KEGG   ORTHOLOGY: K22540
Entry
K22540                      KO                                     
Symbol
HTD2
Name
3-hydroxyacyl-thioester dehydratase, animal type [EC:4.2.1.-]
Pathway
map00061  Fatty acid biosynthesis
map01100  Metabolic pathways
map01212  Fatty acid metabolism
Module
M00873  Fatty acid biosynthesis in mitochondria, animals
Reaction
R04428  (3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase
R04535  (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] hydro-lyase
R04537  (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase
R04544  (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase
R04568  (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] hydro-lyase
R04954  (3R)-3-hydroxyhexanoyl-[acyl-carrier-protein] hydro-lyase
R04965  (3R)-3-hydroxydodecanoyl-[acyl-carrier-protein] hydro-lyase
R10208  (3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (trans-2-enoyl-[acyl-carrier protein]-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00061 Fatty acid biosynthesis
    K22540  HTD2; 3-hydroxyacyl-thioester dehydratase, animal type
Genes
HSA: 109703458(HTD2)
PTR: 134809453(HTD2)
GGO: 134758057(HTD2)
PPYG: 129032453(HTD2)
NLE: 115830346(HTD2)
HMH: 116469177(HTD2)
SSYN: 129479650(HTD2)
MCF: 123566755(HTD2)
MTHB: 126948815
MNI: 105482860(HTD2)
CSAB: 103227809
CATY: 105585625(RPP14)
PANU: 103875477(HTD2)
TGE: 112619243(HTD2)
MLEU: 105552662(RPP14)
RRO: 104660193(HTD2)
RBB: 108543612(RPP14)
TFN: 117083054(HTD2)
PTEH: 111534122(HTD2)
CANG: 105515411(RPP14)
CJC: 118142769(HTD2)
SBQ: 101031682 101032558
CIMI: 108303540(HTD2)
ANAN: 110568288 135268065(HTD2)
MMUR: 105884315 105884919(RPP14)
LCAT: 123623357(HTD2)
PCOQ: 105805890(RPP14)
OGA: 100958119 100960865
MMU: 109729085(Htd2)
MCAL: 110307244 110309428(Htd2)
MCOC: 116072721(Htd2)
ANU: 117705013(Htd2)
MUN: 110554624(Htd2)
CGE: 113832350(Htd2)
MAUA: 110342274(Htd2)
PROB: 127238209(Htd2)
PLEU: 114680727(Htd2)
MORG: 121455129(Htd2)
MFOT: 126513030
AAMP: 119828037(Htd2)
CPOC: 111754587
DSP: 122108214(Htd2)
PLOP: 125358688(Htd2)
MMMA: 107149655(Htd2)
OCU: 100356042
OPI: 118760304(HTD2)
CFA: 111091303(HTD2)
CLUD: 112665971(HTD2)
VVP: 112909725(HTD2)
VLG: 121495987(HTD2)
NPO: 129516833 129522409(HTD2)
AML: 117801905(HTD2)
UMR: 121102488(HTD2)
UAH: 113257018(HTD2)
UAR: 123798796(HTD2)
ELK: 111144067
LLV: 125078389
MNP: 132009823(HTD2)
MLK: 131824069(HTD2)
NVS: 122909313(HTD2)
EJU: 114214683(HTD2)
ZCA: 113918765(HTD2)
MLX: 118005160(HTD2)
NSU: 110584828(HTD2)
LWW: 115937187(HTD2)
FCA: 111559427(HTD2)
PYU: 121016800(HTD2)
PCOO: 112852604(HTD2)
PBG: 122488173(HTD2)
PVIV: 125148247(HTD2)
LRUF: 124524520
PTG: 102950284
PPAD: 109279087
PUC: 125929522
AJU: 106968840
HHV: 120238602(HTD2)
BTA: 112447889(HTD2)
BBUB: 112577783(HTD2)
OAS: 101122389(HTD2)
BTAX: 128057734(HTD2)
ODA: 120851377 120867978(HTD2)
CCAD: 122424321(HTD2) 122433808
MBEZ: 129547968(HTD2)
SSC: 100515579
CFR: 116657110(HTD2)
