Entry
Name
AdoMet-dependent heme synthase;
ahbD (gene name);
SAM-dependent heme synthase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
Fe-coproporphyrin III:S-adenosyl-L-methionine oxidoreductase (decarboxylating)
Reaction(IUBMB)
Fe-coproporphyrin III + 2 S-adenosyl-L-methionine = protoheme + 2 CO2 + 2 5'-deoxyadenosine + 2 L-methionine [RN:
R12002 ]
Reaction(KEGG)
Substrate
Fe-coproporphyrin III [CPD:
C21284 ];
S-adenosyl-L-methionine [CPD:
C00019 ]
Product
Comment
This radical AdoMet enzyme participates in a heme biosynthesis pathway found in archaea and sulfur-reducing bacteria. cf. EC
1.3.98.5 , hydrogen peroxide-dependent heme synthase.
History
EC 1.3.98.6 created 2019
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
K22227 AdoMet-dependent heme synthase
Genes
UPL : DSM104440_02436(pqqE_2)
DSD : GD606_09200(ahbD) GD606_14960
DOG : HP555_07830 HP555_08610
BACI : B1NLA3E_04650 B1NLA3E_07640
BMET : BMMGA3_02640 BMMGA3_08750
BACQ : DOE78_06425 DOE78_24145
BDA : FSZ17_08065 FSZ17_19890
BSHI : LGQ02_10850 LGQ02_11765
BCO : Bcell_1180 Bcell_2937
GMC : GY4MC1_2331 GY4MC1_3071
GTH : Geoth_2413 Geoth_3086
PTL : AOT13_07185 AOT13_10605
PCAL : BV455_01025(albA_1) BV455_03424(albA_3)
AGN : AFK25_08475 AFK25_09635
NMK : CHR53_08140 CHR53_11055
AIA : AWH56_015525 AWH56_016215
BBEV : BBEV_0800(pqqE-1) BBEV_2001(pqqE-2)
BLR : BRLA_c027150(albA_1)
PPOY : RE92_19165 RE92_24470
AFX : JZ786_04725 JZ786_20865
CACE : CACET_c33630(nirJ2)
RHER : EHE19_000315 EHE19_000455 EHE19_015050
DLO : K5I24_10355 K5I24_13460
FWA : DCMF_06455 DCMF_27220
VGU : HYG85_13665 HYG85_13670
MTHO : MOTHE_c12260(albA1)
MTHZ : MOTHA_c13120(albA1)
NCD : ACONDI_00761(mftC_5)
PHAR : NCTC13077_00312(ydeM_1)
MANA : MAMMFC1_03439(albA_5)
STED : SPTER_14960(mftC_3)
CUN : Cul210932_1039(pqqE)
CUQ : Cul210931_0996(pqqE)
CUJ : CUL131002_1025(pqqE)
ICA : Intca_2261 Intca_2834
PAUS : NCTC13651_02438(moaA_2)
TSC : TSC_c00220 TSC_c17570(pqqE)
TOS : Theos_1051 Theos_1995
TBC : A0O31_00426 A0O31_01140(mftC)
TANT : KNN15_00370 KNN15_04230
LCRE : Pla8534_11890(albA)
AMUC : Pan181_49200(albA_2)
PND : Pla175_32010(albA_2)
KST : KSMBR1_1925(nirJ_3) KSMBR1_3784(nirJ_4)
BROC : IPI25_01080 IPI25_09405
BPIT : BPIT_07040 BPIT_15110
JET : L3J17_00065 L3J17_00345
ALUS : STSP2_00887(albA_1)
ABA : Acid345_0817 Acid345_2710
PFER : IRI77_13125 IRI77_16610 IRI77_26475 IRI77_35370
ABAC : LuPra_05322(albA_2)
OCY : OSSY52_02170 OSSY52_02180 OSSY52_19490
NKF : Nkreftii_001318 Nkreftii_002035 Nkreftii_003534
NLI : G3M70_08085 G3M70_14050
MMA : MM_1726(nirJ) MM_1737(nirJ)
MMJ : MSMAS_2942 MSMAS_2949
MRTJ : KHC33_01065 KHC33_07215
HHSR : HSR6_0127 HSR6_1793
HARA : AArcS_1228 AArcS_1968
HALA : Hrd1104_04415 Hrd1104_12110
HSN : DV733_05555 DV733_16260
HDF : AArcSl_2379 AArcSl_2675
HLC : CHINAEXTREME07945 CHINAEXTREME19515
TVO : TVG0874800(TVG0874800)
LOKI : Lokiarch_30590(albA_7)
» show all
Taxonomy
Reference
Authors
Bali S, Lawrence AD, Lobo SA, Saraiva LM, Golding BT, Palmer DJ, Howard MJ, Ferguson SJ, Warren MJ
Title
Molecular hijacking of siroheme for the synthesis of heme and d1 heme.
Journal
Reference
Authors
Kuhner M, Haufschildt K, Neumann A, Storbeck S, Streif J, Layer G
Title
The alternative route to heme in the methanogenic archaeon Methanosarcina barkeri.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.98.6
ExPASy - ENZYME nomenclature database: 1.3.98.6
LinkDB
All DBs