KEGG ORTHOLOGY: K22380

ORTHOLOGY: K22380

Entry

K22380                      KO

Symbol

TMEM129

Name

E3 ubiquitin-protein ligase TM129 [EC:2.3.2.27]

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K22380  TMEM129; E3 ubiquitin-protein ligase TM129
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K22380  TMEM129; E3 ubiquitin-protein ligase TM129
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    K22380  TMEM129; E3 ubiquitin-protein ligase TM129

Genes

HSA:	92305(TMEM129)

PTR:	461065(TMEM129)

PPS:	100992620(TMEM129)

GGO:	101139655(TMEM129)

PON:	100432363(TMEM129)

PPYG:

129035832(TMEM129)

NLE:	105738300(TMEM129)

HMH:	116457139(TMEM129)

SSYN:

129464368(TMEM129)

MCC:	712960(TMEM129)

MCF:	101926320(TMEM129)

MTHB:

126955576

MNI:	105483838(TMEM129)

CSAB:

103246481(TMEM129)

CATY:

105585488(TMEM129)

PANU:

101012879(TMEM129)

TGE:	112625508(TMEM129)

MLEU:

105532658(TMEM129)

RRO:	104678932(TMEM129)

RBB:	108532285(TMEM129)

TFN:	117085036(TMEM129)

PTEH:

111539066(TMEM129)

CANG:

105508018(TMEM129)

CJC:	100408608(TMEM129)

SBQ:	101050785(TMEM129)

CIMI:

108311566(TMEM129)

ANAN:

105727154(TMEM129)

CSYR:

103251611(TMEM129)

MMUR:

105881642(TMEM129)

LCAT:

123622917(TMEM129)

PCOQ:

105825792(TMEM129)

OGA:	100961594(TMEM129)

MMU:	68366(Tmem129)

MCAL:

110294502(Tmem129)

MPAH:

110330636(Tmem129)

RNO:	305458(Tmem129)

MCOC:

116069947(Tmem129)

ANU:	117712552(Tmem129)

ASYL:

127696639(Tmem129)

MUN:	110557327(Tmem129)

CGE:	100765535(Tmem129)

MAUA:

101827658(Tmem129)

PROB:

127233740(Tmem129)

PLEU:

114694055(Tmem129)

MORG:

121436509 121459525

MFOT:

126500893

AAMP:

119816197(Tmem129)

NGI:	103741126(Tmem129)

HGL:	101715795(Tmem129)

CPOC:

100719977(Tmem129)

CCAN:

109694998(Tmem129)

DORD:

105991259(Tmem129)

DSP:	122100682(Tmem129)

PLOP:

125364425(Tmem129)

NCAR:

124994724

ITI:	101974341(Tmem129)

OCU:

127486468

OPI:	101525087(TMEM129)

TUP:	102498499(TMEM129)

GVR:	103587670(TMEM129)

CFA:	608955(TMEM129)

CLUD:

112653129(TMEM129)

VVP:	112920161(TMEM129)

VLG:	121489632(TMEM129)

NPO:	129510613(TMEM129)

AML:	100482020(TMEM129)

UMR:	103676950(TMEM129)

UAH:	113245756(TMEM129)

UAR:	123777872(TMEM129)

ELK:

111149309

LLV:

125093456

MPUF:

101694188(TMEM129)

MNP:	132003658(TMEM129)

MLK:	131827167(TMEM129)

NVS:	122919118(TMEM129)

ORO:	101382108(TMEM129)

EJU:	114198062(TMEM129)

ZCA:	113925130(TMEM129)

MLX:	118010798(TMEM129)

NSU:	110569722(TMEM129)

LWW:	102730726(TMEM129)

FCA:	101095740(TMEM129)

PYU:	121039502(TMEM129)

PCOO:

112858630(TMEM129)

PBG:	122479138(TMEM129)

PVIV:

125159163(TMEM129)

