KEGG   ORTHOLOGY: K22096
Entry
K22096            Tight     KO                                     
Symbol
CYP82X1
Name
(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase [EC:1.14.14.167]
Pathway
map00950  Isoquinoline alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00946  Noscapine biosynthesis, (S)-reticuline => noscapine
Reaction
R11690  (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (8-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K22096  CYP82X1; (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K22096  CYP82X1; (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.167  (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase
     K22096  CYP82X1; (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, plant type
  CYP82 family
   K22096  CYP82X1; (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase
Genes
PSOM: 113322295
AG: AFB74614(CYP82X1)
Reference
PMID:22653730
  Authors
Winzer T, Gazda V, He Z, Kaminski F, Kern M, Larson TR, Li Y, Meade F, Teodor R, Vaistij FE, Walker C, Bowser TA, Graham IA
  Title
A Papaver somniferum 10-gene cluster for synthesis of the anticancer alkaloid noscapine.
  Journal
Science 336:1704-8 (2012)
DOI:10.1126/science.1220757
  Sequence
[ag:AFB74614]
Reference
PMID:25485687
  Authors
Dang TT, Chen X, Facchini PJ
  Title
Acetylation serves as a protective group in noscapine biosynthesis in opium poppy.
  Journal
Nat Chem Biol 11:104-6 (2015)
DOI:10.1038/nchembio.1717
LinkDB

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