CDK: 116158254(HTD2)
VPC: 116283967(HTD2)
BMUS: 118903892(HTD2)
OOR: 125960234(HTD2)
DLE: 111174244(HTD2)
PCAD: 112064963(HTD2)
PSIU: 116762513(HTD2)
NASI: 112400622(HTD2)
ECB: 111768318
EAI: 123279356(HTD2)
MMYO: 118664981 118667943(HTD2) 118667945
MLF: 111828449
MDT: 132215240(HTD2) 132241912
PKL: 118715076(HTD2)
EFUS: 114233308(HTD2)
DRO: 112301293(HTD2)
SHON: 118983383(HTD2)
AJM: 119043376(HTD2)
PDIC: 114501993(HTD2)
PHAS: 123814511(HTD2)
MMF: 118633528(HTD2)
PPAM: 129088429(HTD2)
RFQ: 117037176(HTD2)
PALE: 112484321(HTD2)
PGIG: 120599501(HTD2)
PVP: 111746606
MJV: 118972544(HTD2)
TOD: 119230488(HTD2)
SARA: 101558095
SETR: 126013223(HTD2) 126026117
LAV: 111750580
TMU: 111819738
ETF: 115869546(HTD2)
DNM: 105745412 111761366
MDO: 103101327
GAS: 123230662(HTD2)
SHR: 111719548(HTD2)
AFZ: 127550625
PCW: 110196017
TVP: 118831621(HTD2)
OAA: 114806605(HTD2)
GGA: 112533344(HTD2)
PCOC: 116237405(HTD2)
CJO: 116654008(HTD2)
LMUT: 125698957
NMEL: 110404841
APLA: 101790049(HTD2)
ACYG: 125183771(HTD2)
CATA: 118248173(HTD2)
AFUL: 116492979(HTD2)
LSR: 110472415(HTD2)
SCAN: 115483820(HTD2)
PMOA: 120513980(HTD2)
OTC: 121347141(HTD2)
PRUF: 121352776(HTD2)
FAB: 101809145
OMA: 130258439(HTD2)
PMAJ: 117243655(HTD2)
CCAE: 111935019
CCW: 109143331(HTD2)
ETL: 114056798(HTD2)
ZAB: 113459451(HTD2)
ZLE: 135453139(HTD2)
MMEA: 130589157(HTD2)
HRT: 120758101(HTD2)
SATI: 136365873(HTD2)
FCH: 114016005(HTD2)
SHAB: 115614776(HTD2)
ACUN: 113485023(HTD2)
TALA: 104355952(HTD2)
ACHC: 115353754(HTD2)
AGEN: 126049767
GCL: 127021558
CSTI: 104551589
AVIT: 104268434
NNI: 104016989
PCRI: 104026759
PADL: 103918910
AFOR: 103903328
FGA: 104070237
CLV: 106145808
PLET: 104614862
CUCA: 128853311(HTD2)
BREG: 104630373
ACAR: 114818738(HTD2)
RTD: 128915537(HTD2)
AROW: 112976612(HTD2)
NPD: 112958775(HTD2)
DNE: 112984675(HTD2)
PSS: 112546375(HTD2)
CMY: 114020856(HTD2)
CCAY: 125640609(HTD2)
DCC: 119858832(HTD2)
TST: 117880512(HTD2)
CABI: 116825644(HTD2)
MRV: 120409161(HTD2)
ASAO: 132769442(HTD2)
PVT: 110079940
SUND: 121923711(HTD2)
PBI: 112540543(HTD2)
PMUR: 114923725(HTD2)
CTIG: 120300508(HTD2)
PGUT: 117660654(HTD2)
APRI: 131192607(HTD2)
PTEX: 113449587(HTD2)
VKO: 123034614(HTD2)
PMUA: 114591894(HTD2)
PRAF: 128408526(HTD2)
ZVI: 118080860(HTD2)
HCG: 128341756(HTD2)
STOW: 125430321(HTD2)
EMC: 129328653(HTD2)
XLA: 108704592
NPR: 108791848
RTEM: 120945221
BBUF: 120979511
BGAR: 122943675(HTD2)
MUO: 115471627(HTD2)
GSH: 117351387(HTD2)
SRX: 107745404
SANH: 107658379
SGH: 107586974
CAUA: 113039537 113080104
CGIB: 127942961 127986977
PTET: 122327560
LROH: 127153159
OMC: 131530838
PPRM: 120492963
RKG: 130077327
MAMB: 125263596
CIDE: 127519875
CERY: 137027875
MASI: 127439254
TROS: 130548847
TDW: 130429903 130430134
MANU: 129453187
IPU: 128628638
IFU: 128625327
PHYP: 113537924(htd2)
SMEO: 124402136
TFD: 113639071
TVC: 132838348
TRN: 134301680
AMEX: 103034148
CMAO: 118799810
EEE: 113580586(htd2)
TFS: 130524014