LRUF:

124522626

LGF:	123596285(TMEM129)

AJU:

106978866

PTG:	102965899(TMEM129)

PPAD:

109259321(TMEM129)

PUC:

125922552

PLEZ:

122218694(TMEM129)

HHV:	120226756(TMEM129)

BTA:	518991(TMEM129)

BOM:	102286758(TMEM129)

BIU:	109560722(TMEM129)

BBUB:

102394928(TMEM129)

BBIS:

104983772(TMEM129)

CHX:	102190126(TMEM129)

OAS:	105608252(TMEM129)

BTAX:

128049682(TMEM129)

CSUM:

138082442(TMEM129)

ODA:	120861837(TMEM129)

CCAD:

122428184(TMEM129)

MREE:

136152802(TMEM129)

OVR:	110151550(TMEM129)

MBEZ:

129561921(TMEM129)

SSC:	100513413(TMEM129)

CFR:	102523287(TMEM129)

CBAI:

105072146(TMEM129)

CDK:	105100858(TMEM129)

VPC:	102532558(TMEM129) 102545862

BACU:

102997697(TMEM129)

BMUS:

118895380(TMEM129)

LVE:	103087872(TMEM129)

OOR:	101273683(TMEM129)

LALB:

132520088(TMEM129)

DLE:	111164848(TMEM129)

PCAD:

102974218(TMEM129)

PSIU:

116754192(TMEM129)

NASI:

112391385(TMEM129)

ECB:	100052572(TMEM129)

EPZ:	103556998(TMEM129)

EAI:	106830609(TMEM129)

MYB:	102253882(TMEM129)

MYD:	102774340(TMEM129)

MMYO:

118665339(TMEM129)

MDT:	132222535(TMEM129)

MYUM:

138998441(TMEM129)

PKL:	118707145(TMEM129)

EFUS:

103294514(TMEM129)

MNA:	107524119(TMEM129)

DRO:	112316869(TMEM129)

SHON:

118987817(TMEM129)

AJM:	119035512(TMEM129)

PDIC:

114489926(TMEM129)

PHAS:

123815745(TMEM129)

MMF:	118627499(TMEM129)

PPAM:

129077486(TMEM129)

HAI:	109390957(TMEM129)

RFQ:	117022267(TMEM129)

PALE:

102897953(TMEM129)

PGIG:

120582911(TMEM129)

PVP:	105301854(TMEM129)

RAY:	107518020(TMEM129)

MJV:	108383917(TMEM129)

TOD:	119260268(TMEM129)

SARA:

101557645(TMEM129)

SFUM:

130030291(TMEM129)

SETR:

126032034(TMEM129)

LAV:	100670521(TMEM129)

TMU:

101350665

ETF:	101645160(TMEM129)

DNM:	101429740(TMEM129)

MDO:	100024251(TMEM129)

GAS:	123251463(TMEM129)

SHR:	100914758(TMEM129)

AFZ:

127539660

PCW:	110212248(TMEM129)

TVP:	118853153(TMEM129)

PBRV:

138148579(TMEM129)

OAA:	100092257(TMEM129)

TACU:

119933674(TMEM129)

GGA:	422900(TMEM129)

PCOC:

116225734(TMEM129)

MGP:	100546246(TMEM129)

CJO:	107313964(TMEM129)

TPAI:

128080211(TMEM129)

LMUT:

125691890(TMEM129)

NMEL:

110397985(TMEM129)

APLA:

101791917(TMEM129)

ACYG:

106034309(TMEM129)

CATA:

118248379(TMEM129)

AFUL:

116488957(TMEM129)

TGU:	100228530(TMEM129)

LSR:	110473292(TMEM129)

SCAN:

103823681(TMEM129)

PMOA:

120509391(TMEM129)

OTC:	121335051(TMEM129)

PRUF:

121349033(TMEM129)

ATRC:

139599739(TMEM129)

