KEGG   REACTION: R11690
Entry
R11690                      Reaction                               
Name
(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (8-hydroxylating)
Definition
(13S,14R)-13-O-Acetyl-1-hydroxy-cis-N-methylcanadine + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> (13S,14R)-13-O-Acetyl-1,8-dihydroxy-cis-N-methylcanadine + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C21588 + C03024 + C00007 <=> C21589 + C03161 + C00001
Comment
1-hydroxy-13-O-acetyl-N-methylcanadine 8-hydroxylase
Reaction class
RC03497  C21588_C21589
Enzyme
1.14.14.167
Pathway
rn00950  Isoquinoline alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00946  Noscapine biosynthesis, (S)-reticuline => noscapine
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.167
     R11690  (13S,14R)-13-O-Acetyl-1-hydroxy-cis-N-methylcanadine + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> (13S,14R)-13-O-Acetyl-1,8-dihydroxy-cis-N-methylcanadine + [Oxidized NADPH---hemoprotein reductase] + H2O
Orthology
K22096  (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase [EC:1.14.14.167]
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