KEGG ORTHOLOGY: K23436

ORTHOLOGY: K23436

Entry

K23436                      KO

Symbol

AGBL1, CCP4

Name

cytosolic carboxypeptidase protein 4 [EC:3.4.17.24]

Disease

H00960

Fuchs corneal dystrophy

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K23436  AGBL1, CCP4; cytosolic carboxypeptidase protein 4
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.17  Metallocarboxypeptidases
    3.4.17.24  tubulin-glutamate carboxypeptidase
     K23436  AGBL1, CCP4; cytosolic carboxypeptidase protein 4
Peptidases and inhibitors [BR:ko01002]
Metallo peptidases
  Family M14: carboxypeptidase A family
   K23436  AGBL1, CCP4; cytosolic carboxypeptidase protein 4

Genes

HSA:	123624(AGBL1)

PTR:	467750(AGBL1)

PPS:	100992666(AGBL1)

GGO:	101129763(AGBL1)

PON:	100457638(AGBL1)

PPYG:

129014310(AGBL1)

NLE:	100584395(AGBL1)

HMH:	116481559(AGBL1)

SSYN:

129482109(AGBL1)

MCC:	699665(AGBL1)

MCF:	102121173(AGBL1)

MTHB:

126959739

MNI:	105488361(AGBL1)

CSAB:

103231124(AGBL1)

CATY:

105592435(AGBL1)

PANU:

101011902(AGBL1)

TGE:

112628890

MLEU:

105539021

RRO:

104669579

RBB:	108522470(AGBL1)

TFN:

117070260

PTEH:

111522906(AGBL1)

CANG:

105525227(AGBL1)

CJC:	100387973(AGBL1)

SBQ:	101028014(AGBL1)

CIMI:

108289870(AGBL1)

ANAN:

105707657(AGBL1)

MMUR:

105876515(AGBL1)

LCAT:

123644369(AGBL1)

PCOQ:

105809822(AGBL1)

OGA:	100958164(AGBL1)

MMU:	244071(Agbl1)

MCAL:

110298802(Agbl1)

MPAH:

110317945(Agbl1)

RNO:	308724(Agbl1)

MCOC:

116102415(Agbl1)

ANU:	117710212(Agbl1)

ASYL:

127687522(Agbl1)

MUN:	110563861(Agbl1)

CGE:	100750752(Agbl1)

MAUA:

101844406(Agbl1)

PLEU:

114699885(Agbl1)

MORG:

121447006(Agbl1)

MFOT:

126508635

AAMP:

119802490(Agbl1)

NGI:	103749471(Agbl1)

HGL:	101725425(Agbl1)

CPOC:

100733157(Agbl1)

CCAN:

109685302(Agbl1)

DORD:

105982310(Agbl1)

DSP:	122123964(Agbl1)

PLOP:

125368201(Agbl1)

NCAR:

124977322

MMMA:

107148346(Agbl1)

ITI:	101975284(Agbl1)

OCU:

100352303

OPI:	101523222(AGBL1)

TUP:	102485661(AGBL1)

CFA:	479034(AGBL1)

CLUD:

112653576(AGBL1)

VVP:	112921932(AGBL1)

VLG:	121490114(AGBL1)

NPO:	129510079(AGBL1)

AML:	100479250(AGBL1)

UMR:	103660055(AGBL1)

UAH:	113263567(AGBL1)

UAR:	123802439(AGBL1)

ELK:

111152678

LLV:

125104182

MPUF:

101686443(AGBL1)

MNP:	132029084(AGBL1)

MLK:	131835633(AGBL1)

NVS:	122894685(AGBL1)

ORO:	101373894(AGBL1)

EJU:	114223274(AGBL1)

ZCA:	113909158(AGBL1)

MLX:	118023028(AGBL1)

NSU:	110572192(AGBL1)

LWW:	102738523(AGBL1)

FCA:	101092766(AGBL1)

PYU:	121042422(AGBL1)

PCOO:

112854967(AGBL1)

PBG:	122468253(AGBL1)

PVIV:

125167488(AGBL1)

LRUF:

124517388

LGF:	123582495(AGBL1)

AJU:

106982639

PTG:	102968543(AGBL1)

PPAD:

109273402(AGBL1)

PLEZ:

122221634(AGBL1)

HHV:	120240900(AGBL1)

BTA:	100300175(AGBL1)

BOM:	102283480(AGBL1)

BIU:

109575497

BBUB:

102414193(AGBL1)

BBIS:

104982755(AGBL1)

CHX:	102185399(AGBL1)

OAS:	101115736(AGBL1)

BTAX:

128066446(AGBL1)

CSUM:

138095466(AGBL1)

ODA:	120875368(AGBL1)

CCAD:

122419640(AGBL1)

MREE:

136147064(AGBL1)

OVR:	110147460(AGBL1)