GFR:	102044151(TMEM129)

FAB:	101816181(TMEM129)

OMA:	130252225(TMEM129)

PHI:	102114404(TMEM129)

PMAJ:

107203550(TMEM129)

CCAE:

111927722(TMEM129)

CCW:	104690923(TMEM129)

CBRC:

103611190(TMEM129)

ACOE:

138110032(TMEM129)

ETL:	114071934(TMEM129)

ZAB:	102071985(TMEM129)

ZLE:	135447124(TMEM129)

ACHL:

103808828(TMEM129)

SVG:	106865278(TMEM129)

MMEA:

130579431(TMEM129)

HRT:	120753284(TMEM129)

SATI:

136360256(TMEM129)

CCIC:

134044483(TMEM129)

FPG:	101916398(TMEM129)

FCH:	102052068(TMEM129)

CCRI:

104156379(TMEM129)

NNT:	104400828(TMEM129)

SHAB:

115610736(TMEM129)

ACUN:

113479097(TMEM129)

TALA:

104356428(TMEM129)

ACHC:

115336488(TMEM129)

HALD:

104312054(TMEM129)

HLE:	104837932(TMEM129)

AGEN:

126052321

HHAR:

128138943(TMEM129)

GCL:

127015419

CSTI:

104561339(TMEM129)

LDI:	104352674(TMEM129)

MNB:	103780203(TMEM129)

DPUB:

104303572(TMEM129)

PPUS:

135179569(TMEM129)

AVIT:

104269082(TMEM129)

BRHI:

104496989(TMEM129)

EGZ:	104123585(TMEM129)

NNI:	104018094(TMEM129)

PCRI:

104025969(TMEM129)

PCAO:

104047974(TMEM129)

PADL:

103920984(TMEM129)

AFOR:

103904084(TMEM129)

FGA:	104074507(TMEM129)

GSTE:

104255649(TMEM129)

CLV:	102098430(TMEM129)

MUI:	104535945(TMEM129)

PGUU:

104459772(TMEM129)

PLET:

104615524(TMEM129)

EHS:	104504579(TMEM129)

CMAC:

104483210(TMEM129)

CUCA:

104054935(TMEM129)

TEO:	104370993(TMEM129)

BREG:

104631002(TMEM129)

OHA:	104329656(TMEM129)

ACAR:

104532900(TMEM129)

CPEA:

104391063(TMEM129)

CVF:	104284263(TMEM129)

CRID:

134516389(TMEM129)

AAM:	106498662(TMEM129)

AROW:

112965572(TMEM129)

NPD:	112943082(TMEM129)

TGT:	104578445(TMEM129)

DNE:	112990772(TMEM129)

SCAM:

104151427(TMEM129)

ASN:	102374313(TMEM129)

AMJ:	102566108(TMEM129)

CPOO:

109322319(TMEM129)

GGN:	109304032(TMEM129)

PSS:	102447292(TMEM129)

CMY:	102939559(TMEM129)

CCAY:

125636253(TMEM129)

DCC:	119854307(TMEM129)

CPIC:

101934598(TMEM129)

TST:	117877659(TMEM129)

CABI:

116818635

MRV:	120406424(TMEM129)

ASAO:

132771371(TMEM129)

PVT:	110085584(TMEM129)

SUND:

121927180(TMEM129)

PBI:	103065572(TMEM129)

PMUR:

107298970(TMEM129)

CTIG:

120319702(TMEM129)

TSR:	106555734(TMEM129)

PGUT:

117673248(TMEM129)

APRI:

131198941(TMEM129)

PTEX:

113451203(TMEM129)

NSS:	113426642(TMEM129)

VKO:	123032428(TMEM129)

PMUA:

114596952(TMEM129)

PRAF:

128413611(TMEM129)

ZVI:	118096489(TMEM129)

HCG:	128352475(TMEM129)

GJA:	107117799(TMEM129)

