KEGG ORTHOLOGY: K23967

ORTHOLOGY: K23967

Entry

K23967                      KO

Symbol

SLC12A5, KCC2

Name

solute carrier family 12 (potassium/chloride transporter), member 5

Pathway

map04727

GABAergic synapse

Disease

H00606

Early infantile epileptic encephalopathy

H00808

Idiopathic generalized epilepsies

H01815

Malignant migrating partial seizures in infancy

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    K23967  SLC12A5, KCC2; solute carrier family 12 (potassium/chloride transporter), member 5
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K23967  SLC12A5, KCC2; solute carrier family 12 (potassium/chloride transporter), member 5
Transporters [BR:ko02000]
Solute carrier family (SLC)
  SLC12: Electroneutral cation-coupled Cl cotransporter
   K23967  SLC12A5, KCC2; solute carrier family 12 (potassium/chloride transporter), member 5

Other DBs

GO:

0015379

TC:	2.A.30.1.14 2.A.30.1.18 2.A.30.1.19 2.A.30.1.21

Genes

HSA:	57468(SLC12A5)

PTR:	458295(SLC12A5)

PPS:	100973004(SLC12A5)

GGO:	101125585(SLC12A5)

PON:	100456689(SLC12A5)

PPYG:

129021787(SLC12A5)

NLE:	100587538(SLC12A5)

HMH:	116461333(SLC12A5)

SSYN:

129474726(SLC12A5)

MCC:	707974(SLC12A5)

MCF:	102118056(SLC12A5)

MTHB:

126963799

MNI:	105496467(SLC12A5)

CSAB:

103245072(SLC12A5)

CATY:

105588505(SLC12A5)

PANU:

101007463(SLC12A5)

TGE:	112632529(SLC12A5)

MLEU:

105542291(SLC12A5)

RRO:	104678816(SLC12A5)

RBB:	108533325(SLC12A5)

TFN:	117068859(SLC12A5)

PTEH:

111530011(SLC12A5)

CANG:

105502409(SLC12A5)

CJC:	100415705(SLC12A5)

SBQ:	101036025(SLC12A5)

CIMI:

108313046(SLC12A5)

ANAN:

105727368(SLC12A5)

CSYR:

103260278(SLC12A5)

MMUR:

105859285(SLC12A5)

LCAT:

123622568(SLC12A5)

ERUF:

138401150(SLC12A5)

PCOQ:

105807171(SLC12A5)

OGA:	100943127(SLC12A5)

MMU:	57138(Slc12a5)

MCAL:

110307919(Slc12a5)

MPAH:

110317619(Slc12a5)

RNO:	171373(Slc12a5)

MCOC:

116091384(Slc12a5)

ANU:	117703105(Slc12a5)

ASYL:

127686252(Slc12a5)

MUN:	110549296(Slc12a5)

CGE:	100768413(Slc12a5)

MAUA:

101831181(Slc12a5)

PROB:

127223668(Slc12a5)

PLEU:

114692636(Slc12a5)

PMAV:

102915311(Slc12a5)

MORG:

121460290(Slc12a5)

MFOT:

126506957

AAMP:

119814479(Slc12a5)

CNL:	130881185(Slc12a5)

NGI:	103751233(Slc12a5)

HGL:	101716676(Slc12a5)

CPOC:

100721877(Slc12a5)

CCAN:

109689298(Slc12a5)

DORD:

105981754(Slc12a5)

DSP:	122120229(Slc12a5)

DMER:

138805235(Slc12a5)

PLOP:

125353850(Slc12a5)

NCAR:

124977122

MMMA:

107135898(Slc12a5)

ITI:	101956950(Slc12a5)

OCU:

100354476

OPI:	101533174(SLC12A5)

OCZ:	121157070(SLC12A5)

TUP:	102500090(SLC12A5)

GVR:	103589572(SLC12A5)

CFA:	485905(SLC12A5)

CLUD:

112674055(SLC12A5)

VVP:	112931852(SLC12A5)

