KEGG   ORTHOLOGY: K22227
Entry
K22227                      KO                                     
Symbol
ahbD
Name
AdoMet-dependent heme synthase [EC:1.3.98.6]
Pathway
map00860  Porphyrin metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01240  Biosynthesis of cofactors
Module
M00847  Heme biosynthesis, archaea, siroheme => heme
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K22227  ahbD; AdoMet-dependent heme synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.98  With other, known, physiological acceptors
    1.3.98.6  AdoMet-dependent heme synthase
     K22227  ahbD; AdoMet-dependent heme synthase
Other DBs
RN: R12002
COG: COG0535
Genes
VSR: Vspart_02486
FTN: FTN_0761
FTX: AW25_1260
FTD: AS84_1779
FTY: CH70_1281
FCF: FNFX1_0764
FCN: FN3523_1115
FHI: FSC454_04745
FPH: Fphi_1658
FPT: BZ13_338
FPI: BF30_1936
FPM: LA56_513
FPX: KU46_1639
FPZ: LA55_1131
FPJ: LA02_1355
FRC: KX01_139
UPL: DSM104440_02436(pqqE_2)
GSU: GSU3454
GME: Gmet_0015
GEM: GM21_0014
GEB: GM18_0014
GUR: Gura_0014
GEO: Geob_0014
GLO: Glov_3122
GBM: Gbem_0015
PCA: Pcar_3149
PPD: Ppro_2942
DEU: DBW_1050
DVU: DVU_0855
DVL: Dvul_2128
DVM: DvMF_2901
DDS: Ddes_0287
DEF: CNY67_13555(ahbD)
DTR: RSDT_0965(ahbD)
DFL: DFE_1924
DMA: DMR_04480
DCB: C3Y92_18170(ahbD)
DGG: DGI_2628
DDE: Dde_2577
DMS: E8L03_09620(ahbD)
DAS: Daes_2206
DPI: BN4_20515
PPRF: DPRO_4012(albA)
PSEL: GM415_11940(ahbD)
LIP: LI0206
LIR: LAW_00209
DSX: GD604_02810(ahbD)
PBIZ: LWC08_08455(ahbD)
DBA: Dbac_2393
DRT: Dret_1955
DPS: DP1281
DSF: UWK_00074
DOL: Dole_1223
DML: Dmul_12470(pqqE)
DAL: Dalk_3856
DAT: HRM2_28000(ppqE2)
DTO: TOL2_C22120(ppqE)
DALK: DSCA_64360
DLI: dnl_52850(pqqE)
DMM: dnm_051150(pqqE)
SAT: SYN_02266
SFU: Sfum_3058
DAX: FDQ92_08380(ahbD)
DBR: Deba_0779
PAMO: BAR1_01615
BLI: BL01169
BLD: BLi02077
BAN: BA_1875
BAR: GBAA_1875
BAT: BAS1737
BAI: BAA_1941
BANT: A16_19100
BANR: A16R_19310
BANS: BAPAT_1787
BANV: DJ46_683
BCX: BCA_1941
BCF: bcf_09195
BTL: BALH_1651
BTW: BF38_3097
BMYC: DJ92_2126
BGY: BGLY_2377
BKW: BkAM31D_11655(albA)
GKA: GK0765
GTN: GTNG_0647(pqqE)
GEA: GARCT_00740(albA_2)
PCAL: BV455_01025(albA_1) BV455_03424(albA_3)
AFL: Aflv_1204
AAMY: GFC30_1118
BBEV: BBEV_0800(pqqE-1) BBEV_2001(pqqE-2)
MCAK: MCCS_00980(albA)
BLR: BRLA_c027150(albA_1)
PPY: PPE_03393
PPO: PPM_3629(M1_4008)
PPOL: X809_34115
PMW: B2K_23550
PSAB: PSAB_13045
BTS: Btus_2569
CAC: CA_C2795
CAE: SMB_G2831(albA)
CAY: CEA_G2803
CBE: Cbei_2008
CBZ: Cbs_2008
CBEI: LF65_02177
CKL: CKL_0376
CKR: CKR_0326
CSR: Cspa_c47280(nirJ)
