KEGG ORTHOLOGY: K23297

ORTHOLOGY: K23297

Entry

K23297                      KO

Symbol

C12ORF66

Name

KICSTOR complex protein C12orf66

Disease

H00768

Autosomal recessive intellectual developmental disorder

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K23297  C12ORF66; KICSTOR complex protein C12orf66
Membrane trafficking [BR:ko04131]
Autophagy
  Other autophagy associated proteins
   KICSTOR complex
    K23297  C12ORF66; KICSTOR complex protein C12orf66

Genes

HSA:	144577(KICS2)

PTR:	745077(KICS2)

PPS:	100991549(KICS2)

GGO:	101135963(KICS2)

PON:	100431301(KICS2)

PPYG:

129009414(KICS2)

NLE:	100584073(C11H12orf66)

HMH:	116480807(KICS2)

SSYN:

129466330(KICS2)

MCC:	717230(C11H12orf66)

MCF:	102142075(KICS2)

MTHB:

126930861

MNI:	105473465(CUNH12orf66)

CSAB:

103238635(C11H12orf66)

CATY:

105600542

PANU:

100998435(C9H12orf66)

TGE:	112635533(C11H12orf66)

MLEU:

105534229

RRO:	104680833(C10H12orf66)

RBB:	108530024(CUNH12orf66)

TFN:	117089821(CUNH12orf66)

PTEH:

111551256(C10H12orf66)

CANG:

105502624

CJC:	100398382(KICS2)

SBQ:

101052653

CIMI:

108288402(CUNH12orf66)

ANAN:

105712002(KICS2)

CSYR:

103258606(CUNH12orf66)

MMUR:

105880961(C7H12orf66)

LCAT:

123639560(KICS2)

PCOQ:

105824190

OGA:	100967020(CUNH12orf66)

MMU:	270802(Kics2)

MCAL:

110302973(C10H12orf66)

MPAH:

110326930(C9H12orf66)

RNO:	500843(Kics2)

MCOC:

116076125(CUNH12orf66)

ANU:	117696876(CUNH12orf66)

ASYL:

127670476(Kics2)

MUN:	110559646(Kics2)

CGE:	100757589(C1H12orf66)

MAUA:

101842093(Kics2)

PROB:

127215701(Kics2)

PLEU:

114693291(C18H12orf66)

MORG:

121464379(Kics2)

MFOT:

126494499

AAMP:

119803696(Kics2)

NGI:	103730711(CUNH12orf66)

HGL:

101716099

CPOC:

100713589(CUNH12orf66)

CCAN:

109690578

DORD:

105990804

DSP:	122124098(Kics2)

DMER:

138803872(Kics2)

PLOP:

125361747(Kics2)

NCAR:

124983754

MMMA:

107140097(Kics2)

ITI:	101972583(Kics2)

OCU:	100358245(KICS2)

OPI:	101534537(C4H12orf66)

OCZ:	121157982(KICS2)

TUP:

102484498

CFA:	474426(C10H12orf66)

CLUD:

112677919(KICS2)

VVP:	112922306(CUNH12orf66)

VLG:	121491934(KICS2)

NPO:	129511866(KICS2)

AML:	100483601(C15H12orf66)

UMR:	103656831(KICS2)

UAH:	113256333(KICS2)

UAR:	123787177(KICS2)

ELK:

111159744

LLV:

125106535

MPUF:

101690505

MNP:	132019876(KICS2)

MLK:	131838505(KICS2)

NVS:	122892648(KICS2)

ORO:

101386739

EJU:	114214948(CUNH12orf66)

ZCA:	113921482(C9H12orf66)

MLX:	118008627(CUNH12orf66)

NSU:	110570619(KICS2)

LWW:	102747943(CUNH12orf66)

FCA:	101087165(KICS2)

PYU:	121040824(KICS2)

PCOO:

112863903(CUNH12orf66)

PBG:	122473946(KICS2)

PVIV:

125169593(KICS2)

LRUF:

124501520

LGF:	123591156(KICS2)