VLG:	121478131(SLC12A5)

NPO:	129495143(SLC12A5)

AML:	100475670(SLC12A5)

UMR:	103669853(SLC12A5)

UAH:	113258672(SLC12A5)

UAR:	123797064(SLC12A5)

ELK:

111141395

LLV:

125108651

MPUF:

101673738(SLC12A5)

MNP:	132021988(SLC12A5)

MLK:	131807759(SLC12A5)

NVS:	122916016(SLC12A5)

ORO:	101380800(SLC12A5)

EJU:	114223145(SLC12A5)

ZCA:	113937555(SLC12A5)

MLX:	118011060(SLC12A5)

MANO:

123851846(SLC12A5)

NSU:	110579531(SLC12A5)

LWW:

102726643

FCA:	101085617(SLC12A5)

PYU:	121012097(SLC12A5)

PCOO:

112869469(SLC12A5)

PBG:	122467322(SLC12A5)

PVIV:

125161909(SLC12A5)

LRUF:

124504276

LGF:	123580096(SLC12A5)

AJU:

106969011

PTG:	102971765(SLC12A5)

PPAD:

109272344(SLC12A5)

PUC:

125936518

PLEZ:

122214888(SLC12A5)

HHV:	120243318(SLC12A5)

CCRU:

144233536(SLC12A5)

BTA:	510157(SLC12A5)

BOM:	102273424(SLC12A5)

BIU:	109567508(SLC12A5)

BJV:	133259826(SLC12A5)

BBUB:

102415207(SLC12A5)

BKE:	129626027(SLC12A5)

BBIS:

104985102(SLC12A5)

CHX:	102168745(SLC12A5)

OAS:	101114128(SLC12A5)

OCAN:

138417781(SLC12A5)

BTAX:

128058123(SLC12A5)

CSUM:

138091876(SLC12A5)

ODA:	120869125(SLC12A5)

CCAD:

122448172(SLC12A5)

MREE:

136158034(SLC12A5)

OVR:	110133344(SLC12A5)

MBEZ:

129555992(SLC12A5)

SSC:	100155991(SLC12A5)

CFR:	102510238(SLC12A5)

CBAI:

105071884(SLC12A5)

CDK:	105087846(SLC12A5)

VPC:	102527638(SLC12A5)

BACU:

103015498(SLC12A5)

BMUS:

118880830(SLC12A5)

LVE:	103085959(SLC12A5)

OOR:	101278335(SLC12A5)

LALB:

132506457(SLC12A5)

GMF:	115848235(SLC12A5)

DDP:	132437506(SLC12A5)

DLE:	111170137(SLC12A5)

PCAD:

102978221(SLC12A5)

PSIU:

116740768(SLC12A5)

PPHC:

136134450(SLC12A5)

NASI:

112400881(SLC12A5)

ECB:	100071141(SLC12A5)

EPZ:	103551920(SLC12A5)

EAI:	106842994(SLC12A5)

MYB:	102246513(SLC12A5)

MYD:	102764870(SLC12A5)

MMYO:

118662782(SLC12A5)

MLF:	102439869(SLC12A5)

MDT:	132239873(SLC12A5)

MYUM:

139014085(SLC12A5)

PKL:	118707738(SLC12A5)

EFUS:

103301956(SLC12A5)

MNA:	107530892(SLC12A5)

DRO:	112303820(SLC12A5)

SHON:

118985554(SLC12A5)

AJM:	119063182(SLC12A5)

PDIC:

114506583(SLC12A5)

PHAS:

123814911(SLC12A5)

MMF:	118618321(SLC12A5)

PPAM:

129070435(SLC12A5)

HAI:	109379968(SLC12A5)

RFQ:	117015818(SLC12A5)

PALE:

102889763(SLC12A5)

PGIG:

120603744(SLC12A5)

PVP:	105298250(SLC12A5)

RAY:	107514533(SLC12A5)

MJV:	108392901(SLC12A5)

TOD:	119236078(SLC12A5)