CPAS: Clopa_0539
CPAT: CLPA_c04440(mftC)
CPAE: CPAST_c04440(mftC)
CSQ: CSCA_2640
CACE: CACET_c33630(nirJ2)
CTYK: CTK_C24960
CDY: F3K33_10010(nirJ2)
AMT: Amet_0051
TEB: T8CH_0278(ahbD)
STH: STH1619
SWO: Swol_0691
SLP: Slip_1423
SALQ: SYNTR_0462
CALK: HUE98_13075(nirJ2)
DSY: DSY2221
DHD: Dhaf_3350
SGY: Sgly_1408
PTH: PTH_0976
DRM: Dred_2159
DAE: Dtox_1255
DAU: Daud_1343
TFR: BR63_18660(nirJ2)
AACX: DEACI_2421
HMO: HM1_1969
HCV: FTV88_1673(nirJ2)
TMR: Tmar_1505
SAY: TPY_3049
CTHM: CFE_1685
CHY: CHY_1211
MTA: Moth_1245
MTHO: MOTHE_c12260(albA1)
MTHZ: MOTHA_c13120(albA1)
ADG: Adeg_1256
TACI: TDSAC_1189
NCD: ACONDI_00761(mftC_5)
PHAR: NCTC13077_00312(ydeM_1)
MFUN: GXM21_11860(nirJ2)
PUF: UFO1_2676
PFT: JBW_01904
MANA: MAMMFC1_03439(albA_5)
STED: SPTER_14960(mftC_3)
LPIL: LIP_0128
CEF: CE1938
CDI: DIP1153
CPL: Cp3995_0950(pqqE)
CPP: CpP54B96_0948(pqqE)
CPZ: CpPAT10_0933(pqqE)
COR: Cp267_0975(pqqE)
COD: Cp106_0920(pqqE)
COS: Cp4202_0926(pqqE)
CPSE: CPTA_01501
CPSU: CPTB_00031
CPSF: CPTC_01492
CUL: CULC22_01004(pqqE)
CUC: CULC809_00990(pqqE)
CUE: CULC0102_1111(pqqE)
CUN: Cul210932_1039(pqqE)
CUS: CulFRC11_1012(pqqE)
CUQ: Cul210931_0996(pqqE)
CUZ: Cul05146_1064(pqqE)
CUJ: CUL131002_1025(pqqE)
COA: DR71_1700
CUT: CUTER_10185(pqqE)
CSP: WM42_2363
CKW: CKALI_02890(albA)
CCOE: CETAM_08370(albA)
SFK: KY5_5294c
SQZ: FQU76_03535(blsE)
SCOE: CP976_29205(blsE)
SPLA: CP981_01915(blsE)
SHUN: DWB77_02729(mftC)
JDE: Jden_0047
XCE: Xcel_3125
CFL: Cfla_0999
CFI: Celf_1184
PAC: PPA2096
PACC: PAC1_10610
PACH: PAGK_1989
CACN: RN83_10690
PFRE: RM25_1802
PAUS: NCTC13651_02438(moaA_2)
ACIJ: JS278_00385(mftC)
TLA: TLA_TLA_01755(mftC)
SRO: Sros_4255
NCX: Nocox_06975(albA3)
SAQ: Sare_2907
AFO: Afer_1148
ELE: Elen_2079
EGD: GS424_011800(nirJ2)
GPA: GPA_20660
AEQ: AEQU_0715
RCA: Rcas_1583
STI: Sthe_3103
TAQ: TO73_0006
AMU: Amuc_0792
AGL: PYTT_1939
LCRE: Pla8534_11890(albA)
TTF: THTE_2582
AMUC: Pan181_49200(albA_2)
PND: Pla175_32010(albA_2)
MRI: Mal4_15060(albA_1)
SDYN: Mal52_24490(albA)
AGV: OJF2_18310(albA_1)
KST: KSMBR1_1925(nirJ_3) KSMBR1_3784(nirJ_4)
PCOR: KS4_07590(albA_1)
MCAD: Pan265_21970(albA)
ALUS: STSP2_00887(albA_1)
ACA: ACP_2694
SUS: Acid_7329
ABAC: LuPra_05322(albA_2)
THYD: TTHT_1640
FSC: FSU_0293
TTK: TST_1454
NDE: NIDE0561
NJA: NSJP_1591
THET: F1847_00480(ahbD)
CTHI: THC_1234
TAV: G4V39_06175(ahbD)
TMAI: FVE67_06070(ahbD)
MOX: DAMO_0982
AFU: AF_2413
FPL: Ferp_2134
GAC: GACE_0004
GAH: GAH_00348
THA: TAM4_2088
MBAR: MSBR2_1947
MBAK: MSBR3_1992
MAC: MA_0573(nirJ)