MBEZ:

129550253(AGBL1)

SSC:	100524296(AGBL1)

CFR:	102507055(AGBL1)

CBAI:

105075204(AGBL1)

CDK:	105085471(AGBL1)

VPC:

102530575

BACU:

103011912(AGBL1)

BMUS:

118890631(AGBL1)

LVE:	103073894(AGBL1)

OOR:	101270994(AGBL1)

LALB:

132524271(AGBL1)

DLE:	111169336(AGBL1)

PCAD:

102977787(AGBL1)

PSIU:

116748544(AGBL1)

NASI:

112402398(AGBL1)

ECB:	100070057(AGBL1)

EPZ:	103558371(AGBL1)

EAI:	106832012(AGBL1)

MYB:	102252036(AGBL1)

MYD:	102772229(AGBL1)

MMYO:

118679273(AGBL1)

MLF:

106694369

MDT:	132223062(AGBL1)

MYUM:

138998552(AGBL1)

PKL:	118704319(AGBL1)

EFUS:

103299629(AGBL1)

MNA:	107534457(AGBL1)

DRO:	112306058(AGBL1)

SHON:

118992087

AJM:	119049140(AGBL1)

PDIC:

114488674(AGBL1)

PHAS:

123809806(AGBL1)

MMF:	118641025(AGBL1)

PPAM:

129079871(AGBL1)

RFQ:	117018968(AGBL1)

PALE:

102880556(AGBL1)

PGIG:

120599380(AGBL1)

PVP:	105290261(AGBL1)

RAY:	107514187(AGBL1)

MJV:	108399114(AGBL1)

TOD:	119245135(AGBL1)

SARA:

101550102(AGBL1)

SFUM:

130023410(AGBL1)

SETR:

126022937(AGBL1)

LAV:	100666754(AGBL1)

TMU:

101346640

ETF:	101663111(AGBL1)

DNM:	101430000(AGBL1)

MDO:	100017490(AGBL1)

GAS:	123234206(AGBL1)

AFZ:

127551371

PCW:	110192328(AGBL1)

TVP:	118829621(AGBL1)

PBRV:

138169251(AGBL1)

OAA:	100075393(AGBL1)

TACU:

119928840(AGBL1)

GGA:	427507(AGBL1)

PCOC:

116225593(AGBL1)

MGP:	100551065(AGBL1)

CJO:	107318857(AGBL1)

TPAI:

128075411(AGBL1)

LMUT:

125698221(AGBL1)

NMEL:

110403848(AGBL1)

APLA:

101793469(AGBL1)

ACYG:

106036461(AGBL1)

CATA:

118251928(AGBL1)

AFUL:

116493539(AGBL1)

TGU:	100224531(AGBL1)

LSR:	110470588(AGBL1)

SCAN:

103816212(AGBL1)

PMOA:

120509183(AGBL1)

OTC:	121343602(AGBL1)

PRUF:

121354591(AGBL1)

ATRC:

139597078(AGBL1)

GFR:	102035278(AGBL1)

FAB:	101820233(AGBL1)

OMA:	130257577(AGBL1)

PHI:	102103060(AGBL1)

PMAJ:

107209101(AGBL1)

CCAE:

111934033(AGBL1)

CCW:	104684084(AGBL1)

CBRC:

103621357(AGBL1)

ACOE:

138116613(AGBL1)

ETL:	114058032(AGBL1)

ZAB:	102065386(AGBL1)

ZLE:	135452435(AGBL1)

ACHL:

103811697(AGBL1)

SVG:	106860785(AGBL1)

MMEA:

130573383(AGBL1)

HRT:	120758808(AGBL1)

SATI:

136366824(AGBL1)

CCIC:

134049001(AGBL1)

FPG:	101917771(AGBL1)

FCH:	102050219(AGBL1)

CCRI:

104168618(AGBL1)

NNT:

104408812

SHAB:

115613041(AGBL1)

ACUN:

113483991(AGBL1)

TALA:

104365034(AGBL1)

ACHC:

115342097(AGBL1)

HALD:

104321624

HLE:	104834736(AGBL1)

AGEN:

126043743

HHAR:

128151443(AGBL1)

GCL:

127020743

CSTI:

104561864(AGBL1)

LDI:

104353387

DPUB:

104303361(AGBL1)

PPUS:

135182679(AGBL1)

AVIT:

104274620(AGBL1)

BRHI:

104495046(AGBL1)

EGZ:	104122859(AGBL1)

NNI:	104017235(AGBL1)

PCRI:

104030392(AGBL1)

PCAO:

104042567(AGBL1)

PADL:

103926371(AGBL1)

AFOR:

103896730(AGBL1)

FGA:	104074486(AGBL1)

GSTE:

104260414(AGBL1)

CBOY:

140655655(AGBL1)

CLV:	102094300(AGBL1)

