Nickel-sirohydrochlorin + 2 H+
Orthology
K22011  sirohydrochlorin cobalto/nickelchelatase [EC:4.99.1.3 4.99.1.11]
Other DBs
RHEA: 52799
LinkDB

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