TNG: GSTEN00002197G001 GSTEN00003016G001 GSTEN00012877G001
LCO: 104940354(rpp14)
NCC: 104948461
TBEN: 117497889(rpp14)
CGOB: 115008319(htd2)
PGEO: 117446517(rpp14)
GACU: 117537205
EMAC: 134883203
ELY: 117256521
EFO: 125895582
PLEP: 121951632(rpp14)
SLUC: 118492913
ECRA: 117943536(rpp14)
ESP: 116687470(rpp14)
PFLV: 114554172(htd2)
GAT: 120835651
PPUG: 119230215
AFB: 129106432
CLUM: 117730994
PSWI: 130208430
MSAM: 119885564(rpp14)
SCHU: 122887442
CUD: 121503463(rpp14)
ALAT: 119020380
MZE: 101465350(htd2)
OLA: 101155024
CSAI: 133449205(rpp14)
XMA: 111605755
XCO: 114136073(htd2)
XHE: 116710353(htd2)
PLAI: 106956022(rpp14)
PMEI: 106933158(rpp14)
GAF: 122833999
PPRL: 129354630 129372898
CTUL: 119790336
GMU: 124856782
KMR: 112449719
ALIM: 106522356(rpp14)
NWH: 119412702
AOCE: 111575280 111581695 111584987
MCEP: 125007330(rpp14)
CSEM: 103386679
POV: 109635407
SSEN: 122768499
HHIP: 117760984
HSP: 118104569
PPLT: 128455242
SMAU: 118309477
LCF: 127138913
SDU: 111219474(rpp14)
SLAL: 111668194
XGL: 120783488
HCQ: 109510331(rpp14)
SSCV: 125976953
SBIA: 133506958
PEE: 133408271
PTAO: 133484144
MALB: 109966375
BSPL: 114855987
SJO: 128355900(rpp14)
STRU: 115149945(htd2)
OTW: 112255101
OMY: 110528675
OGO: 124024739
ONE: 115124325(htd2)
OKI: 109891466(htd2)
OKE: 118375330
SALP: 112074118
SNH: 120037984
CCLU: 121577864
ELS: 114828651(htd2)
SFM: 108929815(htd2)
PKI: 111837463
AANG: 118208575
LOC: 107077419
PSPA: 121298243(rpp14)
ARUT: 117964000
PSEX: 120539409
CMK: 103190039
RTP: 109929422
CPLA: 122559038
HOC: 132822128
LERI: 129704468
PMRN: 116952345
LRJ: 133355597(HTD2)
BFO: 118425584
BBEL: 109467964
CIN: 108949282
SCLV: 120337342
SPU: 754233
LPIC: 129264443
ARUN: 117288571
AJC: 117111955
CLON: 129609849
AALI: 118458762
MGEN: 117226667
SOC: 113004956
HST: 109503685
DQU: 106742434
CFO: 109610047
CSOL: 105366205
AROA: 105689652
SOY: 115881552
BMAN: 114241826
MJU: 123864707
MCIX: 123659263
AAGE: 121729626
ATRA: 106136914
API: 115034289
AGS: 114129397
RMD: 113550376
DVT: 126894591
BTAB: 109038585
MQU: 128989252
ZNE: 110838928
CSEC: 111864066
BROR: 134532661
IEL: 124161185
PJA: 122256737
PCHN: 125028775
PTRU: 123516689
MNZ: 135214648
DSV: 119457721
RSAN: 119374632
RMP: 119166725
TUT: 107369463
CSCU: 111622782
CVS: 136990445
LPOL: 106465753
HRO: HELRODRAFT_175453
CRG: 105340412
CANU: 128178558
CVN: 111128521
OED: 125652182
MYI: 110467089
PMAX: 117323513
OBI: 106869720
OSN: 115217442
LAK: 106171102
SMM: Smp_173000
OVI: T265_12458
NVE: 116602303
EPA: 110241968
ATEN: 116299329
AMIL: 114977532
PDAM: 113668995
SPIS: 111338273
TAD: TRIADDRAFT_52813
MBR: MONBRDRAFT_36649
SRE: PTSG_04866
DPP: DICPUDRAFT_11264
PSOJ: PHYSODRAFT_480915
TSY: THSYN_31605
 » show all
Reference
PMID:17898086
  Authors
Autio KJ, Kastaniotis AJ, Pospiech H, Miinalainen IJ, Schonauer MS, Dieckmann CL, Hiltunen JK
  Title
An ancient genetic link between vertebrate mitochondrial fatty acid synthesis and RNA processing.
