KEGG   ORTHOLOGY: K22540
Entry
K22540                      KO                                     
Symbol
HTD2
Name
3-hydroxyacyl-thioester dehydratase, animal type [EC:4.2.1.-]
Pathway
map00061  Fatty acid biosynthesis
map01100  Metabolic pathways
map01212  Fatty acid metabolism
Module
M00873  Fatty acid biosynthesis in mitochondria, animals
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00061 Fatty acid biosynthesis
    K22540  HTD2; 3-hydroxyacyl-thioester dehydratase, animal type
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.-
     K22540  HTD2; 3-hydroxyacyl-thioester dehydratase, animal type
Other DBs
RN: R04428 R04535 R04537 R04544 R04568 R04954 R04965 R10208
Genes
HSA: 109703458(HTD2)
PTR: 112204078
PPS: 112436701(HTD2)
GGO: 115930083(HTD2)
NLE: 115830346(HTD2)
MCF: 123566755(HTD2)
CSAB: 103227809
CATY: 105585625(RPP14)
PANU: 103875477(HTD2)
TGE: 112619243(HTD2)
RRO: 104660192(RPP14) 104660193(HTD2)
RBB: 108543612(RPP14)
TFN: 117083054(HTD2)
PTEH: 111534122(HTD2)
CJC: 100401191(RPP14)
MMUR: 105884315 105884919(RPP14)
MMU: 109729085(Htd2)
MCOC: 116072721(Htd2)
MUN: 110554624
CGE: 113832350(Htd2)
PLEU: 114680727(Htd2)
CPOC: 111754587
DSP: 122108214(Htd2)
OCU: 100356042
OPI: 118760304(HTD2)
CFA: 111091303(HTD2)
VVP: 112909725(HTD2)
VLG: 121495987(HTD2)
UAH: 113257018(HTD2)
UAR: 123798796(HTD2)
ELK: 111144067
LLV: 125078389
EJU: 114214683(HTD2)
ZCA: 113918765(HTD2)
MLX: 118005160(HTD2)
FCA: 111559427
PYU: 121016800(HTD2)
PBG: 122488173(HTD2)
PTG: 102950284
PPAD: 109279087
AJU: 106968840(HTD2)
HHV: 120238602(HTD2)
BTA: 112447889(HTD2)
BBUB: 112577783(HTD2)
OAS: 101122389(HTD2)
ODA: 120851377 120867978(HTD2)
CCAD: 122424321(HTD2) 122433808
SSC: 100515579
CFR: 116657110(HTD2)
CDK: 116158254(HTD2)
VPC: 116283967(HTD2)
DLE: 111174244(HTD2)
PCAD: 112064963(HTD2)
PSIU: 116762513(HTD2)
ECB: 111768318
EAI: 123279356(HTD2)
MLF: 111828449
PKL: 118715076(HTD2)
DRO: 112301293(HTD2)
SHON: 118983383(HTD2)
AJM: 119043376(HTD2)
PDIC: 114501993(HTD2)
PHAS: 123814511(HTD2)
MMF: 118633528(HTD2)
RFQ: 117037176(HTD2)
PALE: 112484321(HTD2)
PGIG: 120599501(HTD2)
PVP: 111746606
TOD: 119230488(HTD2)
SARA: 101558095
LAV: 111750580
TMU: 111819738
MDO: 103101327
GAS: 123230662(HTD2)
SHR: 111719548(HTD2)
PCW: 110196017
OAA: 114806605(HTD2)
GGA: 112533344(HTD2)
PCOC: 116237405(HTD2)
CJO: 116654008(HTD2)
NMEL: 110404841
APLA: 101790049(HTD2)
AFUL: 116492979(HTD2)
LSR: 110472415(HTD2)
SCAN: 115483820(HTD2)
PMOA: 120513980(HTD2)
OTC: 121347141(HTD2)
PRUF: 121352776(HTD2)
FAB: 101809145
CCAE: 111935019
CCW: 109143331(HTD2)
ETL: 114056798(HTD2)
ZAB: 113459451(HTD2)
FCH: 114016005(HTD2)
CLV: 106145808
NNI: 104016989
ACUN: 113485023(HTD2)
TALA: 104355952(HTD2)
PADL: 103918910
ACHC: 115353754(HTD2)
AROW: 112976612(HTD2)
NPD: 112958775(HTD2)
DNE: 112984675(HTD2)
PSS: 112546375(HTD2)
CMY: 114020856(HTD2)
TST: 117880512(HTD2)
CABI: 116825644(HTD2)
MRV: 120409161(HTD2)
PVT: 110079940
SUND: 121923711(HTD2)
PBI: 112540543(HTD2)
PMUR: 114923725(HTD2)
PGUT: 117660654(HTD2)
VKO: 123034614(HTD2)
PMUA: 114591894(HTD2)
ZVI: 118080860(HTD2)
XLA: 108704592
NPR: 108791848
RTEM: 120945221
BBUF: 120979511
BGAR: 122943675(HTD2)
SRX: 107745404
SANH: 107658379
SGH: 107586974
IPU: 108255082(rpp14)
PHYP: 113537924(htd2)
SMEO: 124402136
AMEX: 103034148
EEE: 113580586(htd2)
LCO: 104940354(rpp14)
NCC: 104948461
CGOB: 115008319(htd2)
ELY: 117256521
PLEP: 121951632(rpp14)
SLUC: 118492913
ECRA: 117943536(rpp14)
PFLV: 114554172(htd2)
GAT: 120835651
PPUG: 119230215
MSAM: 119885564(rpp14)
CUD: 121503463(rpp14)
MZE: 101465350(htd2)
OLA: 101155024
XMA: 111605755
XCO: 114136073(htd2)
XHE: 116710353(htd2)
PLAI: 106956022(rpp14)
PMEI: 106933158(rpp14)
GAF: 122833999
CTUL: 119790336
GMU: 124856782
KMR: 112449719
ALIM: 106522356(rpp14)
NWH: 119412702
CSEM: 103386679
POV: 109635407
SSEN: 122768499
HHIP: 117760984
LCF: 108874781(rpp14)
SDU: 111219474(rpp14)
SLAL: 111668194
XGL: 120783488
HCQ: 109510331(rpp14)
MALB: 109966375
OTW: 112255101
OMY: 110528675
OGO: 124024739
ONE: 115124325(htd2)
SALP: 112074118
SNH: 120037984
ELS: 105013320(rpp14) 114828651(htd2)
SFM: 108929815(htd2)
PKI: 111837463
AANG: 118208575
LOC: 107077419
PSPA: 121298243(rpp14)
ARUT: 117964000
CMK: 103190039
RTP: 109929427
BFO: 118425584
BBEL: 109467964
CIN: 108949282
SCLV: 120337342
SPU: 754233
MGEN: 117226667
SOC: 113004956
HST: 109503685
DQU: 106742434
CFO: 109610047
CSOL: 105366205
SOY: 115881552
BMOR: 101737244
BMAN: 114241826
BANY: 112047308
API: 115034289
AGS: 114129397
RMD: 113550376
BTAB: 109038585
ZNE: 110838928
CSEC: 111864066
PJA: 122256737
PTRU: 123516689
DSV: 119457721
RSAN: 119374632
RMP: 119166725
TUT: 107369463
CSCU: 111622782
CRG: 105340412
MYI: 110467089
PMAX: 117323513
OBI: 106869720
OSN: 115217442
LAK: 106171102
NVE: 116602303
EPA: 110241968
ATEN: 116299329
AMIL: 114977532
PDAM: 113668995
SPIS: 111338273
 » show all
Reference
  Authors
Autio KJ, Kastaniotis AJ, Pospiech H, Miinalainen IJ, Schonauer MS, Dieckmann CL, Hiltunen JK
  Title
An ancient genetic link between vertebrate mitochondrial fatty acid synthesis and RNA processing.
  Journal
FASEB J 22:569-78 (2008)
DOI:10.1096/fj.07-8986
  Sequence
[hsa:109703458]
LinkDB

