KEGG   ORTHOLOGY: K22572
Entry
K22572            Tight     KO                                     
Symbol
AF490
Name
5-dehydrofumagillol 5-reductase [EC:1.1.1.437]
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00969  Fumagillin biosynthesis, farnesyl-PP => fumagillin
Reaction
R13106  fumagillol:NADP+ 5-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K22572  AF490; 5-dehydrofumagillol 5-reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.437  5-dehydrofumagillol 5-reductase
     K22572  AF490; 5-dehydrofumagillol 5-reductase
Other DBs
COG: COG1028
Genes
AFM: AFUA_8G00490
Reference
PMID:24568283
  Authors
Lin HC, Tsunematsu Y, Dhingra S, Xu W, Fukutomi M, Chooi YH, Cane DE, Calvo AM, Watanabe K, Tang Y
  Title
Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway.
  Journal
J Am Chem Soc 136:4426-36 (2014)
DOI:10.1021/ja500881e
  Sequence
[afm:AFUA_8G00490]
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