KEGG ORTHOLOGY: K23992

ORTHOLOGY: K23992

Entry

K23992                      KO

Symbol

K23992

Name

1L-myo-inositol 1-phosphate cytidylyltransferase / CDP-L-myo-inositol myo-inositolphosphotransferase [EC:2.7.7.74 2.7.8.34]

Pathway

map00562

Inositol phosphate metabolism

map01100

Metabolic pathways

Reaction

R09669

CTP:1L-myo-inositol 1-phosphate cytidylyltransferase

R09670

CDP-1L-myo-inositol:1L-myo-inositol 1-phosphate myo-inositolphosphotransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K23992  K23992; 1L-myo-inositol 1-phosphate cytidylyltransferase / CDP-L-myo-inositol myo-inositolphosphotransferase
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.74  1L-myo-inositol 1-phosphate cytidylyltransferase
     K23992  K23992; 1L-myo-inositol 1-phosphate cytidylyltransferase / CDP-L-myo-inositol myo-inositolphosphotransferase
   2.7.8  Transferases for other substituted phosphate groups
    2.7.8.34  CDP-L-myo-inositol myo-inositolphosphotransferase
     K23992  K23992; 1L-myo-inositol 1-phosphate cytidylyltransferase / CDP-L-myo-inositol myo-inositolphosphotransferase

Other DBs

COG:	COG1213 COG0558

Genes

MTHD:

A3224_07290

ENM:

EBS_0412

NAR:

Saro_0100

NOR:	FA702_11455

NOL:	NSDW_34720

SPAP:

H3Z74_16915

SSAG:

KV697_19515

ACOB:

P0Y56_05700

ERY:	CP97_03755

PORL:

BG023_11496

PHZ:	CHX26_13940

DBK:	DGMP_08060

DAO:	Desac_2272

SFU:

Sfum_2920

TID:	Thein_0126

TAV:	G4V39_06760

TMAI:

FVE67_04000

DAW:	HS1_001332

CCRO:

PAUU:

BSED:

PCAY:

CTHU:

NTR:	B0W44_00905

TMR:

Tmar_0126

THEF:

E1B22_04180

THEP:

DYI95_000435

TCP:	Q5761_00445

TPZ:	Tph_c20790

KME:	H0A61_00158(spsI)

ATL:	Athai_19700

RXY:

Rxyl_1212

TTR:

Tter_0472

SSM:	Spirs_4227

ADIN:

H7849_05720

RCG:	N7E81_10675

RLO:	GQ464_016105

AAE:	aq_1367(spsI)

PMX:	PERMA_1921

TTK:

TST_0884

NDE:

NIDE0736

NMV:	NITMOv2_0605

NIO:	NITINOP_0313

NJA:

NSJP_1717

NTI:	DNFV4_01008

NALL:

PP769_08355

NNEO:

PQG83_19595

NLI:	G3M70_02610 G3M70_02615

MOX:

DAMO_2608

MIF:	Metin_0454

MIG:	Metig_1787

METF:

CFE53_00410

AFU:

AF_0263

AFG:	AFULGI_00002550

APO:	Arcpr_0766

AVE:	Arcve_1159 Arcve_2013

AST:	Asulf_00859

FPL:	Ferp_0148 Ferp_0859

GAC:

GAH:

PFU:

PFI:

PHO:	PH1219(PH1219)

PAB:

PAB2433

PYN:

PNA2_1704

PYA:	PYCH_00120

PYS:

Py04_1010

PYC:	TQ32_04290

TKO:

TON:

TGA:

TSI:

TBA:	TERMP_01130

THE:

THA:

THM:

TLT:

THS:

TNU:

TEU:

TCH:	CHITON_0904

TPEP:

A0127_03970

TGG:	A3K92_01915

TCE:	A3L02_05685

TBS:	A3L01_06850

THH:	CDI07_06820

TSL:	A3L11_01110

TTD:	A3L14_09240

TPRF:

A3L09_03245

TRL:	A3L10_06295

TPAF:

A3L08_00135

THY:	A3L12_02080

TCQ:	TIRI35C_1679

THEI:

PPAC:

IAG:

PABI:

KCR:

Reference

PMID:17526717

Authors

Rodrigues MV, Borges N, Henriques M, Lamosa P, Ventura R, Fernandes C, Empadinhas N, Maycock C, da Costa MS, Santos H

Title

Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles.