MMA: MM_1726(nirJ) MM_1737(nirJ)
MMAC: MSMAC_1492
METM: MSMTP_2890
MTHR: MSTHT_2087
MTHE: MSTHC_1197
MHOR: MSHOH_3654
MFZ: AOB57_005520(ahbD)
MBU: Mbur_1233
MMET: MCMEM_1685
MELO: J7W08_07370(ahbD)
MMH: Mmah_1454
MPY: Mpsy_2495
MZI: HWN40_09435(ahbD)
MTP: Mthe_1135
MCJ: MCON_1212
MHI: Mhar_0912
MBN: Mboo_0958
MPL: Mpal_2626
HAL: VNG_1185G(pqqE)
HSL: OE_2700F(ahbD)
HHB: Hhub_2684(ahbD)
HALH: HTSR_0128
HMA: rrnAC3489(pqqE)
HHI: HAH_0709(pqqE)
NPH: NP_1546A(ahbD)
HTI: HTIA_0261
HMU: Hmuk_1679
HALL: LC1Hm_0720
HVO: HVO_2144(ahbD)
HME: HFX_2185(cmo_1)
HLA: Hlac_1215
HTU: Htur_1728
NAT: NJ7G_3377
SALI: L593_14195
MEAM: MU439_02535(ahbD)
TAC: Ta0631
TVO: TVG0874800(TVG0874800)
PTO: PTO1014
FAI: FAD_0683
CDIV: CPM_1409
APE: APE_1655
ACJ: ACAM_1037
IHO: Igni_0397
IIS: EYM_05750
HBU: Hbut_0035
STO: STK_01270
SSO: SSO1840(pqqE-5)
SOL: Ssol_2637
SSOA: SULA_2655
SSOL: SULB_2656
SSOF: SULC_2653
SCAS: SACC_25010
SID: M164_1028
SII: LD85_1155
SIH: SiH_0567
SIR: SiRe_0908
SIC: SiL_0777
MSE: Msed_0512
MCN: Mcup_1584
AHO: Ahos_1564
ACIH: HS5_01060
STEP: IC006_2192
PAI: PAE0596
PIS: Pisl_0113
PCL: Pcal_1716
PAS: Pars_2255
PYR: P186_2108
POG: Pogu_2607
TNE: Tneu_1901
CMA: Cmaq_1900
TTN: TTX_0062
TUZ: TUZN_1222
VDI: Vdis_0320
VMO: VMUT_1312
ASC: ASAC_0111
ACIA: SE86_01305
CCAI: NAS2_0062
KCR: Kcr_0773
LOKI: Lokiarch_30590(albA_7)
 » show all
Reference
  Authors
Kuhner M, Haufschildt K, Neumann A, Storbeck S, Streif J, Layer G
  Title
The alternative route to heme in the methanogenic archaeon Methanosarcina barkeri.
  Journal
Archaea 2014:327637 (2014)
DOI:10.1155/2014/327637
  Sequence
LinkDB

KEGG   ENZYME: 1.3.98.6
Entry
EC 1.3.98.6                 Enzyme                                 
Name
AdoMet-dependent heme synthase;
ahbD (gene name);
SAM-dependent heme synthase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With other, known, physiological acceptors
Sysname
Fe-coproporphyrin III:S-adenosyl-L-methionine oxidoreductase (decarboxylating)
Reaction(IUBMB)
Fe-coproporphyrin III + 2 S-adenosyl-L-methionine = protoheme + 2 CO2 + 2 5'-deoxyadenosine + 2 L-methionine [RN:R12002]
Reaction(KEGG)
R12002
Substrate
Fe-coproporphyrin III [CPD:C21284];
S-adenosyl-L-methionine [CPD:C00019]
Product
protoheme [CPD:C00032];
CO2 [CPD:C00011];
5'-deoxyadenosine [CPD:C05198];
L-methionine [CPD:C00073]
Comment
This radical AdoMet enzyme participates in a heme biosynthesis pathway found in archaea and sulfur-reducing bacteria. cf. EC 1.3.98.5, hydrogen peroxide-dependent heme synthase.