AJU:	106981347(KICS2)

PTG:

102959857

PPAD:

109270429(CUNH12orf66)

PUC:

125919282

PLEZ:

122224780(KICS2)

HHV:	120233183(CUNH12orf66)

BTA:	535460(KICS2)

BOM:	102280038(KICS2)

BIU:	109559278(C5H12orf66)

BBUB:

102404173(KICS2)

BBIS:

104989802

CHX:	102182671(C5H12orf66)

OAS:	101111620(KICS2)

BTAX:

128047631(KICS2)

CSUM:

138079247(KICS2)

ODA:	120857685(KICS2)

CCAD:

122427779(KICS2)

MREE:

136167255(KICS2)

OVR:	110123707(KICS2)

MBEZ:

129537114(KICS2)

SSC:	100155363(C5H12orf66)

CFR:	102515481(C12H12orf66)

CBAI:

105081360

CDK:	105089263(C12H12orf66)

VPC:	102529668(C12H12orf66)

BACU:

103019493

BMUS:

118902578(C10H12orf66)

LVE:

103081272

OOR:	101289661(KICS2)

LALB:

132529290(KICS2)

GMF:	115858511(KICS2)

DDP:	132433849(KICS2)

DLE:	111173796(CUNH12orf66)

PCAD:

102978629(KICS2)

PSIU:

116760206(C10H12orf66)

PPHC:

136131266(KICS2)

NASI:

112394403(CUNH12orf66)

ECB:	100051506(C6H12orf66)

EPZ:	103553860(KICS2)

EAI:	106824386(KICS2)

MYB:

102246555

MYD:

102768838

MMYO:

118651064(CUNH12orf66)

MLF:	102423003(CUNH12orf66) 102437401

MDT:	132227864(KICS2)

MYUM:

139006951(KICS2)

PKL:	118730719(CUNH12orf66)

EFUS:

103292493(KICS2)

MNA:

107527122

DRO:	112319163(CUNH12orf66)

SHON:

118998719(KICS2)

AJM:	119045544(KICS2)

PDIC:

114514106(C2H12orf66)

PHAS:

123812970(KICS2)

MMF:	118624009(CUNH12orf66)

PPAM:

129075844(KICS2)

HAI:	109381685(CUNH12orf66)

RFQ:	117029075(C10H12orf66)

PALE:

102892888(CUNH12orf66)

PGIG:

120605009(KICS2)

PVP:	105301088(CUNH12orf66)

RAY:	107508220(CUNH12orf66)

MJV:	108404480(CUNH12orf66)

TOD:	119248117(KICS2)

SARA:

101542018

SFUM:

130038945(KICS2)

SETR:

126021882(KICS2)

LAV:	100660445(CUNH12orf66)

TMU:

101346408

ETF:	101639187(KICS2)

DNM:	101426745(CUNH12orf66)

MDO:	100016413(C8H12orf66)

GAS:	123248947(KICS2)

SHR:	100933755(C5H12orf66)

AFZ:

127563960

PCW:	110211016(CUNH12orf66)

TVP:	118851993(C5H12orf66)

PBRV:

138155489(KICS2)

OAA:	100092829(KICS2)

TACU:

119949517(C2H12orf66)

GGA:	417822(C1H12ORF66)

PCOC:

116226619(CUNH12orf66)

MGP:	100542458(C1H12orf66)

CJO:	107310106(C1H12orf66)

TPAI:

128073867(KICS2)

LMUT:

125703437(KICS2)

NMEL:

110392747(C1H12orf66)

APLA:

101800717(C1H12orf66)

ACYG:

106045456(KICS2)

CATA:

118246805(KICS2)

AFUL:

116502211(C1H12orf66)

TGU:	100218995(C1AH12orf66)

LSR:	110479876(KICS2)

SCAN:

103820395(CUNH12orf66)

PMOA:

120499886(KICS2)

OTC:	121339474(KICS2)

PRUF:

121352553(KICS2)

ATRC:

139588319(KICS2)

GFR:

102044847

FAB:	101808455(C1AH12orf66)

OMA:	130267082(KICS2)

PHI:

102111564

PMAJ:

107204372(C1AH12orf66)

CCAE:

111932430(C1H12orf66)

CCW:	104698353(KICS2)

CBRC:

103614798(CUNH12orf66)

ACOE:

138100556(KICS2)

ETL:	114059391(CUNH12orf66)

ZAB:	102075162(CUNH12orf66)

ZLE:	135442258(KICS2)

ACHL:

103806126

SVG:

106860659

MMEA:

130579887(KICS2)

HRT:	120752032(KICS2)

SATI:

136361296(KICS2)

CCIC:

134043538(KICS2)

FPG:

101911417

FCH:	102051554(CUNH12orf66)

CCRI:

104161248

NNT:

104408020

SHAB:

115605547(C3H12orf66)

ACUN:

113491443(C1H12orf66)

TALA:

104364129(KICS2)

ACHC:

115336273(KICS2)

HALD:

104311459

HLE:

104828203

AGEN:

126034505

HHAR:

128135508(KICS2)

GCL:

CSTI:

LDI:

MNB:

DPUB:

PPUS:

135174740(KICS2)

AVIT:

104275234

BRHI:

104488368

EGZ:	104122198(CUNH12orf66)

NNI:

PCRI:

PCAO:

PADL:

AFOR:

103900418(CUNH12orf66)

FGA:

104077765

CBOR:

142081758(KICS2)

GSTE:

104258396

CBOY:

140652285(KICS2)

MAME:

142406231(KICS2)

CLV:	102085846(CUNH12orf66)

CNIC:

135995459(KICS2)

MUI:

PGUU:

PLET:

EHS:

CMAC:

CUCA:

104055183(KICS2)

TEO:

104379157

BREG:

104630636

OHA:

104326779

ACAR:

104530741(CUNH12orf66)

CPEA:

104388830

CVF:

104288938

RTD:	128915536(KICS2)

CRID:

134510133(KICS2)

LMIC:

141737474(KICS2)

AAM:

106488614

AROW:

112968138(CUNH12orf66)

NPD:	112947668(CUNH12orf66)

TGT:

104564976

DNE:	112978731(CUNH12orf66)

SCAM:

104142073

ASN:	102383155(CUNH12orf66)

AMJ:	102561308(CUNH12orf66)

CPOO:

109315547(CUNH12orf66)

GGN:	109295687(CUNH12orf66)

PSS:	102460528(CUNH12orf66)

CIZ:	142023105(KICS2)

CMY:	102939081(KICS2)

CCAY:

125630252(KICS2)

DCC:	119850073(KICS2)

CPIC:

101946521(KICS2)

TST:	117877420(C1H12orf66)

CABI:

116818546(CUNH12orf66)

MRV:	120384084(KICS2)

ACS:	100554166(c5h12orf66)

ASAO:

132776197(KICS2)

PVT:	110075140(CUNH12orf66)

SUND:

121932028(KICS2)

PBI:	103051595(CUNH12orf66) 103066875

PMUR:

107291841(CUNH12orf66)

CTIG:

120307417(CUNH12orf66)

TSR:

106553500

PGUT:

117655374(KICS2)

PCAE:

139319363(KICS2)

APRI:

131202324(KICS2)

PTEX:

113436036(CUNH12orf66)

NSS:	113412285(CUNH12orf66)

VKO:	123019922(KICS2)

PMUA:

114605233(C10H12orf66)

PRAF:

128422222(KICS2)

ZVI:	118090806(LG9H12orf66)

HCG:	128328406(KICS2)

GJA:

107110950

STOW:

125435760(KICS2)

EMC:	129335426(KICS2)

XLA:	108713164(kics2.S) 432102(kics2.L)

XTR:	100379702(c12orf66)

NPR:	108792584(CUNH12orf66)

RTEM:

120932020(KICS2)

ACAT:

141133951(KICS2)

BBUF:

120980206(KICS2)