KEGG   ORTHOLOGY: K22541
Entry
K22541                      KO                                     
Symbol
HTD2
Name
3-hydroxyacyl-thioester dehydratase, fungi type [EC:4.2.1.-]
Pathway
map00061  Fatty acid biosynthesis
map01100  Metabolic pathways
map01212  Fatty acid metabolism
Module
M00874  Fatty acid biosynthesis in mitochondria, fungi
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00061 Fatty acid biosynthesis
    K22541  HTD2; 3-hydroxyacyl-thioester dehydratase, fungi type
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.-
     K22541  HTD2; 3-hydroxyacyl-thioester dehydratase, fungi type
Other DBs
RN: R04428 R04535 R04537 R04544 R04568 R04954 R04965 R10208
COG: COG3777
Genes
SCE: YHR067W(HTD2)
AGO: AGOS_AAL038W
ERC: Ecym_3220
KLA: KLLA0_E12651g
KMX: KLMA_70369(HTD2)
LTH: KLTH0H14608g
VPO: Kpol_339p8
ZRO: ZYRO0C14322g
CGR: CAGL0J10868g
NCS: NCAS_0H01690(NCAS0H01690)
NDI: NDAI_0C02020(NDAI0C02020)
TPF: TPHA_0E01160(TPHA0E01160)
TBL: TBLA_0C03530(TBLA0C03530)
TDL: TDEL_0E02860(TDEL0E02860)
KAF: KAFR_0D04650(KAFR0D04650)
CAL: CAALFM_C403200CA(CaO19.2670)
SLB: AWJ20_467(HTD2)
SPO: SPBC1105.15c(htd2)
 » show all
Reference
  Authors
Kastaniotis AJ, Autio KJ, Sormunen RT, Hiltunen JK
  Title
Htd2p/Yhr067p is a yeast 3-hydroxyacyl-ACP dehydratase essential for mitochondrial function and morphology.
  Journal
Mol Microbiol 53:1407-21 (2004)
DOI:10.1111/j.1365-2958.2004.04191.x
  Sequence
[sce:YHR067W]
LinkDB

KEGG   REACTION: R10208
Entry
R10208                      Reaction                               
Name
(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (trans-2-enoyl-[acyl-carrier protein]-forming)
Definition
(3R)-3-Hydroxyacyl-[acyl-carrier protein] <=> trans-2,3-Dehydroacyl-[acyl-carrier protein] + H2O
Equation
Comment
general reaction
Reaction class
RC00770  C00693_C01271
Enzyme
4.2.1.59        4.2.1.-
Pathway
rn00061  Fatty acid biosynthesis
rn01100  Metabolic pathways
Orthology
K01716  3-hydroxyacyl-[acyl-carrier protein] dehydratase / trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:4.2.1.59 5.3.3.14]
K02372  3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]
K16363  UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase / 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:3.5.1.108 4.2.1.59]
K22540  3-hydroxyacyl-thioester dehydratase, animal type [EC:4.2.1.-]
K22541  3-hydroxyacyl-thioester dehydratase, fungi type [EC:4.2.1.-]
Reference
1  [PMID:27553474]
  Authors
Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
  Title
Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
  Journal
Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)
DOI:10.1016/j.bbalip.2016.08.011
Other DBs
RHEA: 13100
LinkDB

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