History
EC 1.3.98.6 created 2019
Pathway
ec00860  Porphyrin metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K22227  AdoMet-dependent heme synthase
Genes
VSRVspart_02486
FTNFTN_0761
FTXAW25_1260
FTDAS84_1779
FTYCH70_1281
FCFFNFX1_0764
FCNFN3523_1115
FHIFSC454_04745
FPHFphi_1658
FPTBZ13_338
FPIBF30_1936
FPMLA56_513
FPXKU46_1639
FPZLA55_1131
FPJLA02_1355
FRTF7308_1471
FRFLO80_01865
FRXF7310_06050
FRMBBG19_0921
FRCKX01_139
FMIF0R74_02770
FOOCGC45_04670
DLAI6G47_05705
UPLDSM104440_02436(pqqE_2)
GSUGSU3454
GSKKN400_3399
GMEGmet_0015
GEMGM21_0014
GEBGM18_0014
GPIGPICK_00065
GAOA2G06_16320
GEFFO488_15400
GBZJZM60_05545
GURGura_0014
GEOGeob_0014
GLOGlov_3122
GBMGbem_0015
GBNGEOBRER4_00140
GSBGSUB_03715
GERKP004_19670
GSUBKP001_16655
GNTKP003_19660
PCAPcar_3149
PACEA6070_11730
PEFA7E78_07110
PPDPpro_2942
DESDSOUD_2664
DEUDBW_1050
DVEDESUT3_31720
DVUDVU_0855
DVLDvul_2128
DVMDvMF_2901
DVGDeval_0785
DDSDdes_0287
DFIAXF13_12310
DPGDESPIGER_1625
DEFCNY67_13555(ahbD)
DTRRSDT_0965(ahbD)
DFLDFE_1924
DSDGD606_09200(ahbD) GD606_14960
DMADMR_04480
DCBC3Y92_18170(ahbD)
DGGDGI_2628
DDEDde_2577
DMSE8L03_09620(ahbD)
DSADesal_1240
DHYDESAM_22934
DAFDesaf_2642
DASDaes_2206
DPIBN4_20515
DEJAWY79_14415
PPRFDPRO_4012(albA)
PSELGM415_11940(ahbD)
DDNDND132_3455
LIPLI0206
LIRLAW_00209
DSXGD604_02810(ahbD)
PBIZLWC08_08455(ahbD)
DBADbac_2393
DOAAXF15_04760
DRTDret_1955
DPSDP1281
DSFUWK_00074
DAKDaAHT2_1941
DPRDespr_0852
DEOCAY53_05000
DOGHP555_07830 HP555_08610
DBKDGMP_25760
DOLDole_1223
DMLDmul_12470(pqqE)
DALDalk_3856
DATHRM2_28000(ppqE2)
DTOTOL2_C22120(ppqE)
DOVDSCO28_04560
DWDDSCW_66730
DALKDSCA_64360
DLIdnl_52850(pqqE)
DMMdnm_051150(pqqE)
DEKDSLASN_21470
SATSYN_02266
DAODesac_0397
DTIDesti_2956
SFUSfum_3058
DAXFDQ92_08380(ahbD)
DBRDeba_0779
HMRHipma_0282
DAVDESACE_01530
DHRLGS26_05640
RHJHZY79_02495
PAMOBAR1_01615
BLIBL01169
BLDBLi02077
BLHBaLi_c21430
BSONS101395_02578
BANBA_1875
BARGBAA_1875
BATBAS1737
BAHBAMEG_2719
BAIBAA_1941
BAXH9401_1771
BANTA16_19100
BANRA16R_19310
BANSBAPAT_1787
BANHHYU01_09420
BANVDJ46_683
BCZBCE33L1687
BCUBCAH820_1910
BCXBCA_1941
BALBACI_c18620
BCFbcf_09195
BTKBT9727_1713
BTLBALH_1651
BTMMC28_1049 MC28_F048
BTWBF38_3097
BTYBtoyo_4424
BMYCDJ92_2126
BWDCT694_31920
BACIB1NLA3E_04650 B1NLA3E_07640
BMETBMMGA3_02640 BMMGA3_08750
GSTHW35_15190
BGYBGLY_2377
BACQDOE78_06425 DOE78_24145
BDAFSZ17_08065 FSZ17_19890
BSHILGQ02_10850 LGQ02_11765
BCOBcell_1180 Bcell_2937
BCOHBC6307_03505
BKWBkAM31D_11655(albA)
BONA361_07360
CGOTJ1899_18220
GKAGK0765
GTEGTCCBUS3UF5_8610
GTKGT3570_03690
GTMGT3921_15610
GLIGLN3_14025
GTNGTNG_0647(pqqE)
GYCGYMC61_1573
GYAGYMC52_0696
GCTGC56T3_2774
GMCGY4MC1_2331 GY4MC1_3071
GGHGHH_c07140
GJFM493_03930
GEAGARCT_00740(albA_2)
GELIB49_14150
GSEGT50_13525
GSRGS3922_12185
GEJA0V43_01260
GZAIC807_17480