BGAR:

122928062(KICS2)

DTC:	141059167(KICS2)

PWL:	138288020(KICS2)

MUO:	115479090(C10H12orf66)

GSH:	117367088(C9H12orf66)

DRE:	555715(kics2)

SRX:	107726025 107743608

SANH:

107656252 107658829

SGH:	107580661 107592225

CCAR:

109062900 109097394(kics2)

CAUA:

113048295 113059114

CGIB:

127956877 127977018

PTET:

122343334(kics2)

LROH:

127164611(kics2)

GRF:	141333577(kics2)

OMC:	131538439(kics2)

PPRM:

120476611(kics2)

RKG:	130079924(kics2)

MAMB:

125245590(kics2)

CIDE:

127510855

CERY:

137023805(kics2)

MASI:

127434906 127436942

TROS:

130547616(kics2)

TDW:	130421014(kics2)

MANU:

129432663(kics2)

PDAB:

135746969(kics2)

IPU:	108279873(kics2)

IFU:	128623595(kics2)

PHYP:

113531765(cunh12orf66)

SMEO:

124400734(kics2)

TFD:	113645684(kics2)

TVC:	132858697(kics2)

CGAR:

128534472(kics2)

NGRA:

132870135(kics2)

TRN:	134323773(kics2)

AMEX:

103023944(kics2)

CMAO:

118812550(cunh12orf66)

EEE:	113584406(cunh12orf66)

CHAR:

105912110(kics2)

SPIL:

134070912(kics2)

ASAD:

121698938(kics2)

TRU:	101067049(c18h12orf66)

TFS:	130519196(kics2)

TNG:	GSTEN00034658G001

LCO:	104936524(cxh12orf66)

NCC:

104959783

TBEN:

117497348(cunh12orf66)

PGEO:

117442751(kics2)

EMAC:

134878917(kics2)

ELY:	117248949(c23h12orf66)

EFO:	125883233(kics2)

PLEP:

121938004 121961479

SLUC:

116047912(c20h12orf66)

ECRA:

117938946(c23h12orf66)

ESP:	116672943 116673012

PFLV:

114550206(c23h12orf66)

GAT:	120817248(kics2)

PPUG:

119210967(kics2)

AFB:	129112815(kics2)

CLUM:

117726385(c23h12orf66)

PSWI:

130200571(kics2)

CANA:

137791837(kics2)

CVE:	137866570(kics2)

MSAM:

119895582(cunh12orf66)

SCHU:

122871360(kics2)

CUD:	121505701(kics2)

SPUL:

138599640(kics2)

HTC:	141810620(kics2)

ALAT:

119032764(c14h12orf66)

ASTR:

137589257(kics2)

MZE:	101486172(lg17h12orf66)

ONL:	100696364(lg17h12orf66)

OAU:	116336476(kics2)

OLA:	101154911(c23h12orf66)

OML:	112154025(lg23h12orf66)

CSAI:

133424338(kics2)

XMA:	102228917(c17h12orf66)

XCO:	114161005(c17h12orf66)

XHE:	116736337(c17h12orf66)

PRET:

103459084(clg23h12orf66)

PFOR:

103154029

PLAI:

106953096

PMEI:

106922705

GAF:	122826429(kics2)

PPRL:

129351858(kics2)

CVG:

107090505

CTUL:

119771304(cunh12orf66)

GMU:	124882906(kics2)

NFU:	107386934(csgr01h12orf66)

KMR:	108249646(lg18h12orf66)

ALIM:

106532744

NWH:	119428046(kics2)

AOCE:

111579130(kics2)

EJA:	138213417(kics2)

BFRE:

138614224(kics2)

MCEP:

124999794(kics2)

CSEM:

103382538(c8h12orf66)

POV:	109643608(cunh12orf66)

SSEN:

122766015(kics2)

SSOE:

131457325(kics2)

HHIP:

117757034(c23h12orf66)

HSP:	118101757(kics2)

PPLT:

128428961(kics2)

SMAU:

118290054(kics2)