SARA:

101545796(SLC12A5)

SFUM:

130030080(SLC12A5)

SETR:

126017278(SLC12A5)

LAV:	100665891(SLC12A5)

TMU:

101346104

ETF:	101657051(SLC12A5)

DNM:	101439659(SLC12A5)

MDO:	100017031(SLC12A5)

GAS:	123235270(SLC12A5)

SHR:	100934829(SLC12A5)

AFZ:

127550775

PCW:	110193619(SLC12A5)

TVP:	118841208(SLC12A5)

PBRV:

138141842(SLC12A5)

MLAO:

141505392(SLC12A5)

OAA:	100681795(SLC12A5)

TACU:

119931602(SLC12A5)

GGA:	777252(SLC12A5)

PCOC:

116225505(SLC12A5)

MGP:	100548060(SLC12A5)

CJO:	107323123(SLC12A5)

TPAI:

128080829(SLC12A5)

LMUT:

125701057(SLC12A5)

NMEL:

110408080(SLC12A5)

APLA:

101793609(SLC12A5)

AACU:

137865231(SLC12A5)

OJA:	118176893(SLC12A5)

ACYG:

106047144(SLC12A5)

CATA:

118258379(SLC12A5)

AFUL:

116495628(SLC12A5)

TGU:	100230546(SLC12A5)

LSR:	110476153(SLC12A5)

VMC:	128815910(SLC12A5)

VCHA:

128796728(SLC12A5)

AIB:	137484080(SLC12A5)

SCAN:

103818816(SLC12A5)

PMOA:

120497853(SLC12A5)

OTC:	121343813(SLC12A5)

PRUF:

121359679(SLC12A5)

ATRC:

139599602(SLC12A5)

MATE:

118694426(SLC12A5)

MAEN:

136564068(SLC12A5)

GFR:	102039076(SLC12A5)

FAB:	101814051(SLC12A5)

OMA:	130261443(SLC12A5)

PHI:	102112490(SLC12A5)

PMAJ:

107213221(SLC12A5)

CCW:	104687863(SLC12A5)

CBRC:

103617296(SLC12A5)

ACOE:

138120923(SLC12A5)

ETL:	114063007(SLC12A5)

ZAB:	102071960(SLC12A5)

ZLE:	135456442(SLC12A5)

SVG:	106860858(SLC12A5)

MMEA:

130573478(SLC12A5)

HRT:	120759930(SLC12A5)

SATI:

136368456(SLC12A5)

CFAI:

136298164(SLC12A5)

CCIC:

134051506(SLC12A5)

FPG:	101912982(SLC12A5)

FCH:	102060157(SLC12A5)

FRS:	119154495(SLC12A5)

SHAB:

115615017(SLC12A5)

POCC:

134166258(SLC12A5)

ANOC:

141966851(SLC12A5)

SURA:

141951505(SLC12A5)

TALA:

116965376(SLC12A5)

ACHC:

115338765(SLC12A5)

HLE:	104833149(SLC12A5)

AGEN:

126045360

HHAR:

128139758(SLC12A5)

BBUT:

142028795(SLC12A5)

GCL:

127023155

DPUB:

104301480(SLC12A5)

PPUS:

135188527(SLC12A5)

IIN:	128975272(SLC12A5)

EGZ:	104127956(SLC12A5)

NNI:	104018332(SLC12A5)

PARX:

142064328(SLC12A5)

AFOR:

103899129(SLC12A5)

CBOR:

142089894(SLC12A5)

CBOY:

140659388(SLC12A5)

MAME:

142416840(SLC12A5)

CLV:	102087561(SLC12A5)

CNIC:

135994999(SLC12A5)

CUCA:

104057074(SLC12A5)

PCUR:

138728489(SLC12A5)

GAME:

129214260(SLC12A5)

CPEA:

104385565(SLC12A5)

CVF:	104293959(SLC12A5)

RTD:	128916500(SLC12A5)

CRID:

134522524(SLC12A5)

LMIC:

141750318(SLC12A5)

NARQ:

141471273(SLC12A5)

AAM:	106497583(SLC12A5)

AROW:

112961680(SLC12A5)

NPD:	112949697(SLC12A5)

TGT:

104575469

DNE:

112992150

SCAM:

104140405(SLC12A5)

ASN:	102373683(SLC12A5)

CPOO:

109313298(SLC12A5)

GGN:	109292343(SLC12A5)

CIZ:	142021982(SLC12A5)

CMY:	102941888(SLC12A5)

CCAY:

125622298(SLC12A5)

LKP:	140897273(SLC12A5)

NDS:	141997504(SLC12A5)

DCC:	119841731(SLC12A5)

CPIC:

101935680(SLC12A5)

TST:	117885974(SLC12A5)

EOB:	135887136(SLC12A5)

CABI:

116833815(SLC12A5)

MRV:	120380186(SLC12A5)

EMQ:	137157271(SLC12A5)

ACS:	100554321(slc12a5)

ASAO:

132772944(SLC12A5)

PVT:	110086239(SLC12A5)

SUND:

121929943(SLC12A5)

PBI:	103064066(SLC12A5)

PMUR:

107299439(SLC12A5)

CTIG:

120307560(SLC12A5)

PGUT:

117669600(SLC12A5)

PCAE:

139315531(SLC12A5)

APRI:

131194747(SLC12A5)

PTEX:

113450555(SLC12A5)

NSS:	113425355(SLC12A5)

VKO:	123018853(SLC12A5)

PMUA:

114599898(SLC12A5)

PRAF:

128416736(SLC12A5)

ZVI:	118089294(SLC12A5)

HCG:	128323341(SLC12A5)

GJA:

107107474

STOW:

125432618(SLC12A5)

EMC:	129330121(SLC12A5)

XLA:	100380948(slc12a5.L) 108702731

XTR:	779759(slc12a5)

NPR:	108789112(SLC12A5)

RTEM:

120918558(SLC12A5)

ACAT:

141113247(SLC12A5)

PADS:

140325780(SLC12A5)

BBUF:

121003331(SLC12A5)

BGAR:

122940680(SLC12A5)

DTC:	141069634(SLC12A5)

HSQ:	130297472(SLC12A5)

PCOB:

135055892(SLC12A5)

PWL:	138303945(SLC12A5)

MUO:	115476891(SLC12A5)

GSH:	117368874(SLC12A5)

DRE:	572215(slc12a5a) 797331(slc12a5b)

DAES:

130233212(slc12a5b)

SRX:	107725712 107740262 107744354 107747216

SANH:

107683884 107696391 107702850

SGH:	107550951 107560501 107587628

CCAR:

109052155 109058684 109092015 109110634(slc12a5a)

CAUA:

113051155 113070727 113104808 113104862 113107371

CGIB:

127960290 127963250 128016028 128018366

PTET:

122347417(slc12a5a) 122350727(slc12a5b)

LROH:

127166696(slc12a5a) 127170296(slc12a5b)

GRF:	141286616(slc12a5b) 141347623(slc12a5a)

OMC:	131542650(slc12a5a) 131545669

PPRM:

120486091(slc12a5b) 120494170(slc12a5a)

RKG:	130081937(slc12a5b) 130104141(slc12a5a)

MAMB:

125273351(slc12a5a) 125280219(slc12a5b)

CIDE:

127514639 127517277 127517312

CERY:

137010570(slc12a5a) 137026581(slc12a5b)

MASI:

127414632 127424526 127446028 127449602

TROS:

130557271(slc12a5a) 130568022(slc12a5b)

TDW:	130424589(slc12a5a) 130440027(slc12a5b)

MANU:

129413813(slc12a5b) 129450271(slc12a5a)

PDAB:

135729676(slc12a5b) 135769930(slc12a5a)

IPU:	108265753(slc12a5b) 108271755(slc12a5a)

IFU:	128607519(slc12a5b) 128615203(slc12a5a)