GTHGeoth_2413 Geoth_3086
PTLAOT13_07185 AOT13_10605
PTBDER53_08255
PCALBV455_01025(albA_1) BV455_03424(albA_3)
AFLAflv_1204
AGNAFK25_08475 AFK25_09635
AAMYGFC30_1118
ASEDIRT44_09325
VIRX953_05465
VHLBME96_04645
VIMGWK91_01290
APAKAP3564_14665
GRCGI584_18105
POFGS400_18215
NMKCHR53_08140 CHR53_11055
NTMBTDUT50_11080
AIAAWH56_015525 AWH56_016215
BVQFHE72_04435
HYIK2M58_02660
CTHUHUR95_12995
BBEVBBEV_0800(pqqE-1) BBEV_2001(pqqE-2)
BSEBsel_1538 Bsel_1561
MCAKMCCS_00980(albA)
MACRBHM04_00580
MBOEHT586_10105
MARYLAU42_00285
SBACBVH56_01795
EATEAT1b_2248
EAPKB235_14255
BLRBRLA_c027150(albA_1)
BRWGOP56_06105
PPYPPE_03393
PPMPPSC2_18035
PPOPPM_3629(M1_4008)
PPOLX809_34115
PPQPPSQR21_036310
PPOYRE92_19165 RE92_24470
PMSKNP414_05143
PMQPM3016_4546
PMWB2K_23550
PTAHPL003_26630
PSABPSAB_13045
PDUPDUR_14790
PSTEPSTEL_13805
PPEOABE82_18060
PBVAR543_14615
PCXLPB68_06570
PKBB4V02_07425
PSOPKP014_18135
CCHLFPL14_27725
AFXJZ786_04725 JZ786_20865
BTSBtus_2569
KYRCVV65_12755
EFFskT53_01730
SPAEE2C16_10625
PANCE2636_16300
TVUAB849_010810
CACCA_C2795
CAESMB_G2831(albA)
CAYCEA_G2803
CBECbei_2008
CBZCbs_2008
CBEILF65_02177
CKLCKL_0376
CKRCKR_0326
CSRCspa_c47280(nirJ)
CPASClopa_0539
CPATCLPA_c04440(mftC)
CPAECPAST_c04440(mftC)
CSQCSCA_2640
CACECACET_c33630(nirJ2)
CCKCcar_01385
CTYKCTK_C24960
CEUA7L45_05715
CFMBJL90_02230
CDRKB9W14_06480
CDYF3K33_10010(nirJ2)
AMTAmet_0051
GFEGferi_06075
RHEREHE19_000315 EHE19_000455 EHE19_015050
CSHClosa_1794
ACHTbsdcttw_45250
DLOK5I24_10355 K5I24_13460
TEBT8CH_0278(ahbD)
STHSTH1619
SWOSwol_0691
SLPSlip_1423
SALQSYNTR_0462
CALKHUE98_13075(nirJ2)
DSYDSY2221
DHDDhaf_3350
DDHDesde_2796
DDLDesdi_2314
DMTDESME_09255
SGYSgly_1408
DORDesor_1313
DAIDesaci_1002
DMIDesmer_1940
DEDDHBDCA_p1025
DECDCF50_p1081
DRSDEHRE_09595
DCADesca_1540
PTHPTH_0976
DRMDred_2159
DRUDesru_1625
DFGB0537_10740
DAEDtox_1255
DKUDesku_1517
DAUDaud_1343
TFRBR63_18660(nirJ2)
FWADCMF_06455 DCMF_27220
AACXDEACI_2421
TJRTherJR_1139
DGIDesgi_2071
HMOHM1_1969
HCVFTV88_1673(nirJ2)
TMRTmar_1505
THEPDYI95_007545
SAYTPY_3049
SAPSulac_0844
STHRBXT84_14455
CTHMCFE_1685
VGUHYG85_13665 HYG85_13670
CHYCHY_1211
MTAMoth_1245
MTHOMOTHE_c12260(albA1)
MTHZMOTHA_c13120(albA1)
ADGAdeg_1256
TNRThena_1214
TACITDSAC_1189
NTHNther_1128
NCDACONDI_00761(mftC_5)
HPKHprae_1333
PHARNCTC13077_00312(ydeM_1)
SSGSelsp_1768
SRISELR_22440
SELEADJ74_05500
SELOAXE86_04365
SELTBCS37_10345
MFUNGXM21_11860(nirJ2)
PUFUFO1_2676
PFTJBW_01904
MANAMAMMFC1_03439(albA_5)
STEDSPTER_14960(mftC_3)
LPILLIP_0128
MBAIMB901379_00417
CEFCE1938
CDIDIP1153
CDPCD241_1084
CDHCDB402_1040
CDTCDHC01_1082
CDECDHC02_1062
CDRCDHC03_1057
CDACDHC04_1068
CDZCD31A_1163
CDBCDBH8_1135
CDSCDC7B_1150
CDDCDCE8392_1055
CDWCDPW8_1130
CDVCDVA01_1025
CDIPERS451417_01146
CPUCPFRC_04705
CPLCp3995_0950(pqqE)
CPGCP316_04870
CPPCpP54B96_0948(pqqE)