MUI:	104548389(AGBL1)

PGUU:

104467265

EHS:

104510013

CMAC:

104479622(AGBL1)

CUCA:

104069025(AGBL1)

TEO:	104376653(AGBL1)

BREG:

104643078(AGBL1)

OHA:	104332088(AGBL1)

ACAR:

104527849(AGBL1)

CPEA:

104391957(AGBL1)

CVF:	104288790(AGBL1)

RTD:	128915195(AGBL1)

CRID:

134520278(AGBL1)

AAM:	106497341(AGBL1)

AROW:

112969691(AGBL1)

NPD:	112944807(AGBL1)

TGT:	104576097(AGBL1)

DNE:

112985635

SCAM:

104148385(AGBL1)

ASN:	102375387(AGBL1)

AMJ:	106737155(AGBL1)

CPOO:

109308777(AGBL1)

GGN:	109288304(AGBL1)

PSS:

102454920

CMY:	102943192(AGBL1)

CCAY:

125643994(AGBL1)

DCC:	119862508(AGBL1)

CPIC:

101936265(AGBL1)

TST:	117884477(AGBL1)

CABI:

116840121(AGBL1)

MRV:	120374067(AGBL1)

ASAO:

132762695(AGBL1)

PVT:	110072942(AGBL1)

SUND:

121932423(AGBL1)

PBI:	103067702(AGBL1)

PMUR:

107284150(AGBL1)

CTIG:

120315237(AGBL1)

PGUT:

117669904(AGBL1)

APRI:

131184815(AGBL1)

PTEX:

113441997(AGBL1)

NSS:	113415550(AGBL1)

VKO:	123030792(AGBL1)

PMUA:

114584494(AGBL1)

PRAF:

128401493(AGBL1)

ZVI:	118093025(AGBL1)

HCG:	128334857(AGBL1)

GJA:	107109522(AGBL1)

STOW:

125424535(AGBL1)

EMC:	129345851(AGBL1)

XLA:	108711466(agbl1.L) 108712837(agbl1.S)

XTR:	100485158(agbl1)

NPR:	108786947(AGBL1)

RTEM:

120930332(AGBL1)

BBUF:

120985954(AGBL1)

BGAR:

122927535(AGBL1)

PWL:	138283507(AGBL1)

MUO:	115462483(AGBL1)

GSH:	117348651(AGBL1)

DRE:	100536841(agbl1)

SRX:	107707416 107714006

SANH:

107654140 107701621

SGH:	107581853 107583140

CCAR:

109069815 122135674

CAUA:

113043076 113066391 113082681

CGIB:

PTET:

LROH:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

MASI:

TROS:

TDW:

MANU:

129433998(agbl1)

PDAB:

135753418 135781218 135788153

IPU:

108269067

IFU:

128611019

PHYP:

113546615(agbl1)

SMEO:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:	113579058 113590409

CHAR:

105892127

SPIL:

134094696

TBEN:

117491749

CGOB:

115009878(agbl1)

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

114560446(agbl1)

GAT:

PPUG:

AFB:

CLUM:

CANA:

CVE:

MSAM:

SCHU:

SPUL:

LMIX:

ASTR:

MZE:

ONL:

OAU:

AOCE:

EJA:

BFRE:

MCEP:

CSEM:

POV:

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

111647738(agbl1)

XGL:

120792788

HCQ:	109513058(agbl1)

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

ENY:	140349423(agbl1)

BSPL:

SJO:

SSCO:

GMH:

SASA:

STRU:

OTW:

OMY:

OGO:

ONE:

OKI:

OKE:

OMM:

OCLA:

SALP:

SNH:

CCLU:

ELS:	105018600(agbl1)

OEP:

134020684

SFM:	108926553 108941199

PKI:	111845017 111845721

AANG:

118215535 118228008

AROT:

135242284 135255503

CCOG:

133111399 133130868

LOC:	102692475(agbl1)

PSPA:

121299046

ARUT:

117428351 117429368

PSEX:

120541399

LCM:	102348649(AGBL1)

CMK:

RTP:

HOC:

LERI:

PMRN:

AGIF:

APLN:

PPYR:

DVT:

CSEC:

DMK:

PJA:

PTRU:

RSAN:

RES:

Reference

PMID:21074048

Authors

Rogowski K, van Dijk J, Magiera MM, Bosc C, Deloulme JC, Bosson A, Peris L, Gold ND, Lacroix B, Bosch Grau M, Bec N, Larroque C, Desagher S, Holzer M, Andrieux A, Moutin MJ, Janke C

Title

A family of protein-deglutamylating enzymes associated with neurodegeneration.

Journal

Cell 143:564-78 (2010)
DOI:10.1016/j.cell.2010.10.014

Sequence

[mmu:244071]

LinkDB

DBGET integrated database retrieval system