PHYP:

113532809(slc12a5) 113533457

SMEO:

124383852(slc12a5a) 124399566(slc12a5b)

TFD:	113643060(slc12a5a) 113656049(slc12a5b)

TVC:	132844615(slc12a5a) 132853854(slc12a5b)

CGAR:

128526442(slc12a5a) 128530214(slc12a5b)

NGRA:

132884409(slc12a5a) 132892920(slc12a5b)

TRN:	134316932(slc12a5a) 134317868(slc12a5b)

AMEX:

103035347(slc12a5a) 103040464(slc12a5b)

CMAO:

118808508(slc12a5a) 118813621(slc12a5b)

EEE:	113571623(slc12a5) 113578764

CHAR:

105906774(slc12a5b) 105907484(slc12a5a)

SPIL:

134086961(slc12a5b) 134091836(slc12a5a)

ASAD:

121707863(slc12a5a) 121713604(slc12a5b)

TRU:	101068412(slc12a5)

TFS:	130524392(slc12a5a) 130530023(slc12a5b)

TNG:	GSTEN00033235G001 GSTEN00033866G001

LCO:	104935331 104938195

NCC:	104945703(slc12a5) 104956320

TBEN:

117479512 117489468(slc12a5a)

CGOB:

115007751 115011235

PGEO:

117447078 117449870

GACU:

117539543(slc12a5a) 117540763(slc12a5b)

EMAC:

134870998 134882671(slc12a5a)

ELY:	117256762(slc12a5a) 117258493(slc12a5b)

EFO:	125892191(slc12a5b) 125897925(slc12a5a)

PLEP:

121946701(slc12a5b) 121959116(slc12a5a)

SLUC:

116051435(slc12a5a) 116062161

SVIT:

144517140(slc12a5a) 144520322(slc12a5b)

ECRA:

117943976(slc12a5a) 117948029(slc12a5b)

ESP:	116688254 116693153

PFLV:

114553566 114558511

PFLT:

120556716(slc12a5a) 120559653(slc12a5b)

GAT:	120829758 120835654(slc12a5a)

PPUG:

119222277 119229912(slc12a5a)

AFB:	129099516(slc12a5b) 129105507(slc12a5a)

CLUM:

117730820(slc12a5a) 117734041(slc12a5b)

PSWI:

130208938(slc12a5a)

CANA:

137796825(slc12a5a) 137800350

CVE:	137873954(slc12a5a) 137887008

AMIR:

142950704(slc12a5b) 142955341(slc12a5a)

MSAM:

119885681(slc12a5a)

SCHU:

122883342(slc12a5b) 122884774(slc12a5a)

EARM:

139283460(slc12a5a) 139288535(slc12a5b)

CUD:	121506848(slc12a5a) 121517447(slc12a5b)

SPUL:

138590129(slc12a5b) 138605595(slc12a5a)

LMIX:

132978225(slc12a5a) 132989413(slc12a5b)

HTC:	141789225(slc12a5a) 141798810

ALAT:

119020936(slc12a5a) 119023505(slc12a5b)

ASTR:

137594967(slc12a5a) 137608402(slc12a5b)

PKLU:

139209494 139209794(slc12a5a)

MZE:	101469905 101473208(slc12a5a)

ONL:	100697313 100704187

OAU:	116319281(slc12a5a) 116324794(slc12a5b)

OLA:	101165388 101167708

OML:	112145359(slc12a5a) 112159734(slc12a5b)

CSAI:

133448368(slc12a5a) 133457041(slc12a5b)

XMA:	102230568 102237626

XCO:	114135544 114147138

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122828854(slc12a5b) 122833505(slc12a5a)

PPRL:

129370245(slc12a5b) 129372613(slc12a5a)

CVG:	107097098 107097555

CTUL:

119773307(slc12a5a) 119774056(slc12a5b)

GMU:	124856997(slc12a5a) 124868835(slc12a5b)

NFU:	107385410(slc12a5) 107391132

KMR:	108231590(slc12a5a) 108232092(slc12a5b)