CPKCP1002_08440
CPQCPC231_04705
CPXCPI19_06815
CPZCpPAT10_0933(pqqE)
CORCp267_0975(pqqE)
COPCP31_05100
CODCp106_0920(pqqE)
COSCp4202_0926(pqqE)
COICPCIP5297_04890
COECP258_04885
COUCP162_06405
CPSECPTA_01501
CPSUCPTB_00031
CPSFCPTC_01492
CULCULC22_01004(pqqE)
CUCCULC809_00990(pqqE)
CUECULC0102_1111(pqqE)
CUNCul210932_1039(pqqE)
CUSCulFRC11_1012(pqqE)
CUQCul210931_0996(pqqE)
CUZCul05146_1064(pqqE)
CUJCUL131002_1025(pqqE)
CMDB841_08285
CVTB843_05255
CAXCATYP_03970
COADR71_1700
CMQB840_07940
CEICEPID_09795
CTEDCTEST_03925
CUTCUTER_10185(pqqE)
CLWCLAC_03590
CSPWM42_2363
CSTRCBE89_05485
CRFFRC0190_01123
CAMCI6I65_10810
CGLUI6J20_00735
CSILCBE74_05645
CKWCKALI_02890(albA)
CCOECETAM_08370(albA)
SCXAS200_11130
SCADDN051_04515
SFKKY5_5294c
SQZFQU76_03535(blsE)
SNQCP978_33895
SKACP970_14695
SPADDVK44_27715
SRIMCP984_36815
STSUB7R87_14100
SCOECP976_29205(blsE)
SPLACP981_01915(blsE)
SHUNDWB77_02729(mftC)
SFEUIM697_28250
PSICJ4E96_10865
JDEJden_0047
XCEXcel_3125
XYLET495_11710
XYAET471_04055
CFLCfla_0999
CFICelf_1184
CGACelgi_2331
CEZCBP52_00550
CIRALFM56_14200
ICAIntca_2261 Intca_2834
ARSADJ73_00180
PEIH9L10_13140
DCOSAMEA4475696_0111
AUSIPK37_02630
DEMLGT36_003815
PACPPA2096
PAKHMPREF0675_5147
PAVTIA2EST22_10175
PAXTIA2EST36_10165
PAZTIA2EST2_10125
PAWPAZ_c21670
PADTIIST44_03170
PCNTIB1ST10_10635
PACCPAC1_10610
PACHPAGK_1989
PACNTIA1EST1_10260
CACNRN83_10690
PRAPALO_00595
PRLBCB70_07940
CGRN4412665_00331
PFRPFREUD_18940
PFRERM25_1802
PACDEGX94_04755
PAUSNCTC13651_02438(moaA_2)
PPCHMPREF9154_2111
PBOPACID_31140
AACIASQ49_06615
ACIJJS278_00385(mftC)
AJIC0Z10_01025
TFLRPIT_14180
TFABW733_15485
TEZBKM78_08700
TDFH9L22_02830
TLATLA_TLA_01755(mftC)
RAINRai3103_12700
PRVG7070_08580
BRTJ4N02_16420
NCANoca_1430 Noca_4381
NSNEXE58_03660
NPIG7071_10415
MGGMPLG2_3849
SROSros_4255
NCXNocox_06975(albA3)
STPStrop_2740
SAQSare_2907
AMSAMIS_63190
CATICS0771_64630
ARDAXF14_04585
ACTPB6G06_00875
ACTCCHIBA101_2209
ACTZCWT12_12755
AIRNCTC12972_02075
ASLANCTC11923_00579
FSLEJO69_08125
FLHEJ997_09365
AFOAfer_1148
ATQGH723_05515
CCUCcur_12330
SHIShel_11650
ELEElen_2079
EGDGS424_011800(nirJ2)
GPAGPA_20660
AEQAEQU_0715
AHATADCFC_16430
RTSCE91St31_20600
DLYDehly_0450
DEWDGWBC_1298
DFODform_01373
RRSRoseRS_0941
RCARcas_1583
STISthe_3103
CAPCLDAP_12800
THUGKNN16_13660
PMETG4Y79_20250
DFCDFI_13155 DFI_17075
TTSThthe16_2227
TTLTtJL18_2301
TSCTSC_c00220 TSC_c17570(pqqE)
THCTCCBUS3UF1_170
TOSTheos_1051 Theos_1995
TAQTO73_0006
TBCA0O31_00426 A0O31_01140(mftC)
TANTKNN15_00370 KNN15_04230
OPROcepr_1451
MHDMarky_0519
AMUAmuc_0792
AGLPYTT_1939
SOAG3M56_005270
LCREPla8534_11890(albA)
TTFTHTE_2582
AMUCPan181_49200(albA_2)
PNDPla175_32010(albA_2)
PLHVT85_02285
MRIMal4_15060(albA_1)
SDYNMal52_24490(albA)
AGVOJF2_18310(albA_1)
KSTKSMBR1_1925(nirJ_3) KSMBR1_3784(nirJ_4)