STOW:

125436082(TMEM129)

EMC:	129331674(TMEM129)

XLA:	432097(tmem129.L)

XTR:	548871(tmem129)

NPR:	108785644(TMEM129)

RTEM:

120924360(TMEM129)

BBUF:

120990416(TMEM129)

BGAR:

122927310(TMEM129)

PWL:	138249829(TMEM129)

MUO:	115461351(TMEM129)

GSH:	117363437(TMEM129)

DRE:	406756(tmem129)

SRX:	107746164(tmem129)

SANH:

107688585(tmem129)

SGH:	107591883(tmem129)

CCAR:

109075954(tmem129)

CAUA:

113113439(tmem129)

CGIB:

128026885

PTET:

122357254(tmem129)

LROH:

127176446(tmem129)

OMC:	131553042(tmem129)

PPRM:

120494837(tmem129)

RKG:	130085471(tmem129)

MAMB:

125261080(tmem129)

CIDE:

127494453

CERY:

137023772(tmem129)

MASI:

127413327 127418159

TROS:

130563617(tmem129)

TDW:	130437782(tmem129)

MANU:

129422701(tmem129)

PDAB:

135735368 135757469

AMEX:

103037548(tmem129)

CMAO:

118807233(tmem129)

EEE:	113590578(tmem129)

CHAR:

105913096(tmem129)

SPIL:

134069067(tmem129)

LCO:	104937160(tmem129)

NCC:	104959500(tmem129)

TBEN:

117485401(tmem129)

CGOB:

115014879(tmem129)

PGEO:

117454467(tmem129)

GACU:

117562200(tmem129)

EMAC:

134859686(tmem129)

ELY:	117260511(tmem129)

EFO:	125894696(tmem129)

PLEP:

121947964(tmem129)

SLUC:

116060305(tmem129)

ECRA:

117951379(tmem129)

ESP:	116685714(tmem129)

PFLV:

114562684(tmem129)

GAT:	120817957(tmem129)

PPUG:

119210677(tmem129)

AFB:	129117102(tmem129)

CLUM:

117737495(tmem129)

PSWI:

130209420(tmem129)

CANA:

137796999(tmem129)

CVE:	137875151(tmem129)

MSAM:

119888154(tmem129)

SCHU:

122880492(tmem129)

CUD:	121515998(tmem129)

SPUL:

138598404(tmem129)

LMIX:

132982490(tmem129)

ALAT:

119007821(tmem129)

MZE:	101471925(tmem129)

ONL:	100706875(tmem129)

OAU:	116318202(tmem129)

OLA:	101168527(tmem129)

OML:	112153179(tmem129)

CSAI:

133447327(tmem129)

XMA:	102217560(tmem129)

XCO:	114153304(tmem129)

XHE:	116714845(tmem129)

PRET:

103460554(tmem129)

PFOR:

103130312(tmem129)

PLAI:

106934614(tmem129)

PMEI:

106907579(tmem129) 106911584

GAF:	122836851(tmem129)

PPRL:

129354139(tmem129)

CVG:	107101926(tmem129)

CTUL:

119787340(tmem129)

GMU:	124860707(tmem129)

NFU:	107388381(tmem129)

KMR:	108246082(tmem129)

ALIM:

106532243(tmem129)

NWH:	119411655(tmem129)

AOCE:

111566166(tmem129)

EJA:	138215367(tmem129)

BFRE:

138614205(tmem129)

MCEP:

125008694(tmem129)

CSEM:

103391435(tmem129)

POV:	109627157(tmem129)

SSEN:

122778056(tmem129)

SSOE:

131473085(tmem129)

HHIP:

117769699(tmem129)

HSP:	118112569(tmem129)

PPLT:

128445724(tmem129)

SMAU:

118319331(tmem129)

LCF:

108875498

SDU:	111230409(tmem129)

SLAL:

111663584(tmem129)