Journal

J Bacteriol 189:5405-12 (2007)
DOI:10.1128/JB.00465-07

Sequence

[rxy:Rxyl_1212]

LinkDB

ORTHOLOGY: K07291

Entry

K07291                      KO

Symbol

dipps

Name

CDP-L-myo-inositol myo-inositolphosphotransferase [EC:2.7.8.34]

Pathway

map00562

Inositol phosphate metabolism

map01100

Metabolic pathways

Reaction

R09670

CDP-1L-myo-inositol:1L-myo-inositol 1-phosphate myo-inositolphosphotransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K07291  dipps; CDP-L-myo-inositol myo-inositolphosphotransferase
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.8  Transferases for other substituted phosphate groups
    2.7.8.34  CDP-L-myo-inositol myo-inositolphosphotransferase
     K07291  dipps; CDP-L-myo-inositol myo-inositolphosphotransferase

Other DBs

COG:

COG0558

Genes

TBH:	Tbon_07195

TMM:	Tmari_1424

TMI:	THEMA_07225

TMW:

TMQ:

TMX:

TPT:

TNP:

TRQ:

TNA:

THQ:	T2812B_07095

THZ:	CELL2_07155

THR:	TRQ7_06830

APE:	APE_1516.1

ACJ:

ACAM_0952

HBU:

Hbut_0151

PFM:	Pyrfu_0047

PDL:	Pyrde_0747

PABI:

PABY_04630

PARE:

PYJP_15570

» show all

Reference

PMID:17360515

Authors

Rodionov DA, Kurnasov OV, Stec B, Wang Y, Roberts MF, Osterman AL

Title

Genomic identification and in vitro reconstitution of a complete biosynthetic pathway for the osmolyte di-myo-inositol-phosphate.

Journal

Proc Natl Acad Sci U S A 104:4279-84 (2007)
DOI:10.1073/pnas.0609279104

LinkDB

ENZYME: 2.7.8.34

Entry

EC 2.7.8.34                 Enzyme

Name

CDP-L-myo-inositol myo-inositolphosphotransferase;
CDP-inositol:inositol-1-phosphate transferase (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS));
DIPPS (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS))

Class

Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups

Sysname

CDP-1L-myo-inositol:1L-myo-inositol 1-phosphate myo-inositolphosphotransferase

Reaction(IUBMB)

CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate = CMP + bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate [RN:R09670]

Reaction(KEGG)

R09670

Substrate

CDP-1L-myo-inositol [CPD:C19794];
1L-myo-inositol 1-phosphate [CPD:C04006]

Product

CMP [CPD:C00055];
bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate

Comment

In many organisms this activity is catalysed by a bifunctional enzyme. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 (CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase) uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-1L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors. The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3-phosphate, a widespread organic solute in microorganisms adapted to hot environments.

History

EC 2.7.8.34 created 2011

Pathway

ec00562

Inositol phosphate metabolism

ec01100

Metabolic pathways

Orthology

K07291

CDP-L-myo-inositol myo-inositolphosphotransferase

K23992

1L-myo-inositol 1-phosphate cytidylyltransferase / CDP-L-myo-inositol myo-inositolphosphotransferase

Genes

MTHD:

A3224_07290

ENM:

EBS_0412

NAR:

Saro_0100

NOR:	FA702_11455

NOL:	NSDW_34720

SPAP:

H3Z74_16915

SSAG:

KV697_19515

ACOB:

P0Y56_05700

ERY:	CP97_03755

PORL:

BG023_11496

PHZ:	CHX26_13940

DBK:	DGMP_08060

DAO:	Desac_2272

SFU:

Sfum_2920

TID:	Thein_0126

TAV:	G4V39_06760

TMAI:

FVE67_04000

DAW:	HS1_001332

CCRO:

CMC5_075830

PAUU:

E8A73_025990

BSED:

DN745_05540

PCAY:

FRD00_02815

CTHU:

HUR95_02260

NTR:	B0W44_00905

TMR:

Tmar_0126

THEF:

E1B22_04180

THEP:

DYI95_000435

TCP:	Q5761_00445

TPZ:	Tph_c20790

KME:	H0A61_00158(spsI)

ATL:	Athai_19700

RXY:

Rxyl_1212

TBH:	Tbon_07195

TTR:

Tter_0472

SSM:	Spirs_4227

ADIN:

H7849_05720

RCG:	N7E81_10675

RLO:	GQ464_016105

AAE:	aq_1367(spsI)

PMX:	PERMA_1921

TTK:

TST_0884

TMM:	Tmari_1424

TMI:	THEMA_07225

TMW:

THMA_1448

TMQ:

THMB_1448

TMX:

THMC_1448

TPT:

Tpet_1375

TNP:

Tnap_1393

TRQ:

TRQ2_1311

TNA:

CTN_1075

THQ:	T2812B_07095

THZ:	CELL2_07155

THR:	TRQ7_06830

NDE:

NIDE0736

NMV:	NITMOv2_0605

NIO:	NITINOP_0313

NJA:

NSJP_1717

NTI:	DNFV4_01008

NALL:

PP769_08355

NNEO:

PQG83_19595

NLI:	G3M70_02610 G3M70_02615

MOX:

DAMO_2608

MIF:	Metin_0454

MIG:	Metig_1787

METF:

CFE53_00410

AFU:

AF_0263

AFG:	AFULGI_00002550

APO:	Arcpr_0766

AVE:	Arcve_1159 Arcve_2013

AST:	Asulf_00859

FPL:	Ferp_0148 Ferp_0859

GAC:

GACE_2065

GAH:

GAH_01161

PFU:

PF1058

PFI:

PFC_04525

PHO:	PH1219(PH1219)

PAB:

PAB2433

PYN:

PNA2_1704

PYA:	PYCH_00120

PYS:

Py04_1010

PYC:	TQ32_04290

TKO:

TK2279

TON:

TON_1248

TGA:

TGAM_1853

TSI:

TSIB_1010

TBA:	TERMP_01130

THE:

GQS_09430

THA:

TAM4_5

THM:

CL1_1475

TLT:

OCC_08385

THS:

TES1_1181

TNU:

BD01_1626

TEU:

TEU_00190

TCH:	CHITON_0904

TPEP:

A0127_03970

TGG:	A3K92_01915

TCE:	A3L02_05685

TBS:	A3L01_06850

THH:	CDI07_06820

TSL:	A3L11_01110

TTD:	A3L14_09240

TPRF:

A3L09_03245

TRL:	A3L10_06295

TPAF:

A3L08_00135

THY:	A3L12_02080

TCQ:	TIRI35C_1679

THEI:

K1720_08170

PPAC:

PAP_05835

APE:	APE_1516.1

ACJ:

ACAM_0952

IAG:

Igag_0487

HBU:

Hbut_0151

PFM:	Pyrfu_0047

PDL:	Pyrde_0747

PABI:

PABY_04620 PABY_04630

PARE:

PYJP_15570

KCR:

Kcr_0184

» show all

Reference

1 [PMID:17526717]

Authors

Rodrigues MV, Borges N, Henriques M, Lamosa P, Ventura R, Fernandes C, Empadinhas N, Maycock C, da Costa MS, Santos H

Title

Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles.

Journal

J Bacteriol 189:5405-12 (2007)
DOI:10.1128/JB.00465-07

Sequence

[aae:aq_1367] [afu:AF_0263] [pfu:PF1058] [rxy:Rxyl_1212] [tko:TK2279]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.8.34

IUBMB Enzyme Nomenclature:

2.7.8.34

ExPASy - ENZYME nomenclature database:

2.7.8.34

BRENDA, the Enzyme Database:

2.7.8.34

LinkDB

REACTION: R09670

Entry

R09670                      Reaction

Name

CDP-1L-myo-inositol:1L-myo-inositol 1-phosphate myo-inositolphosphotransferase

Definition

CDP-1L-myo-inositol + 1D-myo-Inositol 3-phosphate <=> CMP + Bis(1L-myo-inositol)-3,1'-phosphate 1-phosphate

Equation

C19794 + C04006 <=> C00055 + C19799

Reaction class

RC00002

C00055_C19794

RC00078

C04006_C19799

Enzyme

2.7.8.34

Pathway

rn00562

Inositol phosphate metabolism

rn01100

Metabolic pathways

Brite

Enzymatic reactions [BR:br08201]
2. Transferase reactions
  2.7  Transferring phosphorus-containing groups
   2.7.8  Transferases for other substituted phosphate groups
    2.7.8.34
     R09670  CDP-1L-myo-inositol + 1D-myo-Inositol 3-phosphate <=> CMP + Bis(1L-myo-inositol)-3,1'-phosphate 1-phosphate

Orthology

K07291

CDP-L-myo-inositol myo-inositolphosphotransferase [EC:2.7.8.34]

K23992

1L-myo-inositol 1-phosphate cytidylyltransferase / CDP-L-myo-inositol myo-inositolphosphotransferase [EC:2.7.7.74 2.7.8.34]

Other DBs

RHEA:

31330

LinkDB

DBGET integrated database retrieval system