BROCIPI25_01080 IPI25_09405
BPITBPIT_07040 BPIT_15110
JETL3J17_00065 L3J17_00345
PCORKS4_07590(albA_1)
MCADPan265_21970(albA)
ALUSSTSP2_00887(albA_1)
TAERGT409_03775
OCKEXM22_13520
ABAAcid345_0817 Acid345_2710
ACAACP_2694
SUSAcid_7329
PFERIRI77_13125 IRI77_16610 IRI77_26475 IRI77_35370
CHLOJ8C02_01230
ABACLuPra_05322(albA_2)
THYDTTHT_1640
SCORJ3U87_23245
FSUFisuc_3027
FSCFSU_0293
GGRHKW67_02895
EFALFH779_00135
TTKTST_1454
TAMTheam_1244
DTEDester_0271
OCYOSSY52_02170 OSSY52_02180 OSSY52_19490
DINSelin_2336
DDFDEFDS_1457
DAPDacet_1278
CNICalni_1044
FSIFlexsi_1248
GTLEP073_07160
TYETHEYE_A0807
DTPJZK55_12830
NDENIDE0561
NMVNITMOv2_0497
NIONITINOP_1331
NJANSJP_1591
NKFNkreftii_001318 Nkreftii_002035 Nkreftii_003534
TIDThein_0772
TOPTOPB45_0421
THETF1847_00480(ahbD)
CTHITHC_1234
TAVG4V39_06175(ahbD)
TMAIFVE67_06070(ahbD)
NLIG3M70_08085 G3M70_14050
MOXDAMO_0982
AFUAF_2413
APOArcpr_0723
AVEArcve_0469
ASTAsulf_00101
FPLFerp_2134
GACGACE_0004
GAHGAH_00348
THATAM4_2088
TPRFA3L09_01460
MBAMbar_A1458
MBYMSBRM_0435
MBWMSBRW_3269
MBARMSBR2_1947
MBAKMSBR3_1992
MACMA_0573(nirJ)
MMAMM_1726(nirJ) MM_1737(nirJ)
MMAZMmTuc01_1811
MMJMSMAS_2942 MSMAS_2949
MMACMSMAC_1492
MVCMSVAZ_0560
MEKMSKOL_0538
MLSMSLAZ_0312
METMMSMTP_2890
MEFMSWH1_2709
MEQMSWHS_2328
MSJMSSAC_0507
MSZMSSIH_0468
MSWMSSIT_0491
MTHRMSTHT_2087
MTHEMSTHC_1197
MHORMSHOH_3654
MFZAOB57_005520(ahbD)
MBUMbur_1233
MMETMCMEM_1685
MELOJ7W08_07370(ahbD)
MMHMmah_1454
MHAZBHR79_06410
MEVMetev_0228
MZHMzhil_1490
MPYMpsy_2495
MZIHWN40_09435(ahbD)
MHZMetho_0828
MTPMthe_1135
MCJMCON_1212
MHIMhar_0912
MRTJKHC33_01065 KHC33_07215
MEMMemar_0879
MCHKMchiMG62_13780
MBNMboo_0958
MPLMpal_2626
HALVNG_1185G(pqqE)
HSLOE_2700F(ahbD)
HHBHhub_2684(ahbD)
HAGSJT689_06160
HABOJRZ79_04625
HNOLT974_10210
HANRLJ422_04855
HALHHTSR_0128
HHSRHSR6_0127 HSR6_1793
HSUHLASF_0169
HSFHLASA_0169
HALREFA46_013565
HARAAArcS_1228 AArcS_1968
HALXM0R89_04650
HMArrnAC3489(pqqE)
HHIHAH_0709(pqqE)
HHNHISP_03655
HABSG26_11405
HTABVU17_03485
HALJG9465_17335
HSINKDQ40_09975
NPHNP_1546A(ahbD)
NHOHWV23_07940
NSALHWV07_19180
HUTHuta_0031 Huta_2983
HTIHTIA_0261
HALAHrd1104_04415 Hrd1104_12110
HMUHmuk_1679
HALZE5139_11520
HALLLC1Hm_0720
HAZPGBQ70_11515
HALIBV210_15400
HSNDV733_05555 DV733_16260
HDSHSR122_0153
HRRHZS55_12335
HPELHZS54_16180
HLTI7X12_01720
HARCHARCEL1_04460
HDOMUK72_03110
HVOHVO_2144(ahbD)
HMEHFX_2185(cmo_1)
HGIABY42_10055
HALEG3A49_14145
HBOHbor_34360
HAQDU484_11255
HAJDU500_11530
HAERDU502_08900
HRAEI982_04765
HLMDV707_15920
HLAHlac_1215
HEZZEO776_07105
HALQHrr1229_015635
HSSJ7656_09330
HSAIHPS36_14790
HAZZKI388_04780
HALNB4589_006655
HMPK6T50_16840
HREK6T36_17645
HRMK6T25_13595
HACBHbl1158_16030
HDFAArcSl_2379 AArcSl_2675
HAHHalar_1527
HTUHtur_1728
HJTDVR14_02655
HALYHYG82_01545
HSALJMJ58_20825
HLOJ0X27_02835
HAKZJ0X25_15415