XGL:	120785335(tmem129)

HCQ:	109522843(tmem129)

SSCV:

125977461(tmem129)

SBIA:

133508780(tmem129)

PEE:	133407664(tmem129)

PTAO:

133484677(tmem129)

BPEC:

110155789(tmem129)

ENY:	140349314(tmem129)

MALB:

109957475(tmem129)

BSPL:

114864943(tmem129)

SJO:	128362911(tmem129)

SSCO:

133985505(tmem129)

GMH:	115552231(tmem129)

SASA:

100380489(tmem129)

STRU:

115205501(tmem129)

OTW:	112256005(tmem129)

OMY:	110504741(tmem129)

OGO:	124010897(tmem129)

ONE:	115129276(tmem129)

OKI:	109905016(tmem129)

OKE:	118363316(tmem129)

OMM:	135545654(tmem129)

OCLA:

139391115

SALP:

111967311(tmem129)

SNH:	120062487(tmem129)

CCLU:

121586721(tmem129)

ELS:	105026856(tmem129)

OEP:	134032764(tmem129)

SFM:	108920776(tmem129)

PKI:	111837693(tmem129)

AANG:

118232351(tmem129)

AROT:

135259596(tmem129)

CCOG:

133135607(tmem129)

LOC:	102686327(tmem129)

PSPA:

121325572(tmem129)

ARUT:

117421002(tmem129)

PSEX:

120527859(tmem129)

LCM:	102346465(TMEM129)

CMK:	103181463(tmem129)

RTP:	109933922(tmem129)

CPLA:

122559983(tmem129)

HOC:	132828400(tmem129)

LERI:

129707638(tmem129)

PMRN:

116940608(TMEM129)

LRJ:	133343446(TMEM129)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG14646(CG14646)

DER:

6552133

DSE:

6613819

DSI:	Dsimw501_GD19727(Dsim_GD19727)

DYA:	Dyak_GE25414

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI10611

DAZ:

108619684

DNV:

108652345

DHE:

111602011

DVI:	116650257 6631032

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:	119683487 119683494

MDE:

SCAC:

LCQ:

LSQ:

CVJ:

GFS:

ECOE:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ017446

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

TLN:

HST:

DQU:

CFO:

FEX:

PMEC:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

DPA:

ESIM:

EFOR:

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_204740

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:	113506406 113506633

SLIU:

OFU:

ONU:

ATRA:

GMW:	113511519 128200786 128200787 128200789 128200790 128200791 128200792

PXY:

PGW:

CSTB:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:	128998483 128999149

PHU:	Phum_PHUM456530

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

HAMR:

DPX:	DAPPUDRAFT_308710

DMK:

DPZ:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

MNZ:

MRJ:

PORN:

HAZT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

CSCU:

CVS:

LPOL:

PMEO:

CEL:	CELE_C34F6.7(C34F6.7)

CBR:

CBG_17398

CRQ:	GCK72_023742

NAI:	NECAME_01749

BMY:	BM_BM10973(Bm10973)

LOA:	LOAG_05163

TSP:

Tsp_01897

HRO:	HELRODRAFT_106891

LGI:	LOTGIDRAFT_205320

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_069810

SHX:	MS3_00009132

OVI:	T265_03587

EGL:

LLON:

NVE:

EPA:

ATEN:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_31347

AQU:

100635642

» show all

Reference

PMID:24807418

Authors

van de Weijer ML, Bassik MC, Luteijn RD, Voorburg CM, Lohuis MA, Kremmer E, Hoeben RC, LeProust EM, Chen S, Hoelen H, Ressing ME, Patena W, Weissman JS, McManus MT, Wiertz EJ, Lebbink RJ

Title

A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation.

Journal

Nat Commun 5:3832 (2014)
DOI:10.1038/ncomms4832

Sequence

[hsa:92305]

LinkDB

DBGET integrated database retrieval system