LCF:	108895882(kics2)

SDU:	111224859(cunh12orf66)

SLAL:

111657664(cunh12orf66)

XGL:	120797433(kics2)

HCQ:	109532643(cunh12orf66)

SSCV:

125991968(kics2)

SBIA:

133493539(kics2)

PEE:	133396885(kics2)

PTAO:

133471629(kics2)

BPEC:

110161771(cunh12orf66)

ENY:	140367573(kics2)

MALB:

109967612(cunh12orf66)

BSPL:

114861694(kics2)

SJO:	128385145(kics2)

SSCO:

134004748(kics2)

TTY:	137175700(kics2)

GMH:	115542693(c4h12orf66)

SASA:

106576040 106609147(cssa07h12orf66)

STRU:

115180044 115198693

OTW:	112214386 112216819

OMY:	110490215 110500251

OGO:	123994705 124013919

ONE:	115106909 115133208

OKI:	109864349 109896793

OKE:	118366185 118392295

OMM:	135514750 135516025

OCLA:

139378736 139392794

SALP:

111950854 111951438

SNH:	120031767 120049866

SFON:

129838573 129865319

CCLU:

121543703 121546273

ELS:	105020158(lg23h12orf66)

OEP:	134038027(kics2)

SFM:	108931461(c2h12orf66)

PKI:	111833320(cunh12orf66)

AANG:

118232205(c7h12orf66)

AROT:

135259834(kics2)

CCOG:

133134701(kics2)

LOC:	102686959(clg8h12orf66)

PSPA:

121318100(kics2)

ARUT:

117414933 117419413

PSEX:

120533824(kics2)

LCM:

102346682

CMK:	103179817(kics2)

RTP:	109919863(kics2)

CPLA:

122559848(kics2)

HOC:	132824626(kics2)

SCAU:

119955042(c20h12orf66)

LERI:

129706382(kics2)

HAKA:

140734561(kics2)

PMRN:

116949379(C36H12orf66)

LRJ:	133342615(KICS2)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

LVG:

AJJ:	139974659 139974736

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:

CCOA:

TCZ:

TSEP:

PBAR:

VEM:

COBS:

TLN:

HST:

DQU:

CFO:

FEX:

PMEC:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:	122629407 122629410

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

CTYP:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

DPA:

ESIM:

EFOR:

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

LDA:

HVI:

MQU:

FOC:

TPAL:

ZNE:

CSEC:

PAME:

BROR:

DPX:	DAPPUDRAFT_304951

DMK:

DPZ:

AFRA:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

MNZ:

MRJ:

PORN:

HAZT:

EAF:

LSM:

PPOI:

DSV:

RSAN:

RMP:

DPTE:

DFR:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

PMEO:

NAI:	NECAME_05598

BMY:	BM_BM9573(Bm9573)

LOA:	LOAG_07741

HRO:	HELRODRAFT_184949

LGI:	LOTGIDRAFT_167458

PVUL:

PCAN:

LSAX:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

OED:

MYI:

PMAX:

AIRR:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:	106158398 112041230

SMM:	Smp_155770

OVI:	T265_15308

EGL:

EGR_07022

LLON:

135503065

NVE:	5499648 5514744

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_58437

AQU:

105311954

RIE:	OCT59_001863

DDI:	DDB_G0278475

DPP:	DICPUDRAFT_158261

DFA:

DFA_01080

ACAN:

ACA1_204030

PIF:	PITG_11119

PSOJ:

PHYSODRAFT_482732

SPAR:

SPRG_07084 SPRG_17524

» show all

Reference

PMID:28199306

Authors

Wolfson RL, Chantranupong L, Wyant GA, Gu X, Orozco JM, Shen K, Condon KJ, Petri S, Kedir J, Scaria SM, Abu-Remaileh M, Frankel WN, Sabatini DM

Title

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.

Journal

Nature 543:438-442 (2017)
DOI:10.1038/nature21423

Sequence

[hsa:144577]

LinkDB

DBGET integrated database retrieval system