HXAHalxa_2697
NATNJ7G_3377
NPENatpe_2540
NVRFEJ81_11555
NPLFGF80_11255
NGENatgr_2129
HRUHalru_2990
NOUNatoc_1445
SALIL593_14195
SAIMK0C01_06825
HLCCHINAEXTREME07945 CHINAEXTREME19515
NAGAArcMg_3004
NANAArc1_0699
NASGCU68_19715
MEAMMU439_02535(ahbD)
TACTa0631
TVOTVG0874800(TVG0874800)
PTOPTO1014
FACFACI_IFERC01G1712
FAIFAD_0683
CDIVCPM_1409
APEAPE_1655
ACJACAM_1037
IHOIgni_0397
IISEYM_05750
HBUHbut_0035
PFMPyrfu_0575
PDLPyrde_0573
STOSTK_01270
SOHD1869_15030
SSOSSO1840(pqqE-5)
SOLSsol_2637
SSOASULA_2655
SSOLSULB_2656
SSOFSULC_2653
SSHIJ5U23_02099
SCASSACC_25010
SISLS215_0549
SIAM1425_1048
SIMM1627_1111
SIDM164_1028
SIYYG5714_1028
SINYN1551_1849
SIILD85_1155
SIHSiH_0567
SIRSiRe_0908
SICSiL_0777
SULABFU36_00145
SULEGFS03_05480
SULOGFS33_10780
SULLEWF20_01550
MSEMsed_0512
MCNMcup_1584
MHKDFR87_05230
MPRUDFR88_04045
MTENGWK48_07920
MJNMjAS7_1253
AHOAhos_1564
AMANB6F84_13255
ABRIDFR85_12305
ASULDFR86_11225
AAMBD1866_02945
ACIHHS5_01060
SACDHS1genome_0636
SAZOD1868_01315
STEPIC006_2192
PAIPAE0596
PISPisl_0113
PCLPcal_1716
PASPars_2255
PYRP186_2108
POGPogu_2607
TNETneu_1901
PYWPYWP30_02139
CMACmaq_1900
TTNTTX_0062
TUZTUZN_1222
VDIVdis_0320
VMOVMUT_1312
TCBTCARB_1004
THELIG193_01130
ASCASAC_0111
ACIASE86_01305
CLGCalag_0055
CCAINAS2_0062
KCRKcr_0773
MIYMicr_00105
LOKILokiarch_30590(albA_7)
 » show all
Reference
1  [PMID:21969545]
  Authors
Bali S, Lawrence AD, Lobo SA, Saraiva LM, Golding BT, Palmer DJ, Howard MJ, Ferguson SJ, Warren MJ
  Title
Molecular hijacking of siroheme for the synthesis of heme and d1 heme.
  Journal
Proc Natl Acad Sci U S A 108:18260-5 (2011)
DOI:10.1073/pnas.1108228108
Reference
2  [PMID:24669201]
  Authors
Kuhner M, Haufschildt K, Neumann A, Storbeck S, Streif J, Layer G
  Title
The alternative route to heme in the methanogenic archaeon Methanosarcina barkeri.
  Journal
Archaea 2014:327637 (2014)
DOI:10.1155/2014/327637
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.98.6
IUBMB Enzyme Nomenclature: 1.3.98.6
ExPASy - ENZYME nomenclature database: 1.3.98.6
BRENDA, the Enzyme Database: 1.3.98.6
LinkDB

KEGG   REACTION: R12002
Entry
R12002                      Reaction                               
Name
Fe-coproporphyrin III:S-adenosyl-L-methionine oxidoreductase (decarboxylating)
Definition
Fe-coproporphyrin III + 2 S-Adenosyl-L-methionine <=> Heme + 2 CO2 + 2 5'-Deoxyadenosine + 2 L-Methionine
Equation
C21284 + 2 C00019 <=> C00032 + 2 C00011 + 2 C05198 + 2 C00073
Reaction class
RC00884  C00032_C21284
Enzyme
Pathway
rn00860  Porphyrin metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01240  Biosynthesis of cofactors
Module
M00847  Heme biosynthesis, archaea, siroheme => heme
Orthology
K22227  AdoMet-dependent heme synthase [EC:1.3.98.6]
LinkDB

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