ALIM:

106517663 106523074

NWH:	119411869(slc12a5a) 119416643

LTU:	140272223(slc12a5b) 140303101(slc12a5a)

AOCE:

111584756(slc12a5a)

EJA:	138193262 138197368(slc12a5a)

BFRE:

138616626(slc12a5a) 138636205(slc12a5b)

MCEP:

125006521(slc12a5a) 125023955(slc12a5b)

CSEM:

103386749

POV:	109635308 109635573

SSEN:

122768268(slc12a5a) 122777241(slc12a5b)

SSOE:

131461343(slc12a5a) 131468871(slc12a5b)

HHIP:

117761646(slc12a5a) 117764329(slc12a5b)

HSP:	118105155(slc12a5a) 118111615(slc12a5b)

PPLT:

128442960(slc12a5b) 128448961(slc12a5a)

SMAU:

118308954(slc12a5a) 118317343(slc12a5b)

LCF:	108873542(slc12a5a) 108889499(slc12a5b)

SDU:	111217281 111219414

SLAL:

111662324 111667168

XGL:	120782932(slc12a5a) 120803850(slc12a5b)

HCQ:	109507923 109528739

SSCV:

125977378(slc12a5a) 125989394(slc12a5b)

SBIA:

133494778 133507959(slc12a5a)

PEE:	133403684 133409226(slc12a5a)

PTAO:

133480484(slc12a5b) 133484188(slc12a5a)

BPEC:

110158059 110174334

ENY:	140363248 140365582(slc12a5a)

MALB:

109951136 109951331

BSPL:

114855488(slc12a5a) 114858263

SJO:	128356241(slc12a5a) 128356794

SSCO:

133977955(slc12a5a) 133987141(slc12a5b)

TTY:	137181206(slc12a5a) 137184670(slc12a5b)

GMH:	115529221(slc12a5) 115553368

SASA:

106565077 106566649 106571859 106583680

STRU:

115150086 115166320 115168458 115208377

OTW:	112215726 112222271 112255357(slc12a5a) 112267067

OMY:	110492468 110493888 110529040 110531958

OGO:	124003767 124026085(slc12a5a) 124031663 124045644

ONE:	115102047 115131840 115142852 115144217

OKI:	109869521 109890319 109891153

OKE:	118359427 118361125 118388930 118399720

OMM:	135527925 135539552 135541368(slc12a5a)

OCLA:

139368829 139370672 139413865 139416242

SALP:

111960734 111966874 111976942

SNH:	120058761(slc12a5b) 120061653 120064447 120064854(slc12a5a)

SFON:

129815714 129830445 129840644 129861062

CCLU:

121538594 121545357 121574663 121577966(slc12a5a)

ELS:	105007608 105007671(slc12a5)

OEP:	134018854(slc12a5b) 134018882(slc12a5a)

SFM:	108930435 108936610(slc12a5)

PKI:	111835898(slc12a5) 111844684

AANG:

118208200(slc12a5b) 118211609(slc12a5a)

AROT:

135233961(slc12a5b) 135237806(slc12a5a)

CCOG:

133110025(slc12a5a) 133138476

LOC:	102694176(slc12a5) 102696718

PSPA:

121298245 121319438

ARUT:

117423729 117432547

PSEX:

120515121(slc12a5a)

LCM:	102358345(SLC12A5)

CMK:	103191302(si:cabz01102082.1)

RTP:

CPLA:

CPUN:

HOC:

SCAU:

STOZ:

LERI:

HAKA:

PMRN:

PMEO:

Reference

PMID:12106695

Authors

Song L, Mercado A, Vazquez N, Xie Q, Desai R, George AL Jr, Gamba G, Mount DB

Title

Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter.

Journal

Brain Res Mol Brain Res 103:91-105 (2002)
DOI:10.1016/s0169-328x(02)00190-0

Sequence

[hsa:57468]

LinkDB

DBGET integrated database retrieval system