  Journal
FASEB J 22:569-78 (2008)
DOI:10.1096/fj.07-8986
  Sequence
[hsa:109703458]
LinkDB

KEGG   ORTHOLOGY: K22541
Entry
K22541                      KO                                     
Symbol
HTD2
Name
3-hydroxyacyl-thioester dehydratase, fungi type [EC:4.2.1.-]
Pathway
map00061  Fatty acid biosynthesis
map01100  Metabolic pathways
map01212  Fatty acid metabolism
Module
M00874  Fatty acid biosynthesis in mitochondria, fungi
Reaction
R04428  (3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase
R04535  (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] hydro-lyase
R04537  (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase
R04544  (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase
R04568  (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] hydro-lyase
R04954  (3R)-3-hydroxyhexanoyl-[acyl-carrier-protein] hydro-lyase
R04965  (3R)-3-hydroxydodecanoyl-[acyl-carrier-protein] hydro-lyase
R10208  (3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (trans-2-enoyl-[acyl-carrier protein]-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00061 Fatty acid biosynthesis
    K22541  HTD2; 3-hydroxyacyl-thioester dehydratase, fungi type
Other DBs
COG: COG3777
Genes
SCE: YHR067W(HTD2)
SEUB: DI49_2470
SPAO: SPAR_H01080
AGO: AGOS_AAL038W
ERC: Ecym_3220
KLA: KLLA0_E12651g
KMX: KLMA_70369(HTD2)
LTH: KLTH0H14608g
VPO: Kpol_339p8
ZRO: ZYRO0C14322g
CGR: 2889513(GVI51_J10681)
NCS: NCAS_0H01690(NCAS0H01690)
NDI: NDAI_0C02020(NDAI0C02020)
TPF: TPHA_0E01160(TPHA0E01160)
TBL: TBLA_0C03530(TBLA0C03530)
TGB: HG536_0E02990
TDL: TDEL_0E02860(TDEL0E02860)
KAF: KAFR_0D04650(KAFR0D04650)
KNG: KNAG_0B04680(KNAG0B04680)
ZMK: HG535_0C03160
SLUD: SCDLUD_004652
DHA: DEHA2G17710g
PIC: PICST_58974
PGU: PGUG_04573
SPAA: SPAPADRAFT_58702
LEL: PVL30_004184
LBG: 92210308(LODBEIA_P51120)
CAL: CAALFM_C403200CA(CaO19.2670)
CTP: CTRG_00509
COT: CORT_0E03410
CDU: CD36_43050
CTEN: 18246072(PSN45_000165)
CLU: CLUG_05035
CLUS: A9F13_03g01969
CAUR: CJI96_0001261
PPA: PAS_chr3_0631
PKZ: C5L36_0C03580
BBRX: BRETT_000083
OPA: HPODL_00977
SPO: 2539744(htd2)
 » show all
Reference
PMID:15387819
  Authors
Kastaniotis AJ, Autio KJ, Sormunen RT, Hiltunen JK
  Title
Htd2p/Yhr067p is a yeast 3-hydroxyacyl-ACP dehydratase essential for mitochondrial function and morphology.
  Journal
Mol Microbiol 53:1407-21 (2004)
DOI:10.1111/j.1365-2958.2004.04191.x
  Sequence
[sce:YHR067W]
LinkDB

KEGG   REACTION: R10208
Entry
R10208                      Reaction                               
Name
(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (trans-2-enoyl-[acyl-carrier protein]-forming)
Definition
(3R)-3-Hydroxyacyl-[acyl-carrier protein] <=> trans-2,3-Dehydroacyl-[acyl-carrier protein] + H2O
Equation
C01271 <=> C00693 + C00001
Comment
general reaction
Reaction class
RC00770  C00693_C01271
Enzyme
4.2.1.59        4.2.1.-
Pathway
rn00061  Fatty acid biosynthesis
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.59
     R10208  (3R)-3-Hydroxyacyl-[acyl-carrier protein] <=> trans-2,3-Dehydroacyl-[acyl-carrier protein] + H2O
    4.2.1.-
     R10208  (3R)-3-Hydroxyacyl-[acyl-carrier protein] <=> trans-2,3-Dehydroacyl-[acyl-carrier protein] + H2O
IUBMB reaction hierarchy [BR:br08202]
 4. Lyase reactions
  4.2.1.59
   R10208  (3R)-3-Hydroxyacyl-[acyl-carrier protein] <=> trans-2,3-Dehydroacyl-[acyl-carrier protein]
Orthology
K01716  3-hydroxyacyl-[acyl-carrier protein] dehydratase / trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:4.2.1.59 5.3.3.14]
K02372  3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]
K16363  UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase / 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:3.5.1.108 4.2.1.59]
K22540  3-hydroxyacyl-thioester dehydratase, animal type [EC:4.2.1.-]
K22541  3-hydroxyacyl-thioester dehydratase, fungi type [EC:4.2.1.-]
Reference
1  [PMID:27553474]
  Authors
Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
  Title
Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
  Journal
Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)
DOI:10.1016/j.bbalip.2016.08.011
Other DBs
RHEA: 13100
LinkDB

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