KEGG   ORTHOLOGY: K22365
Entry
K22365            Tight     KO                                     
Symbol
CYP71D1
Name
tabersonine 3-oxygenase [EC:1.14.14.50]
Pathway
map00901  Indole alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00965  Vinblastine biosynthesis, geissoschizine => vinblastine
Reaction
R11810  16-methoxytabersonine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (3-hydroxylating)
R11811  tabersonine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (3-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00901 Indole alkaloid biosynthesis
    K22365  CYP71D1; tabersonine 3-oxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K22365  CYP71D1; tabersonine 3-oxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.50  tabersonine 3-oxygenase
     K22365  CYP71D1; tabersonine 3-oxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, plant type
  CYP71 family
   K22365  CYP71D1; tabersonine 3-oxygenase
Genes
AG: AKM12282(CYP71D1V2)
Reference
PMID:25918424
  Authors
Qu Y, Easson ML, Froese J, Simionescu R, Hudlicky T, De Luca V
  Title
Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast.
  Journal
Proc Natl Acad Sci U S A 112:6224-9 (2015)
DOI:10.1073/pnas.1501821112
  Sequence
[ag:AKM12282]
LinkDB

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